8,635 Results Found

Coding sequences of the CLC family genes SaCLCd, SaCLCf, and SaCLCg, the putative orthologs of Arabidopsis thaliana AtCLCd, AtCLCf, and AtCLCg genes, were cloned from the euhalophyte Suaeda altissima (L.) Pall. The key conserved motifs and glutamates...

Drosophila spermatocytes have giant centrioles that display unique properties. Both the parent centrioles maintain a distinct cartwheel and nucleate a cilium-like region that persists during the meiotic divisions and organizes a structured sperm axon...

Recently, great interest has been gained regarding fibroblast activation protein (FAP) as an excellent target for theranostics. Several FAP inhibitor molecules such as [⁶⁸Ga]Ga-labelled FAPI-02, 04, 46, and DOTA.SA.FAPi have been introduced and are h...

Lateral root (LR) formation promotes plant resistance, whereas high-level ethylene induced by abiotic stress will inhibit LR emergence. Considering that local auxin accumulation is a precondition for LR generation, auxin-induced genes inhibiting ethy...

CLC family genes, comprising anion channels and anion/H⁺ antiporters, are widely represented in nearly all prokaryotes and eukaryotes. CLC proteins carry out a plethora of functions at the cellular level. Here the coding sequences of the SaCLCa2 and...

Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA^5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclinical study...

Background/Objectives: Artificial intelligence-based software as a medical device (AI-SaMD) refers to AI-powered software used for medical purposes without being embedded in physical devices. Despite increasing approvals over the past decade, researc...

The MYB transcription factors (TFs) have substantial functions in anthocyanin synthesis as well as being widely associated with plant responses to various adversities. In the present investigation, we found an unreported MYB TF from Solanum acul...

Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential...

Sepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condition with high morbidity and mortality among emergency patients, and it poses a significant risk of chronic renal failure. Clinical treatments for SA-AKI remain reac...

Staphylococcus aureus sequence type (ST) 398 is a lineage affecting both humans and livestock worldwide. However, the mechanisms underlying its clonal evolution are still not clearly elucidated. We applied whole-genome sequencing (WGS) typing to 45 S...

Insects and mammals have atypical centrioles in their sperm. However, it is unclear how these atypical centrioles form. Drosophila melanogaster sperm has one typical centriole called the giant centriole (GC) and one atypical centriole called the prox...

In this paper, the different Ti:Sapphire crystal configurations of the final amplifiers, depending on the Chirped Pulse Amplification laser system parameters, such as the repetition rates and pulse energy, are discussed. Restrictions placed on the fi...

Bisabolene-type sesquiterpenoids, which have multiple bioactivities, including anticancer activity, are one of the main groups of compounds in the essential oil extracted from Santalum album L. and other Santalum species. Bisabolene synthetase (SaBS)...

Antimicrobial immune response is mediated by a signal-transducing sensor, peptidoglycan recognition protein-SA (PGRP-SA), that can recognize non-self molecules. Although several studies have focused on the involvement of Drosophila PGRP-SA in antimic...

Based on the spiking dynamics of the electrically controlled vertical-cavity surface-emitting laser with an embedded saturable absorber (VCSEL-SA), we propose an image transmission system using two unidirectionally coupled VCSEL-SAs and numerically i...

Background/Objectives: The Sigma-1 receptor (Sigmar1), an intracellular chaperone protein, is ubiquitously expressed throughout the body, but its role in peripheral organs, such as the kidneys, remains unclear. Here, we investigated the protective ef...

In today’s global markets, issues related to Corporate Social Responsibility have greater importance on business performance, and international standards are defined as tools for companies to internalize their sustainability requests. The aim o...

Cancer immunoprevention leverages the immune system’s surveillance mechanisms to mitigate tumor development. Vaccines that constitute a tumor antigen and an immune adjuvant are perceived as immunoprevention modalities. However, relevant tumor a...

The Drosophila eye displays peculiar sensory organs of unknown function, the mechanosensory bristles, that are intercalated among the adjacent ommatidia. Like the other Drosophila sensory organs, the mechanosensory bristles consist of a bipolar neuro...

Proteinaceous nanovaccine delivery systems have significantly promoted the development of various high-efficiency vaccines. However, the widely used method of coupling the expression of scaffolds and antigens may result in their structural interferen...

Galileo Signal Authentication Service (SAS) is an assisted signal authentication capability under development by Galileo, designed to enhance the robustness of the European Global Navigation Satellite System (GNSS) against malicious attacks like spoo...

In the tailed bacteriophages, DNA is packaged into spherical procapsids, leading to expansion into angular, thin-walled mature capsids. In many cases, this maturation is accompanied by cleavage of the major capsid protein (CP) and other capsid-associ...

Ecdysteroid hormones are key regulators of insect development and metamorphosis. Ecdysone-inducible E75, a major component of insect ecdysone signaling pathway, has been well characterized in holometabolous insects, however, barely in hemimetabolous...

Companies are increasingly required to deal with sustainability issues through the adoption of Corporate Social Responsibility (CSR) practices. Among the different CSR aspects, workers securities fulfill a necessary issue. SA8000 is an internationall...

The attenuated Japanese encephalitis virus (JEV) strain SA14-14-2 has been successfully utilized to prevent JEV infection; however, the attenuation determinants have not been fully elucidated. The envelope (E) protein of the attenuated JEV SA14-14-2...

In the framework of electromechanical energy conversion devices for vibrational energy harvesting, magnetostrictive materials are an attractive alternative solution to the brittleness of piezoelectric materials. Electromagnetic systems have low volta...

A pulse oximeter model linking arterial (SaO₂) and peripheral (SpO₂) oxygen saturation is the terminal part of a mathematical model of neonatal oxygen transport. Previous studies have confirmed the overestimation of oxygen saturation measured by puls...

With the aim of improving the anti-aging properties of nitrile-butadiene rubber (NBR), a functional organic filler, namely LDH–SAS, prepared by intercalating 4-amino-benzenesulfonic acid monosodium salt (SAS) into layered double hydroxides (LDH...

This paper presents a space mission planning tool, which was developed for LEO (Low Earth Orbit) observation satellites. The tool is focused on a two-phase planning strategy with clustering preprocessing and mission planning, where an improved cluste...

Bacillus subtilis SA-15 is a plant growth-promoting bacterium isolated from non-farming soil. We aimed to identify lipopeptides produced by B. subtilis SA-15 and evaluate the control efficacy of B. subtilis SA-15 against large patch disease caused by...

The austenitization kinetics of SA508 Gr.3 steel during heating was studied using the isoconversional method combined with continuous thermal dilatometric tests for the first time. The model-free austenitization kinetics was built and the effective a...

The primary constituents of the essential oil derived from Santalum album L. are (Z)-α-santalol, (Z)-β-santalol, (Z)-α-exo-bergamotol, and (Z)-epi-β- santalol. SaCYP736A167 plays a pivotal role in the biosynthesis of these sesqu...

Background: Self-amplifying mRNA (sa-mRNA) represents a promising platform for vaccines and gene therapies, offering sustained protein expression at low doses through self-replication. For vaccines targeting respiratory pathogens, pulmonary delivery...

Staphylococcus aureus Cas9 (SaCas9) is a widely used genome editing tool. Understanding its molecular mechanisms of DNA cleavage could effectively guide the engineering optimization of this system. Here, we determined the first cryo-electron microsco...

Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and...

Probiotics are increasingly being used as a nutritional supplement by athletes to improve exercise performance and reduce post-exercise fatigue. Lactobacillus salivarius is a natural flora in the gastrointestinal tract of humans and animals. Lactobac...

The conserved MYST proteins form the largest family of histone acetyltransferases (HATs) that acetylate lysines within the N-terminal tails of histone, enabling active gene transcription. Here, we have investigated the biological and regulatory funct...

A new temperature-dependent cyclic plastic model, combining the nonlinear cyclic softening and kinematic hardening rules is established for a nuclear material of SA508-3 steel. A modified isotropic hardening rule is proposed to capture the temperatur...

The Soil Moisture and Ocean Salinity (SMOS) mission is an Earth Explorer Opportunity mission from the European Space Agency (ESA). Its goal is to produce global maps of soil moisture and ocean salinity using the Microwave Imaging Radiometer by Apertu...

The SA-4-1BBL, an oligomeric novel form of the natural ligand for the 4-1BB co-stimulatory receptor of the tumor necrosis factor (TNF) superfamily, as a recombinant protein has potent pleiotropic effects on cells of innate, adaptive, and regulatory i...

The NADP-malic enzyme (NADP-ME) catalyzes the reversible decarboxylation of L-malate to produce pyruvate, CO₂, and NADPH in the presence of a bivalent cation. In addition, this enzyme plays crucial roles in plant developmental and environment respons...

Embolism, hyperglycemia, high intraocular pressure-induced increased reactive oxygen species (ROS) production, and microglial activation result in endothelial/retinal ganglion cell death. Here, we conducted in vitro and in vivo ischemia/reperfusion (...

In this paper, Ti:Sa amplifiers with crystals of the different geometries are discussed. Benefits of using this active medium for a thin disk (TD) and slab amplifiers are evaluated numerically and tested experimentally. Thermal management for amplifi...

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs gene...

To solve the problem of low classification accuracy caused by differences in object types, shapes, and scales in SAS images, an object classification method based on a deformable residual network and transfer learning is proposed. First, a lightweigh...

Uncompensated motion errors can seriously affect the imaging quality of synthetic aperture sonars (SASs). In the existing line-by-line motion compensation (MOCO) algorithms for wide-beam multiple-receiver SAS systems, the approximate form of the rang...

K-homologous (KH) family is a type of nucleic acid-binding protein containing the KH domain and has been found to affect splicing and transcriptional regulation. However, KH family genes haven’t been investigated in plant species systematically...

The distributed material warehouse is the crucial link in the process of modern enterprise construction, and the goal of the enterprise is to save the cost of material distribution and reduce the time of distribution. In order to obtain the optimal o...

HIV-1 Vif plays an essential role in viral replication by antagonizing anti-viral cellular restriction factors, a family of APOBEC3 proteins. We have previously shown that naturally-occurring single-nucleotide mutations in the SA1D2prox region, which...