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941 Results Found

  • Article
  • Open Access
299 Views
15 Pages

Efficient Fine-Grained LuT-Based Optimization of AES MixColumns and InvMixColumns for FPGA Implementation

  • Oussama Azzouzi,
  • Mohamed Anane,
  • Mohamed Chahine Ghanem,
  • Yassine Himeur and
  • Hamza Kheddar

14 December 2025

This paper presents fine-grained Field Programmable Gate Arrays (FPGA) architectures for the Advanced Encryption Standard (AES) MixColumns and InvMixColumns transformations, targeting improved performance and resource utilization. The proposed method...

  • Article
  • Open Access
5 Citations
2,808 Views
14 Pages

Quality Assurance Investigations and Impurity Characterization during Upscaling of [177Lu]Lu-PSMAI&T

  • Stefan Schmitl,
  • Julia Raitanen,
  • Stephan Witoszynskyj,
  • Eva-Maria Patronas,
  • Lukas Nics,
  • Marius Ozenil,
  • Victoria Weissenböck,
  • Thomas L. Mindt,
  • Marcus Hacker and
  • Markus Mitterhauser
  • + 1 author

21 November 2023

[177Lu]Lu-PSMAI&T is widely used for the radioligand therapy of metastatic castration-resistant prostate cancer (mCRPC). Since this kind of therapy has gained a large momentum in recent years, an upscaled production process yielding multiple pati...

  • Article
  • Open Access
16 Citations
4,892 Views
15 Pages

Production and Quality Control of [177Lu]Lu-PSMA-I&T: Development of an Investigational Medicinal Product Dossier for Clinical Trials

  • Valentina Di Iorio,
  • Stefano Boschi,
  • Cristina Cuni,
  • Manuela Monti,
  • Stefano Severi,
  • Giovanni Paganelli and
  • Carla Masini

28 June 2022

Since prostate cancer is the most commonly diagnosed malignancy in men, the theranostic approach has become very attractive since the discovery of urea-based PSMA inhibitors. Different molecules have been synthesized starting from the Glu-urea-Lys sc...

  • Article
  • Open Access
12 Citations
4,476 Views
25 Pages

Reducing LUT Count for FPGA-Based Mealy FSMs

  • Alexander Barkalov,
  • Larysa Titarenko and
  • Kazimierz Krzywicki

25 July 2020

Very often, digital systems include sequential blocks which can be represented using a model of Mealy finite state machine (FSM). It is very important to improve such FSM characteristics as the number of used logic elements, operating frequency and p...

  • Article
  • Open Access
10 Citations
8,240 Views
11 Pages

This paper presents a fast method to extract logic functions of look-up tables (LUTs) from a bitstream in Xilinx FPGAs. In general, FPGAs utilize LUTs as a primary resource to realize a logic function, and a typical N-input LUT comprises 2N 1-bit SRA...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,353 Views
35 Pages

Improving Hardware in LUT-Based Mealy FSMs

  • Alexander Barkalov,
  • Larysa Titarenko and
  • Kazimierz Krzywicki

11 August 2022

The main contribution of this paper is a novel design method reducing the number of look-up table (LUT) elements in the circuits of three-block Mealy finite-state machines (FSMs). The proposed method is based on using codes of collections of outputs...

  • Article
  • Open Access
1 Citations
561 Views
16 Pages

Flexible and Area-Efficient Codesign Implementation of AES on FPGA

  • Oussama Azzouzi,
  • Mohamed Anane,
  • Mohamed Chahine Ghanem,
  • Yassine Himeur and
  • Dominik Wojtczak

As embedded and IoT systems demand secure and compact encryption, developing cryptographic solutions that are both lightweight and efficient remains a major challenge. Many existing AES implementations either lack flexibility or consume excessive har...

  • Article
  • Open Access
2,226 Views
18 Pages

An Efficient Multi-Output LUT Mapping Technique for Field-Programmable Gate Arrays

  • Sheng Lu,
  • Liuting Shang,
  • Qianhou Qu,
  • Sungyong Jung,
  • Qilian Liang and
  • Chenyun Pan

The use of multi-output look-up tables (LUTs) is a widely adopted approach in contemporary commercial field-programmable gate arrays (FPGAs). Larger LUT configurations (e.g., six-input LUTs) can be partitioned into smaller LUTs (e.g., two five-input...

  • Article
  • Open Access
1,898 Views
24 Pages

Reducing Hardware in LUT-Based Mealy FSMs with Encoded Collections of Outputs

  • Alexander Barkalov,
  • Larysa Titarenko and
  • Małgorzata Mazurkiewicz

19 October 2022

A method is proposed that is focused on reducing the chip area occupied by logic elements creating the circuit of Mealy finite state machines (FSMs). The proposed method is aimed at FSM circuits implemented with internal resources of field-programmab...

  • Feature Paper
  • Article
  • Open Access
11 Citations
2,242 Views
30 Pages

Improving Characteristics of LUT-Based Mealy FSMs with Twofold State Assignment

  • Alexander Barkalov,
  • Larysa Titarenko,
  • Kazimierz Krzywicki and
  • Svetlana Saburova

Practically, any digital system includes sequential blocks. This article is devoted to a case when sequential blocks are represented by models of Mealy finite state machines (FSMs). The performance (maximum operating frequency) is one of the most imp...

  • Article
  • Open Access
3 Citations
2,977 Views
29 Pages

Improving Characteristics of LUT-Based Three-Block Mealy FSMs’ Circuits

  • Alexander Barkalov,
  • Larysa Titarenko,
  • Kazimierz Krzywicki and
  • Svetlana Saburova

One of the very important problems connected with FPGA-based design is reducing the hardware amount in implemented circuits. In this paper, we discuss the implementation of Mealy finite state machines (FSMs) by circuits consisting of look-up tables (...

  • Article
  • Open Access
8 Citations
5,962 Views
16 Pages

Factors Affecting the Lut Desert Tourism in Iran: Developing an Interpretive-Structural Model

  • Beniamino Murgante,
  • Mohammad Eskandari Sani,
  • Sara Pishgahi,
  • Moslem Zarghamfard and
  • Fatemeh Kahaki

29 June 2021

The Lut desert is one of the largest and most attractive deserts in Iran. The value of desert tourism remains unclear for Iran’s economy and has only recently been taken into consideration by the authorities, although its true national and internatio...

  • Article
  • Open Access
7 Citations
2,904 Views
34 Pages

Improving the Characteristics of Multi-Level LUT-Based Mealy FSMs

  • Alexander Barkalov,
  • Larysa Titarenko,
  • Kazimierz Krzywicki and
  • Svetlana Saburova

5 November 2020

Contemporary digital systems include many varying sequential blocks. In the article, we discuss a case when Mealy finite state machines (FSMs) describe the behavior of sequential blocks. In many cases, the performance is the most important characteri...

  • Article
  • Open Access
2,183 Views
31 Pages

Improving the Spatial Characteristics of Three-Level LUT-Based Mealy FSM Circuits

  • Alexander Barkalov,
  • Larysa Titarenko,
  • Małgorzata Mazurkiewicz and
  • Kazimierz Krzywicki

26 February 2023

The main purpose of the method proposed in this article is to reduce the number of look-up-table (LUT) elements in logic circuits of sequential devices. The devices are represented by models of Mealy finite state machines (FSMs). Thesee are so-called...

  • Article
  • Open Access
3 Citations
2,177 Views
32 Pages

Improving Characteristics of LUT-Based Sequential Blocks for Cyber-Physical Systems

  • Alexander Barkalov,
  • Larysa Titarenko and
  • Kazimierz Krzywicki

4 April 2022

A method is proposed for optimizing circuits of sequential devices which are used in cyber-physical systems (CPSs) implemented using field programmable gate arrays (FPGAs). The optimizing hardware is a very important problem connected with implementi...

  • Article
  • Open Access
2 Citations
2,679 Views
26 Pages

Using a Double-Core Structure to Reduce the LUT Count in FPGA-Based Mealy FSMs

  • Alexander Barkalov,
  • Larysa Titarenko and
  • Kazimierz Krzywicki

27 September 2022

A method is proposed which aims at reducing the numbers of look-up table (LUT) elements in logic circuits of Mealy finite state machines (FSMs). The FSMs with twofold state assignment are discussed. The reduction is achieved due to using two cores of...

  • Article
  • Open Access
1 Citations
2,944 Views
26 Pages

Using Codes of Output Collections for Hardware Reduction in Circuits of LUT-Based Finite State Machines

  • Alexander Barkalov,
  • Larysa Titarenko,
  • Kazimierz Krzywicki and
  • Kamil Mielcarek

A method is proposed which aims to reduce the hardware in FPGA-based circuits of Mealy finite state machines (FSMs). The proposed method is a type of structural decomposition method. Its main goal is the reducing the number of look-up table (LUT) ele...

  • Communication
  • Open Access
1,653 Views
10 Pages

Performance Investigation of Joint LUT and GS Algorithm at the Transceiver for Nonlinear and CD Compensation

  • Xiaoying Zhang,
  • Jiahao Huo,
  • Haolin Bai,
  • Peng Qin,
  • Wei Huangfu and
  • Keping Long

In order to meet the increasing requirements of speed and distance, an advanced digital signal processing (DSP) algorithm is preferred without changing the system structure in intensity modulation and the direct detection (IM/DD) system. As the trans...

  • Article
  • Open Access
675 Views
12 Pages

We propose a probabilistic shaping (PS) scheme based on a single-layer lookup table (LUT) that employs only one LUT for symbol mapping while achieving favorable system performance. This scheme reduces the average power of the signal by adjusting the...

  • Article
  • Open Access
3 Citations
3,876 Views
20 Pages

The precise determination of the state of health (SOH) of lithium-ion batteries is critical in the domain of battery management systems. The proposed model in this research paper emulates any deep learning or machine learning model by utilizing a Loo...

  • Article
  • Open Access
7 Citations
4,202 Views
22 Pages

Travel to Mars-like Places on Earth: A New Branch of Sustainable Ecotourism in Lut Desert World Heritage Site, Iran

  • Amir Ghorbani,
  • Ali Zangiabadi,
  • Hossein Mousazadeh,
  • Farahnaz Akbarzadeh Almani,
  • Kai Zhu and
  • Lóránt Dénes Dávid

16 June 2023

Traveling to space and walking on other planets has always been a great dream for many tourists. Given that space tourism is not available to everyone, adventurers have always been looking for special and strange places that evoke the feeling of trav...

  • Article
  • Open Access
72 Citations
9,672 Views
26 Pages

12 August 2015

The upcoming satellite mission EnMAP offers the opportunity to retrieve information on the seasonal development of vegetation parameters on a regional scale based on hyperspectral data. This study aims to investigate whether an analysis method for th...

  • Review
  • Open Access
6 Citations
4,527 Views
13 Pages

The Investigative Role of Statins in Ameliorating Lower Urinary Tract Symptoms (LUTS): A Systematic Review

  • Giorgio Ivan Russo,
  • Gaetano Larganà,
  • Arcangelo Sebastianelli,
  • Andrea Cocci,
  • Marina Di Mauro,
  • Ilenia Rapallo,
  • Giuseppe Morgia,
  • Matteo Mario Morgia,
  • Sandro La Vignera and
  • Mauro Gacci
  • + 4 authors

22 January 2021

Previous data have shown that patients with metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement (BPE) could be refractory to the medical treatment. In this context, the evidence suggests a role...

  • Article
  • Open Access
48 Citations
15,692 Views
25 Pages

23 September 2016

Multiplication is the dominant operation for many applications implemented on field-programmable gate arrays (FPGAs). Although most current FPGA families have embedded hard multipliers, soft multipliers using lookup tables (LUTs) in the logic fabric...

  • Article
  • Open Access
1,560 Views
12 Pages

Cracking the LUTS Code: A Pre-Urodynamic Tool for DU vs. BOO Diagnosis in Female Patients with Non-Neurogenic LUTS

  • Karolina Garbas,
  • Łukasz Zapała,
  • Aleksander Ślusarczyk,
  • Tomasz Piecha and
  • Piotr Radziszewski

23 May 2025

Background: Detrusor underactivity (DU) and bladder outlet obstruction (BOO) are common causes of voiding dysfunction in women with lower urinary tract symptoms (LUTS). However, differentiating between them remains challenging due to overlapping clin...

  • Review
  • Open Access
3 Citations
14,013 Views
21 Pages

28 July 2021

Lower urinary tract symptoms (LUTS) are classically characterized as being related to storage (e.g., frequency, urgency, and nocturia) or flow (e.g., weak stream, intermittency, straining, and incomplete emptying). Conventional prescription medicatio...

  • Article
  • Open Access
3 Citations
2,053 Views
13 Pages

Prostate Dimensions and Their Impact on LUTS and Erectile Function: Is Length the Missing Link?

  • Daniel Porav-Hodade,
  • Mihai Dorin Vartolomei,
  • Toader Septimiu Voidazan,
  • Raul Gherasim,
  • Iulia Andras,
  • Ciprian Todea-Moga,
  • Bogdan Ovidiu Feciche,
  • Silvestru-Alexandru Big,
  • Mártha Orsolya Katalin Ilona and
  • Nicolae Crisan

25 November 2024

Background/Objectives: The objective of this study is to explore potential correlations between prostate volume, LUTS, and IIEF, with a particular emphasis on the relationship between prostate dimensions—width, height, and length—and both...

  • Feature Paper
  • Article
  • Open Access
8 Citations
7,821 Views
29 Pages

Multiplication by a constant is a common operation for many signal, image, and video processing applications that are implemented in field-programmable gate arrays (FPGAs). Constant-coefficient multipliers (KCMs) are often implemented in the logic fa...

  • Review
  • Open Access
2 Citations
15,778 Views
25 Pages

6 August 2021

Parts I and II of this three-part series indicated how a global review of both English-language and non-English language papers, plus a focus on a lipidosterolic extract of Serenoa repens (LSESr) having a standardized fatty acid profile, have togethe...

  • Systematic Review
  • Open Access
1 Citations
1,448 Views
20 Pages

Exploring Childhood Lower Urinary Tract Symptoms (LUTS), Urinary Tract Infections (UTIs) and the Microbiome—A Systematic Review

  • Mauro Van den Ende,
  • Laure Van de Steen,
  • Karel Everaert,
  • François Hervé and
  • George Bou Kheir

30 April 2025

Pediatric lower urinary tract symptoms (LUTS) are influenced by age and coexist with nocturnal enuresis (NE) and bladder-bowel dysfunction (BBD). Urinary tract infections (UTIs) are common and linked to LUTS, though the causal relationship remains un...

  • Article
  • Open Access
10 Citations
3,189 Views
12 Pages

Background: The aim of this study was to investigate the effect of lower urinary tract symptoms (LUTS) on behavior related to treatment of Polish adults aged ≥ 40 years. Methods: We conducted a computer-assisted telephone survey with a study sampl...

  • Review
  • Open Access
3 Citations
9,071 Views
16 Pages

2 August 2021

Part I of this 3-part series provided the groundwork for understanding the role of a standardized lipidosterolic extract of Serenoa repens (LSESr) in the treatment of LUTS. It documented that a treatment having a high therapeutic index (i.e., a ratio...

  • Article
  • Open Access
3 Citations
5,236 Views
13 Pages

Turbo Decoder Design based on an LUT-Normalized Log-MAP Algorithm

  • Jun Li,
  • Xiumin Wang,
  • Jinlong He,
  • Chen Su and
  • Liang Shan

20 August 2019

Turbo codes have been widely used in wireless communication systems due to their good error correction performance. Under time division long term evolution (TD-LTE) of the 3rd generation partnership project (3GPP) wireless communication standard, a L...

  • Article
  • Open Access
9 Citations
4,447 Views
20 Pages

5 June 2020

The main purpose of the paper is to present technology mapping of FSM (finite state machine) oriented to LUT (look-up table)-based FPGA (field-programmable gate array). The combinational part of an automaton, which consists of a transition block and...

  • Case Report
  • Open Access
276 Views
9 Pages

Urinary Bladder Hamartoma: Narrative Literature Review of an Exotic Pathology and Rare Cause of LUTS

  • Mohammed Rafea Kanaan,
  • Meryem Akkoyun,
  • Marcel Lafos,
  • Markus Antonius Kuczyk and
  • Hossein Tezval

24 November 2025

Urinary bladder hamartoma is an exceptionally rare benign lesion composed of disorganized yet mature tissue elements native to the bladder, including urothelium, fibrous stroma, smooth muscle, and occasionally adipose tissue. Unlike malignant tumors,...

  • Article
  • Open Access
3 Citations
2,650 Views
10 Pages

A High-Efficiency Consultation Improves Urological Diagnosis in Patients with Complex LUTS—A Pilot Study

  • Alexandru Ciudin,
  • Bernat Padulles,
  • Pasqualino Manasia,
  • Josep Alcoberro,
  • Sanae Ounia,
  • Maria Lopez,
  • Natalia Allue,
  • Joan Maria Ferrer,
  • Jaume Duran and
  • Antonio Aguilar

(1) Background: The diagnosis of moderate-severe lower urinary tract symptoms (LUTS) is not easy due to the complexity of the micturition act. Sequential diagnostic tests can be time consuming due to waiting lists. Thus, we developed a diagnostic mod...

  • Article
  • Open Access
11 Citations
5,002 Views
12 Pages

Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study

  • Lucia Muraca,
  • Antonio Scuteri,
  • Elisabetta Burdino,
  • Gianmarco Marcianò,
  • Vincenzo Rania,
  • Luca Catarisano,
  • Alessandro Casarella,
  • Erika Cione,
  • Caterina Palleria and
  • Luca Gallelli
  • + 7 authors

27 June 2022

Benign prostatic hyperplasia (BPH) is a common cause of male lower urinary tract symptoms (LUTS) that can reduce quality of life. Even if several drugs can be used in its treatment, the development of adverse drug reactions (ADRs) represents the most...

  • Article
  • Open Access
3 Citations
1,983 Views
13 Pages

Light Intensity Enhances the Lutein Production in Chromochloris zofingiensis Mutant LUT-4

  • Qiaohong Chen,
  • Mingmeng Liu,
  • Wujuan Mi,
  • Dong Wan,
  • Gaofei Song,
  • Weichao Huang and
  • Yonghong Bi

29 June 2024

Chromochloris zofingiensis, a unicellular green alga, is a potential source of natural carotenoids. In this study, the mutant LUT-4 was acquired from the chemical mutagenesis pool of C. zofingiensis strain. The biomass yield and lutein content of LUT...

  • Article
  • Open Access
5 Citations
5,197 Views
12 Pages

Efficacy and Safety of the Hexanic Extract of Serenoa repens vs. Watchful Waiting in Men with Moderate to Severe LUTS-BPH: Results of a Paired Matched Clinical Study

  • Antonio Alcaraz,
  • Mauro Gacci,
  • Vincenzo Ficarra,
  • José Medina-Polo,
  • Andrea Salonia,
  • Jesús M. Fernández-Gómez,
  • Alexandru Ciudin,
  • David Castro-Díaz,
  • Alfredo Rodríguez-Antolín and
  • on behalf of the QUALIPROST Study Group
  • + 9 authors

12 February 2022

We investigated changes in symptoms and quality of life (QoL) in men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) receiving the hexanic extract of Serenoa repens (HESr) and compared resu...

  • Article
  • Open Access
13 Citations
7,075 Views
17 Pages

Design and Testing of a LUT Airfoil for Straight-Bladed Vertical Axis Wind Turbines

  • Shoutu Li,
  • Ye Li,
  • Congxin Yang,
  • Xuyao Zhang,
  • Qing Wang,
  • Deshun Li,
  • Wei Zhong and
  • Tongguang Wang

16 November 2018

The airfoil plays an important role in improving the performance of wind turbines. However, there is less research dedicated to the airfoils for Vertical Axis Wind Turbines (VAWTs) compared to the research on Horizontal Axis Wind Turbines (HAWTs). Wi...

  • Article
  • Open Access
17 Citations
5,602 Views
14 Pages

Clinical Benefit of Tamsulosin and the Hexanic Extract of Serenoa Repens, in Combination or as Monotherapy, in Patients with Moderate/Severe LUTS-BPH: A Subset Analysis of the QUALIPROST Study

  • Antonio Alcaraz,
  • Alfredo Rodríguez-Antolín,
  • Joaquín Carballido-Rodríguez,
  • David Castro-Díaz,
  • Manuel Esteban-Fuertes,
  • José M. Cózar-Olmo,
  • Vincenzo Ficarra,
  • Rafael Medina-López,
  • Jesús M. Fernández-Gómez and
  • on behalf of The QUALIPROST Study Group
  • + 5 authors

9 September 2020

To investigate whether tamsulosin (TAM) and the hexanic extract of Serenoa repens (HESr) are more effective in combination than as monotherapy in men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (L...

  • Article
  • Open Access
4 Citations
4,570 Views
13 Pages

Efficacy and Tolerability of 6-Month Treatment with Tamsulosin Plus the Hexanic Extract of Serenoa repens versus Tamsulosin Plus 5-Alpha-Reductase Inhibitors for Moderate-to-Severe LUTS-BPH Patients: Results of a Paired Matched Clinical Study

  • Antonio Alcaraz,
  • David Castro-Díaz,
  • Mauro Gacci,
  • Andrea Salonia,
  • Vincenzo Ficarra,
  • Joaquín Carballido-Rodríguez,
  • Alfredo Rodríguez-Antolín,
  • José Medina-Polo,
  • Jesús M. Fernández-Gómez and
  • on behalf of the QUALIPROST Study Group
  • + 8 authors

22 June 2022

The objective of this subset analysis was to evaluate and compare the efficacy and tolerability of two combination treatments for men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). Data w...

  • Article
  • Open Access
13 Citations
4,404 Views
9 Pages

Oral Preparation of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin (Ialuril® Soft Gels) for the Prevention of LUTS after Intravesical Chemotherapy

  • Celeste Manfredi,
  • Lorenzo Spirito,
  • Francesco Paolo Calace,
  • Raffaele Balsamo,
  • Marco Terribile,
  • Marco Stizzo,
  • Lorenzo Romano,
  • Luigi Napolitano,
  • Gianluigi Califano and
  • Davide Arcaniolo
  • + 7 authors

Intravesical chemotherapy may cause chemical cystitis and related lower urinary tract symptoms (LUTS). The aims of this study were to evaluate the efficacy and safety of an oral preparation of hyaluronic acid (HA), chondroitin sulfate (CS), curcumin,...

  • Article
  • Open Access
780 Views
28 Pages

24 November 2025

FPGAs are well suited for prototyping complex digital systems for industrial and research purposes, as well as for the practical application of artificial intelligence (AI) methods in industrial autonomous control, automotives and space. FPGAs serve...

  • Article
  • Open Access
10 Citations
4,987 Views
10 Pages

Parosmia COVID-19 Related Treated by a Combination of Olfactory Training and Ultramicronized PEA-LUT: A Prospective Randomized Controlled Trial

  • Arianna Di Stadio,
  • Elena Cantone,
  • Pietro De Luca,
  • Claudio Di Nola,
  • Eva A. Massimilla,
  • Giovanni Motta,
  • Ignazio La Mantia and
  • Gaetano Motta

During COVID-19 pandemic, clinicians have had to deal with an ever-increasing number of cases of olfactory disturbances after SARS-CoV-2 infections and in some people this problem persisted for long time after negativization from virus. This a prospe...

  • Article
  • Open Access
6 Citations
2,203 Views
13 Pages

Evaluation of Immunogenicity to Three Doses of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Lung Transplant Patients

  • Mariasilvia Guardiani,
  • Maria Antonella Zingaropoli,
  • Francesco Cogliati Dezza,
  • Anastasia Centofanti,
  • Carolina Carillo,
  • Eeva Tortellini,
  • Federica Dominelli,
  • Anna Napoli,
  • Cosmo Del Borgo and
  • Gianluca Russo
  • + 5 authors

30 September 2022

The aim of the study was to explore the humoral and T-cell response in lung transplant (LuT) patients. Two-time points were considered, before (T0) and after (Tpost) the third dose of the BNT162b2 mRNA vaccine, comparing LuT with healthy donors (HD)....

  • Article
  • Open Access
7 Citations
2,869 Views
12 Pages

High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors

  • Lenka Besse,
  • Andrej Besse,
  • Marianne Kraus,
  • Elmer Maurits,
  • Herman S. Overkleeft,
  • Beat Bornhauser,
  • Jean-Pierre Bourquin and
  • Christoph Driessen

22 October 2021

Proteasome inhibitors (PIs) are approved backbone treatments in multiple myeloma. More recently, inhibition of proteasome activity with the PI bortezomib has been clinically evaluated as a novel treatment strategy in pediatric acute lymphoblastic leu...

  • Article
  • Open Access
5 Citations
2,685 Views
10 Pages

Background/Objectives: Luteolin (LUT) is a natural flavonoid with known anti-inflammatory, antioxidant, and anti-cancer properties. Cervical cancer, particularly prevalent in certain regions, remains a significant health challenge due to its high rec...

  • Article
  • Open Access
22 Citations
4,858 Views
13 Pages

Hematotoxicity and Nephrotoxicity in Prostate Cancer Patients Undergoing Radioligand Therapy with [177Lu]Lu-PSMA I&T

  • Philipp E. Hartrampf,
  • Franz-Xaver Weinzierl,
  • Sebastian E. Serfling,
  • Martin G. Pomper,
  • Steven P. Rowe,
  • Takahiro Higuchi,
  • Anna Katharina Seitz,
  • Hubert Kübler,
  • Andreas K. Buck and
  • Rudolf A. Werner

27 January 2022

(1) Background: Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) has shown remarkable results in patients with advanced prostate cancer. We aimed to evaluate the toxicity profile of the PSMA ligand [177Lu]Lu-PSMA I&T....

  • Article
  • Open Access
5 Citations
2,970 Views
14 Pages

19 December 2020

Purpose: The aim of this study was to measure, at the population level, the prevalence, bother, and treatment-related behavior for lower urinary tract symptoms (LUTS) and overactive bladder syndrome (OAB) in a large cohort of cardiology patients. Met...

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