Adult T-cell leukemia/lymphoma (ATL) is an intractable disease affecting nearly 4% of Human T-cell Leukemia Virus Type 1 (HTLV-1) carriers. Acute ATL has a unique interaction with bone characterized by aggressive bone invasion, osteolytic metastasis,...
Androgen receptor splice variants (AR-SVs) contribute to the aggressive growth of castration-resistant prostate cancer (CRPC). AR-SVs, including AR-V7, are expressed in ~30% of CRPC, but minimally in treatment-naïve primary prostate cancer (PCa)...
Slave Province in Canada is an Archean granite–supracrustal terrane at the northwestern corner of the Canadian Shield. It is bordered by the Thelon–Taltson orogen (2.0 to 1.9 Ga) to the southeast and the Wopmay orogen (1.9 to 1.8 Ga) to t...
Androgen receptor (AR, a member of the steroid hormone receptor family) status has become increasingly important as both a prognostic marker and potential therapeutic target in breast cancer. AR is expressed in up to 90% of estrogen receptor (ER) pos...
Seamounts are features generated by hot spots and associated intraplate volcanic activity. The geochemical characteristics of igneous rocks constituting seamounts provide evidence of important details of dynamic processes in the Earth, such as mantle...
Typically, 40Ar/39Ar dating of phlogopites from deep-seated xenoliths of kimberlite pipes produces estimates that suggest much older ages than those when these pipes were intruded. High-pressure (3 GPa) laboratory experiments enabled the authors to e...
The argon isotopic compositions of chondrule-forming minerals of the Allende (CV3) meteorite were examined to evaluate the possibility of in situ 40Ar/39Ar dating of planetary surface rocks based on cosmogenic 39Ar without neutron irradiation in a re...
Integrated 40Ar/39Ar and U-Pb geochronology, combined with microstructural analysis of Early Cretaceous volcanics from eastern China, challenge conventional interpretations of flat 40Ar/39Ar age spectra. K-feldspar sample JD-1K (122.12 ± 0.81...
Comprehensive collisional radiative (CR) models have been developed for the diagnostic of argon plasma using Ar and Ar+ emission lines. The present CR models consist of 42 and 114 fine-structure levels of Ar and Ar+, respectively. Various populating...
A number of Augmented Reality (AR) frameworks are now available and used to support the development of mobile AR applications. In this paper, we measure and compare the recognition performance of the commercial AR frameworks and identify potential is...
Chrome chlorites are usually found as secondary phases formed by hydrothermal alteration of chromite deposits and associated mafic/ultramafic rocks. Here, we report the 40Ar/39Ar age of chrome chlorites separated from the Luobusa massive chromitites...
The 40Ar/39Ar method applied to K-feldspars and muscovite has been often used to construct continuous thermal history paths between ~150–600 °C, which are usually applied to structural and tectonic questions in many varied geological settings. Howeve...
Prostate cancer (PCa) relies in part on AR-signaling for disease development and progression. Earlier, we developed drug candidate galeterone, which advanced through phase 2-clinical trials in treating castration-resistant PCa (CRPC). Subsequently, w...
Detrital zircon U-Pb and muscovite 40Ar/39Ar dating are useful tools for investigating sediment provenance and regional tectonic histories. However, the two types of data from same sample do not necessarily give consistent results. Here, we compare p...
The Liushuping deposit, located on the northeast margin of the Bikou Block, is the middle-sized gold-zinc deposit (with ore reserves of 15.67 × 104 t Zn and 2.2 t Au) in the Mianxian–Lueyang–Yangpingguan area. The orebodies occur in...
The recently discovered Daping tungsten deposit is located about 25 km north of Tongcheng County, Hubei Province, in the northern margin of the Sijiapu granite deposit of the Mufushan composite batholith. The ore body is produced in the northeast-ori...
Data and services are available anywhere at any time thanks to the Internet and mobile devices. Nowadays, there are new ways of representing data through trendy technologies such as augmented reality (AR), which extends our perception of reality thro...
The Bayan Obo deposit, located on the northern margin of the North China Plate (NCP), is the world’s largest comprehensive Fe-REE-Nb deposit. After its formation, this deposit was affected by multiple tectonic thermal events, but the ages of th...
The in vacuo release of Ar and other noble gases is well understood for single minerals. However, natural samples, even those seemingly pure under the optical microscope, mostly consist of mm-to-µm scale intergrowths of different minerals. Typi...
The Maozaishan Sn deposit, located south of the Dayishan ore field in the Nanling Range, is a newly explored greisen-type Sn deposit. Two muscovite samples from tin-bearing ores yielded 40Ar/39Ar plateau ages of 154.7 ± 1.1 Ma (Mean standard w...
The Boqueirão granitic pegmatite, alias Alto da Cabeça pegmatite, is situated in Borborema Pegmatitic Province (BPP) in Northeast Brazil. This pegmatitic province hosts globally important reserves of tantalum and beryllium, as well as s...
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/−...
Over the past decade, advances in prostate cancer research have led to discovery and development of novel biomarkers and effective treatments. As treatment options diversify, it is critical to further develop and use optimal biomarkers for the purpos...
Economic and subeconomic concentrations of Sn, In, rare earth elements (REE), Ta, and Nb are known in Central Brazil, in the Goias Tin Province. The Sn-P enriched albitites studied in this paper occur in sharp contact with peraluminous granites of th...
Alzheimer’s, Parkinson’s, and multiple sclerosis are neurodegenerative diseases related by neuronal degeneration and death in specific areas of the central nervous system. These pathologies are associated with neuroinflammation, which is involved in...
The Malyy (Little) Murun massif of the Aldan Shield of the Siberian Craton has long been a kind of Siberian Mecca for geologists. It has attracted thousands of geologists, prospectors, and mineral collectors despite its remote location. It is famous...
Background: The outgrowth of castration-resistant prostate cancer (CRPC) dictates patient morbidity and mortality. Recurrence of prostate cancer (PC) following androgen-deprivation therapy (ADT) often occurs due to constitutively active androgen rece...
As an important part of the northern Huaiyang tectonic belt, the Mesozoic Xiaotian basin hosts a series of gold and alunite deposits. However, the ages of these deposits remain unclear, constraining the further understanding of the genesis of these d...
Controversy surrounds the genetic relationship between gold mineralization and magmatism, especially in deposits in granite. Jiaodong Peninsula is the leading gold province in China, and most deposits are in Mesozoic granites; moreover, debate on the...
A Paleoproterozoic 40Ar/39Ar age, interpreted as the gold metallogenic epoch of the Lijiapuzi deposit in NE China, is reported in this paper. The ore body of this deposit is hosted in the marbles and schists of the Paleoproterozoic Dashiqiao Formatio...
The Lake George antimony mine was at one time North America’s largest producer of antimony. Despite being widely known for the antimony mineralization, the deposit also hosts a range of styles of mineralization such as multiple generations of W...
The Shimensi deposit (Northern Jiangxi, South China) is a recently discovered super-large tungsten deposit. Muscovite 40Ar/39Ar dating yielded a plateau age of 145.7 ± 0.9 Ma, with normal and inverse isochronal ages being 145.4 ± 1.4 Ma and 145.3 ± 1...
The Heilongjiang Complex provides a crucial geological record of the evolutionary history of the Mudanjiang Ocean, making it significant for understanding the accretion process between the Jiamusi Block and the Songliao Block. In this study, we analy...
The composite Albian–Eocene orogenic wedge of the northern part of the Inner Western Carpathians (IWC) comprises the European Variscan basement with the Upper Carboniferous–Triassic cover and the Jurassic to Upper Cretaceous sedimentary successions o...
Detection of androgen receptor (AR) variant 7 (AR-V7) is emerging as a clinically important biomarker in castrate resistant prostate cancer (CRPC). Detection is possible from tumor tissue, which is often inaccessible in the advanced disease setting....
Ordovician-Silurian subduction, Early Devonian arc-contient collision and followed post-collision extension are recorded in the north of the North China Craton. Most previous research has focused on the first two processes. Discussion on the post-col...
The Great Xing’an Range (GXR) is a significant belt of polymetallic deposits located in the eastern segment of the Central Asian Orogenic Belt. The recently found Huoluotai porphyry Cu (Mo) deposit is situated in the northern GXR region in nort...
The Guodian Fe deposit is representative of the newly discovered Qihe–Yucheng high-grade Fe skarn ore cluster, Luxi Block, eastern North China Craton (NCC). The age of the Pandian Fe deposit remains elusive, which hinders the understanding of i...
The Bailingshan submarine volcanic-hosted iron deposit in the Eastern Tianshan provides an opportunity to investigate skarn hydrothermal evolution and high-grade Fe mineralization. This study integrates garnet petrography, in situ major- and trace-el...
Discordant biotite 40Ar/39Ar age spectra are commonly reported in the literature. These can be caused by a number of processes related to in vacuo heating, homogenization of the argon distribution, and production of misleadingly flat age spectra. Pro...
The Weilasituo Li–polymetallic deposit, located on the western slope of the southern Great Xing’an Range in the eastern Central Asian Orogenic Belt, is hosted by quartz porphyry with crypto-explosive breccia-type Li mineralisation atop an...
Porphyry and epithermal deposits are important sources of base and precious metals. Most actively mined deposits have been exhumed such that ore bodies are relatively close to the surface and are therefore locatable and economic to extract. Identifyi...
This study combines Raman Spectroscopy on Carbonaceous Matter (RSCM) thermometry and 40Ar/39Ar dating to constrain the thermal structure of the Variscan Para-autochthonous Unit (PAU) in the southern French Massif Central. The RSCM data define a regio...
The simultaneous localization and mapping (SLAM) market is growing rapidly with advances in Machine Learning, Drones, and Augmented Reality (AR) technologies. However, due to the absence of an open source-based SLAM library for developing AR content,...
Background: Circulating tumor cells (CTC), androgen receptor full-length (AR-FL), and androgen receptor splice variant 7 (AR-V7) are prognostic in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). AR-V7 seems to predict res...
We report the first radiogenic Nd-Sr isotope data in the magmatic rocks island-arc ophiolite assemblage from the middle branch of the East Sayan ophiolite complexes to better constrain geodynamic processes in this segment of the CAOB in southern cent...
With the increasing demand for near real-time atmospheric water vapor monitoring, this study evaluates the performance of the open-source PRIDE PPP-AR software (version 3.0.5) for retrieving Zenith Total Delay (ZTD) and Integrated Water Vapor (IWV) o...
Augmented reality (AR) applications are currently used in many fields for communication and educational purposes. Tourism is also a sector where augmented reality is used for destination marketing and cultural heritage promotion. This study will focu...
The recently explored Xitian tungsten-tin (W-Sn) polymetallic ore field, located in Hunan province, South China, is one of the largest ore fields in the Nanling Range (NLR). Two major metallogenic types appeared in this ore field, skarn- and quartz v...
Background: Epigenetic modification influences androgen receptor (AR) activation, often resulting in prostate cancer (PCa) development and progression. Silencing histone-modifying enzymes (histone deacetylases-HDACs) either genetically or pharmacolog...
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