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Journal of Clinical Medicine, Volume 14, Issue 20

2025 October-2 - 323 articles

Cover Story: Artificial intelligence (AI) is increasingly applied to enhance diagnostic accuracy and efficiency. This study aimed to evaluate the precision of an AI-based method for assessing facial asymmetry. A total of 130 patients were analyzed using 3D facial images captured with the Vectra® M3 system, comparing manual and AI-based methods. Seven bilateral landmarks were identified manually to calculate an asymmetry index, while the AI algorithm automatically detected the same landmarks and computed the index. The accuracy of automated landmark identification was compared with manual measurements. The results demonstrated strong agreement between the two methods for five landmarks. The AI-based approach provides an efficient and reliable tool for facial asymmetry analysis using 3D imaging. View this paper
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Articles (323)

  • Article
  • Open Access
1 Citations
1,671 Views
10 Pages

21 October 2025

Objective: As the survival of individuals born with congenital heart disease (CHD) improves into adulthood, the focus has shifted from traditional clinical outcomes to patient-reported outcome measures that better reflect the impact of the disease on...

(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Congenital Heart Disease)
  • Systematic Review
  • Open Access
2 Citations
3,318 Views
14 Pages

Breastfeeding During and After Breast Cancer Diagnosis—A Systematic Review of the Literature

  • Anna Ampatzi,
  • Nikoleta Aikaterini Xixi,
  • Rozeta Sokou,
  • Eleni Karapati,
  • Zoi Iliodromiti,
  • Paraskevi Volaki,
  • Styliani Paliatsiou,
  • Nicoletta Iacovidou and
  • Theodora Boutsikou

21 October 2025

Background/Objectives: Breast cancer diagnosis in lactating women is relatively uncommon. The term Pregnancy-Associated Breast Cancer (PABC) refers to breast cancer diagnosed during pregnancy or within the first year postpartum. There are several fac...

(This article belongs to the Section Clinical Pediatrics)
  • Article
  • Open Access
3 Citations
1,322 Views
22 Pages

Comparative Biomechanical Evaluation of Bicortical Screw Versus Plate Fixation in Jones Fractures of the Fifth Metatarsal Using 3D-Printed Models

  • Robert Daniel Dobrotă,
  • Mark Pogărășteanu,
  • Dumitru Ferechide,
  • Ioana-Codruța Lebada and
  • Marius Moga

21 October 2025

Background: Jones fractures of the 5th metatarsal are frequently associated with nonunion due to limited vascularization and repetitive mechanical stress. The aim of the study was to compare the biomechanical performance of T-plate and bicortical scr...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
2 Citations
2,164 Views
12 Pages

Surgical Pulmonary Embolectomy Versus Systemic Thrombolysis in High-Risk Pulmonary Embolism: A Retrospective Single-Center Analysis

  • Arash Motekallemi,
  • Linus C. Markus Rohrwild,
  • Jonas Ajouri,
  • Ridvan Dryana,
  • Tamari Tvildiani,
  • Verena Vach,
  • Ralf M. Muellenbach and
  • Ali Asghar Peivandi

21 October 2025

Background: Pulmonary embolism (PE) is a life-threatening condition with high mortality, particularly in high-risk cases where rapid clinical deterioration is common. The optimal management strategy for high-risk PE remains debated. Systemic thrombol...

(This article belongs to the Section General Surgery)
  • Protocol
  • Open Access
7 Citations
2,653 Views
15 Pages

Sleep Disturbances Across Dementias and Cognitive Decline: Study Protocol for a Systematic Review and Network Meta-Analysis of Polysomnographic Findings

  • Annibale Antonioni,
  • Arianna Della Valle,
  • Caterina Leitner,
  • Emanuela Maria Raho,
  • Edward Cesnik,
  • Jay Guido Capone,
  • Maria Elena Flacco,
  • Francesca Casoni,
  • Paola Proserpio and
  • Andrea Galbiati
  • + 1 author

21 October 2025

Sleep disturbances are increasingly recognized as early and clinically meaningful features in the pathophysiology of neurodegenerative diseases. Polysomnography (PSG), i.e., the gold standard for objectively characterizing sleep architecture, may pro...

(This article belongs to the Special Issue Sleep in Neurology—Sleep Disorders and Dysfunction of the Nervous System)
  • Feature Paper
  • Article
  • Open Access
1,411 Views
15 Pages

Interventions for Fontan Pathway Obstruction in Patients Following Total Cavopulmonary Connection

  • Nicole Piber,
  • Christina Ruda,
  • Thibault Schaeffer,
  • Muneaki Matsubara,
  • Jonas Palm,
  • Teresa Lemmen,
  • Paul Philipp Heinisch,
  • Stanimir Georgiev,
  • Alfred Hager and
  • Masamichi Ono
  • + 3 authors

21 October 2025

Background/Objectives: Obstruction of the Fontan pathway is a severe morbidity after total cavopulmonary connection (TCPC). This study aimed to evaluate the incidence and location of TCPC pathway obstruction and corresponding interventions. Methods:...

(This article belongs to the Section General Surgery)
  • Article
  • Open Access
1,251 Views
11 Pages

21 October 2025

Background: We aimed to analyze various gait parameters before and after THA for patients with a highly dislocated hip to examine gait recovery and whether it is continued. Methods: This was a retrospective, single-center study. We enrolled 10 patien...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
4 Citations
2,915 Views
15 Pages

Home Is Not Always Safe: Pediatric Unintentional Home Injuries in a Tertiary Emergency Department Setting

  • Göksel Vatansever,
  • Erkan Şimşekli,
  • İdil Sivaslı,
  • Ayşe Elçin Özge,
  • Ahmet Hakan Aksu,
  • Adnan Barutçu,
  • İhsan Özdemir,
  • Emre Yaşar Karbancıoğlu,
  • Gülnur Göllü and
  • Deniz Tekin
  • + 3 authors

21 October 2025

Background/Objectives: Unintentional home injuries (UHIs) are a major yet preventable cause of morbidity and mortality among children. This study aimed to analyze the epidemiological characteristics, injury mechanisms, and clinical outcomes of pediat...

(This article belongs to the Section Clinical Pediatrics)
  • Article
  • Open Access
2,436 Views
22 Pages

Development and Validation of Prognostic Models for Treatment Response of Patients with B-Cell Lymphoma: Standard Statistical and Machine-Learning Approaches

  • Adugnaw Zeleke Alem,
  • Itismita Mohanty,
  • Nalini Pati,
  • Cameron Wellard,
  • Eliza Chung,
  • Eliza A. Hawkes,
  • Zoe K. McQuilten,
  • Erica M. Wood,
  • Stephen Opat and
  • Theophile Niyonsenga

21 October 2025

Background: Achieving a complete response after therapy is an important predictor of long-term survival in lymphoma patients. However, previous predictive models have primarily focused on overall survival (OS) and progression-free survival (PFS), oft...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
2 Citations
2,186 Views
13 Pages

Short-Term Outcomes After Transtibial Repair of Medial Meniscus Posterior Root Tears: A Case Series

  • Dan Viorel Nistor,
  • Samuel Piu,
  • Diana Raluca Mihu and
  • Romana von Mengershausen

21 October 2025

Background/Objectives: While arthroscopic repair is established for the treatment of medial meniscus posterior root tears (MMPRT), the relationship between physiotherapy (PT) exposure, meniscal extrusion (ME), and structural healing remains unclear....

(This article belongs to the Special Issue Clinical Application of Knee Arthroscopy)
  • Feature Paper
  • Review
  • Open Access
4 Citations
3,615 Views
19 Pages

21 October 2025

Weaning from invasive mechanical ventilation (IMV) is a key element in the management of critically ill patients, encompassing the entire process of discontinuing IMV. Despite its importance, considerable uncertainties remain regarding the optimal st...

(This article belongs to the Special Issue Non-Invasive Respiratory Support: Current Insights and Future Directions)
  • Article
  • Open Access
2 Citations
1,885 Views
13 Pages

21 October 2025

Objectives: This study aims to evaluate the efficacy and safety of valproic acid (VPA) transition regimens (from intravenous to oral tablets) for anti-seizure treatment. Methods: A retrospective analysis was conducted on inpatients treated with intra...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
1 Citations
1,088 Views
10 Pages

Early Use of Cryoprecipitate Versus Plasma and Clinical Outcomes in Major Spine Surgery

  • Aparna Depuru,
  • Jong Ok La,
  • Miriam M. Treggiari and
  • Nicole R. Guinn

21 October 2025

Background/Objectives: Major spine surgery often leads to significant blood loss and coagulopathy, necessitating blood product transfusion. Cryoprecipitate and plasma are two blood products commonly used to manage coagulopathy, but outcomes associate...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
2,017 Views
21 Pages

21 October 2025

Background: This longitudinal cohort study evaluated implant-associated bone remodeling and paranasal sinus (PNS) status after the insertion of patient-specific titanium orbital implants (PSIs) in adult trauma patients. Sixteen patients with various...

(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
  • Article
  • Open Access
2 Citations
2,299 Views
15 Pages

Comparative Effectiveness of SGLT2i and GLP-1RA on Blood Pressure in Hypertensive Patients with Type 2 Diabetes: A Saudi Multicenter Retrospective Study

  • Ghadah Alshehri,
  • Raghad Alrashidi,
  • Renad Alhaqbani,
  • Reema Almeshari,
  • Nader Bin Sheraim,
  • Alwaleed Alharbi,
  • Majed S. Al Yami,
  • Abdulmohsen Alanazi,
  • Nourah Alsalamah and
  • Amani Alrossies

21 October 2025

Background/Objectives: Sodium–glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown blood pressure (BP) reduction in type 2 diabetes (T2D). However, head-to-head comparisons in hypertensi...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
1,561 Views
13 Pages

Colpocleisis—Still a Valuable Option: A Point of Technique

  • Diana Hoehn,
  • Hannes Egli,
  • Martin Chase Marak,
  • Gloria Ryu,
  • Anna-Sophie Villiger,
  • Giovanni Ruggeri,
  • Michael David Mueller and
  • Annette Kuhn

21 October 2025

Background/Objectives: Pelvic organ prolapse (POP) is a common condition that increases with age and affects up to 40% of women. Colpocleisis is a possible native-tissue repair used in elderly persons not interested in vaginally penetrative sex to co...

(This article belongs to the Special Issue Pelvic Organ Prolapse: Current Challenges and Future Perspectives)
  • Review
  • Open Access
4 Citations
2,212 Views
29 Pages

Clinical Applications of Virtual and Augmented Reality in Radiology: A Scoping Review

  • Somin Mindy Lee,
  • Henrique Coimbra Baffi,
  • Tolulope Ola,
  • Brian Tsang,
  • Aaryan Gupta,
  • Ricardo Faingold,
  • Jennifer Stimec and
  • Andrea S. Doria

21 October 2025

Background: Virtual reality (VR) and augmented reality (AR) have emerged as innovative tools in healthcare, particularly using diagnostic and interventional imaging methods, offering new avenues for enhancing patient care and procedural outcomes. The...

(This article belongs to the Section Nuclear Medicine & Radiology)
  • Systematic Review
  • Open Access
1 Citations
2,817 Views
29 Pages

21 October 2025

Background/Objectives: Rectal cancer is a significant global health concern, requiring precise staging and response assessment to make treatment decisions. Magnetic resonance imaging (MRI) is the standard imaging modality for evaluating tumor stage a...

(This article belongs to the Section Nuclear Medicine & Radiology)
  • Article
  • Open Access
3 Citations
2,727 Views
16 Pages

Implementation of Remote Patient Monitoring and Earlier CERT Activation: Effects on ICU Transfer and Mortality

  • Victor Narcisse,
  • Farhan Ishaq,
  • Melissa Gomez,
  • Sarah Homer,
  • Laura Griffin,
  • Sarah Pletcher and
  • Ngoc-Anh Nguyen

21 October 2025

Introduction: Timely detection of clinical deterioration in hospitalized patients remains a challenge, often limited by intermittent vital signs (VS) monitoring and delayed escalation. Remote patient monitoring (RPM) offers a medium of high-frequency...

(This article belongs to the Section Intensive Care)
  • Article
  • Open Access
1,253 Views
15 Pages

The Effect of Bazedoxifene and Fulvestrant for Preventing Ovarian Hyperstimulation Syndrome: An Experimental Study

  • Fatma Ozdemir,
  • Gokhan Acmaz,
  • Arzu Hanim Yay,
  • Ozge Cengiz Mat,
  • Gozde Erturk Zararsiz,
  • Banu Acmaz,
  • Ipek Muderris,
  • Sabahattin Muhtaroglu,
  • Erol Karakas and
  • Mevlude Inanc

21 October 2025

Background: Ovarian hyperstimulation syndrome (OHSS) remains a major complication during controlled ovarian stimulation, particularly in women with high estradiol levels. This study aimed to investigate whether bazedoxifene or fulvestrant could be ef...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
3 Citations
1,296 Views
17 Pages

Extended ECG Monitoring in Patients with Hypertrophic Cardiomyopathy: The Tempo-HCM Study

  • Juan Caro-Codón,
  • Sergio Castrejón,
  • Rosalía Cadenas,
  • Carlos Casanova,
  • Andrea Vélez,
  • Mayte Basurte,
  • Gemma Lacuey,
  • Vicente Climent,
  • Óscar Salvador and
  • Jose L. Merino
  • + 8 authors

21 October 2025

Background/Objectives: Current guidelines recommend 24–48 h Holter for risk stratification and atrial fibrillation (AF) screening in hypertrophic cardiomyopathy (HCM). However, the limited duration of this approach may not provide optimal sensi...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
5 Citations
2,218 Views
13 Pages

21 October 2025

Background/Objectives: Horizontal alveolar ridge deficiency is a common clinical challenge in dental implant placement. The osseodensification (OD) technique has been proposed as a minimally invasive alternative to conventional osteotomy. This study...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Systematic Review
  • Open Access
2 Citations
2,299 Views
13 Pages

Role of Point-of-Care Ultrasound in Inpatient Perioperative Medical Management: A Systematic Review

  • Dhairya M. Jarsania,
  • Mike J. Breunig,
  • Gururaj J. Kolar,
  • Meltiady Issa,
  • Ryan Kingsley,
  • Mohammed Nadir Bhuiyan,
  • Cynthia J. Chelf and
  • Robert W. Kirchoff

21 October 2025

Background: Point-of-care ultrasonography (POCUS) is becoming an increasingly relevant tool in hospital medicine, but its effective application in inpatient perioperative medicine remains to be determined. Much of the POCUS literature describes its u...

(This article belongs to the Section Anesthesiology)
  • Systematic Review
  • Open Access
4 Citations
3,060 Views
17 Pages

Suction-Assisted Laryngoscopy and Airway Decontamination (SALAD) for Emergency Airway Management: A Systematic Review of Evidence and Implementation

  • Saniyah Shaikh,
  • Hamad Hejazi,
  • Safwaan Shaikh,
  • Adeeba Sajid,
  • Rida Shahab,
  • Ayesha Deed,
  • Rida Afnan,
  • Anam Hashmi,
  • Raiyan Ehtesham Ahmed Sharieff and
  • Marcelo A. F. Ribeiro
  • + 1 author

21 October 2025

Background: Emergency airway management is a crucial and complex procedure frequently performed in the emergency department (ED). Airway contamination usually caused by blood, secretions, and emesis impairs ventilation, reduces successful intubation,...

(This article belongs to the Special Issue Airway Management: From Basic Techniques to Innovative Technologies)
  • Article
  • Open Access
5 Citations
1,203 Views
13 Pages

Comparison of Deep Neural Networks for the Classification of Adventitious Lung Sounds

  • Said Polanco-Martagón,
  • Yahir Hernández-Mier,
  • Marco Aurelio Nuño-Maganda,
  • José Hugo Barrón-Zambrano,
  • Andrea Magadán-Salazar and
  • César Alejandro Medellín-Vergara

21 October 2025

Background: Automatic adventitious lung sound classification using deep learning is a promising strategy for objective respiratory disease screening. Evaluating model performance is challenging, particularly with imbalanced clinical datasets. This st...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
5 Citations
1,455 Views
15 Pages

21 October 2025

Background/Objectives: Non-variceal upper gastrointestinal bleeding (NVUGIB) is associated with considerable morbidity and mortality, particularly in emergency department (ED) settings. While traditional clinical scores such as the Glasgow-Blatchford...

(This article belongs to the Special Issue Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases)
  • Article
  • Open Access
3 Citations
4,441 Views
13 Pages

Low-Dose Indapamide vs. Hydrochlorothiazide in Idiopathic Hypercalciuria: A Randomized Prospective Trial

  • Maria Peraire,
  • Jorge Guimerà,
  • Antonia Costa-Bauzá,
  • Pilar Sanchís,
  • Felix Grases and
  • Enrique Pieras

21 October 2025

Background: Idiopathic hypercalciuria (IH) is the most common genetic metabolic disorder in patients with urinary stones and is usually treated with thiazide-type diuretics. However, direct evidence comparing low-dose indapamide and hydrochlorothiazi...

(This article belongs to the Section Nephrology & Urology)
  • Perspective
  • Open Access
5 Citations
4,105 Views
21 Pages

21 October 2025

Aortic stenosis (AS) is the most common valvular heart disease in industrialized countries. Stress echocardiography (SE), using either exercise or dobutamine protocols, has emerged as a critical tool to overcome limitations of resting echocardiograph...

(This article belongs to the Special Issue Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases)
  • Perspective
  • Open Access
3 Citations
3,172 Views
31 Pages

21 October 2025

Since the earliest investigations into the impact of sleep-related breathing disorders on cardiovascular risk, the association between sleep–wake disorders and major cerebrovascular events has been increasingly and robustly established. Recent...

(This article belongs to the Section Clinical Neurology)
  • Review
  • Open Access
5 Citations
5,484 Views
23 Pages

Non-Invasive Wearable Technology to Predict Heart Failure Decompensation

  • Jack Devin,
  • Eden Powell,
  • Dylan McGagh,
  • Tyler Jones,
  • Brian Wang,
  • Pierre Le Page,
  • Andrew J. M. Lewis,
  • Oliver J. Rider,
  • Andrew R. J. Mitchell and
  • John A. Henry

21 October 2025

Heart failure (HF) remains a leading cause of recurrent hospitalisations worldwide, largely driven by acute episodes of decompensation. Early identification of impending decompensation could enable timely intervention and potentially prevent costly a...

(This article belongs to the Special Issue Advanced Therapy for Heart Failure and Other Combined Diseases)
  • Article
  • Open Access
1,192 Views
11 Pages

21 October 2025

Background and Objectives: There are few studies suggesting that the Triglyceride–Glucose Index (TyG), which is mostly defined as a predictor of diabetes, can be used as a predictor of coronary artery disease. In this study, we investigated the...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
1,139 Views
9 Pages

Retrospective Evaluation of Maxillary Sinus Volume Changes Following Bone-Anchored Midface Distraction Osteogenesis in Cleft Patients: A Case–Series Study

  • Aleksandra Kołodziejska,
  • Patryk Kołodziejski,
  • Maria Gutowska,
  • Martyna Dowgierd,
  • Agnieszka Predko-Engel,
  • Monika Jurczuk and
  • Krzysztof Dowgierd

21 October 2025

Background/Objectives: This study retrospectively evaluated maxillary sinus volume changes and linear changes in the craniofacial region after Le Fort I distraction osteogenesis using a rigid external distraction system. Methods: Ten patients who und...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Article
  • Open Access
790 Views
11 Pages

Incomplete Follow-Up and Competing Risks as Sources of Bias in Vascular Surgical Investigations

  • Andrej Udelnow,
  • Semion Smorodin,
  • Efim Sinicin,
  • Joerg Tautenhahn,
  • Joerg Herold,
  • Udo Barth and
  • Zuhir Halloul

21 October 2025

Background/Objectives: The aim of this study was to determine whether incomplete follow-up and competing event risks may be associated with the clinical course after treatment and with known risk factors, such as chronic limb-threatening ischemia (CL...

(This article belongs to the Special Issue Clinical Advances in Aortic Disease and Revascularization)
  • Correction
  • Open Access
546 Views
3 Pages

Correction: Di Lorenzo et al. Staff Attitude Towards Coercive Measures in Hospital and Community Psychiatric Settings. J. Clin. Med. 2025, 14, 2886

  • Rosaria Di Lorenzo,
  • Francesca Mucchi,
  • Nadia Magnani,
  • Fabrizio Starace,
  • Jessica Bonisoli,
  • Carolina Bottone,
  • Ilaria Ragazzini,
  • Paola Ferri and
  • Donatella Marrama

21 October 2025

There were three errors in the original publication [...]

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
1 Citations
1,583 Views
16 Pages

Kinematic Assessment of the Physician’s Body Position and Musculoskeletal Loads During Breast and Abdominal Ultrasound Examinations

  • Mateusz Winder,
  • Maria Hankus,
  • Marcin Ciekalski,
  • Izabela Rosół,
  • Anna Miller-Banaś,
  • Agata Guzik-Kopyto,
  • Katarzyna Steinhof-Radwańska and
  • Robert Michnik

20 October 2025

Background: Ultrasound is a non-invasive imaging technique that provides real-time evaluation of anatomical structures. While versatile in examining various organs, it can be physically demanding for physicians due to the need for challenging positio...

(This article belongs to the Section Nuclear Medicine & Radiology)
  • Article
  • Open Access
1,750 Views
10 Pages

20 October 2025

Background: Obstetrical brachial plexus palsy (OBPP) often results in medial shoulder contracture, with limited abduction and external rotation due to muscle imbalance and joint deformities. Late nerve transfers, such as spinal accessory nerve (SAN)...

(This article belongs to the Special Issue Innovation in Hand Surgery)
  • Article
  • Open Access
1 Citations
988 Views
16 Pages

20 October 2025

Background and Objectives: The Naples Prognostic Score (NPS), a composite index indicative of nutritional and inflammatory status, has been suggested as an important prognostic marker. Uric acid, an indicator of oxidative stress and endothelial impai...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
802 Views
9 Pages

Maternal Serum Thrombospondin-4 Levels in Gestational Hypertension and Risk of Preeclampsia

  • Özgür Volkan Akbulut,
  • Ahmet Arif Filiz,
  • Belgin Savran Üçok,
  • Mustafa Bağcı and
  • Zehra Vural Yılmaz

20 October 2025

Background: Gestational hypertension (GHT) is associated with adverse maternal and perinatal outcomes, and reliable biomarkers for risk stratification remain limited. Thrombospondin-4 (TSP-4), a matricellular glycoprotein implicated in vascular remod...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
1,072 Views
15 Pages

20 October 2025

Background/Objectives: The anterior communicating artery (AcomA) is one of the most common sites of intracranial aneurysms. We aimed to investigate the effect of routine extradural anterior clinoidectomy (EAC) and extradural lamina terminalis fenestr...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
4 Citations
4,082 Views
16 Pages

20 October 2025

Background: Lumbar facet joint degeneration is a common source of chronic low back pain. Radiofrequency (RF) ablation is widely used, whereas cryoablation (CA) remains less extensively investigated. Evidence directly comparing the long-term outcomes...

(This article belongs to the Section Anesthesiology)
  • Case Report
  • Open Access
1,463 Views
12 Pages

Should Chronic Subretinal Hemorrhage Be Treated Surgically?

  • Wojciech Luboń,
  • Małgorzata Luboń and
  • Wojciech Rokicki

20 October 2025

Closed-globe blunt ocular trauma may lead to severe ophthalmic complications, including intraocular hemorrhages, traumatic cataract, and retinopathy, the management of which remains a significant clinical challenge. We report the case of a 55-year-ol...

(This article belongs to the Special Issue Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect)
  • Article
  • Open Access
4 Citations
3,004 Views
12 Pages

Real-Life Effectiveness and Safety of Bimekizumab in Plaque Psoriasis Involving Difficult-to-Treat Areas: A 52-Week, Retrospective Real-World, Single-Center Study

  • Matteo Bianco,
  • Francesco D’Oria,
  • Gioele Ghezzi,
  • Luciano Ibba,
  • Sara Di Giulio,
  • Mario Valenti,
  • Antonio Costanzo,
  • Alessandra Narcisi and
  • Luigi Gargiulo

20 October 2025

Background: Psoriasis is a chronic inflammatory disease that frequently affects difficult-to-treat areas such as the scalp, nails, genitalia, and palms/soles, with significant physical and psychological burden. Bimekizumab, a monoclonal antibody targ...

(This article belongs to the Special Issue Psoriasis in Focus: Current Research, Treatments, and Future Directions)
  • Article
  • Open Access
4 Citations
4,268 Views
18 Pages

20 October 2025

Background/Objectives: Dietary supplement (DS) use has become increasingly prevalent among adult athletes worldwide and carries both potential benefits and risks. This study aimed to examine the prevalence and perspectives of DS use among adult athle...

(This article belongs to the Section Clinical Nutrition & Dietetics)
  • Article
  • Open Access
7 Citations
1,600 Views
16 Pages

Transbronchial Mediastinal Cryobiopsy Guided by Endobronchial Ultrasound in Addition to Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Ilo-Mediastinal Lymphadenopathy Without Obvious Primary Lung Neoplastic Lesion: A Prospective Multicenter Study

  • Francesco Todisco,
  • Filippo Patrucco,
  • Aleksandar Veljkovic,
  • Gian Carlo Vallese,
  • Davide Indellicati,
  • Letizia Valsecchi,
  • Luca Riberi,
  • Giuseppe Ielo,
  • Paola Rebecca Iovine and
  • Massimo Comune
  • + 2 authors

20 October 2025

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) represents the gold standard technique for the diagnosis and staging of lung carcinoma. However, its diagnostic yield may be limited for granulomatous pathologie...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
1 Citations
906 Views
15 Pages

Role of Procurement Practice on Early Allograft Dysfunction in Liver Transplantation: A Propensity-Weighted Single-Center Analysis

  • Quirino Lai,
  • Licia Iannello,
  • Alice Viscione,
  • Fabio Melandro,
  • Giulia Diamantini,
  • Silvia Quaresima,
  • Flaminia Ferri,
  • Stefano Ginanni Corradini,
  • Gianluca Mennini and
  • Massimo Rossi

20 October 2025

Background/Objectives: Liver transplantation (LT) remains the standard treatment for end-stage liver disease. While donation after brain death (DBD) is the predominant source of grafts, non-standard donors are increasingly used. Optimizing procuremen...

(This article belongs to the Special Issue Liver Transplantation: Current Hurdles and Future Perspectives)
  • Article
  • Open Access
1,337 Views
13 Pages

Recurrence of Head and Neck Squamous Cell Carcinoma: Did the COVID-19 Pandemic Have an Impact on Therapeutic Management?

  • Benjamin Reliquet,
  • Thomas Thibault,
  • Paul Elhomsy,
  • Dounia Chbihi,
  • Mireille Folia and
  • Caroline Guigou

20 October 2025

Objectives: To our knowledge, no previous study has specifically investigated the impact of COVID-19 on the management of recurrent squamous cell carcinoma (HNSCC) of the upper aerodigestive tract. The aim was to investigate the impact of the COVID-1...

(This article belongs to the Section Otolaryngology)
  • Article
  • Open Access
1 Citations
1,132 Views
17 Pages

Prognostic Impact of Obesity, Cardiometabolic Risk Factors, and Vascular Function Markers on Outcomes in Ischemic Cardiomyopathy

  • Konstantinos Mourouzis,
  • Vasiliki Tsigkou,
  • Gerasimos Siasos,
  • Evangelos Oikonomou,
  • Marina Zaromitidou,
  • Evanthia Bletsa,
  • Nikolaos Gouliopoulos,
  • Panagiota K. Stampouloglou,
  • Konstantinos Tsioufis and
  • Dimitris Tousoulis
  • + 1 author

20 October 2025

Background/Objectives: Ischemic cardiomyopathy is a major cause of morbidity and mortality. Obesity is paradoxically associated with better outcomes, while clustering of cardiometabolic risk factors (CMRFs)—diabetes mellitus, arterial hypertens...

(This article belongs to the Special Issue Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment)
  • Article
  • Open Access
1,714 Views
13 Pages

Differential NMR Lipoprotein Profiles and Prediction of Insulin Resistance and Metabolic Syndrome by LP-IR Among Adult Chronic Hepatitis B Patients

  • Karen J. Campoverde Reyes,
  • Javier Guevara,
  • Hamidreza Karimi-Sari,
  • Daniela Goyes,
  • Kamolyut Lapumnuaypol,
  • Pir A. Shah,
  • Satinder P. Kaur,
  • Margery A. Connelly,
  • Z. Gordon Jiang and
  • Daryl T.-Y. Lau

20 October 2025

Background/Objectives: Chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease (MASLD) are associated with risk of advanced hepatic fibrosis and cirrhosis. Given the increased risk, the presence of insulin resistance, metabol...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
1,269 Views
16 Pages

L-FABP as a Potential Biomolecular Marker of Liver Graft Injury

  • Ana Kalamutova,
  • Danaja Plevel,
  • Mihajlo Djokic,
  • Ales Jerin,
  • Blaž Trotovšek and
  • Miha Petric

20 October 2025

Background: In recent years, indications for liver transplantation have expanded, while the age of transplant recipients has significantly increased due to improvements in perioperative management. As clinical manifestations of posttransplant complic...

(This article belongs to the Special Issue Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes)
  • Article
  • Open Access
1 Citations
1,283 Views
10 Pages

Kono-S Anastomosis in Pediatric Crohn’s Disease: Experience at a Tertiary Referral Center

  • Valeria Dipasquale,
  • Claudio Romano,
  • Carmelo Romeo,
  • Pietro Impellizzeri,
  • Angela Simona Montalto and
  • Giuseppe Navarra

20 October 2025

Objectives: The Kono-S anastomosis is a bowel-sparing surgical technique developed to reduce postoperative recurrence in Crohn’s disease (CD). While its efficacy has been established in adults, data in pediatric populations remain scarce. This...

(This article belongs to the Section Clinical Pediatrics)

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J. Clin. Med. - ISSN 2077-0383