Special Issue "Advanced Functional Materials for Biomedicinal Applications"
A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Composites".
Deadline for manuscript submissions: 20 August 2022 | Viewed by 29507
Special Issue Editor

Interests: biocompatible materials; mammalian cells; cell adhesion; antimicrobial activity; anticancer activity; plasma treatment; laser modification; fluorescence microscopy; photodynamic therapy; theranostics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomaterials, engineered substances that interact with biological systems with applications in medicine, have been in the spotlight recently, since there has been enormous progress in the field of materials itself. Therefore, this Special Issue focuses on recent progress and novel trends in (bio)material science. Special attention will be devoted to biomaterials with advanced functions and unique properties applicable in medicine and biology but also as tools for research.
This Special Issue “Advanced Functional Materials for Biomedicinal Applications” will underline the most recent discoveries and progress in all fields of science related to advanced materials with possible applications in medicine and biology. This Special Issue will focus particularly on, but not be limited to, cell culture, tissue engineering, drug delivery, antimicrobial activity, material characterization, bioimaging, and bioactivity. Reviews, regular research articles, and short communications on this topic are invited from research groups from all over the world to encourage the dissemination of scientific knowledge through this open-access journal. Researchers working in the field of biomaterials and related disciplines are encouraged to publish their recent findings in this Special Issue of Materials.
Dr. Silvie Rimpelová
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Biocompatible materials
- Surface treatment
- Coating
- Surface properties
- Nanomaterials
- Nanoparticles
- Drug delivery
- Cell adhesion
- Proliferation
- Primary fibroblasts
- Stem cells
- Tissue engineering
- Regenerative medicine
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Olivera Šauperl1, Lidija Fras Zemljic1, Julija Volmajer Valh1, Jasna Tompa1
1University of Maribor, Faculty of Mechanical Engineering, Institute of Engineering Materials and Design, Smetanova ulica 17, 2000 Maribor, Slovenia
Abstract:
The presented research work deals with the production of chitosan-eugenol copolymers by chemical and enzymatic grafting and their application to viscose substrates with the aim of producing antimicrobial and antioxidative active textiles. ATR - FTIR and 1H-NMR spectroscopy were used to evaluate the efficiency of grafting and to compare both grafting procedures. Potentiometric titration was chosen to determine the amount of accessible amino groups of graft copolymers indicating the antimicrobial activity of chitosan. Spectrophotometric methods, such as i) Folin - Ciocalteu, ii) reduction of iron ions and iii) α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging methods were used to determine the total content of phenolic compounds, i.e. to infer the antioxidant activity of the graft copolymers produced. Thermal analysis (TGA/DSC) was also part of the research to study the thermal properties of the graft copolymers, i.e. to evaluate the effectiveness of grafting. The viscose functionalized by the prepared copolymers was evaluated by ATR - FT IR spectroscopy and Acid Orange VII spectrophotometric method to assess the adsorption success, i.e. to determine the proportion of available antimicrobial active amino groups of chitosan. Scanning electron microscopy (SEM) was also performed to study the fibre morphology. Finally, an antimicrobial fibre test was performed to determine the reduction of selected pathogenic microorganisms and the antioxidant activity of the fibres was provided as well. It has been concluded that fibres have a high bioactive profile and therefore have the potential to be used in the development of medical textiles.
2. Electrochemically Assisted Deposition of Biomimetic ACP Coatings on CpTi Grade 4 in an Acetate Bath
Patrycja Osak, Joanna Maszybrocka, Grzegorz Dercz, Julian Kubisztal, Bożena Łosiewicz*
Institute of Materials Engineering, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland; [email protected] (P.O.); [email protected] (J.M.); [email protected] (G.D.); [email protected] (J.K.); [email protected] (B.Ł.)
* Correspondence: [email protected]; Tel.: +48-32-3497-527 (B.Ł.)
Abstract: Calcium phosphate (CaP) coatings are able to improve the osseointegration process due to their chemical composition similar to that of bone tissues. Among the methods of producing CaP coatings, the electrochemically assisted deposition (ECAD) is particularly important due to high repeatability and the possibility of deposition at ambient temperature and neutral pH, which allows to co-deposit inorganic and organic components. In this work, the ECAD of biomimetic CaP coatings from an acetate bath with a Ca:P ratio of 1.67, was developed. The effect of the ECAD conditions on CaP coatings deposited on commercially pure titanium grade 4 (CpTi G4) subjected to sandblasting and autoclaving, was presented. The physicochemical characteristics of the ECAD-derived coatings was carried out using XRD, GIXRD, SEM, EDS, ATR-FTIR, 2D roughness profiles, and amplitude sensitive eddy current method. It was showed that amorphous calcium phosphate (ACP) coatings can be obtained at a potential ranging from -1.5 to -10 V relative to the open circuit potential for 10 to 60 min varying the temperature of the deposition bath from 20 to 70 °C. The thickness and surface roughness of the ACP coatings were an increasing function of potential, time and temperature. The optimal ACP coatings for use in dentistry were deposited at a potential of -3 V for 30 min at ambient temperature. The deposition mechanism of the ACP coatings was discussed in details.
Keywords: calcium phosphate coatings; electrochemically assisted deposition; titanium
3. Title: Effect of local and systemic administration of atorvastatin for optimization on bone repair of critical defects: An animal study
Authors: Fábio Vieira de Miranda DDS, MSc, PhD1; Willian Phillip Pereira da Silva DDS, MSc1; Gustavo Antonio Correa Momesso DDS, MSc, PhD1; Leonardo Alan Delanora DDS1, Bárbara Ribeiro Rios DDS1, Tiburtino José de Lima Neto DDS1, Edilson Ervolino DDS, MSc2, PhD; Jamil Awad Shibli DDS, MSc, PhD3; Osvaldo Magro Filho DDS, MSc, PhD; Leonardo Perez Faverani DDS, MSc, PhD.
Affiliations:
1 - Department of Diagnosis and Surgery. Sao Paulo State University—Unesp. Aracatuba School of Dentistry, Sao Paulo 16015-050, Brazil
2 - Department of Basic Sciences. Sao Paulo State University—Unesp. Aracatuba School of Dentistry, Sao Paulo 16015-050, Brazil
3 - Dental Research Division, Department of Periodontology and Oral Implantology, University of Guarulhos (UnG), Guarulhos, SP 07115-230, Brazil
Article proposal for Materials – Special Issue
Bone regeneration studies have been investigated the groups of statins to stimulate the osteogenic factors, which the major question is about administration more appropriate to obtain better results. Thus, this study aims to compare the effect of Atorvastatin applied locally and systemically on critical defects of calvaria rats. Thirty-six rats Wistar adults will be randomly divided into three groups, the collagen membrane application group with distilled water (GAD) with critical size defects containing distilled water; the systemic application group of Atorvastatin (GAS) will be performed with critical size defects and the animals will be treated with atorvastatin (3.6mg/kg/day) per gavage; and the local application group of Atorvastatin (GAL) with critical size defects containing Atorvastatin. Each group will be evaluated by histometric analysis through measurement of the residual defect, area of newly formed bone (NFB), area of the membrane and soft tissue, cell count (osteocytes, osteoblasts, inflammatory cells), and immunohistochemistry reactions using antibodies against CD31, VEGF, BMP-2, and Osteocalcin. All quantitative data will be subjected firstly to a normality test (Shapiro-Wilk) and according to the distribution of the data, a parametric or non-parametric test will be applied, considering P<.05. All tests will be applied in the SigmaPlot 12.0 Sofware (Exakt Graph and Data Analysis, San Jose, Ca, USA).
Keywords: Osteogenesis. Atorvastatin. Bone regeneration.
4. Egg Yolk Plasma as a nature-inspired functional biomaterial for tissue engineering and 3D-cell culture of human salivary glands.
Andre M. Charbonneau, PhD, and Simon D. Tran, DMD, PhD, FRCDC
McGill Craniofacial Tissue Engineering and Stem Cells Laboratory,
Faculty of Dentistry, McGill University,
Montréal, Québec, Canada
Email: [email protected]
Title: Evaluation of chemical and enzymatic synthesis of chitosan/eugenol graft copolymers intendent for cellulose functionalization for medical use
Authors: Olivera Šauperl; Lidija Fras Zemljic; Julija Volmajer Valh; Jasna Tompa
Affiliation: University of Maribor, Faculty of Mechanical Engineering, Institute of Engineering Materials and Design, Smetanova ulica 17, 2000 Maribor, Slovenia
Abstract: The presented research work deals with the production of chitosan-eugenol copolymers by chemical and enzymatic grafting and their application to viscose substrates with the aim of producing antimicrobial and antioxidative active textiles. ATR - FTIR and 1H-NMR spectroscopy were used to evaluate the efficiency of grafting and to compare both grafting procedures. Potentiometric titration was chosen to determine the amount of accessible amino groups of graft copolymers indicating the antimicrobial activity of chitosan. Spectrophotometric methods, such as i) Folin - Ciocalteu, ii) reduction of iron ions and iii) α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging methods were used to determine the total content of phenolic compounds, i.e. to infer the antioxidant activity of the graft copolymers produced. Thermal analysis (TGA/DSC) was also part of the research to study the thermal properties of the graft copolymers, i.e. to evaluate the effectiveness of grafting. The viscose functionalized by the prepared copolymers was evaluated by ATR - FT IR spectroscopy and Acid Orange VII spectrophotometric method to assess the adsorption success, i.e. to determine the proportion of available antimicrobial active amino groups of chitosan. Scanning electron microscopy (SEM) was also performed to study the fibre morphology. Finally, an antimicrobial fibre test was performed to determine the reduction of selected pathogenic microorganisms and the antioxidant activity of the fibres was provided as well. It has been concluded that fibres have a high bioactive profile and therefore have the potential to be used in the development of medical textiles.