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Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF

Department of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy
Department of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3118;
Received: 14 September 2018 / Revised: 4 October 2018 / Accepted: 6 October 2018 / Published: 11 October 2018
(This article belongs to the Special Issue Protein Structural Dynamics)
Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-sulfur cluster maturation machinery. The [2Fe] sub-cluster instead requires a dedicated set of maturase proteins, HydE, HydF, and HydG that work to assemble the cluster and deliver it to the apo-hydrogenase. In particular, the delivery is performed by HydF. In this review, we will perform an overview of the latest knowledge on the maturation machinery of the H-cluster, focusing in particular on HydF. View Full-Text
Keywords: hydrogenases; [FeFe]-hydrogenases; HydF; HydG; HydE; maturases hydrogenases; [FeFe]-hydrogenases; HydF; HydG; HydE; maturases
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Bortolus, M.; Costantini, P.; Doni, D.; Carbonera, D. Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF. Int. J. Mol. Sci. 2018, 19, 3118.

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