Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants
2.3. Pulmonary Function Tests
2.3.1. Hospital Spirometry
2.3.2. Home Electronic Spirometry
2.4. Satisfaction Survey
2.5. Stage of Disease (Vignos Scale, Brooke Scale)
2.6. Statistical Analysis
3. Results
3.1. Participants
3.2. Pulmonary Function Test
3.2.1. Home Spirometry Frequency and Correctness
3.2.2. Hospital vs. Home Spirometry
3.2.3. Regression Analysis
3.3. Survey Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ID | Age | Weight | Height | BMI | AS | VS | BS | |||
---|---|---|---|---|---|---|---|---|---|---|
Years | kg | Centile | cm | Centile | Centile | |||||
1 | 13 | 34 | 3 | 137 | 1 | 18.1 | 40 | 1 | 2 | 6 |
2 | 10 | 24.5 | 1 | 119 | 1 | 17.3 | 48 | 1 | 2 | 3 |
3 | 14 | 57 | 52 | 145 | 1 | 27.1 | 96 | 1 | 3 | 4 |
4 | 15 | 90 | 97 | 181 | 80 | 27.5 | 97 | 0 | 9 | 4 |
5 | 15 | 82 | 97 | 160 | 1 | 32.0 | 99 | 0 | 8 | 5 |
6 | 11 | 55.5 | 88 | 150.5 | 40 | 24.5 | 94 | 1 | 1 | 6 |
7 | 10 | 42 | 76 | 142 | 38 | 20.8 | 86 | 0 | 8 | 6 |
8 | 10 | 50 | 93 | 140 | 34 | 25.5 | 97 | 0 | 8 | 6 |
9 | 11 | 48 | 76 | 133 | 16 | 27.1 | 91 | 1 | 2 | 5 |
10 | 16 | 64 | 79 | 170 | 64 | 22.1 | 81 | 0 | 9 | 1 |
11 | 10 | 56 | 95 | 141 | 28 | 28.2 | 98 | 0 | 9 | 5 |
12 | 9 | 43 | 88 | 138 | 41 | 22.6 | 93 | 1 | 1 | 2 |
13 | 16 | 49 | 8 | 160 | 2 | 19.1 | 34 | 1 | 1 | 1 |
14 | 15 | 70 | 70 | 166 | 7 | 25.4 | 91 | 0 | 9 | 2 |
Mean ± SD/Median (IQR) | 12.5 ± 2.6 | 54.7 ± 17.6 | 65.9 ± 35.7 | 148.9 ± 16.7 | 25.3 ± 25.6 | 24.1 ± 4.3 | 81.8 ± 23.0 | - | 4.9 ± 3.4 | 4.0 ± 1.9 |
Home Spirometry | |||||
---|---|---|---|---|---|
ID | Days of Measurements | Total Measurements | Acceptable Measurements | ||
nb | % | nb | nb | % | |
1 | 10.0 | 35.7 | 11 | 8 | 73 |
2 | 28.0 | 100.0 | 57 | 0 | 0 |
3 | 3.0 | 10.7 | 3 | 0 | 0 |
4 | 3.0 | 10.7 | 3 | 0 | 0 |
5 | 8.0 | 28.6 | 11 | 0 | 0 |
6 | 28.0 | 100.0 | 45 | 0 | 0 |
7 | 21.0 | 75.0 | 27 | 0 | 0 |
8 | 26.0 | 92.8 | 28 | 21 | 75 |
9 | 7.0 | 25.0 | 12 | 3 | 25 |
10 | 8.0 | 28.6 | 12 | 2 | 17 |
11 | 7.0 | 25.0 | 10 | 0 | 0 |
12 | 7.0 | 25.0 | 8 | 0 | 0 |
13 | 19.0 | 67.9 | 27 | 5 | 19 |
14 | 23.0 | 82.1 | 29 | 5 | 17 |
Mean ± SD | 14.1 ± 9.5 | 50.5 ± 33.8 | 20.2 ± 16.0 | 3.1 ± 5.7 | 16.1 ± 26.1 |
ID | Home (AioCare) Spirometry | Hospital (Jaeger) Spirometry | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
FVC (L) | FEV1 (L) | PEF (L/min) | FVC (%) | FEV1 (%) | PEF (%) | FVC (L) | FEV1 (L) | PEF (L/min) | FVC (%) | FEV1 (%) | PEF (%) | |
1 | 2.07 ± 0.05 | 1.80 ± 0.07 | 243 ± 10 | 79.9 ± 1.7 | 77.7 ± 2.8 | 83.5 ± 3.6 | 1.73 ± 0.22 | 1.44 ± 0.71 | 208 ± 1.33 | 77.4 ± 0.43 | 76.9 ± 0.41 | 80.7 ± 0.45 |
2 | 1.05 ± 0.30 | 0.90 ± 0.19 | 86 ± 27 | 62.3 ± 17.8 | 60.2 ± 12.6 | 41.2 ± 12.9 | 1.22 ± 0.42 | 1.2 ± 0.45 | 98 ± 6.55 | 87.1 ± 2.25 | 98.7 ± 1.44 | 52.8 ± 4.31 |
3 | 1.79 ± 0.33 | 1.55 ± 0.24 | 165 ± 2 | 60.4 ± 11.0 | 59.1 ± 9.0 | 50.3 ± 0.5 | 2.22 ± 0.32 | 1.79 ± 0.43 | 244 ± 2.2 | 84.1 ± 0.41 | 81.2 ± 0.23 | 83.0 ± 0.33 |
4 | 2.25 ± 1.84 | 1.83 ± 1.58 | 170 ± 144 | 43.2 ± 35.3 | 41.5 ± 35.8 | 32.5 ± 27.7 | 2.94 ± 0.34 | 2.63 ± 0.9 | 333 ± 17 | 65.5 ± 0.34 | 69.7 ± 2.3 | 69.6 ± 3.5 |
5 | 4.02 ± 1.97 | 2.22 ± 0.52 | 186 ± 43 | 106.9 ± 52.3 | 67.8 ± 15.9 | 38.3 ± 8.9 | 2.82 ± 1.22 | 2.09 ± 0.21 | 212 ± 14 | 87.5 ± 0.93 | 76.5 ± 1.32 | 57.3 ± 2.11 |
6 | 2.78 ± 0.19 | 2.59 ± 0.15 | 332 ± 14 | 97.0 ± 6.5 | 106.7 ± 6.4 | 93.4 ± 3.8 | 2.76 ± 0.55 | 2.49 ± 0.65 | 321 ± 11 | 101.8 ± 3.21 | 107.7 ± 2.54 | 100.1 ± 1.54 |
7 | 2.32 ± 0.23 | 2.05 ± 0.20 | 195 ± 35 | 90.4 ± 9.0 | 93.9 ± 9.0 | 62.1 ± 11.2 | 2.13 ± 0.34 | 1.92 ± 0.31 | 231 ± 11 | 85.7 ± 0.34 | 92.1 ± 2.11 | 82.6 ± 2.57 |
8 | 2.49 ± 0.61 | 2.14 ± 0.18 | 233 ± 19 | 111.8 ± 27.4 | 110.8 ± 9.1 | 76.5 ± 6.2 | 2.13 ± −0.43 | 1.86 ± 0.54 | 232 ± 14 | 89.4 ± 2.12 | 93.1 ± 3.20 | 85.5 ± 3.5 |
9 | 1.40 ± 0.42 | 1.00 ± 0.31 | 145 ± 49 | 70.8 ± 21.1 | 58.4 ± 17.9 | 53.1 ± 17.8 | 1.58 ± 0.55 | 1.15 ± 0.45 | 215 ± 12 | 77.1 ± 1.32 | 66.9 ± 2.54 | 89.6 ± 6.23 |
10 | 2.14 ± 0.48 | 1.81 ± 0.22 | 228 ± 53 | 50.7 ± 11.3 | 49.7 ± 6.0 | 44.1 ± 10.3 | 2.00 ± 0.41 | 1.98 ± 0.92 | 233 ± 16 | 47.5 ± 2.40 | 56.8 ± 3.13 | 54.6 ± 3.22 |
11 | 1.62 ± 0.42 | 1.06 ± 0.25 | 110 ± 26 | 72.5 ± 19.1 | 55.0 ± 12.7 | 35.5 ± 8.4 | 1.38 ± 0.74 | 1.13 ± 0.34 | 115 ± 14 | 56.6 ± 2.43 | 55.5 ± 1.34 | 41.6 ± 3.44 |
12 | 2.04 ± 0.10 | 1.84 ± 0.09 | 206 ± 32 | 91.4 ± 4.7 | 95.2 ± 4.5 | 68.6 ± 10.6 | 1.94 ± 0.75 | 1.70 ± 0.39 | 187 ± 31 | 85.0 ± 2.4 | 88.8 ± 4.1 | 71.6 ± 3.5 |
13 | 2.63 ± 0.24 | 2.39 ± 0.27 | 243 ± 41 | 69.9 ± 6.3 | 73.2 ± 8.3 | 50.2 ± 8.5 | 2.74 ± 0.34 | 2.48 ± 0.49 | 258 ± 23 | 77.6 ± 2,4 | 84.5 ± 5.2 | 69.8 ± 5.43 |
14 | 2.96 ± 0.14 | 2.52 ± 0.12 | 249 ± 13 | 70.0 ± 3.4 | 69.0 ± 3.3 | 48.8 ± 2.6 | 2.76 ± 0.45 | 2.39 ± 0.34 | 238 ± 32 | 70.0 ± 3.2 | 73.3 ± 1.55 | 59.0 ± 3.56 |
Home (AioCare) Spirometry %pv | Hospital (Jaeger) Spirometry %pv | Mean Difference Home vs. Hospital Spirometry | p-Value * | Correlation r ** | |
---|---|---|---|---|---|
FVC (L) | 2.25 ± 0.73 | 2.17 ± 0.57 | 0.09 ± 0.44 | 0.476 | 0.80 |
FEV1 (L) | 1.84 ± 0.55 | 1.88 ± 0.51 | −0.04 ± 0.29 | 0.624 | 0.85 |
PEF (L/min) | 199 ± 63 | 223 ± 64 | −23.86 ± 51.32 | 0.106 | 0.67 |
FVC%pv | 76.94 ± 20.36 | 78.02 ± 14.21 | −1.08 ± 15.17 | 0.795 | 0.67 |
FEV1%pv | 72.72 ± 21.47 | 80.12 ± 15.23 | −7.40 ± 14.43 | 0.077 | 0.74 |
PEF%pv | 55.57 ± 18.68 | 71.27 ± 16.58 | −15.70 ± 12.47 | 0.0004 | 0.76 |
Model 1 Age, BMI, AS, VS, BS, FEV1%pv | ||
AIC: | 101.00 | |
Variables: | Coefficient (95%CI) | p-value |
Intercept | 14.69 (−15.64–45.03) | 0.3628 |
BMI | −0.73 (−1.71–0.26) | 0.1744 |
FEV1%pv | 0.234 (0.039–0.430) | 0.0387 |
Model 2: age, BMI, AS, VS, BS, FVC%pv | ||
AIC: | 102.19 | |
Variables | Coefficient (95%CI) | p-value |
Intercept | 24.71 (−2.81–52.22) | 0.1062 |
BMI | −1.45 (−2.17–−0.13) | 0.0494 |
FVC%pv | 0.2226 (0.0090–0.4362) | 0.0659 |
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Wasilewska, E.; Sobierajska-Rek, A.; Małgorzewicz, S.; Soliński, M.; Szalewska, D.; Jassem, E. Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 8967. https://doi.org/10.3390/ijerph18178967
Wasilewska E, Sobierajska-Rek A, Małgorzewicz S, Soliński M, Szalewska D, Jassem E. Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot Study. International Journal of Environmental Research and Public Health. 2021; 18(17):8967. https://doi.org/10.3390/ijerph18178967
Chicago/Turabian StyleWasilewska, Eliza, Agnieszka Sobierajska-Rek, Sylwia Małgorzewicz, Mateusz Soliński, Dominika Szalewska, and Ewa Jassem. 2021. "Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot Study" International Journal of Environmental Research and Public Health 18, no. 17: 8967. https://doi.org/10.3390/ijerph18178967