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Journal of Clinical Medicine, Volume 14, Issue 21

November-1 2025 - 441 articles

Cover Story: Few therapeutic options meaningfully improve symptomatology plus quality of life (QoL) in Parkinson’s disease (PD), emphasising the need for novel, evidence-based interventions. This study evaluated the efficacy of photobiomodulation therapy (PBMt) combined with exercise on motor and non-motor outcomes in PD. Sixty-three participants were first enrolled in an 8-week randomised, sham-controlled stage with a 4-week washout, followed by a crossover to all active treatments with a 4-week washout, then an optional extended treatment of up to 48 weeks. Moderate–vigorous exercise was maintained. Extended PBMt yielded significant improvements in timed up and go (TUG), anxiety, and MDS-UPDRS II, with UPDRS total and other outcome measures approaching significance. This supports its potential as a safe, scalable, home-based adjunct to standard PD management. View this paper
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Articles (441)

  • Systematic Review
  • Open Access
905 Views
20 Pages

Motor Imagery for Post-Stroke Upper Limb Recovery: A Meta-Analysis of RCTs on Fugl-Meyer Upper Extremity Scores

  • Luis Polo-Ferrero,
  • Javier Torres-Alonso,
  • Juan Luis Sánchez-González,
  • Sara Hernández-Rubia,
  • Rubén Pérez-Elvira and
  • Javier Oltra-Cucarella

6 November 2025

Objectives: Motor imagery (MI) may enhance post-stroke recovery, but evidence of its benefit over conventional rehabilitation therapy (CRT) is inconsistent. This study evaluated the effect of MI combined with CRT on upper-limb recovery, accounting fo...

  • Article
  • Open Access
911 Views
16 Pages

Personalized Prediction of Clozapine Treatment Response Using Therapeutic Drug Monitoring Data in Japanese Patients with Treatment-Resistant Schizophrenia

  • Tatsuo Nakahara,
  • Yukiko Harada,
  • Naho Nakayama,
  • Kijiro Hashimoto,
  • Naoya Kida,
  • Toshiaki Onitsuka,
  • Hiroo Noda,
  • Kenji Murasugi,
  • Yoshihiro Takimoto and
  • Wataru Omori
  • + 5 authors

6 November 2025

Background: Clozapine is the only antipsychotic medication proven effective in patients with treatment-resistant schizophrenia (TRS). However, many patients have serum concentrations outside the recommended therapeutic window, and clozapine exhibits...

  • Article
  • Open Access
504 Views
11 Pages

6 November 2025

Background: Total knee arthroplasty (TKA) is a widely performed and highly successful procedure, with cemented fixation historically considered the standard. Advances in implant design have renewed interest in cementless fixation, which shows compara...

  • Technical Note
  • Open Access
375 Views
10 Pages

Bone-Preserving Robotic Conversion of Medial UKA to TKA: A Step-by-Step Technique

  • Jaad Mahlouly,
  • Alexander Antoniadis,
  • Thibaut Royon and
  • Julien Wegrzyn

6 November 2025

Converting a medial unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA) presents challenges in bone preservation, alignment, and soft-tissue balance. Robotic assistance enables three-dimensional CT-based planning, precise bone p...

  • Review
  • Open Access
1,049 Views
17 Pages

6 November 2025

As global populations age, dementia has become a major public health challenge that warrants sustainable, person-centered, and community-integrated models of care. In Japan, the recent introduction of board-certified general medicine (GM) physicians,...

  • Review
  • Open Access
526 Views
19 Pages

Managing Complex Anatomical Scenarios in Tavi: Evidence and an Institutional Perspective

  • Orlando Piro,
  • Mattia Granato,
  • Simona Covino,
  • Emanuele Cigala,
  • Mario Crisci,
  • Riccardo Granata,
  • Ida Monteforte,
  • Paola Mocavero,
  • Chiara Sordelli and
  • Emilio Di Lorenzo

6 November 2025

Transcatheter aortic valve implantation (TAVI) is the default therapy for most elderly patients with severe aortic stenosis, but outcomes in complex anatomy depend on imaging-guided planning and disciplined technique. This article aims to present our...

  • Article
  • Open Access
346 Views
11 Pages

6 November 2025

Background/Objectives: GPA is a PR3-ANCA–predominant small vessel vasculitis with organ involvement. Real-world, single-centre data are needed to interpret evolving therapies and phenotype patterns in national conditions. Material and Methods:...

  • Article
  • Open Access
978 Views
8 Pages

Early Results of Using AI in Mammography Screening for Breast Cancer

  • Hadar Sandler Rahat,
  • Tal Friehmann,
  • Marva Dahan Shemesh,
  • Shlomit Tamir,
  • Eli Atar,
  • Tzippy Shochat,
  • Arnon Makori and
  • Ahuva Grubstein

6 November 2025

Background: Recent advancements in Artificial Intelligence (AI) have the potential to address the challenges of mammographic screening programs by enhancing the performance of Computer-Aided Detection (CAD) systems, improving detection accuracy, and...

  • Article
  • Open Access
454 Views
12 Pages

Clinical Utility of Pan-Immune Inflammation Value (PIV) in Predicting Prognosis of Endometrial Cancer

  • Nurhan Onal Kalkan,
  • Zuhat Urakcı,
  • Berrak Mermit Erçek,
  • Erkan Bilen,
  • Hayati Arvas and
  • Mehmet Hadi Akkuş

6 November 2025

Background: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. While early-stage disease has favorable outcomes, advanced or recurrent EC remains associated with poor prognosis. Novel prognostic markers are ne...

  • Feature Paper
  • Article
  • Open Access
387 Views
21 Pages

Three-Year Follow-Up of the First 100 Patients Treated with the Balloon-Expandable Myval Transcatheter Aortic Valve System: A Single-Centre Experience

  • Balázs Magyari,
  • Bálint Kittka,
  • Ilona Goják,
  • Gábor Kasza,
  • Kristóf Schönfeld,
  • László Botond Szapáry,
  • Mihály Simon,
  • Rudolf Kiss,
  • Andrea Bertalan and
  • Edit Várady
  • + 3 authors

6 November 2025

Background/Objectives: To report our single-centre experience with the first 100 patients who underwent transcatheter aortic valve replacement (TAVR) with the new balloon-expandable Myval system. We report 3-year outcomes in low- to high-risk TAVR pa...

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J. Clin. Med. - ISSN 2077-0383