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Special Issue "Extracellular Matrix in Heart Disease"
Deadline for manuscript submissions: 31 July 2020.
Interests: cardiovascular pharmacology; cardiovascular disease; myocardial infarction; cardiac hypertrophy; arrhythmia; heart failure; pulmonary arterial hypertension; fibrosis; extracellular matrix; cardiac fibroblast; cardiomyocyte; matricryptin/matrikine; matricellular protein; matrix metalloproteinase; cardiac electrophysiology
Components of the extracellular matrix (ECM), such as collagen, fibronectin, laminin, and proteoglycan, maintain cardiac structure and function by forming a complicated three-dimensional network. Cell–ECM interaction is also important for regulating the functions of cardiomyocytes and non-cardiomyocytes. An imbalance between the production and degradation of the ECM during the development and progression of heart disease is associated with pathological cardiac remodeling, including hypertrophy and fibrosis. Recently, it has been reported that matricellular proteins, a family of non-structural ECM proteins, and matricryptins/matrikines, bioactive fragments of ECM proteins, are involved in cardiac remodeling. In this Special Issue, we expect to gather novel knowledge that will lead to the discovery of drugs targeting the ECM and its fragments for heart disease.
Dr. Muneyoshi Okada
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- extracellular matrix
- cardiac remodeling
- heart failure
- matricellular protein
- matrix metalloproteinase
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Role of extracellular matrix in the pathogenesis of patent ductus arteriosus
Authors: Jong Hau Hsu, etc.
Title: The diabetic, the hypertensive and the antracycline exposed heart: differences and similarities in extracellular remodeling
Authors: Kirsti Ytrehus, Anne D. Hafstad, etc.
Title: MMP and TIMP activity in extracellular matrix remodeling during left ventricular diastolic dysfunction: a systematic review
Authors: C.G.M. van Dijk and MM Krebber, C. Cheng, J.A. Joles, M.C. Verhaar