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  • Review
  • Open Access
72 Citations
249,055 Views
22 Pages

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein

  • Vladimir N. Uversky,
  • Elrashdy M. Redwan,
  • William Makis and
  • Alberto Rubio-Casillas

Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel vaccine platform based on mRNA technology was introduced to the market. Globally, around 13.38 billion COVID-19 vaccine doses of diverse platforms have been administer...

  • Case Report
  • Open Access
16 Citations
116,222 Views
8 Pages

An Unconventional Case Study of Neoadjuvant Oncolytic Virotherapy for Recurrent Breast Cancer

  • Dubravko Forčić,
  • Karmen Mršić,
  • Melita Perić-Balja,
  • Tihana Kurtović,
  • Snježana Ramić,
  • Tajana Silovski,
  • Ivo Pedišić,
  • Ivan Milas and
  • Beata Halassy

23 August 2024

Intratumoural oncolytic virotherapy may have promise as a means to debulk and downstage inoperable tumours in preparation for successful surgery. Here, we describe the unique case of a 50-year-old self-experimenting female virologist with locally rec...

  • Article
  • Open Access
1 Citations
70,312 Views
16 Pages

Impact of mRNA and Inactivated COVID-19 Vaccines on Ovarian Reserve

  • Enes Karaman,
  • Adem Yavuz,
  • Erol Karakas,
  • Esra Balcioglu,
  • Busra Karaca,
  • Hande Nur Doganay,
  • Koray Gorkem Sacinti and
  • Orhan Yildiz

24 March 2025

Objectives: This study aimed to elucidate the effects of messenger RNA (mRNA) and inactivated coronavirus disease 2019 (COVID-19) vaccines on ovarian histology and reserve in rats. Methods: Thirty female Wistar albino rats, aged 16–24 weeks, we...

  • Article
  • Open Access
14 Citations
48,481 Views
16 Pages

Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers

  • Amelie Semmler,
  • Anna Katharina Mundorf,
  • Anna Sabrina Kuechler,
  • Karin Schulze-Bosse,
  • Harald Heidecke,
  • Kai Schulze-Forster,
  • Matthias Schott,
  • Markus Uhrberg,
  • Sandra Weinhold and
  • Karl J. Lackner
  • + 4 authors

26 October 2023

SARS-CoV-2 mRNA vaccination can entail chronic fatigue/dysautonomia tentatively termed post-acute COVID-19 vaccination syndrome (PACVS). We explored receptor autoantibodies and interleukin-6 (IL-6) as somatic correlates of PACVS. Blood markers determ...

  • Article
  • Open Access
5 Citations
45,842 Views
17 Pages

NEURO-COVAX: An Italian Population-Based Study of Neurological Complications after COVID-19 Vaccinations

  • Maria Salsone,
  • Carlo Signorelli,
  • Alessandro Oldani,
  • Valerio Fabio Alberti,
  • Vincenza Castronovo,
  • Salvatore Mazzitelli,
  • Massimo Minerva and
  • Luigi Ferini-Strambi

21 October 2023

Objective: In this Italian population-based study, we aimed to evaluate the neurological complications after the first and/or second dose of COVID-19 vaccines and factors potentially associated with these adverse effects. Methods: Our study included...

  • Perspective
  • Open Access
4 Citations
42,292 Views
9 Pages

14 November 2024

The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have con...

  • Review
  • Open Access
16 Citations
37,876 Views
16 Pages

Arising Concerns of Atypical Manifestations in Patients with Hand, Foot, and Mouth Disease

  • Yu Chen,
  • Bowen Dai,
  • Shujie Han,
  • Guangcai Duan,
  • Haiyan Yang,
  • Shuaiyin Chen,
  • Wangquan Ji and
  • Yuefei Jin

10 February 2023

Hand, foot, and mouth disease (HFMD) is a mild exanthematous, febrile disease, but it also remains a threat to global public health. HFMD is characterized by a brief febrile illness in children and with a typical skin rash of the hand and foot, with...

  • Case Report
  • Open Access
2 Citations
34,093 Views
10 Pages

Fatal Myocarditis following COVID-19 mRNA Immunization: A Case Report and Differential Diagnosis Review

  • Pedro Manuel Barros de Sousa,
  • Elon Almeida Silva,
  • Marcos Adriano Garcia Campos,
  • Joyce Santos Lages,
  • Rita da Graça Carvalhal Frazão Corrêa and
  • Gyl Eanes Barros Silva

13 February 2024

Carditis in childhood is a rare disease with several etiologies. We report a case of infant death due to pericarditis and myocarditis after the mRNA vaccine against COVID-19 (COVIDmRNAV). A 7-year-old male child received the first dose of the COVIDmR...

  • Article
  • Open Access
20 Citations
31,466 Views
14 Pages

COVID-19 Vaccination Did Not Increase the Risk of Potentially Related Serious Adverse Events: 18-Month Cohort Study in an Italian Province

  • Maria Elena Flacco,
  • Cecilia Acuti Martellucci,
  • Graziella Soldato,
  • Giuseppe Di Martino,
  • Roberto Carota,
  • Marco De Benedictis,
  • Graziano Di Marco,
  • Giustino Parruti,
  • Rossano Di Luzio and
  • Antonio Caponetti
  • + 1 author

23 December 2022

This cohort study on the entire population of an Italian Province assessed the incidence of potentially vaccine-related serious adverse events (PVR-SAEs) by COVID-19 vaccination status. From January 2021 to July 2022, we extracted all deaths and hosp...

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Vaccines - ISSN 2076-393X