When searching for the optimal solution, Equivalent Consumption Minimum Strategy (ECMS) has to calculate and compare the total equivalent fuel rate of huge candidates covered all over the control domain for each time instant. Therefore, this strategy...
The mechanical coupling of multiple powertrain components makes the energy management of 4-wheel-drive (4WD) plug-in fuel cell electric vehicles (PFCEVs) relatively complex. Optimizing energy management strategies (EMSs) for this complex system is es...
To increase the efficiency of electrified vehicles, many energy management strategies (driving strategies) have been proposed. These include both offline optimization techniques to identify a system’s theoretical optimum and online optimization...
Rule-based energy management strategies not only make little use of the efficient area of engines and generators but also need to perform better planning in the time domain. This paper proposed a multi-signal vehicle speed prediction model based on t...
A real-time optimized model predictive control–equivalent consumption minimization strategy (MPC-ECMS) is proposed for the energy management of shipboard gas turbine–photovoltaic hybrid energy storage (GT-PV-HESS) power systems. Different...
Driven by increasingly stringent requirements for energy saving and emission reduction in non-road machinery, hybrid wheel loaders have attracted growing attention as a practical pathway toward cleaner construction equipment. However, conventional en...
In order to reduce fuel consumption and reduce the deviation between the final battery state-of-charge (SOC) value and the target value at the same time, a novel double-layer multi-objective optimization method is proposed, which adopts an improved a...
Fuel reductions can be confounded by battery depletion or unreported control corrections. This theoretical study examines phase-informed equivalent-consumption minimization (ECMS) with a soft state-of-charge (SOC) safeguard in an ideal power-split vi...
Large bone defects remain a major clinical challenge, as current treatments primarily provide mechanical stability while often insufficiently addressing the biological microenvironment. The cell-deposited extracellular matrix (CD-ECM) represents a pr...
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevanc...
Fuel cell commercial vehicles are widely used in commercial transport for their high efficiency and long range. However, in mixed operating scenarios, their energy economy and fuel cell operational stability cannot be fully balanced. Traditional stra...
To fulfil the CO2 emission reduction targets of the European Union (EU), heavy-duty (HD) trucks need to operate 15% more efficiently by 2025 and 30% by 2030. Their electrification is necessary as conventional HD trucks are already optimized for the l...
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free....
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could pro...
Adipose tissue, an energy storage and endocrine organ, is emerging as an essential player for ECM remodeling. Fibrosis is one of the hallmarks of obese adipose tissue, featuring excessive ECM deposition and enhanced collagen alignment. A variety of E...
While most primary tumors can be effectively treated, therapeutics fail to efficiently eliminate metastases. Metastases arise from cancer cells that leave the primary tumor and seed distant sites. Recent studies have shown that cancer cells dissemina...
The extracellular microenvironment regulates many of the mechanical and biochemical cues that direct musculoskeletal development and are involved in musculoskeletal disease. The extracellular matrix (ECM) is a main component of this microenvironment....
The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins. Studies have demonstrated t...
The extracellular matrix (ECM) is the complex three-dimensional network of fibrous proteins and proteoglycans that constitutes an essential part of every tissue to provide support for normal tissue homeostasis. Tissue specificity of the ECM in its to...
The foreign body reaction to neuronal electrode implants limits potential applications as well as the therapeutic period. Developments in the basic electrode design might improve the tissue compatibility and thereby reduce the foreign body reaction....
ECM stiffness significantly influences the differentiation of adipose-derived stem cells (ADSCs), with YAP—a key transcription factor in the Hippo signaling pathway—playing a pivotal role. This study investigates the effects of ECM stiffn...
Porous scaffolds play a crucial role in bone tissue regeneration and have been extensively investigated in this field. By incorporating a decellularized extracellular matrix (dECM) onto tissue-engineered scaffolds, bone regeneration can be enhanced b...
Objective: Glioma is the most prevalent and fatal intracranial malignant tumor. Extracellular matrix protein 2 (ECM2) has rarely been studied in gliomas. Therefore, we explored the role of ECM2 in lower-grade gliomas (LGGs). Methods: The RNA-seq and...
Collagen, along with proteoglycans, glycosaminoglycans, glycoproteins, and various growth factors, forms the extracellular matrix (ECM) and contributes to the complexity and diversity of different tissues. Herein, we compared the physicochemical and...
Recent applications of decellularized tissue have included the use of hydrogels for injectable materials and three-dimensional (3D) bioprinting bioink for tissue regeneration. Microvascular formation is required for the delivery of oxygen and nutrien...
Electric discharge machining (EDM) is a type of high-precision machining usually applied to hard-material machining for mold manufacturing and in the aerospace industry. Longer process times typically reduce facility efficiency. The use of electroche...
The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and the fenestrated endothelial cells in the formation of the slit diaphragm for the filtration...
Due to its advantages of good surface quality and not being affected by material hardness, electrochemical machining (ECM) is suitable for the machining of blisk, which is known for its hard-to-machine materials and complex shapes. However, because o...
The aim of this study was to verify the applicability of high-concentration collagen-based bioink with MSC (ADSC) and decellularized ECM granules for the formation of cartilage tissue de novo after subcutaneous implantation of the scaffolds in rats....
Bioethical limitations impair deeper studies in human placental physiology, then most studies use human term placentas or murine models. To overcome these challenges, new models have been proposed to mimetize the placental three-dimensional microenvi...
In addition to soluble biochemical factors, biophysical cues from the extracellular matrix (ECM) can play an integral role in regulating cell behavior. Previous work has demonstrated that varying ECM dimensionality (3D vs. 2D) and structure (fibrilla...
Hydrogels show promise in cartilage tissue engineering (CTE) by supporting chondrocytes and maintaining their phenotype and extracellular matrix (ECM) production. Under prolonged mechanical forces, however, hydrogels can be structurally unstable, lea...
Micro-electrochemical machining (micro-ECM) is a non-contact subtractive process in which material is removed by anodic dissolution. This review examines 150 publications from 1992 to 2026 on hybrid and assisted machining, tool electrode design and f...
The design of composite tissue scaffolds containing an extracellular matrix (ECM) and synthetic polymer fibers is a new approach to create bioactive scaffolds that can enhance cell function. Currently, studies investigating the effects of ECM-deposit...
The extracellular matrix (ECM) composition greatly influences cancer progression, leading to differential invasion, migration, and metastatic potential. In breast cancer, ECM components, such as fibroblasts and ECM proteins, have the potential to alt...
A dome-shaped elastic poly(l-lactide-co-caprolactone) (PLCL) scaffold with a channel and pore structure was fabricated by a combinative method of 3D printing technology and the gel pressing method (13 mm in diameter and 6.5 mm in thickness) for patie...
Wentilactone A (WA) is a tetranorditerpenoid isolated from marine algae. We previously found that WA inhibited cancer cell proliferation with little toxicity. In this study, we show that high expression of extracellular matrix protein-1 (ECM1) promot...
This paper presents a comprehensive review of cardiorespiratory auscultation sensing devices (i.e., stethoscopes), which is useful for understanding the theoretical aspects and practical design notes. In this paper, we first introduce the acoustic pr...
This paper presents an equivalent consumption minimization strategy (ECMS) based on model predictive control for series hybrid electric mine trucks (SHE-MTs), the objective of which is to minimize fuel consumption. Two critical works are presented to...
Aligned fibrous scaffolds are essential for directing soft-tissue regeneration, yet synthetic polymers lack native biochemical cues. To bridge this gap, bioactive and anisotropic scaffolds were developed by combining melt electrowriting (MEW) with de...
Primary cilia play a significant role in influencing cell fate, including apoptosis in multiple cell types. In the lesional epidermis of vitiligo patients, a reduced number of ciliated cells was observed. Our study also revealed a downregulation of o...
Background/Objectives: Pelvic organ prolapse (POP) is increasingly recognized as a localized extracellular matrix (ECM) remodeling disorder. Conventional clinical predictors do not fully explain interindividual variation in tissue quality or surgical...
Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cos...
Chronic diabetic wounds are often characterized by persistent hypoxia and poor healing outcomes, highlighting the need for regenerative grafts that not only promote tissue repair but also provide insights into the wound microenvironment. In this stud...
Zr-based metallic glasses (MGs) are promising materials for mold manufacturing due to their unique mechanical and chemical properties. However, the high hardness of metallic glasses and their tendency to crystallize at high temperatures make it chall...
A flexible and bioactive scaffold for adipose tissue engineering was fabricated and evaluated by dual nozzle three-dimensional printing. A highly elastic poly (L-lactide-co-ε-caprolactone) (PLCL) copolymer, which acted as the main scaffolding, and hu...
Current 3D cancer models (in vitro) fail to reproduce complex cancer cell extracellular matrices (ECMs) and the interrelationships occurring (in vivo) in the tumor microenvironment (TME). Herein, we propose 3D in vitro colorectal cancer microtissues...
Due to their hardness and low tool wear, tungsten carbides are widely used in industrial applications, such as spray nozzles, wire drawing dies and spinning nozzles. However, there is no conventional machining process that is capable of fabricating m...
The aim of our research was to find new biomarkers that could be potentially used in the diagnosis, differentiation and monitoring of inflammatory bowel diseases (IBD). Since extracellular matrix (ECM) remodeling contributes to the pathological chang...
The epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression, being responsible in many cases for the onset of the metastatic cascade and being integral in the ability of cells to resist drug treatment. Most studies of EMT...
of 98