A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19
Abstract
:1. Introduction
2. Materials and Methods
2.1. Routine Histology
2.2. Immunohistochemistry
2.3. Preparation of Positive Control Samples for the Immunohistochemical Detection of the Vaccine-Induced Spike Protein
2.4. Case Presentation and Description
2.4.1. Clinical History
2.4.2. Autopsy
3. Results
3.1. Autopsy Findings
3.2. Other Findings
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- Oral cavity: tongue bite was detected with bleeding under the tongue muscle (tongue bite is common with epileptic seizures).
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- Adrenal glands: bilateral mild cortical hyperplasia.
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- Colon: the elongated sigmoid colon was elongated with fecal impaction.
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- Kidneys: slight diffuse glomerulosclerosis and arterio-sclerosis, renal cortical scars (up to 10 mm in diameter), bilateral mild active nephritis and urocystitis as well as evidence of shock kidney disorder.
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- Liver: slight lipofuscinosis.
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- Spleen: mild acute splenitis.
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- Stomach: mild diffuse gastric mucosal bleeding.
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- Thyroid gland: bilateral nodular goiter with chocolate cysts (up to 0.5 cm in diameter).
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- Prostate gland: benign nodular prostatic hyperplasia and chronic persistent prostatitis.
3.3. Immunohistochemical Analyses
3.4. Autopsy-Based Diagnosis
4. Discussion
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Target Antigen | Manufacturer | Clone | Dilution | Incubation Time |
---|---|---|---|---|
CD3 (expressed by T-Lymphocytes) | cytomed | ZM-45 | 1:200 | 30 min |
CD68 (expressed by monocytic cells) | DAKO | PG-M1 | 1:100 | 30 min |
SARS-CoV-2-Spike subunit 1 | ProSci | 9083 | 1:500 | 30 min |
SARS-CoV-2-Nucleocapsid | ProSci | 35–720 | 1:500 | 30 min |
Item | Measure |
---|---|
Body weight | 60 kg |
Hight | 175 cm |
Heart weight | 410 g |
Brain weight | 1560 g |
Liver weight | 1500 g |
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Mörz, M. A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19. Vaccines 2022, 10, 1651. https://doi.org/10.3390/vaccines10101651
Mörz M. A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19. Vaccines. 2022; 10(10):1651. https://doi.org/10.3390/vaccines10101651
Chicago/Turabian StyleMörz, Michael. 2022. "A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19" Vaccines 10, no. 10: 1651. https://doi.org/10.3390/vaccines10101651