Announcements

Tuberculosis is a disease that is both preventable and treatable, significantly affecting people’s health and quality of life worldwide. Every year, we commemorate World Tuberculosis Day to raise public awareness of the devastating health, social, and economic consequences of tuberculosis (TB) and to intensify efforts to end the global TB epidemic. The date signifies the day in 1882 when Dr. Robert Koch announced his discovery of the bacterium responsible for TB, which paved the way for diagnosing and curing this disease. We hope that established journals in the fields of Biology Life Sciences and Medicine & Pharmacology at MDPI, including Pathogens, Microorganisms, Reports, Medical Sciences, Healthcare and Diagnostics will continue to serve as a communication platform for innovative ideas regarding prevention and treatment.

“Impact of Severity of COVID-19 in TB Disease Patients: Experience from an Italian Infectious Disease Referral Hospital”
by Virginia Di Bari, Carlotta Cerva, Raffaella Libertone, Serena Maria Carli, Maria Musso, Delia Goletti, Alessandra Aiello, Antonio Mazzarelli, Angela Cannas, Giulia Matusali, Fabrizio Palmieri, Gina Gualano and on behalf of the TB-INMI Working Group
Infect. Dis. Rep. 2025, 17(1), 11; https://doi.org/10.3390/idr17010011 

“Cigarette Smoking as a Risk Factor for Tuberculosis in Adults: Epidemiology and Aspects of Disease Pathogenesis”
by Charles Feldman, Annette J. Theron, Moloko C. Cholo and Ronald Anderson
Pathogens 2024, 13(2), 151; https://doi.org/10.3390/pathogens13020151 

“Situation Analysis of Early Implementation of Programmatic Management of Tuberculosis Preventive Treatment among Household Contacts of Pulmonary TB Patients in Delhi, India”
by Yasir Alvi, Sairu Philip, Tanu Anand, Palanivel Chinnakali, Farzana Islam, Neeta Singla, Pruthu Thekkur, Ashwani Khanna and BK Vashishat
Trop. Med. Infect. Dis. 2024, 9(1), 24; https://doi.org/10.3390/tropicalmed9010024 

“HLA-DPB1*05:01 and HLA-A*11:01 Is Associated with Adverse Drug Reactions to Isoniazid and Rifampin for Treatment of Latent Tuberculosis Infection in South Korea”
by Bomi Kim, Jungok Kim, Sun-Young Yoon, Hae Suk Cheong, Min-Jung Kwon, Joon-Sup Yeom, Han-Na Kim and Eun-Jeong Joo
Clin. Med. 2024, 13(12), 3563; https://doi.org/10.3390/jcm13123563 

“Pharmacists’ Role in Global TB Elimination: Practices, Pitfalls, and Potential”
by Alina Cernasev, Jonathan Stillo, Jolie Black, Mythili Batchu, Elaina Bell and Cynthia A. Tschampl
Healthcare 2024, 12(11), 1137; https://doi.org/10.3390/healthcare12111137 

“Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance”
by Biplab Singha, Sumit Murmu, Tripti Nair, Rahul Singh Rawat, Aditya Kumar Sharma and Vijay Soni
Metabolites 2024, 14(1), 63; https://doi.org/10.3390/metabo14010063 

“Exploring the Impact of Silicosis Incidence on Tuberculosis Mortality and Morbidity: A Multi-Country Study”
by Muayad Albadrani
Med. Sci. 2023, 11(4), 63; https://doi.org/10.3390/medsci11040063

This year, World Down Syndrome Day will be celebrated on 21 March 2025. Each year, approximately 3,000 to 5,000 children are born with this chromosome disorder. In 2025, we call for people around the world to “end the stereotypes”.

Aiming at improving the quality of life of people with Down syndrome and propelling the scientific development in this field, we would like to recommend some related articles, Special Issues, and journals in MDPI as suitable communication platforms for you. We believe that sharing research like this can help raise awareness of Down syndrome.

“When Language Is Not Enough: How to Explain ToM Abilities of Individuals with Williams Syndrome and Down Syndrome”
by Claire Touchet, Régis Pochon and Laure Ibernon
Disabilities 2025, 5(1), 4; https://doi.org/10.3390/disabilities5010004

“Assessing Uveitis Risk following Pediatric Down Syndrome Diagnosis: A TriNetX Database Study”
by Alan Y. Hsu, Yu-Hsun Wang, Chun-Ju Lin, You-Ling Li, Ning-Yi Hsia, Chun-Ting Lai, Hou-Ting Kuo, Huan-Sheng Chen, Yi-Yu Tsai and James Cheng-Chung Wei
Medicina 2024, 60(5), 710; https://doi.org/10.3390/medicina60050710

“Impact of Resistance Training on Body Composition and Physical Function in Individuals with Down Syndrome: A Meta-Analysis”
by Hou-Ting Kuo, Ting-Hsu Lee, Li-An Su, Li-Yun Wu, Ping-Yan Mao and Ciao-Ci Yang
Diagnostics 2024, 14(23), 2620; https://doi.org/10.3390/diagnostics14232620

“The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome”
by Ann-Charlotte Granholm and Eric D. Hamlett
J. Clin. Med. 2024, 13(5), 1338; https://doi.org/10.3390/jcm13051338

“Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation”
by Beatrice Uguagliati and Mariagrazia Grilli
Cells 2024, 13(24), 2037; https://doi.org/10.3390/cells13242037

“Lipid Profile, Eating Habit, and Physical Activity in Children with Down Syndrome: A Prospective Study”
by Luca Pecoraro, Melissa Zadra, Francesco Cavallin, Silvana Lauriola, Giorgio Piacentini and Angelo Pietrobelli
Diseases 2024, 12(4), 68; https://doi.org/10.3390/diseases12040068

“Impact of Physical Activity on Autonomy and Quality of Life in Individuals with Down Syndrome: A Systematic Review”
by Antonio Muñoz-Llerena, Laura Ladrón-de-Guevara, Daniel Medina-Rebollo and Virginia Alcaraz-Rodríguez
Healthcare 2024, 12(2), 181; https://doi.org/10.3390/healthcare12020181

“Health Checks for People with Down Syndrome: A Pooled Analysis of Three Randomized Controlled Trials”
by Robert S. Ware, Catherine Franklin, Lyn McPherson and Nicholas G. Lennox
Disabilities 2024, 4(1), 101-110; https://doi.org/10.3390/disabilities4010007

“DNMT3B rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome”
by Dijana Majstorović, Anita Barišić, Ivana Babić Božović, Iva Bilić Čače, Neven Čače, Mauro Štifanić and Jadranka Vraneković
Genes 2023, 14(3), 576; https://doi.org/10.3390/genes14030576

“Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules”
by Lanzillotta, Chiara, and Fabio Di Domenico
Biomolecules 2021, 11(2), 266; https://doi.org/10.3390/biom11020266

“Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts”
by Panagaki, Theodora, Elisa B. Randi, and Csaba Szabo
Biomolecules 2020, 10(4), 653; https://doi.org/10.3390/biom10040653

“The Care Economy and Disability Inclusion”	“Fragile X Syndrome and Fragile X Premutation Associated Conditions”
“Physical Activity, Exercise, and Sport in People with Disabilities: Strategies for Health Promotion”	“Cellular and Molecular Alterations in the Down Syndrome Brain: A Starting Point for the Design of Therapeutic Approaches”

Kidneys, like the “purification factory” of the body, filter waste and excess water from the blood. However, nowadays, the incidence of kidney disease is rising and it has become an invisible killer that poses a serious threat to health. We welcome you to read the following highly cited papers published in Journal of Clinical Medicine (JCM, ISSN: 2077-0383) , and hope that these articles can bring new ideas for kidney disease research. In addition, some Special Issues on this topic are currently open for submission.

1. “Pathomechanisms of Diabetic Kidney Disease”
by Satyesh K. Sinha and Susanne B. Nicholas
J. Clin. Med. 2023, 12(23), 7349; https://doi.org/10.3390/jcm12237349
Full text available online: https://www.mdpi.com/2077-0383/12/23/7349

2. “Renal Biopsy for Diagnosis in Kidney Disease: Indication, Technique, and Safety”
by Peter Schnuelle
J. Clin. Med. 2023, 12(19), 6424; https://doi.org/10.3390/jcm12196424
Full text available online: https://www.mdpi.com/2077-0383/12/19/6424

3. “Preventing Rejection of the Kidney Transplant”
by Divyanshu Malhotra and Priyanka Jethwani
J. Clin. Med. 2023, 12(18), 5938; https://doi.org/10.3390/jcm12185938 
Full text available online: https://www.mdpi.com/2077-0383/12/18/5938

4. “The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease”
by Maria Petrovna Kruglova, Alexander Vladimirovich Ivanov, Anatolij Nikolaevich Fedoseev, Edward Danielevich Virus, Victor Aleksandrovich Stupin, Vladimir Anatolyevich Parfenov, Svetlana Andreevna Titova, Polina Igorevna Lazareva, Aslan Amirkhanovich Kubatiev and Ekaterina Vladimirovna Silina
J. Clin. Med. 2023, 12(17), 5653; https://doi.org/10.3390/jcm12175653
Full text available online: https://www.mdpi.com/2077-0383/12/17/5653

5. “Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review”
by Jun Kamei, Masafumi Kanamoto, Yutaka Igarashi, Kodai Suzuki, Kensuke Fujita, Tsukasa Kuwana, Takayuki Ogura, Katsunori Mochizuki, Yuki Banshotani, Hiroyasu Ishikura et al.
J. Clin. Med. 2023, 12(19), 6388; https://doi.org/10.3390/jcm12196388
Full text available online: https://www.mdpi.com/2077-0383/12/19/6388

6. “Sex-Related Aspects in Diabetic Kidney Disease—An Update”
by Ivonne Loeffler and Nadja Ziller
J. Clin. Med. 2023, 12(8), 2834; https://doi.org/10.3390/jcm12082834
Full text available online: https://www.mdpi.com/2077-0383/12/8/2834

7. “Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations”
by Christina Tamargo, Mohamad Hanouneh and C. Elena Cervantes
J. Clin. Med. 2024, 13(9), 2455; https://doi.org/10.3390/jcm13092455
Full text available online: https://www.mdpi.com/2077-0383/13/9/2455

8. “Chronic Kidney Disease in the Older Adult Patient with Diabetes”
by Raja Ravender, Maria-Eleni Roumelioti, Darren W. Schmidt, Mark L. Unruh and Christos Argyropoulos
J. Clin. Med. 2024, 13(2), 348; https://doi.org/10.3390/jcm13020348
Full text available online: https://www.mdpi.com/2077-0383/13/2/348

9. “Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts”
by Francesca Mallamaci and Giovanni Tripepi
J. Clin. Med. 2024, 13(3), 678; https://doi.org/10.3390/jcm13030678
Full text available online: https://www.mdpi.com/2077-0383/13/3/678

10. “Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets”
by Allison B. Reiss, Berlin Jacob, Aarij Zubair, Ankita Srivastava, Maryann Johnson and Joshua De Leon
J. Clin. Med. 2024, 13(7), 1881; https://doi.org/10.3390/jcm13071881
Full text available online: https://www.mdpi.com/2077-0383/13/7/1881

11. “Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease”
by Didier Sánchez-Ospina, Sebastián Mas-Fontao, Carolina Gracia-Iguacel, Alejandro Avello, Marina González de Rivera, Maddalen Mujika-Marticorena and Emilio Gonzalez-Parra
J. Clin. Med. 2024, 13(5), 1428; https://doi.org/10.3390/jcm13051428
Full text available online: https://www.mdpi.com/2077-0383/13/5/1428

12. “Kidney Stones of Type I vs. Type II Diabetic Patients: Are There Any Differences?”
by Cătălin Pricop, Marius Ivănuță, Mihaela Nikolic and Dragoş Puia
J. Clin. Med. 2024, 13(20), 6110; https://doi.org/10.3390/jcm13206110
Full text available online: https://www.mdpi.com/2077-0383/13/20/6110

Special Issues:
“Challenges and Opportunities in Geriatric Nephrology and Urology” Guest Editor: Prof. Dr. Giulio Romano Submission deadline: 20 May 2025	“Kidney Transplantation: Current Challenges and Future Perspectives” Guest Editors: Dr. Alberto Piana and Dr. Angelo Territo Submission deadline: 20 May 2025
“Targeted Treatment of Kidney Stones” Guest Editors: Prof. Dr. Carmen Gonzalez-Enguita and Dr. Alberto Budía-Alba Submission deadline: 30 June 2025	“Acute Kidney Events in Intensive Care Patients” Guest Editor: Prof. Dr. Kada Klouche Submission deadline: 31 August 2025

We are delighted to share some highly cited papers from the Section “Oncology” that were published in Journal of Clinical Medicine (JCM, ISSN: 2077-0383) in 2024. You are welcome to read these highly cited papers and find the latest publications through the following link: https://www.mdpi.com/search?journal=jcm&section=500. Additionally, some Special Issues in the “Oncology” Section are currently open for submissions. The following is a list of articles and Special Issues that we believe may interest you:

1. “The Prognostic Significance of Histological Subtypes in Patients with Muscle-Invasive Bladder Cancer: An Overview of the Current Literature”
by Francesco Claps, Arianna Biasatti, Luca Di Gianfrancesco, Luca Ongaro, Gianluca Giannarini, Nicola Pavan, Antonio Amodeo, Alchiede Simonato, Alessandro Crestani, Alessia Cimadamore et al.
J. Clin. Med. 2024, 13(15), 4349; https://doi.org/10.3390/jcm13154349
Full text available online: https://www.mdpi.com/2077-0383/13/15/4349

2. “Prostate Cancer Liver Metastasis: An Ominous Metastatic Site in Need of Distinct Management Strategies”
by Audrey Shiner, Rubens Copia Sperandio, Mahdi Naimi and Urban Emmenegger
J. Clin. Med. 2024, 13(3), 734; https://doi.org/10.3390/jcm13030734
Full text available online: https://www.mdpi.com/2077-0383/13/3/734

3. “From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential”
by Irene Mignini, Giulia Piccirilli, Linda Galasso, Fabrizio Termite, Giorgio Esposto, Maria Elena Ainora, Antonio Gasbarrini and Maria Assunta Zocco
J. Clin. Med. 2024, 13(2), 420; https://doi.org/10.3390/jcm13020420
Full text available online: https://www.mdpi.com/2077-0383/13/2/420

4. “Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence”
by Ibrahim O. Sawaid and Abraham O. Samson
J. Clin. Med. 2024, 13(7), 1970; https://doi.org/10.3390/jcm13071970
Full text available online: https://www.mdpi.com/2077-0383/13/7/1970

5. “Robotic-Assisted versus Laparoscopic Surgery for Rectal Cancer: An Analysis of Clinical and Financial Outcomes from a Tertiary Referral Center”
by Jasper Max Gebhardt, Neno Werner, Andrea Stroux, Frank Förster, Ioannis Pozios, Claudia Seifarth, Christian Schineis, Benjamin Weixler, Katharina Beyer and Johannes Christian Lauscher
J. Clin. Med. 2024, 13(6), 1795; https://doi.org/10.3390/jcm13061795
Full text available online: https://www.mdpi.com/2077-0383/13/6/1795

6. “Reliability of Ultrasonographic Assessment of Depth of Invasion and Tumor Thickness in Intraoral Mucosa Lesions: A Preliminary Experience”
by Anna Russo, Vittorio Patanè, Luigia Fusco, Lorenzo Faggioni, Ciro Emiliano Boschetti, Mario Santagata, Emanuele Neri, Salvatore Cappabianca and Alfonso Reginelli
J. Clin. Med. 2024, 13(9), 2595; https://doi.org/10.3390/jcm13092595
Full text available online: https://www.mdpi.com/2077-0383/13/9/2595

7. “Hormone Receptor-Positive/HER2-Positive Breast Cancer: Hormone Therapy and Anti-HER2 Treatment: An Update on Treatment Strategies”
by Chiara Tommasi, Giulia Airò, Fabiana Pratticò, Irene Testi, Matilde Corianò, Benedetta Pellegrino, Nerina Denaro, Laura Demurtas, Mariele Dessì, Sara Murgia et al.
J. Clin. Med. 2024, 13(7), 1873; https://doi.org/10.3390/jcm13071873
Full text available online: https://www.mdpi.com/2077-0383/13/7/1873

8. “Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in the Treatment of Gastric Cancer: Feasibility, Efficacy and Safety—A Systematic Review and Meta-Analysis”
by Francisca Ramalho-Vasconcelos, Raquel Gomes, Raquel Bouça-Machado, Marisa Aral, Jorge Nogueiro, Tiago Bouça-Machado, Bernardo Sousa-Pinto and Hugo Santos-Sousa
J. Clin. Med. 2024, 13(11), 3320; https://doi.org/10.3390/jcm13113320
Full text available online: https://www.mdpi.com/2077-0383/13/11/3320

9. “Diagnostic, Theranostic and Prognostic Value of Thyroglobulin in Thyroid Cancer”
by Luca Giovanella, Federica D’Aurizio, Petra Petranović Ovčariček and Rainer Görges
J. Clin. Med. 2024, 13(9), 2463; https://doi.org/10.3390/jcm13092463
Full text available online: https://www.mdpi.com/2077-0383/13/9/2463

We are pleased to announce that the winner of the JCM 2024 Young Investigator Award is Dr. Gabriela Lima de Melo Ghisi.

Dr. Gabriela Lima de Melo Ghisi is a scientist at the University Health Network (UHN) in Canada, with a research focus on implementation of patient education interventions across different chronic disease settings and global access to chronic disease management. She holds adjunct professor positions at the University of Toronto and York University (Canada), UFMG (Brazil), and the University of Sydney (Australia). Dr. Ghisi has published over 160 peer-reviewed manuscripts. Ranked among the top three heart rehabilitation researchers globally (SciVal/Scopus 2019-2025), she also serves on the editorial boards of four leading medical journals.

Dr. Ghisi has led global initiatives to enhance cardiac health education, including developing and evaluating evidence-based patient education curricula in cardiac rehabilitation (CR) programs across 10 countries. She co-developed the first women-focused CR clinical practice guidelines and introduced tailored educational curricula in Canada.

Since 2016, Dr. Ghisi has held leadership roles with the International Council of Cardiovascular Prevention and Rehabilitation (ICCPR), part of the World Heart Federation (WHF), where she currently serves as Chair. Dr. Ghisi’s proven ability to translate research into practical tools and best practices has shaped CR delivery worldwide, positioning her as a global leader in the field and a key contributor to the success of this project.

Upon receiving this honour, Dr. Ghisi wanted to convey the following sentiments: “As someone who has dedicated much of my career to advancing cardiovascular prevention and rehabilitation, I believe that open access is essential for scientific progress. Coming from a middle-income country, I have seen firsthand how important it is to ensure that knowledge is accessible to all, regardless of geographic or financial constraints. Open access platforms like MDPI play a pivotal role in democratizing science, allowing researchers, clinicians, and patients alike to benefit from the latest evidence and innovations.

Being recognized by such a prestigious journal not only motivates me to continue my work, but it also reinforces the importance of collaborative, accessible science in improving global healthcare. I look forward to contributing to the ongoing dialogue and advancing cardiovascular care for patients worldwide”.

This is an outstanding achievement in today’s competitive academic environment. Please join us in congratulating Dr. Ghisi on her outstanding achievements.

As the awardee, Dr. Gabriela Lima de Melo Ghisi will receive the following honorarium:

• CHF 2000;
• An electronic certificate;
• A free voucher for article processing fees valid for one year.

We would like to thank all the nominators from various fields of study and all Award Committee Members for their evaluation of the many excellent nominations.

You can access more awards information via the following link: https://www.mdpi.com/journal/jcm/awards.

JCM Editorial Office

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an open access journal and has an updated 2023 Impact Factor of 3.0 and is ranked 59/329 (Q1) in the of “Medicine, General & Internal” category. All of its publications are freely available for reading and downloading and are devoted to the dissemination of important medical knowledge. In order to offer scholars more opportunities to present their research, we support the use of graphical and video abstracts. Video abstracts offer a dynamic and engaging way to present the content of submissions. They can provide a more in-depth and accessible explanation of research, increasing its reach for a wider audience.

Here are the requirements for video abstracts: (1): File formats: mp4, webm, ogv (mp4 format is usually recommended); (2): File size: no more than 200 MB; (3) Video length: no more than 5 minutes.

Video abstracts not only contribute to increasing the visibility of papers but also enhance the overall impact of research. We look forward to reading submitted papers with video abstracts.

1. “Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial”
by Ludger Gerdesmeyer, Johannes Vester, Christian Schneider, Britt Wildemann, Christine Frank, Myron Schultz, Bernd Seilheimer, Alta Smit and Gino Kerkhoffs
J. Clin. Med. 2024, 13(3), 841; https://doi.org/10.3390/jcm13030841
Full text available online: https://www.mdpi.com/2077-0383/13/3/841

2. “Sub-Tenon’s Block in Patients with Previous Encircling Band Surgery—A Feasibility Study”
by Johannes Harte, Gesar Ugen, Joana Berger-Estilita, Andreas Ebneter and Friedrich Lersch
J. Clin. Med. 2024, 13(24), 7735; https://doi.org/10.3390/jcm13247735
Full text available online: https://www.mdpi.com/2077-0383/13/24/7735

3. “Systematic Review of Executive Function Stimulation Methods in the ADHD Population”
by Carlos Ramos-Galarza, Deyaneira Brito, Brayan Rodríguez, Brenda Guerrero, Jorge Cruz-Cárdenas and Mónica Bolaños-Pasquel
J. Clin. Med. 2024, 13(14), 4208; https://doi.org/10.3390/jcm13144208
Full text available online: https://www.mdpi.com/2077-0383/13/14/4208

4. “The Utility of Three-Dimensional Printing in Physician-Modified Stent Grafts for Aortic Lesions Repair”
by Wiktoria Antonina Zasada, Hubert Stępak, Magdalena Węglewska, Łukasz Świątek, Jerzy Kluba and Zbigniew Krasiński
J. Clin. Med. 2024, 13(10), 2977; https://doi.org/10.3390/jcm13102977
Full text available online: https://www.mdpi.com/2077-0383/13/10/2977

5. “Topographic Keratoconus Incidence in Greece Diagnosed in Routine Consecutive Cataract Procedures: A Consecutive Case Series of 1250 Cases over 5 Years”
by Anastasios John Kanellopoulos and Alexander J. Kanellopoulos
J. Clin. Med. 2024, 13(8), 2378; https://doi.org/10.3390/jcm13082378
Full text available online: https://www.mdpi.com/2077-0383/13/8/2378

6. “Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets”
by Allison B. Reiss, Berlin Jacob, Aarij Zubair, Ankita Srivastava, Maryann Johnson and Joshua De Leon
J. Clin. Med. 2024, 13(7), 1881; https://doi.org/10.3390/jcm13071881
Full text available online: https://www.mdpi.com/2077-0383/13/7/1881

7. “The Presence of Myosteatosis Is Associated with Age, Severity of Liver Disease and Poor Outcome and May Represent a Prodromal Phase of Sarcopenia in Patients with Liver Cirrhosis”
by Eleni Geladari, Theodoros Alexopoulos, Meropi D. Kontogianni, Larisa Vasilieva, Iliana Mani, Roxane Tenta, Vasilios Sevastianos, Ioannis Vlachogiannakos and Alexandra Alexopoulou
J. Clin. Med. 2023, 12(9), 3332; https://doi.org/10.3390/jcm12093332
Full text available online: https://www.mdpi.com/2077-0383/12/9/3332

8. “Validation of an Automated Artificial Intelligence Algorithm for the Quantification of Major OCT Parameters in Diabetic Macular Edema”
by Edoardo Midena, Lisa Toto, Luisa Frizziero, Giuseppe Covello, Tommaso Torresin, Giulia Midena, Luca Danieli, Elisabetta Pilotto, Michele Figus, Cesare Mariotti and Marco Lupidi
J. Clin. Med. 2023, 12(6), 2134; https://doi.org/10.3390/jcm12062134
Full text available online: https://www.mdpi.com/2077-0383/12/6/2134

9. “Gender-Related Outcomes after Surgical Resection and Level of Satisfaction in Patients with Left Atrial Tumors”
by Viyan Sido, Annika Volkwein, Martin Hartrumpf, Christian Braun, Ralf-Uwe Kühnel, Roya Ostovar, Filip Schröter, Sofia Chopsonidou and Johannes Maximilian Albes
J. Clin. Med. 2023, 12(5), 2075; https://doi.org/10.3390/jcm12052075
Full text available online: https://www.mdpi.com/2077-0383/12/5/2075

Many systemic diseases may affect oral health. This may be a manifestation of the systemic disease itself or an indirect effect due to medical treatment of this disease. Conversely, oral health can also affect the functioning of other parts of the human body. Although many such interactions between systemic diseases and oral diseases have been described in the scientific literature, the causal relationship still often remains unclear. Therefore, in this webinar, international experts will discuss some examples of interactions between systemic diseases and oral health in depth in order to gain more insight into these interactions.

Date: 25 March 2025

Time: 3:00 p.m. CET | 10:00 a.m. EDT

Webinar ID: 810 2190 0155

Webinar Secretariat: journal.webinar@mdpi.com

Webinar announcement: https://sciforum.net/event/JCM-14

Register now for free!

After registering, you will receive a confirmation email containing information on how to join the webinar. Registrations with academic or institutional email addresses will be prioritized. 

Unable to attend? Feel free to still register and we will inform you when the recording is available.

Webinar Chair and Keynote Speakers:

• Dr. Henk S. Brand, Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, the Netherlands;
• Prof. Dr. Petra Șurlin, Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania;
• Prof. Dr. Frank A. Scannapieco, Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA;
• Prof. Dr. Andreea Cristiana Didilescu, Department of Embryology and Microbiology, Faculty of Dentistry, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Relevant Special Issue:

“Interaction Between Systemic Diseases and Oral Diseases”

Guest Editor: Dr. Henk S. Brand

Deadline for manuscript submission: 31 March 2025

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an open access journal with an updated CiteScore (2023) of 5.7, ranked 80/636 (Q1) in the “General Medicine” category. This is a direct result of the numerous high-quality, highly cited papers that have graced their pages. These papers not only showcase cutting-edge research in clinical medicine but also contribute significantly to the journal. A huge thank you to all the authors for their invaluable contributions. We invite you to enjoy and review part I of these papers together, hoping to bring different inspirations.

1. “2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department”
by Matteo Guarino, Benedetta Perna, Alice Eleonora Cesaro, Martina Maritati, Michele Domenico Spampinato, Carlo Contini and Roberto De Giorgio
J. Clin. Med. 2023, 12(9), 3188; https://doi.org/10.3390/jcm12093188
Full text available online: https://www.mdpi.com/2077-0383/12/9/3188

2. “Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics”
by Samradhi Singh, Namrata Pal, Swasti Shubham, Devojit Kumar Sarma, Vinod Verma, Francesco Marotta and Manoj Kumar
J. Clin. Med. 2023, 12(4), 1454; https://doi.org/10.3390/jcm12041454
Full text available online: https://www.mdpi.com/2077-0383/12/4/1454

3. “Noise-Induced Hearing Loss”
by Nirvikalpa Natarajan, Shelley Batts and Konstantina M. Stankovic
J. Clin. Med. 2023, 12(6), 2347; https://doi.org/10.3390/jcm12062347
Full text available online: https://www.mdpi.com/2077-0383/12/6/2347

4. “Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment”
by Vanina Nicol, Claire Verdaguer, Camille Daste, Hélène Bisseriex, Éric Lapeyre, Marie-Martine Lefèvre-Colau, François Rannou, Alexandra Rören, Julia Facione and Christelle Nguyen
J. Clin. Med. 2023, 12(4), 1685; https://doi.org/10.3390/jcm12041685
Full text available online: https://www.mdpi.com/2077-0383/12/4/1685

5. “Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults”
by Yiyuan Xia, Chunlei Xia, Lida Wu, Zheng Li, Hui Li and Junxia Zhang
J. Clin. Med. 2023, 12(3), 1128; https://doi.org/10.3390/jcm12031128
Full text available online: https://www.mdpi.com/2077-0383/12/3/1128

6. “Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy”
by Amaresh K. Ranjan and Anil Gulati
J. Clin. Med. 2023, 12(20), 6653; https://doi.org/10.3390/jcm12206653
Full text available online: https://www.mdpi.com/2077-0383/12/20/6653

7. “Current Treatment Landscape for Early Triple-Negative Breast Cancer (TNBC)”
by Jieun Lee
J. Clin. Med. 2023, 12(4), 1524; https://doi.org/10.3390/jcm12041524
Full text available online: https://www.mdpi.com/2077-0383/12/4/1524

8. “Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy”
by Gian Marco Leone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti and Paolo Fagone
J. Clin. Med. 2023, 12(4), 1630; https://doi.org/10.3390/jcm12041630
Full text available online: https://www.mdpi.com/2077-0383/12/4/1630

9. “Stage IV Colorectal Cancer Management and Treatment”
by Oscar Hernandez Dominguez, Sumeyye Yilmaz and Scott R. Steele
J. Clin. Med. 2023, 12(5), 2072; https://doi.org/10.3390/jcm12052072
Full text available online: https://www.mdpi.com/2077-0383/12/5/2072

10. “Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box”
by Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina et al.
J. Clin. Med. 2023, 12(12), 4074; https://doi.org/10.3390/jcm12124074
Full text available online: https://www.mdpi.com/2077-0383/12/12/4074

11. “Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review”
by Sofia D. Shaikh, Natalie Sun, Andrew Canakis, William Y. Park and Horst Christian Weber
J. Clin. Med. 2023, 12(7), 2558; https://doi.org/10.3390/jcm12072558
Full text available online: https://www.mdpi.com/2077-0383/12/7/2558

12. “The Global Burden of Valvular Heart Disease: From Clinical Epidemiology to Management”
by Gloria Santangelo, Francesca Bursi, Andrea Faggiano, Silvia Moscardelli, Pasquale Simone Simeoli, Marco Guazzi, Roberto Lorusso, Stefano Carugo and Pompilio Faggiano
J. Clin. Med. 2023, 12(6), 2178; https://doi.org/10.3390/jcm12062178
Full text available online: https://www.mdpi.com/2077-0383/12/6/2178

MDPI is pleased to share a significant milestone in its mission to advance scholarly research and promote the dissemination of knowledge—300+ MDPI journals are now indexed in Web of Science (WoS). This milestone highlights the global recognition, interdisciplinary impact and enhanced visibility of our journals. It also reflects our adherence to rigorous editorial standards, scientific integrity, and our mission to foster open scientific exchange in all forms, across all disciplines. 

To explore the full list of our journals indexed in WoS, please visit https://www.mdpi.com/about/journals/wos. Beyond expanding the coverage of our publications in the leading academic databases, we are dedicated to ensuring that our journals are included in as many scope-specific databases as possible. This increases the visibility of our authors’ work and extends the reach of their significant data. 

This milestone would not have been possible without the efforts and expertise of our academic editors, reviewers and authors. Their commitment and collaboration have been instrumental in creating an inclusive, accessible, and impactful publishing platform. We also extend our gratitude to the global research community for their trust as we continue to break new ground in academic publishing. This milestone is not just a celebration of MDPI’s progress but also recognition of the collective strides made by researchers worldwide. 

As we celebrate this remarkable accomplishment, MDPI remains steadfast in its commitment to open access publishing and ensuring that high-quality research reaches and inspires a global audience.

Epilepsy is a chronic brain disorder that cannot be ignored and affects many patients. Its causative factors are complex, and clinicians and scientists are constantly updating their research on the condition. Journal of Clinical Medicine (JCM, ISSN: 2077-0383) has collected open academic research on epilepsy. Some relevant Special Issues are currently open for the submissions; we encourage you to read these highly popular works in depth. Please click the links below to learn more about these papers:

1. “Epilepsy in Dravet Syndrome—Current and Future Therapeutic Opportunities”
by Chao Gao, Mikolaj Pielas, Fuyong Jiao, Daoqi Mei, Xiaona Wang, Katarzyna Kotulska and Sergiusz Jozwiak
J. Clin. Med. 2023, 12(7), 2532; https://doi.org/10.3390/jcm12072532
Full text available online: https://www.mdpi.com/2077-0383/12/7/2532

2. “Glycaemic Imbalances in Seizures and Epilepsy of Paediatric Age: A Literature Review”
by Emanuele Bartolini, Anna Rita Ferrari, Simona Fiori and Stefania Della Vecchia
J. Clin. Med. 2023, 12(7), 2580; https://doi.org/10.3390/jcm12072580
Full text available online: https://www.mdpi.com/2077-0383/12/7/2580

3. “Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study”
by Ana Dos Santos Rufino, Magnus Påhlman, Ingrid Olsson and Kate Himmelmann
J. Clin. Med. 2023, 12(1), 346; https://doi.org/10.3390/jcm12010346
Full text available online: https://www.mdpi.com/2077-0383/12/1/346

4. “Therapeutic Strategies in Children with Epilepsy: A Quality-of-Life-Related Perspective”
by Hideaki Kanemura
J. Clin. Med. 2024, 13(2), 405; https://doi.org/10.3390/jcm13020405
Full text available online: https://www.mdpi.com/2077-0383/13/2/405

5. “Cenobamate Plasma Levels in Patients with Epilepsy: Correlation with Efficacy and Tolerability?”
by Bernhard J. Steinhoff, Dimitra Georgiou, Daniel Dietmann and Tassanai Intravooth
J. Clin. Med. 2024, 13(10), 2757; https://doi.org/10.3390/jcm13102757
Full text available online: https://www.mdpi.com/2077-0383/13/10/2757

6. “Cognitive Impairment in People with Epilepsy”
by Ajda Novak, Karmen Vizjak and Martin Rakusa
J. Clin. Med. 2022, 11(1), 267; https://doi.org/10.3390/jcm11010267
Full text available online: https://www.mdpi.com/2077-0383/11/1/267

7. “Detecting Reasons for Nonadherence to Medication in Adults with Epilepsy: A Review of Self-Report Measures and Key Predictors”
by Sarah Mendorf, Tino Prell and Aline Schönenberg
J. Clin. Med. 2022, 11(15), 4308; https://doi.org/10.3390/jcm11154308
Full text available online: https://www.mdpi.com/2077-0383/11/15/4308

8. “Vagus Nerve Stimulation for Drug Resistant Epilepsy: Clinical Outcome, Adverse Events, and Potential Prognostic Factors in a Single Center Experience”
by Ming Shan, Hongliang Mao, Hutao Xie, Yifei Gan, Delong Wu, Jian Song, Yutong Bai and Jianguo Zhang
J. Clin. Med. 2022, 11(24), 7536; https://doi.org/10.3390/jcm11247536
Full text available online: https://www.mdpi.com/2077-0383/11/24/7536

9. “Early Epilepsy Surgery in Benign Cerebral Tumors: Avoid Your ‘Low-Grade’ Becoming a ‘Long-Term’ Epilepsy-Associated Tumor”
by Catrin Mann, Nadine Conradi, Elisabeth Neuhaus, Jürgen Konczalla, Thomas M. Freiman, Andrea Spyrantis, Katharina Weber, Patrick Harter, Felix Rosenow, Adam Strzelczyk et al.
J. Clin. Med. 2022, 11(19), 5892; https://doi.org/10.3390/jcm11195892
Full text available online: https://www.mdpi.com/2077-0383/11/19/5892

10. “A Multi-Disciplinary Team Approach to Genomic Testing for Drug-Resistant Epilepsy Patients—The GENIE Study”
by Lata Vadlamudi, Carmen Maree Bennett, Melanie Tom, Ghusoon Abdulrasool, Kristian Brion, Ben Lundie, Hnin Aung, Chiyan Lau, Jonathan Rodgers, Kate Riney et al.
J. Clin. Med. 2022, 11(14), 4238; https://doi.org/10.3390/jcm11144238
Full text available online: https://www.mdpi.com/2077-0383/11/14/4238

Special Issues:
“Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects” Guest Editor: Dr. Hideaki Kanemura Submission deadline: 20 May 2025	“Neurosurgery: Current Challenges and New Perspectives” Guest Editors: Dr. Adip G. Bhargav and Prof. Dr. Paul J. Camarata Submission deadline: 30 June 2025