Next Article in Journal / Special Issue
Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines
Previous Article in Journal
New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens
Previous Article in Special Issue
In silico Designed Ebola Virus T-Cell Multi-Epitope DNA Vaccine Constructions Are Immunogenic in Mice
Open AccessReview

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

ProTherImmune, 3656 Happy Valley Road, Lafayette, CA 94549, USA
Vaccines 2019, 7(2), 37; https://doi.org/10.3390/vaccines7020037
Received: 7 March 2019 / Revised: 19 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Advances in DNA Vaccines)
This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies. While both have been under development since the 1990s, in recent years, significant excitement has turned to mRNA despite the licensure of several veterinary DNA vaccines. Both have required efforts to increase their potency either via manipulating the plasmid DNA and the mRNA directly or through the addition of adjuvants or immunomodulators as well as delivery systems and formulations. The greater inherent inflammatory nature of the mRNA vaccines is discussed for both its potential immunological utility for vaccines and for the potential toxicity. The status of the clinical trials of mRNA vaccines is described along with a comparison to DNA vaccines, specifically the immunogenicity of both licensed veterinary DNA vaccines and select DNA vaccine candidates in human clinical trials. View Full-Text
Keywords: DNA vaccine; mRNA vaccine; plasmid DNA; in vitro transcribed mRNA; immune responses; formulations; Cytolytic T Lymphocytes; antibodies; innate immunity DNA vaccine; mRNA vaccine; plasmid DNA; in vitro transcribed mRNA; immune responses; formulations; Cytolytic T Lymphocytes; antibodies; innate immunity
MDPI and ACS Style

Liu, M.A. A Comparison of Plasmid DNA and mRNA as Vaccine Technologies. Vaccines 2019, 7, 37.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop