3,865 Results Found

The SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected...

The treatment for hepatocellular carcinoma (HCC), a severe cancer with a very high mortality rate, begins with the surgical resection of the primary tumor. For metastasis or for tumors that cannot be resected, sorafenib, a multi-tyrosine protein kina...

In this work, Ho₂O₃ nanosheets were synthesized by a hydrothermal method. A series of Sr-modified Ho₂O₃ nanosheets (Sr-Ho₂O₃-NS) with a Sr/Ho molar ratio between 0.02 and 0.06 were prepared via an impregnation method. These catalysts were characteriz...

Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate (DMF) structure are reported in this paper. These compounds are obtained by modification of the DMF backbone. Particularly, maintaining the α, β-unsaturated dicarbonyl funct...

The manuscript describes the phase composition, microstructure, some physical and mechanical properties of the Ti-Al system with addition of 2 at. % Dy (TAD) and Ho (TAH) obtained by “hydride technology”. Phase diagrams for Ti-Al-Dy and T...

Glioblastoma multiforme (GBM) represents the deadliest tumor among brain cancers. It is a solid tumor characterized by uncontrolled cell proliferation generating the hypoxic niches in the cancer core. By inducing the transcription of hypoxic inducibl...

Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. They were developed to antagonize the adverse effects of estrogen and have been shown to be effective against...

Background/Objectives: In an attempt to combine the benefits of the Holmium:YAG (Ho:YAG) laser and Thulium Fiber Laser (TFL), the “Magneto” mode lowers the peak power of the Ho:YAG laser, generating longer duration pulses. The purpose of...

HoBi-like pestivirus (HoBiPeV), classified under Pestivirus H species, is an emerging cattle pathogen of high economic impact. However, the origin and evolution of HoBiPeV are not very clear due to a lack of full genomic sequences from diverse clades...

The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic...

The E3 ubiquitin-protein ligase HOS1 is an important integrator of temperature information and developmental processes. HOS1 is a negative regulator of plant cold tolerance, and silencing HOS1 leads to increased cold tolerance. In the present work, w...

Overexpression of the inducible heme oxygenase (HO-1) isoform in visceral renal glomerular epithelial cells (podocytes) using in vivo transgenesis methods was shown to increase glomerular expression of the complement regulatory protein decay-accelera...

An experimental study of the phase equilibria of the Ho-rich part of the Ho-Ir-O ternary system at 1073 K by means of x-ray diffraction, differential scanning calorimetry, and scanning electron microscopy has been carried out. Ho-hcp and four binary...

Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) have significant roles in the development of a hyperinflammatory state in infectious diseases. We aimed to investigate the association of the serum concentrations of Nrf2...

Metastatic osteosarcoma often results in poor prognosis despite the application of surgical en bloc excision along with chemotherapy. HO-3867 is a curcumin analog that induces cell apoptosis in several cancers, but the apoptotic effect and its mechan...

This work reports the enhanced emission at 2.7 µm in Er³⁺/Ho³⁺-codoped fluorotellurite glass upon a conventional 980 nm laser diode. The significantly reduced green upconversion and 1.5 µm emission intensity in Er³⁺/Ho³⁺-codoped samples are observed....

We present a single-longitudinal-mode Ho:Sc₂SiO₅ (Ho:SSO) laser pumped by a Tm:YAP laser for the first time. Two intra-cavity Fabry–Perot etalons were used to realize the single-longitudinal mode of operation. The maximum output power of 590 mW at 21...

Ferulic acid (FA) is phenolic compound found in fruits. Many studies have reported that FA has diverse therapeutic effects against metabolic diseases. However, the mechanism by which FA modulates adipogenesis via the expression of heme oxygenase-1 (H...

In this study, density functional theory (DFT) with Hubbard U correction calculations (DFT+U) was used to examine the ferromagnetic properties of HoM₂ Laves phases (M = {Al, Ni}) under external hydrostatic pressure from 0 GPa to 1.0 GPa. The resultin...

Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a major transcriptional regulator of antioxidant reactions. Heme oxygenase-1 (HO-1), a gen...

This paper presents a new model of the term structure of interest rates that is based on the continuous Ho–Lee one. In this model, we suggest that the drift and volatility coefficients depend additionally on a generalized inverse Gaussian (GIG)...

In this research, we investigate and discuss the characteristics of HoFeO₃ nanoparticles synthesized by the co-precipitation method at low temperature (t° ≤ 4 °C). The single-phase HoFeO₃ samples with the orthorhombic structure formed after annealing...

Chorioamnionitis (CHORIO), placental insufficiency, and preterm birth are well-known antecedents of perinatal brain injury (PBI). Heme-oxygenase-1 (HO-1) is an important inducible enzyme in oxidative and inflammatory conditions. In the brain, HO-1 an...

Heme metabolism is crucial for the function and longevity of legume nodules, with leghemoglobins (Lbs) serving as the primary heme sink and heme oxygenase (HO) mediating heme degradation. However, the precise functional relationship between HO and Lb...

In this work, the synthesis and characterization of Li₂MgGeO₄:Ho³⁺ ceramics were reported. The X-ray diffraction measurements revealed that the studied ceramics belong to the monoclinic Li₂MgGeO₄. Luminescence properties were analyzed in the visible...

Heme-oxygenase (HO)-1 is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties and previous reports have also emphasized the antiviral properties of HO-1, either directly or via induction of interferons. To investigate the pot...

Single crystals of Ho₂O₃-doped Y₂O₃ stabilized ZrO₂ (YSZ) with different Y₂O₃ and Ho₂O₃ contents were grown by the optical floating zone method. XRD and Raman spectra were measured and showed that crystal samples all had tetragonal structures. Measur...

Introduction: Osteoarthritis (OA), a leading cause of disability among the elderly, is characterized by progressive joint tissue destruction. Fucoidan, a sulfated polysaccharide with known anti-inflammatory and antioxidant properties, has been invest...

In Arabidopsis, the RING finger-containing E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) functions as a main regulator of the cold signaling. In this study, CRISPR/Cas9-mediated targeted mutagenesis of the HOS1 gene in...

A significant share of food waste originates in the food services domain and HoReCa sector. Organizational improvements leading to the decrease of food waste and related costs in HoReCa are needed to make progress in this issue. A systems engineering...

We previously reported that a novel marine compound, xyloketal B, has strong antioxidative actions in different models of cardiovascular diseases. Induction of heme oxygenase-1 (HO-1), an important endogenous antioxidant enzyme, has been considered a...

None of our investigations have identified stress in response to the HSP70 and HO-1 proteins in metals under stress in our study, which aimed to understand the genetic basis of the metal tolerance of Arundo donax. Thus, the present work aimed to inve...

This work reports on the fabrication and analysis of near-infrared and mid-infrared luminescence spectra and their decays in fluoroindate glasses co-doped with Yb³⁺/Ho³⁺. The attention has been paid to the analysis of the Yb³⁺→ Ho³⁺ energy transfer p...

Background: Prostate cancer (PCa) dissemination shows a tendency to develop in the bone, where heme oxygenase 1 (HO-1) plays a critical role in bone remodeling. Previously by LC/ESI-MSMS, we screened for HO-1 interacting proteins and identified annex...

Diode-pumped solid-state lasers using novel Yb:LaF₃ and Tm,Ho:LaF₃ crystals as laser gain materials are demonstrated herein. The Yb:LaF₃ and Tm,Ho:LaF₃ crystals were grown using the Bridgman method. By matching their absorption bands, continuous-wave...

The inevitable thermal demagnetization of magnets at high-temperatures is a key issue for Nd-Fe-B based permanent magnetic materials, especially for electric motors. Here, we report the effect of partially substituting the element Holmium (Ho) on the...

Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer. It contains a number of coumarin compounds and the group of interest is the pyranocoumarin, which comprises decursin and decurs...

Prostate cancer (PCa) is the second most diagnosed malignancy and the fifth leading cause of cancer associated death in men worldwide. Dysregulation of cellular energetics has become a hallmark of cancer, evidenced by numerous connections between sig...

HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clinical outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To iden...

We report a passively Q-switched Ho:YVO₄ laser pumped at 1.94 µm with multilayer graphene as a saturable absorber. At the absorbed pump power of 9.3 W, the maximum average output power of 2.2 W was obtained in Ho:YVO₄ laser with minimum pulse width o...

Calcific aortic valve stenosis (CAVS) is a heart disease characterized by the progressive fibro-calcific remodeling of the aortic valves, an actively regulated process with the involvement of the reactive oxygen species-mediated differentiation of va...

Co-doping at Ba and Ti sites with double rare-earth elements has proven an effective strategy for enhancing the dielectric properties of BaTiO₃ ceramics. Among intermediate-sized rare-earth ions, Tb and Ho exhibit amphoteric behavior, occupying both...

Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human cancer, and in these cases, poor clinical outcomes are normally reported. Indeed, the inhibition of HO-1 is being considered as an anticancer approach. Imi...

Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are indep...

Highly transparent Ho:Y₂O₃ ceramics for laser diode lighting were prepared using the vacuum sintering method with 0.3 at.% Nb₂O₅ as a sintering additive. The microstructures, transmittance, and luminescence properties of the Ho:Y₂O₃ ceramic samples w...

Retinal ischemia-reperfusion (rI/R) generates an oxidative condition causing the death of neuronal cells. Epigallocatechin 3-gallate (EGCG) has antioxidant and anti-inflammatory properties. Nonetheless, its correlation with the pathway of nuclear fac...

Extremely low frequency electromagnetic fields (ELF-EMFs) have been known to modulate inflammatory responses by targeting signal transduction pathways and influencing cellular redox balance through the generation of oxidants and antioxidants. Here, w...

Cities in West Africa have master and local plans to plan and guide land use and prevent urban sprawl. However, their spatial growth is not in line with the principles and indicators of harmonious development. To what extent has the spatial growth of...

Obesity is a risk factor for vascular dysfunction and insulin resistance. The study aim was to demonstrate that adipocyte-specific HO-1 (heme oxygenase-1) gene therapy is a therapeutic approach for preventing the development of obesity-induced metabo...

Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of...