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Article

Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

by 1,2,3, 4,5, 1,2, 2,3,6, 1,3, 7, 1,2,3,*,†, 2,3,6,*,†, 1,3 and 1,3
1
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
3
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Department of Preventive Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan
5
Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7
Department of Laboratory Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Katarzyna Socha
Nutrients 2021, 13(6), 2077; https://doi.org/10.3390/nu13062077
Received: 27 May 2021 / Revised: 15 June 2021 / Accepted: 15 June 2021 / Published: 17 June 2021
(This article belongs to the Special Issue Zinc and Copper Levels in the Body and Human Health)
Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients. View Full-Text
Keywords: serum zinc; diastolic function; E/e’ ratio; left atrial volume index; hemodialysis serum zinc; diastolic function; E/e’ ratio; left atrial volume index; hemodialysis
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MDPI and ACS Style

Huang, J.-C.; Huang, Y.-C.; Wu, P.-Y.; Lee, W.-H.; Tsai, Y.-C.; Chen, Y.-P.; Chen, S.-C.; Su, H.-M.; Chiu, Y.-W.; Chang, J.-M. Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients. Nutrients 2021, 13, 2077. https://doi.org/10.3390/nu13062077

AMA Style

Huang J-C, Huang Y-C, Wu P-Y, Lee W-H, Tsai Y-C, Chen Y-P, Chen S-C, Su H-M, Chiu Y-W, Chang J-M. Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients. Nutrients. 2021; 13(6):2077. https://doi.org/10.3390/nu13062077

Chicago/Turabian Style

Huang, Jiun-Chi, Ya-Chin Huang, Pei-Yu Wu, Wen-Hsien Lee, Yi-Chun Tsai, Yi-Ping Chen, Szu-Chia Chen, Ho-Ming Su, Yi-Wen Chiu, and Jer-Ming Chang. 2021. "Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients" Nutrients 13, no. 6: 2077. https://doi.org/10.3390/nu13062077

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