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613 Results Found

  • Article
  • Open Access
32 Citations
5,172 Views
18 Pages

1 May 2019

The operation of a wastewater treatment plant (WWTP) is a typical complex control problem, with nonlinear dynamics and coupling effects among the variables, which renders the implementation of real-time optimal control an enormous challenge. In this...

  • Feature Paper
  • Article
  • Open Access
8 Citations
7,696 Views
14 Pages

26 March 2022

The ASM1 model was elaborated by the IWA Task Group for Mathematical Modelling, with the aim of explaining and predicting the output values of organic matter concentration in activated sludge processes, especially for domestic wastewaters. In recent...

  • Article
  • Open Access
8 Citations
5,710 Views
23 Pages

Fostering the Sustainability of Artisanal and Small-Scale Mining (ASM) of Barite in Nasarawa State, Nigeria

  • Itohan Otoijamun,
  • Moses Kigozi,
  • Sikiru Ottan Abdulraman,
  • Adelana Rasak Adetunji and
  • Azikiwe Peter Onwualu

24 May 2021

The exploration and mining of Nigerian barite are primarily by artisanal and small-scale miners (ASM) whose operations are characterized by poor productivity. As a result, the quantity and quality of barites produced do not satisfy the nation’s oil s...

  • Article
  • Open Access
11 Citations
3,685 Views
8 Pages

Modelization of Nutrient Removal Processes at a Large WWTP Using a Modified ASM2d Model

  • Jakub Drewnowski,
  • Jacek Makinia,
  • Lukasz Kopec and
  • Francisco-Jesus Fernandez-Morales

The biodegradation of particulate substrates starts by a hydrolytic stage. Hydrolysis is a slow reaction and usually becomes the rate limiting step of the organic substrates biodegradation. The objective of this work was to evaluate a novel hydrolysi...

  • Review
  • Open Access
2 Citations
3,531 Views
12 Pages

Application of the Advanced Surface Modification Process to the ASME Code Case for Sections III and XI of Nuclear Power Plants

  • Sungwoo Cho,
  • Hyun-Uk Hong,
  • Nicholas Mohr,
  • Marc Albert,
  • John Broussard,
  • Auezhan Amanov and
  • Young-Sik Pyun

1 February 2020

The advanced surface modification process is known as a promising solution to improve the performance of machine components and systems, especially for vehicles, nuclear power plants, biomedical device, etc. There have been several successful applica...

  • Article
  • Open Access
9 Citations
27,613 Views
21 Pages

6 September 2021

Geometrical tolerances are defined in the ISO Geometrical Product Specification system that is used worldwide, but on the other hand, the ASME Y14.5 standard is used in American companies to define how far actual parts may be away from their nominal...

  • Article
  • Open Access
6 Citations
2,945 Views
17 Pages

A 5-Year Study of Antiseizure Medications (ASMs) Monitoring in Patients with Neuropsychiatric Disorders in an Italian Clinical Center

  • Letizia Biso,
  • Marco Carli,
  • Shivakumar Kolachalam,
  • Giorgio Monticelli,
  • Pasquale Fabio Calabrò,
  • Antonello di Paolo,
  • Filippo Sean Giorgi,
  • Guido Bocci and
  • Marco Scarselli

Despite receiving appropriate antiseizure medications (ASMs), a relevant percentage of neuropsychiatric patients do not benefit from this approach, and one reason is subtherapeutic ASMs plasma concentration (C(p)) due to improper drug adherence, inte...

  • Article
  • Open Access
3 Citations
3,111 Views
21 Pages

A Study on Creep-Fatigue Evaluation of Nuclear Cladded Components by ASME-III Division 5

  • Gyeong-Hoi Koo,
  • Sang-Yun Lee,
  • Joo-Hwan Seo,
  • Kang-Hyun Song,
  • Geun-Suk Choi and
  • Myong-Sung Sohn

21 March 2023

In this paper, a study on creep-fatigue evaluation on the cladded nuclear component subjecting to low pressure and high temperature services is carried out. To do this, the codes and standards presented by ASME-III Division 5 are reviewed, and a deta...

  • Feature Paper
  • Article
  • Open Access
8 Citations
4,277 Views
19 Pages

17 March 2022

Wastewater treatment plants (WWTPs) are high-energy-consuming units. Reasonable operation strategies can enable WWTPs to meet discharge standards while reducing the operating cost. In this study, the activated sludge model 2d (ASM2d), Pareto analysis...

  • Article
  • Open Access
17 Citations
4,084 Views
18 Pages

Comparative Study of Balancing SRT by Using Modified ASM2d in Control and Operation Strategy at Full-Scale WWTP

  • Jakub Drewnowski,
  • Jacek Mąkinia,
  • Aleksandra Szaja,
  • Grzegorz Łagód,
  • Łukasz Kopeć and
  • José Alonso Aguilar

7 March 2019

Detailed knowledge on the composition of the influent going into the wastewater treatment system is essential for the development of a reliable computer model. In the context of WWTPs (wastewater treatment plants), the wastewater characteristics are...

  • Article
  • Open Access
13 Citations
26,859 Views
32 Pages

16 June 2023

This study aims to address the hazards associated with the design and manufacture of pressure vessels used for storing dangerous liquids, specifically focusing on the increased demand for liquefied petroleum gas (LPG) worldwide. The construction of m...

  • Article
  • Open Access
4 Citations
2,504 Views
15 Pages

12 August 2024

Background and Objectives: Oxidative stress resulting from a disturbance of the endogenous redox system is suspected in numerous diseases of the central nervous system, including epilepsy. In addition, antiseizure medications (ASMs), especially those...

  • Article
  • Open Access
16 Citations
6,193 Views
16 Pages

29 March 2019

The purpose of this research is to compare both British standard BS 7910 (2013) and American standard API 579/ASME FFS-1 (2016) stress intensity factor (SIF) solutions by considering a series of semielliptical surface cracks located in the external s...

  • Article
  • Open Access
3 Citations
3,184 Views
13 Pages

Acid sphingomyelinase (ASM) regulates a variety of physiological processes and plays an important role in emotional behavior. The role of ASM in fear-related behavior has not been investigated so far. Using transgenic mice overexpressing ASM (ASMtg)...

  • Article
  • Open Access
11 Citations
3,615 Views
21 Pages

Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D

  • Yuqing Wu,
  • Cao Li,
  • Huiming Peng,
  • Ashraf Swaidan,
  • Andrea Riehle,
  • Barbara Pollmeier,
  • Yang Zhang,
  • Erich Gulbins and
  • Heike Grassmé

3 November 2020

Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most severe diseases worldwide. The initial pulmonary localization of the pathogen often develops into systemic infection with high lethality. The present work investigated the role of...

  • Article
  • Open Access
4 Citations
1,453 Views
13 Pages

β-Tocotrienol Decreases PDGF-BB-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Inhibiting RhoA and Reducing ROS Production

  • Aditya Sri Listyoko,
  • Ryota Okazaki,
  • Tomoya Harada,
  • Miki Takata,
  • Masato Morita,
  • Hiroki Ishikawa,
  • Yoshihiro Funaki and
  • Akira Yamasaki

Background: Tocotrienols exhibit antioxidant and anti-inflammatory activities. RhoA, a small GTPase protein, plays a crucial role in regulating contractility in airway smooth muscle (ASM). Previous studies have demonstrated that γ-tocotrienols...

  • Review
  • Open Access
106 Citations
15,944 Views
38 Pages

The Asian Summer Monsoon: Teleconnections and Forcing Mechanisms—A Review from Chinese Speleothem δ18O Records

  • Haiwei Zhang,
  • Yassine Ait Brahim,
  • Hanying Li,
  • Jingyao Zhao,
  • Gayatri Kathayat,
  • Ye Tian,
  • Jonathan Baker,
  • Jian Wang,
  • Fan Zhang and
  • Hai Cheng
  • + 2 authors

23 July 2019

Asian summer monsoon (ASM) variability significantly affects hydro-climate, and thus socio-economics, in the East Asian region, where nearly one-third of the global population resides. Over the last two decades, speleothem δ18O records from Chi...

  • Review
  • Open Access
54 Citations
13,816 Views
25 Pages

The Indian Summer Monsoon from a Speleothem δ18O Perspective—A Review

  • Nikita Kaushal,
  • Sebastian F. M. Breitenbach,
  • Franziska A. Lechleitner,
  • Ashish Sinha,
  • Vinod C. Tewari,
  • Syed Masood Ahmad,
  • Max Berkelhammer,
  • Shraddha Band,
  • Madhusudan Yadava and
  • Gideon M. Henderson
  • + 1 author

7 December 2018

As one of the most prominent seasonally recurring atmospheric circulation patterns, the Asian summer monsoon (ASM) plays a vital role for the life and livelihood of about one-third of the global population. Changes in the strength and seasonality of...

  • Article
  • Open Access
787 Views
20 Pages

18 December 2025

Artisanal and Small-scale Mining (ASM) significantly impacts the Democratic Republic of Congo’s (DRC) socio-economic landscape and environmental integrity, yet its dynamic and informal nature makes monitoring challenging. This study addresses t...

  • Review
  • Open Access
2,119 Views
20 Pages

1 March 2022

As a feedback control methodology exclusively targeting asynchronous sequential machines (ASMs), corrective control has been rapidly developing for the past two decades. This paper presents a comprehensive survey on the theory and application of dyna...

  • Article
  • Open Access
3 Citations
2,952 Views
10 Pages

27 December 2022

Aggressive space mapping (ASM) is a common filter simulation and debugging method. It plays an important role in the field of microwave device design. This paper introduces ASM and presents the design and fabrication of a compact fifth-order microstr...

  • Brief Report
  • Open Access
4 Citations
3,339 Views
10 Pages

Replacement of Valproic Acid with New Anti-Seizure Medications in Idiopathic Generalized Epilepsy

  • Ayataka Fujimoto,
  • Hideo Enoki,
  • Keisuke Hatano,
  • Keishiro Sato and
  • Tohru Okanishi

5 August 2022

Background: Little is known regarding the non-inferiority of new anti-seizure medications (ASMs) in terms of replacing valproic acid (VPA) in patients with idiopathic generalized epilepsy (IGE). We hypothesized that replacement of VPA with new ASMs w...

  • Review
  • Open Access
43 Citations
8,479 Views
27 Pages

20 August 2021

Here, we present the main features of human acid sphingomyelinase (ASM), its biosynthesis, processing and intracellular trafficking, its structure, its broad substrate specificity, and the proposed mode of action at the surface of the phospholipid su...

  • Article
  • Open Access
16 Citations
4,758 Views
16 Pages

The Influence of COD Fraction Forms and Molecules Size on Hydrolysis Process Developed by Comparative OUR Studies in Activated Sludge Modelling

  • Jakub Drewnowski,
  • Bartosz Szeląg,
  • Li Xie,
  • Xi Lu,
  • Mahesh Ganesapillai,
  • Chinmoy Kanti Deb,
  • Joanna Szulżyk-Cieplak and
  • Grzegorz Łagód

19 February 2020

The activated sludge models (ASMs) commonly used by the International Water Association (IWA) task group are based on chemical oxygen demand (COD) fractionations. However, the proper evaluation of COD fractions, which is crucial for modelling and esp...

  • Article
  • Open Access
3 Citations
2,565 Views
14 Pages

Accumulating evidence suggests an involvement of sphingolipids, vital components of cell membranes and regulators of cellular processes, in the pathophysiology of both Parkinson’s disease and major depressive disorder, indicating a potential co...

  • Article
  • Open Access
16 Citations
3,284 Views
16 Pages

An Actuator Surface Model to Simulate Vertical Axis Turbines

  • Lucy Massie,
  • Pablo Ouro,
  • Thorsten Stoesser and
  • Qianyu Luo

12 December 2019

An actuator surface model (ASM) to be employed to simulate the effect of a vertical axis turbine on the hydrodynamics in its vicinity, particularly its wake is introduced. The advantage of the newly developed ASM is that it can represent the complex...

  • Article
  • Open Access
1 Citations
3,307 Views
20 Pages

Present in the Aquatic Environment, Unclear Evidence in Top Predators—The Unknown Effects of Anti-Seizure Medication on Eurasian Otters (Lutra lutra) from Northern Germany

  • Simon Rohner,
  • Martina Gramer,
  • Ivo Wiesweg,
  • Oliver Scherf-Clavel,
  • Peter Wohlsein,
  • Martin Schmelz,
  • Ursula Siebert,
  • Franziska Richter and
  • Manuela Gernert

31 March 2023

Emerging contaminants are produced globally at high rates and often ultimately find their way into the aquatic environment. These include substances contained in anti-seizure medication (ASM), which are currently appearing in surface waters at increa...

  • Article
  • Open Access
9 Citations
4,750 Views
20 Pages

17 September 2020

Activated sludge models (ASMs) are often used in the simulation of the wastewater treatment process to evaluate whether the effluent quality parameters of a wastewater treatment plant meet the standards. The premise of successful simulation is to cho...

  • Article
  • Open Access
2 Citations
2,109 Views
18 Pages

Improving Runoff Prediction Accuracy in a Mountainous Watershed Using a Remote Sensing-Based Approach

  • Solmaz Fathololoumi,
  • Ali Reza Vaezi,
  • Seyed Kazem Alavipanah,
  • Ardavan Ghorbani,
  • Mohammad Karimi Firozjaei and
  • Asim Biswas

23 August 2023

Due to the limited number and sparse distribution of meteorological and hydrometric stations in most watersheds, the runoff estimation based on these stations may not be accurate. However, the accurate determination of the Antecedent Soil Moisture (A...

  • Article
  • Open Access
1,201 Views
15 Pages

Experiences Reported by People with Epilepsy During Antiseizure Medication Shortages in the UK: A Cross-Sectional Survey

  • Eric Amankona Abrefa Kyeremaa,
  • Tom Shillito,
  • Caroline Smith,
  • Charlotte Lawthom,
  • Sion Scott and
  • David Wright

10 November 2025

(1) Background: Medication shortages have become increasingly common in the UK. However, there is limited evidence regarding the experiences of people with epilepsy and their caregivers during these shortages. The aim of this study is to explore the...

  • Article
  • Open Access
8 Citations
3,075 Views
19 Pages

12 May 2023

We used DNA metabarcoding to compare macrozoobenthic species colonization between autonomous reef monitoring structures (ARMS) and artificial seaweed monitoring systems (ASMS). We deployed both substrates in two different locations (Ría de Vig...

  • Article
  • Open Access
3 Citations
2,975 Views
18 Pages

Artisanal Mining River Dredge Detection Using SAR: A Method Comparison

  • Marissa A. Alessi,
  • Peter G. Chirico and
  • Marco Millones

12 December 2023

Challenges exist in monitoring artisanal and small-scale mining (ASM) activities, given their dynamic and often informal nature. ASM takes form through various techniques and scales, including riverine dredging, which often targets the abundant alluv...

  • Article
  • Open Access
8 Citations
2,612 Views
23 Pages

19 January 2024

Stability-dependent far-field offshore wind-farm wakes are detected in Supervisory Control and Data Acquisition (SCADA) wind power records from wind farms located in the North Sea. The results are used to assess the strengths and weaknesses of the Op...

  • Article
  • Open Access
8 Citations
3,090 Views
7 Pages

Prevalence and Related Risk Factors of Vitamin D Deficiency in Saudi Children with Epilepsy

  • Reem Al Khalifah,
  • Muddathir H. Hamad,
  • Abrar Hudairi,
  • Lujain K. Al-Sulimani,
  • Doua Al Homyani,
  • Dimah Al Saqabi and
  • Fahad A. Bashiri

5 November 2022

Background: Vitamin D has a role in the pathogenesis of many medical disorders, especially those of the central nervous system. It is essential in maintaining the bone health of children. However, patients with epilepsy are at high risk of developing...

  • Article
  • Open Access
14 Citations
4,747 Views
26 Pages

21 May 2021

Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitat...

  • Article
  • Open Access
7 Citations
5,583 Views
26 Pages

Model-Based Solution for Upgrading Nitrogen Removal for a Full-Scale Municipal Wastewater Treatment Plant with CASS Process

  • Mengmeng Liu,
  • Meixue Chen,
  • Rong Qi,
  • Dawei Yu,
  • Min Yang,
  • Jiaxi Zheng,
  • Yuansong Wei and
  • Haizhou Du

15 March 2021

Aiming at providing cost-effective approach for upgrading the existing municipal wastewater treatment plants in the cold region of China to meet more stringent discharge standards of nitrogen removal, a full-scale sewage treatment plant with the CASS...

  • Article
  • Open Access
1,532 Views
15 Pages

20 October 2021

Static corrective controllers are more efficient than dynamic ones since they consist of only logic elements, whereas their existence conditions are more restrictive. In this paper, we present a static corrective control scheme for fault diagnosis an...

  • Article
  • Open Access
16 Citations
4,751 Views
21 Pages

Comparative Transcriptome Analysis of Pine Trees Treated with Resistance-Inducing Substances against the Nematode Bursaphelenchus xylophilus

  • Jungwook Park,
  • Hee Won Jeon,
  • Hyejung Jung,
  • Hyun-Hee Lee,
  • Junheon Kim,
  • Ae Ran Park,
  • Namgyu Kim,
  • Gil Han,
  • Jin-Cheol Kim and
  • Young-Su Seo

26 August 2020

The pinewood nematode (PWN) Bursaphelenchus xylophilus causes pine wilt disease, which results in substantial economic and environmental losses across pine forests worldwide. Although systemic acquired resistance (SAR) is effective in controlling PWN...

  • Article
  • Open Access
5 Citations
4,228 Views
20 Pages

Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach

  • Aliza Naz,
  • Sumbul Asif,
  • Khairiah Mubarak Alwutayd,
  • Sara Sarfaraz,
  • Sumra Wajid Abbasi,
  • Asim Abbasi,
  • Abdulkareem M. Alenazi and
  • Mohamed E. Hasan

27 March 2023

Over the past few years, COVID-19 has caused widespread suffering worldwide. There is great research potential in this domain and it is also necessary. The main objective of this study was to identify potential inhibitors against acid sphingomyelinas...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,956 Views
12 Pages

Simulation of an Oxic-Settling-Anaerobic Pilot Plant Operated under Real Conditions Using the Activated Sludge Model No.2d

  • Rosa Vitanza,
  • Angelo Cortesi,
  • Vittorino Gallo,
  • Maria E. De Arana and
  • Ioanna A. Vasiliadou

1 December 2021

Oxic-settling-anaerobic (OSA) process has been introduced into the treatment line of wastewater in order to upgrade activated sludge processes and to reduce the production of excess sludge. The aim of the present study was to simulate the performance...

  • Article
  • Open Access
2,130 Views
12 Pages

Effect of Antiseizure Medication on the Salience Network in Patients with Epilepsy with Generalized Tonic-Clonic Seizures Alone

  • Cătălina Elena Bistriceanu,
  • Georgiana-Anca Vulpoi,
  • Iulian Stoleriu and
  • Dan Iulian Cuciureanu

This study aimed to investigate the effects of antiepileptic drugs on salience network regions in patients with epilepsy with generalized tonic-clonic seizures alone (EGTCSa). A retrospective observational case-control study was performed on 40 patie...

  • Article
  • Open Access
12 Citations
4,502 Views
18 Pages

Steady-State and Dynamic Simulation for Wastewater Treatment Plant Management: Case Study of Maghnia City, North-West Algeria

  • Sidi Mohamed Tiar,
  • Madani Bessedik,
  • Chérifa Abdelbaki,
  • Nadia Badr ElSayed,
  • Abderrahim Badraoui,
  • Amaria Slimani and
  • Navneet Kumar

12 January 2024

Given the critical importance of addressing effluent quality concerns, the present study was dedicated to developing a dynamic simulation model based on the Activated Sludge Model 1 (ASM1) of a wastewater treatment plant located in Maghnia City, Alge...

  • Article
  • Open Access
18 Citations
6,836 Views
24 Pages

Health and Safety Risk Mitigation among Artisanal and Small-Scale Gold Miners in Zimbabwe

  • Josephine Singo,
  • Dingani Moyo,
  • John Bosco Isunju,
  • Stephan Bose-O’Reilly,
  • Nadine Steckling-Muschack,
  • Jana Becker and
  • Antony Mamuse

Artisanal and small-scale gold mining (ASGM) is often associated with no or compromised attention to health and safety. Although headlines of fatal accidents in Zimbabwe characterise ASGM, little attention is paid to prevention strategies. This study...

  • Review
  • Open Access
15 Citations
3,618 Views
19 Pages

Antiseizure Medications in Alzheimer’s Disease from Preclinical to Clinical Evidence

  • Francesca Bosco,
  • Lorenza Guarnieri,
  • Vincenzo Rania,
  • Ernesto Palma,
  • Rita Citraro,
  • Maria Tiziana Corasaniti,
  • Antonio Leo and
  • Giovambattista De Sarro

10 August 2023

Alzheimer’s disease (AD) and epilepsy are common neurological disorders in the elderly. A bi-directional link between these neurological diseases has been reported, with patients with either condition carrying almost a two-fold risk of contract...

  • Article
  • Open Access
9 Citations
3,943 Views
22 Pages

Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells

  • Tsung-Lin Lee,
  • Shyang-Guang Wang,
  • Wen-Ling Chan,
  • Ching-Hsiao Lee,
  • Tian-Shung Wu,
  • Meng-Liang Lin and
  • Shih-Shun Chen

5 February 2020

The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response...

  • Article
  • Open Access
3 Citations
4,448 Views
21 Pages

27 December 2022

The fatigue assessment of tube connections under cyclic pressure is discussed using four kinds of methods from ASME VIII-2 and EN 13445-3. FEA results are compared to the fatigue test, and some conclusions are obtained. Method 1 is the most widely us...

  • Article
  • Open Access
45 Citations
8,396 Views
26 Pages

4 October 2020

Mathematical modeling has become an indispensable tool for sustainable wastewater management, especially for the simulation of complex biochemical processes involved in the activated sludge process (ASP), which requires a substantial amount of data r...

  • Article
  • Open Access
2,559 Views
18 Pages

Unraveling the Radioprotective Mechanisms of UV-Resistant Bacillus subtilis ASM-1 Extracted Compounds through Molecular Docking

  • Asim Ur Rahman,
  • Aftab Ali,
  • Faisal Ahmad,
  • Sajjad Ahmad,
  • Metab Alharbi,
  • Abdullah F. Alasmari,
  • Amna Fayyaz,
  • Qurrat ul ain Rana,
  • Samiullah Khan and
  • Aamer Ali Shah
  • + 2 authors

11 August 2023

Radioresistant microorganisms possess inimitable capabilities enabling them to thrive under extreme radiation. However, the existence of radiosensitive microorganisms inhabiting such an inhospitable environment is still a mystery. The current study e...

  • Article
  • Open Access
3,022 Views
17 Pages

Revamping Optimization of a Pressure Piping System Using Artificial Neural Networks

  • Riccardo Caponetto,
  • Giovanna Fargione,
  • Fabio Giudice and
  • Marco Schiavo

1 November 2022

The paper proposes a new methodology for revamping design and optimization of a process piping system. Starting from ASME B31.3 Process Piping prescriptions for stress analysis, a nonlinear model is built to express the relationship between stress di...

  • Article
  • Open Access
5 Citations
5,633 Views
13 Pages

Structural Characterization of the S-glycosylated Bacteriocin ASM1 from Lactobacillus plantarum

  • Alexander K. Goroncy,
  • Trevor S. Loo,
  • Adrian M. Koolaard,
  • Mark L. Patchett and
  • Gillian E. Norris

In order to protect their environmental niche, most bacteria secret antimicrobial substances designed to target specific bacterial strains that are often closely related to the producer strain. Bacteriocins, small, ribosomally synthesised antimicrobi...

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