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Open AccessReview

Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF

1
Department of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy
2
Department of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3118; https://doi.org/10.3390/ijms19103118
Received: 14 September 2018 / Revised: 4 October 2018 / Accepted: 6 October 2018 / Published: 11 October 2018
(This article belongs to the Special Issue Protein Structural Dynamics)
Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-sulfur cluster maturation machinery. The [2Fe] sub-cluster instead requires a dedicated set of maturase proteins, HydE, HydF, and HydG that work to assemble the cluster and deliver it to the apo-hydrogenase. In particular, the delivery is performed by HydF. In this review, we will perform an overview of the latest knowledge on the maturation machinery of the H-cluster, focusing in particular on HydF. View Full-Text
Keywords: hydrogenases; [FeFe]-hydrogenases; HydF; HydG; HydE; maturases hydrogenases; [FeFe]-hydrogenases; HydF; HydG; HydE; maturases
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Bortolus, M.; Costantini, P.; Doni, D.; Carbonera, D. Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF. Int. J. Mol. Sci. 2018, 19, 3118.

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