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31,249 Results Found

  • Article
  • Open Access
712 Views
9 Pages

7 March 2025

In this manuscript, we define the (E,F)-invex set, (E,F)-invex functions, and (E,F)-preinvex functions on Euclidean space, i.e., simply vector space. We extend these concepts on the Riemannian manifold. We also detail the fundamental properties of (E...

  • Review
  • Open Access
67 Citations
18,132 Views
12 Pages

30 April 2015

Vitamin E is found in high quantities in vegetable oils. Although vitamin E has multiple functions in humans and animals, its key function is protecting cells from oxidative damage. Since its discovery, several studies have demonstrated that vitamin...

  • Article
  • Open Access
6 Citations
2,797 Views
16 Pages

Transcriptome Analysis Reveals the Multiple Functions of pBD2 in IPEC-J2 Cells against E. coli

  • Shaoqiang Lian,
  • Xiaqing Lin,
  • Fengting Zhan,
  • Xiaoyang Shen,
  • Yu Liang and
  • Chunli Li

28 August 2022

Defensins play an important role in fighting bacteria, and are a good candidate for bactericidal agents. However, the function and mechanism of defensins in regulating host responses against bacteria is unclear. In this study, transcriptome analysis...

  • Article
  • Open Access
1,685 Views
29 Pages

Optimal Portfolio Analysis Using Power and Natural Logarithm Utility Functions with E-Commerce Data

  • Apni Diyanti,
  • Moch. Fandi Ansori,
  • Susilo Hariyanto and
  • Ratna Herdiana

Determining the optimal portfolio is important in the investment process because it includes the selection of appropriate fund allocation to manage financial risk effectively. Although risk cannot be entirely eliminated, it is managed through strateg...

  • Article
  • Open Access
1 Citations
2,071 Views
14 Pages

9 May 2023

Estimating accurate radiation doses when a radioactive source’s location is unknown can protect workers from radiation exposure. Unfortunately, depending on a detector’s shape and directional response variations, conventional G(E) functio...

  • Article
  • Open Access
2 Citations
2,177 Views
27 Pages

19 December 2022

Given a sample, E-Bayesian estimates, which are the expected Bayesian estimators over the joint distributions of two hyperparameters in the prior distribution, are developed for the inverse Weibull distribution rate parameter under the scaled squared...

  • Article
  • Open Access
619 Views
12 Pages

25 July 2025

Indefinite integrals of products of exponential functions, power functions and generalized hypergeometric functions of some types are considered. Necessary and sufficient conditions are established for the algebraic independence of large sets of such...

  • Article
  • Open Access
3 Citations
1,830 Views
7 Pages

28 December 2022

Functions that are integrals of products of generalized hypergeometric functions of some kind are considered. The conditions for the representability of these functions as a polynomial in hypergeometric ones are found. The necessary and sufficient co...

  • Article
  • Open Access
1 Citations
2,725 Views
8 Pages

10 June 2021

The notions of cogredience and contragredience, which have great importance to the question of algebraic independence of linear differential equation solutions, are discussed in the paper. Conditions of equivalence of two definitions of cogredience a...

  • Review
  • Open Access
97 Citations
27,521 Views
41 Pages

IgE Antibodies: From Structure to Function and Clinical Translation

  • Brian J. Sutton,
  • Anna M. Davies,
  • Heather J. Bax and
  • Sophia N. Karagiannis

22 February 2019

Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through binding to Fc receptors FcεRI and FcεRII/CD23. Structural studies of IgE-Fc alone...

  • Article
  • Open Access
1 Citations
3,201 Views
20 Pages

User-Adapted Web Services by Extending the eIDAS Specification with Functional Attributes

  • Lourdes Marco,
  • Alejandro Pozo,
  • Gabriel Huecas,
  • Juan Quemada and
  • Álvaro Alonso

To provide web services adapted to the users’ functional capabilities, diversity must be considered from the conceptualization and design phases of the services’ development. In previous work, we proposed a model that allows the provisioning of adapt...

  • Review
  • Open Access
7 Citations
2,559 Views
11 Pages

Multiple Functions of Hepatitis E Virus ORF3

  • Fengyuan Jiao,
  • Yu Zhao,
  • Gengxu Zhou,
  • Chi Meng,
  • Lingjie Wang,
  • Shengping Wu,
  • Jixiang Li,
  • Liting Cao,
  • Bo Zhou and
  • Hanwei Jiao
  • + 1 author

Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The path...

  • Case Report
  • Open Access
475 Views
11 Pages

Longitudinal Multimodal Assessment of Structure and Function in INPP5E-Related Retinopathy

  • Andrea Cusumano,
  • Marco Lombardo,
  • Benedetto Falsini,
  • Michele D’Ambrosio,
  • Jacopo Sebastiani,
  • Enrica Marchionni,
  • Maria Rosaria D’Apice,
  • Barbara Rizzacasa,
  • Francesco Martelli and
  • Giuseppe Novelli

26 November 2025

Background: INPP5E-related retinopathy (INPP5E-RR) is a rare genetic disorder caused by biallelic pathogenic variants in the INPP5E gene, which encodes an enzyme critical for phosphoinositide signaling. While early-onset rod–cone dystrophy is a...

  • Article
  • Open Access
2,003 Views
15 Pages

Identification of Candidate Genes and eQTLs Related to Porcine Reproductive Function

  • Tong Zeng,
  • Ji Wang,
  • Zhexi Liu,
  • Xiaofeng Wang,
  • Han Zhang,
  • Xiaohua Ai,
  • Xuemei Deng and
  • Keliang Wu

3 April 2025

Expression quantitative trait locus (eQTL) mapping is an effective tool for identifying genetic variations that regulate gene expression. An increasing number of studies suggested that SNPs associated with complex traits in farm animals are considere...

  • Article
  • Open Access
2 Citations
2,582 Views
16 Pages

Identification and Functional Implications of the E5 Oncogene Polymorphisms of Human Papillomavirus Type 16

  • Antônio Humberto P. da Silva-Júnior,
  • Ruany Cristyne de Oliveira Silva,
  • Ana Pavla A. Diniz Gurgel,
  • Marconi Rêgo Barros-Júnior,
  • Kamylla Conceição Gomes Nascimento,
  • Daffany Luana Santos,
  • Lindomar J. Pena,
  • Rita de Cássia Pereira Lima,
  • Marcus Vinicius de Aragão Batista and
  • Antonio Carlos de Freitas
  • + 1 author

The persistence of the human papillomavirus type 16 (HPV16) infection on the cervical epithelium contributes to the progression of cervical cancer. Studies have demonstrated that HPV16 genetic variants may be associated with different risks of develo...

  • Article
  • Open Access
1 Citations
2,954 Views
20 Pages

Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function

  • Yang Wu,
  • Fujie Zhao,
  • Venkata N. Sure,
  • Abdulgafar Ibrahim,
  • Changjiang Yu,
  • Sean M. Carr and
  • Ping Song

17 January 2023

(1) Background: Apolipoprotein E (ApoE) is a critical plasma apolipoprotein for lipid transport and nonlipid-related functions. Humans possess three isoforms of ApoE (2, 3, and 4). ApoE2, which exhibits beneficial effects on cardiac health, has not b...

  • Communication
  • Open Access
15 Citations
3,426 Views
11 Pages

8 March 2021

Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in...

  • Article
  • Open Access
6 Citations
4,439 Views
10 Pages

Vitamin E nicotinate (tocopherol nicotinate, tocopheryl nicotinate; TN) is an ester of two vitamins, tocopherol (vitamin E) and niacin (vitamin B3), in which niacin is linked to the hydroxyl group of active vitamin E. This vitamin E ester can be chem...

  • Article
  • Open Access
8 Citations
5,771 Views
20 Pages

Statically Aggregate Verifiable Random Functions and Application to E-Lottery

  • Bei Liang,
  • Gustavo Banegas and
  • Aikaterini Mitrokotsa

Cohen, Goldwasser, and Vaikuntanathan (TCC’15) introduced the concept of aggregate pseudo-random functions (PRFs), which allow efficiently computing the aggregate of PRF values over exponential-sized sets. In this paper, we explore the aggregat...

  • Article
  • Open Access
9 Citations
3,661 Views
10 Pages

Self-Assembly of Functional Nucleic Acid-Based Colorimetric Competition Assay for the Detection of Immunoglobulin E

  • Xuexia Lin,
  • Caiyun Yu,
  • Honggui Lin,
  • Cui Wang,
  • Jianlong Su,
  • Jie Cheng,
  • Ranjith Kumar Kankala and
  • Shu-Feng Zhou

14 May 2019

In this work, we have developed a simple and rapid colorimetric assay for the detection of immunoglobulin E (IgE) using functional nucleic acids (FNAs) and a solid-phase competition enzyme-linked immunosorbent assay (ELISA). The FNAs including aptame...

  • Article
  • Open Access
3 Citations
1,823 Views
14 Pages

31 October 2023

Cyclophilin E (CypE) belongs to the cyclophilin family and exhibits peptidyl-prolyl cis-trans isomerase (PPIase) activity. It participates in various biological processes through the regulation of peptidyl-prolyl isomerization. However, the specific...

  • Article
  • Open Access
1 Citations
1,171 Views
25 Pages

21 July 2025

The study examined the effect of BIE eCoaching on the functional communication training (FCT) implementation skills of pre-service teachers (PTs) and the effect of FCT implemented by PTs on reducing problem behaviors and increasing communication skil...

  • Article
  • Open Access
19 Citations
6,939 Views
15 Pages

15 March 2023

The transition dairy cows are challenged by various stresses such as decreased dry matter intake, liver dysfunction, increased inflammation, and oxidative stress, particularly in subtropical regions. These might increase the requirement for vitamin E...

  • Article
  • Open Access
12 Citations
3,532 Views
22 Pages

Effect of Dietary Enrichment with Flaxseed, Vitamin E and Selenium, and of Market Class on the Broiler Breast Meat—Part 1: Nutritional and Functional Traits

  • Ambrogina Albergamo,
  • Rossella Vadalà,
  • Vincenzo Nava,
  • Giovanni Bartolomeo,
  • Rossana Rando,
  • Nadia Colombo,
  • Roberto Gualtieri,
  • Massimiliano Petracci,
  • Giuseppa Di Bella and
  • Nicola Cicero
  • + 1 author

16 April 2022

The effect of dietary enrichment with flaxseed, selenium and vitamin E, and market class on the nutritional and functional value of breast meat was evaluated. A completely randomized block design was set up, where the experimental unit (n = 6000 bird...

  • Article
  • Open Access
13 Citations
3,993 Views
12 Pages

Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot Study

  • Eliza Wasilewska,
  • Agnieszka Sobierajska-Rek,
  • Sylwia Małgorzewicz,
  • Mateusz Soliński,
  • Dominika Szalewska and
  • Ewa Jassem

Background: Duchenne muscular dystrophy (DMD) is the most common, progressive, irreversible muscular dystrophy. Pulmonary function is crucial for duration of life in this disease. Currently, the European Respiratory Society is focused on digital heal...

  • Article
  • Open Access
14 Citations
4,682 Views
19 Pages

This two-year follow-up assessment was performed on 721 elementary (Grades 2–4) and middle (Grade 1) school students who used, and 62 Grade 4 (Control) students who did not use, E-learning environments from schools in Beijing and Shandong Provi...

  • Technical Note
  • Open Access
2 Citations
2,154 Views
10 Pages

19 August 2024

China’s Chang’E-5 (CE-5) mission has successfully landed in the Northern Oceanus Procellarum of the Moon. Lunar mineralogical spectrometer (LMS), as one of the important payloads onboard CE-5 Lander–Ascender Combination, aims to stu...

  • Article
  • Open Access
6 Citations
2,364 Views
10 Pages

21 September 2024

Background/Objectives: Oxidative stress, an imbalance between oxidants and antioxidants, is known to affect pulmonary function (PF), thereby leading to the development of chronic obstructive pulmonary disease (COPD). However, data on the associations...

  • Article
  • Open Access
4 Citations
3,826 Views
25 Pages

29 August 2024

Milk boasts an array of potent bioactive compounds, such as lactoferrin (Lf), immunoglobulins, and functional proteins, all delivering substantial therapeutic benefits. In this study, Immune Powder (a functional dairy formulation) and its primary com...

  • Article
  • Open Access
7 Citations
2,368 Views
9 Pages

11 August 2022

In order to put forward an efficient and eco-friendly approach to degrade dye-containing industrial effluents, an n-Fe3O4/ACF nanocomposite was synthesized using the facile precipitation method and applied as a functional cathode for a heterogeneous...

  • Article
  • Open Access
1,193 Views
19 Pages

High-Density Lipoprotein Cholesterol and Cognitive Function in Older Korean Adults Without Dementia: Apolipoprotein E4 as a Moderating Factor

  • Young Min Choe,
  • Hye Ji Choi,
  • Musung Keum,
  • Boung Chul Lee,
  • Guk-Hee Suh,
  • Shin Gyeom Kim,
  • Hyun Soo Kim,
  • Jaeuk Hwang,
  • Dahyun Yi and
  • Jee Wook Kim

14 July 2025

Background: High-density lipoprotein cholesterol (HDL-C) is known for its cardiovascular and neuroprotective effects, but its association with cognitive function remains unclear, particularly in relation to genetic factors such as apolipoprotein E &e...

  • Review
  • Open Access
27 Citations
4,488 Views
18 Pages

14 April 2021

Alongside its contribution in maintaining skin homeostasis and its probable involvement in fetal and placental development, cystatin M/E (also known as cystatin 6) was first described as a tumor suppressor of breast cancer. This review aims to provid...

  • Article
  • Open Access
1 Citations
1,901 Views
12 Pages

New Generalization of Geodesic Convex Function

  • Ohud Bulayhan Almutairi and
  • Wedad Saleh

23 March 2023

As a generalization of a geodesic function, this paper introduces the notion of the geodesic φE-convex function. Some properties of the φE-convex function and geodesic φE-convex function are established. The concepts of a geodesic φE-...

  • Article
  • Open Access
8 Citations
4,316 Views
17 Pages

Design of Hardware Accelerators for Optimized and Quantized Neural Networks to Detect Atrial Fibrillation in Patch ECG Device with RISC-V

  • Ingo Hoyer,
  • Alexander Utz,
  • André Lüdecke,
  • Holger Kappert,
  • Maurice Rohr,
  • Christoph Hoog Antink and
  • Karsten Seidl

1 March 2023

Atrial Fibrillation (AF) is one of the most common heart arrhythmias. It is known to cause up to 15% of all strokes. In current times, modern detection systems for arrhythmias, such as single-use patch electrocardiogram (ECG) devices, have to be ener...

  • Review
  • Open Access
162 Citations
14,541 Views
18 Pages

1 December 2017

Tocopherols, together with tocotrienols and plastochromanols belong to a group of lipophilic compounds also called tocochromanols or vitamin E. Considered to be one of the most powerful antioxidants, tocochromanols are solely synthesized by photosynt...

  • Article
  • Open Access
18 Citations
5,642 Views
20 Pages

HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells

  • Bianca Altvater,
  • Sareetha Kailayangiri,
  • Lina F. Pérez Lanuza,
  • Katja Urban,
  • Lea Greune,
  • Maike Flügge,
  • Jutta Meltzer,
  • Nicole Farwick,
  • Simone König and
  • Claudia Rossig
  • + 2 authors

8 June 2021

Immune-inhibitory barriers in the tumor microenvironment of solid cancers counteract effective T cell therapies. Based on our finding that Ewing sarcomas (EwS) respond to chimeric antigen receptor (CAR) gene-modified effector cells through upregulati...

  • Article
  • Open Access
4 Citations
2,589 Views
15 Pages

11 June 2021

In its “Sustainable and Smart Mobility Strategy”, the European Commission assumes a 90% reduction in traffic emissions by 2050. The decarbonisation of transport logistics as a major contributor to climate change is, therefore, indicated. There are ma...

  • Article
  • Open Access
2,175 Views
20 Pages

9 November 2022

In this paper, we defined weighted (Eλ,q)(Cλ,1) statistical convergence. We also proved some properties of this type of statistical convergence by applying (Eλ,q)(Cλ,1) summability method. Moreover, we used (Eλ,q)(C...

  • Article
  • Open Access
1 Citations
2,195 Views
15 Pages

KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation

  • Antonia González-Garrido,
  • Omar López-Ramírez,
  • Abel Cerda-Mireles,
  • Thania Navarrete-Miranda,
  • Aranza Iztanami Flores-Arenas,
  • Arturo Rojo-Domínguez,
  • Leticia Arregui,
  • Pedro Iturralde,
  • Erika Antúnez-Argüelles and
  • Teresa Villarreal-Molina
  • + 3 authors

Genetic testing is crucial in inherited arrhythmogenic channelopathies; however, the clinical interpretation of genetic variants remains challenging. Incomplete penetrance, oligogenic, polygenic or multifactorial forms of channelopathies further comp...

  • Article
  • Open Access
17 Citations
5,195 Views
18 Pages

Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke

  • Xiaohui Wang,
  • Rongwen Li,
  • Alex Zacharek,
  • Julie Landschoot-Ward,
  • Fengjie Wang,
  • Kuan-Han Hank Wu,
  • Michael Chopp,
  • Jieli Chen and
  • Xu Cui

28 October 2018

The ATP-binding cassette transporter member A1 (ABCA1) and apolipoprotein E (ApoE) are major cholesterol transporters that play important roles in cholesterol homeostasis in the brain. Previous research demonstrated that specific deletion of brain-AB...

  • Article
  • Open Access
8 Citations
3,901 Views
11 Pages

26 December 2018

In this paper, we study differential equations arising from the generating functions of Hermit Kamp e ´ de F e ´ riet polynomials. Use this differential equation to give explicit identities for Hermite Kamp e ´ d...

  • Article
  • Open Access
2 Citations
7,409 Views
20 Pages

22 November 2012

As key factors in intercellular adhesion processes, cadherins play important roles in a plethora of developmental processes, including gametogenesis. In a previous study on cadherin localization in the gonads of honey bees, performed with heterologou...

  • Article
  • Open Access
8 Citations
2,081 Views
22 Pages

24 June 2022

The E-Bayesian estimation approach has been presented for estimating the parameter and/or reliability characteristics of various models. Several investigations in the literature have considered this method under the assumption that just one parameter...

  • Article
  • Open Access
1 Citations
1,549 Views
26 Pages

Bayesian and E-Bayesian Estimation for a Modified Topp Leone–Chen Distribution Based on a Progressive Type-II Censoring Scheme

  • Zakiah I. Kalantan,
  • Eman M. Swielum,
  • Neama T. AL-Sayed,
  • Abeer A. EL-Helbawy,
  • Gannat R. AL-Dayian and
  • Mervat Abd Elaal

2 August 2024

Abstract: This paper is concerned with applying the Bayesian and E-Bayesian approaches to estimating the unknown parameters of the modified Topp–Leone–Chen distribution under a progressive Type-II censored sample plan. The paper explores...

  • Review
  • Open Access
46 Citations
7,968 Views
24 Pages

Structures and Functions of Pestivirus Glycoproteins: Not Simply Surface Matters

  • Fun-In Wang,
  • Ming-Chung Deng,
  • Yu-Liang Huang and
  • Chia-Yi Chang

29 June 2015

Pestiviruses, which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and function...

  • Article
  • Open Access
7 Citations
1,689 Views
45 Pages

Fuzzy Logic Approach for Evaluating Electromobility Alternatives in Last-Mile Delivery: Belgrade as a Case Study

  • Dragan Lazarević,
  • Đorđe Popović,
  • Muhammed Yasin Çodur and
  • Momčilo Dobrodolac

13 December 2024

This paper proposes a methodology based on the fuzzy approach, which provides decision-making support to the organizer of last-mile delivery (LMD) in selecting sustainable delivery models for a specific territory. Solving this task is essential to en...

  • Review
  • Open Access
130 Citations
9,529 Views
16 Pages

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System

  • Weigang Liu,
  • Xun Tang,
  • Xuehong Qi,
  • Xue Fu,
  • Shantwana Ghimire,
  • Rui Ma,
  • Shigui Li,
  • Ning Zhang and
  • Huaijun Si

Owing to a sessile lifestyle in nature, plants are routinely faced with diverse hostile environments such as various abiotic and biotic stresses, which lead to accumulation of free radicals in cells, cell damage, protein denaturation, etc., causing a...

  • Article
  • Open Access
17 Citations
44,827 Views
13 Pages

19 June 2019

Lifestyle risk factors for erectile and sexual function include smoking, excessive alcohol consumption, lack of physical activity, psychological stress, and adherence to unhealthy diets. In the present study, we evaluated the effects of mixed nuts su...

  • Article
  • Open Access
4 Citations
2,784 Views
10 Pages

Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

  • Jiun-Chi Huang,
  • Ya-Chin Huang,
  • Pei-Yu Wu,
  • Wen-Hsien Lee,
  • Yi-Chun Tsai,
  • Yi-Ping Chen,
  • Szu-Chia Chen,
  • Ho-Ming Su,
  • Yi-Wen Chiu and
  • Jer-Ming Chang

17 June 2021

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified...

  • Article
  • Open Access
26 Citations
4,795 Views
16 Pages

12 January 2022

Detection of microbial contamination in water is imperative to ensure water quality. We have developed an electrochemical method for the detection of E. coli using bi-functional magnetic nanoparticle (MNP) conjugates. The bi-functional MNP conjugates...

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