Special Issue "Staphylococcus Aureus Infection"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 September 2015).
Interests: T-cells in Staphylococcus aureus infection, S.aureus vaccine development, S.aureus evasion of phagocytes
The recent WHO report, ‘Antimicrobial resistance: global report on surveillance’ highlights the epidemic of antibiotic resistance in Staphylococcus aureus as a particular threat to society. Antibiotic resistance is a global crisis, which urgently requires alternative strategies to standard antibiotic therapy. There is an immediate unmet clinical need for an anti-S. aureus vaccine. Despite major efforts and significant financial investment by drug companies, an anti-S. aureus vaccine still eludes us. One of the critical factors impeding progress towards an efficacious anti-S. aureus vaccine has been an insufficient understanding of how this organism interacts with the host and in particular a paucity of insight into S. aureus immune mechanisms in humans. Compounding matters is S. aureus propensity for immune evasion. Novel therapeutic strategies will be required to disarm these immune evasion strategies, thus, promoting host immunity against infection. To-date, all vaccine candidates have worked on the premise of inducing protective anti-S. aureus antibodies. However, recent studies have revealed the importance of T-cells in coordinating phagocytic cell function and promoting bacterial clearance. It is now widely accepted that protective immunity to S. aureus requires a contribution from both cellular and humoral immunity. It is clear that any future success towards realizing an efficacious anti-S. aureus vaccine or the development of alternative immunomodulatory therapies against S. aureus will require that we increase our understanding of how this organism interacts with the host. For this Special Issue of Pathogens we invite you to submit a review article/original research article related to S. aureus host-pathogen interactions, and look forward to your contribution.
Dr. Rachel McLoughlin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Staphylococcus aureus
- innate immunity
- adaptive immunity
- immune evasion