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Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression

Department of Biological and Environmental Science, Dongguk University, Goyang 410-820, Korea
Department of Biological Science, Gachon University, Seongnam 461-701, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(6), 4862-4874;
Received: 15 April 2015 / Revised: 7 June 2015 / Accepted: 11 June 2015 / Published: 15 June 2015
(This article belongs to the Special Issue Natural Products for Human Health)
Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer. It contains a number of coumarin compounds and the group of interest is the pyranocoumarin, which comprises decursin and decursinol angelate. This group has an effect on controlling inflammation, which is caused by excessive nitric oxide (NO) production. Heme oxygenases (HOs), particularly HO-1, play a role in regulating the production of NO. Thus, this study aimed to investigate the anti-inflammatory effects of AG by measuring HO-1 expression. Treatments with CH2Cl2 layer and Angelica gigas extract (AGE) showed the highest NO inhibition effects. Decursin, decursinol angelate, and nodakenin were isolated from the CH2Cl2 layer of AGE. Decursin also demonstrated the highest anti-oxidative effect among the coumarins. Although decursin had the best NO inhibition and anti-oxidative effects, the effects of AGE treatment far surpassed that of decursin. This is owing to the combination effect of the coumarins present within AGE, which is a solvent extract of AG. The expression of HO-1 is an effective indicator of the anti-inflammatory effects of AG. Based on the results of the coumarin compounds, HO-1 expression was found to be dose dependent and specific to decursin. View Full-Text
Keywords: Angelica gigas; decursin; coumarins; Anti-inflammation; HO-1 expression; vascular smooth muscle cells Angelica gigas; decursin; coumarins; Anti-inflammation; HO-1 expression; vascular smooth muscle cells
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Cho, J.H.; Kwon, J.E.; Cho, Y.; Kim, I.; Kang, S.C. Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression. Nutrients 2015, 7, 4862-4874.

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