Dr Jekyll and Mr Hyde is hierarchical in its very title—alphabetically Hyde precedes Jekyll, but Jekyll’s superior education and culture are associated with social status whereas Hyde’s ‘Mr.’ is a courtesy title often hedged in with demonic or animal...
Jacques Derrida’s theory of deconstruction provides an ideal means of appreciating and interrogating the duality central to both Robert Louis Stevenson’s Strange Case of Dr Jekyll and Mr Hyde and its adaptations. Moreover, because deconst...
In this study, 48 inhibitors were docked to 107 allosteric centers of human immunodeficiency virus 1 (HIV-1) reverse transcriptase from the Protein Data Bank (PDB). Based on the average binding scores, quantitative structure-activity relationship (QS...
Literary-rhetorical devices like figurative language and analogy can help explain concepts that exceed our capacity to grasp intuitively. It is not surprising these devices are used to discuss virulence, pathogenesis, and antibiotics. Allusions to Ro...
Cellular senescence is a state of stable cell cycle arrest that can be triggered in response to various insults and is characterized by distinct morphological hallmarks, gene expression profiles, and the senescence-associated secretory phenotype (SAS...
Selectins belong to a group of adhesion molecules that fulfill an essential role in immune and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the information carried by glycan structures, and non-covalent interacti...
Lipids play Jekyll and Hyde in the liver. On the one hand, the lipid-laden status of hepatic stellate cells is a hallmark of healthy liver. On the other hand, the opposite is true for lipid-laden hepatocytes—they obstruct liver function. Neglec...
“Jekyll and Hyde” refers to persons with an unpredictably dual personality, who are battling between good and evil within themselves In this regard, even cells consist of good and evil counterparts. Normal stem cells (NSCs) and cancer stem cells (CSC...
The physiological response to a psychological stressor broadly impacts energy metabolism. Inversely, changes in energy availability affect the physiological response to the stressor in terms of hypothalamus, pituitary adrenal axis (HPA), and sympathe...
Rhizobia are soil bacteria that can establish a symbiotic association with legumes. As a result, plant nodules are formed on the roots of the host plants where rhizobia differentiate to bacteroids capable of fixing atmospheric nitrogen into ammonia....
Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-su...
The French Society of Toxinology (SFET) organized its 27th annual meeting on 9–10 December 2021 as a virtual meeting (e-RT27). The central theme of this meeting was “Toxins: Mr Hyde or Dr Jekyll?”, emphasizing the latest findings on...
The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow...
This article examines two neo-Victorian novels by American writers—Valerie Martin’s Mary Reilly (1990) and Elaine Bergstrom’s Blood to Blood (2000)—which “write back” to Robert Louis Stevenson’s Strange Case...
Drawing from a variety of examples in world literature, this paper exposits a pervasive, diachronic literary motif in which an early human—the mythic protohuman—exists superior to contemporary humans, whose greatness is reflected in physical stature...
Candida albicans is a major fungal pathogen of humans, accounting for 15% of nosocomial infections with an estimated attributable mortality of 47%. C. albicans is usually a benign member of the human microbiome in healthy people. Under constant expos...
The 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet [...]
Secretion of extracellular vesicles (EVs) is a fundamental property of living cells. EVs are known to transfer biological signals between cells and thus regulate the functional state of recipient cells. Such vesicles mediate the intercellular transpo...
Current discussions on the objective attributes contributing to concert hall quality started formally in 1962 with the publication of Leo Beranek’s book “Music, Acoustics, and Architecture”. From his consulting work in the late 1950...
Since their discovery, R-loops have been associated with both physiological and pathological functions that are conserved across species. R-loops are a source of replication stress and genome instability, as seen in neurodegenerative disorders and ca...
The pro-tumorigenic activity of fibroblast growth factor (FGF) 19 (FGF15 in its rodent orthologue) in hepatocellular carcinoma (HCC), as well as the unsolved problem that ischemia-reperfusion (IR) injury supposes in liver surgeries, are well known. H...
The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to com...
Oxidation of fatty acids uses l-carnitine to transport acyl moieties to mitochondria in a so-called carnitine shuttle. The process of β-oxidation also takes place in cancer cells. The majority of carnitine comes from the diet and is transported...
The consumption of artificial and low-calorie sweeteners (ASs, LCSs) is an important component of the Western diet. ASs play a role in the pathogenesis of metabolic syndrome, dysbiosis, inflammatory bowel diseases (IBDs), and various inflammatory con...
Antibiotics as antibacterial drugs have saved many lives, but have also become a victim of their own success. Their widespread abuse reduces their anti-infective effectiveness and causes the development of bacterial resistance. Moreover, irrational a...
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, characterized by central cognitive dysfunction, memory loss, and intellectual decline poses a major public health problem affecting millions of people around the globe. Despite...
Human populations and their use of land have reshaped landscapes for thousands of years, creating the anthropogenic biomes (anthromes) that now cover most of the terrestrial biosphere. Here we introduce the first global reconstruction and mapping of...
This study investigates the architectural design factors that influence the adoption of eco-friendly solar energy technologies for the partial retrofitting of older residential buildings in densely populated urban areas in a developed country. This r...
Is Mr. Hyde more similar to his alter ego Dr. Jekyll, because of their physical identity, or to Jack the Ripper, because both evoke fear and loathing? The relative weight of emotional and visual dimensions in similarity judgements is still unclear. W...
Studying changes in land use per capita is critical for understanding the interactions between humans and ecosystems, and for modeling the impacts of land use changes on climate systems. However, many uncertainties in historical estimates significant...
One of the key discussions emerging from within the centre and centre-left of British politics is the means of combining a commitment to diversity with the aim of achieving social solidarity. While there has been a populist strand to this debate rece...
Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) is the main mediator of angiogenic signaling in endothelial cells and a primary responder to VEGF. VEGF dependent VEGFR-2 activation regulates endothelial cell migration and proliferation, as we...
Radiative thermal transport of metamaterials has begun to play a significant role in thermal science and has great engineering applications. When the key features of structures become comparable to the thermal wavelength at a particular temperature,...
Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as IFN-γ, which i...
The Greater Mekong River Subregion (GMS) is a global biodiversity hotspot. Macrofungi play an essential role as decomposers, parasites, and symbionts, and are also an important source of medicine, food, and income for many communities in the GMS; how...
Prescribed fire is often used by land managers as an effective means of implementing fuel treatments to achieve a variety of goals. Smoke generated from these activities can put them at odds with air quality regulations. We set out to characterize th...
In situ neutron diffraction of the uniaxial tension test was used to study the effect of the surrounding matrix microstructure on the mechanical stability of retained austenite in high-carbon bearing steels. Comparing the samples with bainitic micros...
This study investigated how sporadic river datasets could be used to quantify temporal variations in the base flow index (BFI). The BFI represents the baseflow component of river flow which is often used as a proxy indicator for groundwater discharge...
Our discovery of low-threshold stimulation-induced locomotion in the pedunculopontine nucleus (PPN) led to the clinical use of deep brain stimulation (DBS) for the treatment of disorders such as Parkinson’s disease (PD) that manifest gait and p...
Blunt-force traumatic brain injury (TBI) affects an increasing number of people worldwide as the range of injury severity and heterogeneity of injury pathologies have been recognized. Most current damage models utilize non-regenerative organisms, les...
Supported housing services provide help to some of the most vulnerable in society, yet across the world face increasing pressures from residualisation in the form of service reduction and stretched budgets. In response to these challenges, providers...
Research reveals that organisations in general are keen to provide their staff with the support needed to boost their competency in BIM and subsequently leverage the effectiveness of its implementation. However, employers need a decision-making tool...
During our ongoing studies of bambusicolous fungi in southwest China and Thailand, three saprobic pleosporalean taxa were discovered on bamboos in Yunnan Province of China. Occultibambusa hongheensis and Seriascoma bambusae spp. nov. are introduced b...
Freshwater hyphomycetes are a highly diverse group of fungi with a worldwide distribution and have been mostly reported from tropical and subtropical regions. During investigations of freshwater fungi from the Greater Mekong subregion in China and Th...
This study led to the discovery of three entomopathogenic fungi associated with Kuwanaspis howardi, a scale insect on Phyllostachys heteroclada (fishscale bamboo) and Pleioblastus amarus (bitter bamboo) in China. Two of these species belong to Podone...
Fungi are an essential component of any ecosystem, but they can also cause mild and severe plant diseases. Plant diseases are caused by a wide array of fungal groups that affect a diverse range of hosts with different tissue specificities. Fungi were...
Pleurotheciales is the largest order in Savoryellomycetidae with a large proportion of species known from freshwater habitats. In order to investigate the phylogenetic relationships of taxa within Pleurotheciales and contribute to their diversity, su...
This review brings together the research efforts on salt marsh fungi, including their geographical distribution and host association. A total of 486 taxa associated with different hosts in salt marsh ecosystems are listed in this review. The taxa bel...
We aimed to determine the contribution of high alcohol intake to fracture probability, calculated using a fracture-risk assessment tool (FRAX). Participants were 262 men (ages 60–90 y) in the Geelong Osteoporosis Study. Alcohol consumption was docume...
Since its introduction in the 1960s, external quality assessment has developed to become an essential component of the quality management system of the diagnostic laboratory. External quality assessment provides a long term, retrospective view of lab...
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