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Targeted Treatment of Kidney Stones
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Targeted Treatment of Kidney Stones

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 3712

Special Issue Editors

Prof. Dr. Carmen Gonzalez-Enguita

E-Mail Website
Guest Editor
Hospital Universitario Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, Spain
Interests: urology; kidney stone; prostate cancer
Dr. Alberto Budía-Alba

E-Mail Website
Guest Editor
Urology Department, Polytechnic and University La Fe Hospital, 46026 Valencia, Spain
Interests: endourology; urolithiasis; urologic oncology; prostate; prostate cancer; surgical oncology

Special Issue Information

Dear Colleagues,

The primary objective of this Special Issue is to provide clinicians and researchers with a comprehensive understanding of the targeted treatment modalities available for kidney stones. We aim to highlight the recent developments in minimally invasive techniques, such as shockwave lithotripsy, ureteroscopy, percutaneous nephrolithotomy and laser lithotripsy. Additionally, we seek to address the challenges associated with stone composition analysis, patient selection and post-treatment follow-up.

We encourage submissions that cover a wide range of topics, including, but not limited to, the following:

  1. Advances in surgical interventions for complex stone cases;
  2. Pharmacological approaches for preventing stone recurrence;
  3. Evaluation and comparison of different imaging modalities for stone detection and characterization;
  4. Patient selection criteria and personalized treatment strategies.

By showcasing the latest advancements in targeted treatment, we hope to improve patient outcomes, reduce complications and enhance the overall quality of care. We encourage researchers to contribute their work to this Special Issue and help advance the field of targeted treatment for kidney stones.

Prof. Dr. Carmen Gonzalez-Enguita
Dr. Alberto Budía-Alba
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • shockwave lithotripsy
  • ureteroscopy
  • percutaneous nephrolithotomy
  • laser lithotripsy
  • minimally invasive techniques
  • stone recurrence prevention

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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13 pages, 2146 KiB  
Article
Small Diameter (7.5 Fr) Single-Use Flexible Ureteroscopy with Direct In-Scope Suction (DISSTM) in Conjunction with Aspiration-Assisted Flexible Access Sheath: A New Hype for Real Stone-Free?
by Petrișor Geavlete, Cristian Mareș, Răzvan Mulțescu, Dragoș Georgescu, Cosmin-Victor Ene, Valentin Iordache and Bogdan Geavlete
J. Clin. Med. 2024, 13(23), 7191; https://doi.org/10.3390/jcm13237191 - 27 Nov 2024
Viewed by 1653
Abstract
Background: Renal lithiasis continues to represent a great challenge for modern urology in terms of minimally invasive management of lithotripsy procedures. The recent revolution of endoscopes with the miniaturization of instruments and the development of improved disposable ureteroscopes combined with recent suction [...] Read more.
Background: Renal lithiasis continues to represent a great challenge for modern urology in terms of minimally invasive management of lithotripsy procedures. The recent revolution of endoscopes with the miniaturization of instruments and the development of improved disposable ureteroscopes combined with recent suction methods such as suction access sheaths or direct in-scope suction (DISSTM) systems promise to further improve the outcome of renal stone treatment. Methods: Considering this technological advance, this study aims to evaluate the results obtained by combining these methods in three groups: Group 1—Single-use 7.5 Fr flexible ureteroscope with standard access sheath, Group 2—Single-use 7.5 Fr flexible ureteroscope with direct in-scope suction (DISSTM) with standard access sheath, Group 3—Single-use 7.5 Fr flexible ureteroscope with DISSTM with suction access sheath. A total number of 105 consecutive patients were enrolled in the study, divided equally in each group. Several parameters were followed, such as size and location of the stones, operative time, duration of hospitalization, the need for ureteral stent insertion, residual fragments, and subjective evaluation of the lithotripsy environment visualization. Results: The best results were highlighted in Group 3 for almost all evaluated parameters. Significant improvements were indicated in terms of stone-free rates. Conclusions: Additional large studies are needed to support these initial results, but preliminary data indicate a valuable advantage for every urologist who treats urolithiasis. Full article
(This article belongs to the Special Issue Targeted Treatment of Kidney Stones)
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Review

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23 pages, 4337 KiB  
Review
Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment
by Elena Popova, Sergey Tkachev, Artur Shapoval, Anastasia Karpenko, Yuliya Lee, Pavel Chislov, Boris Ershov, Danila Golub, Gevorg Galechyan, Daniil Bogoedov, Anastasiya Akovantseva, Elvira Gafarova, Roman Musaelyan, Maria Schekleina, Stuart Clark, Stanislav Ali, Alim Dymov, Andrey Vinarov, Petr Glybochko and Peter Timashev
J. Clin. Med. 2025, 14(3), 997; https://doi.org/10.3390/jcm14030997 - 5 Feb 2025
Viewed by 1505
Abstract
Despite the recent advances in minimally invasive surgery, kidney stones still pose a significant clinical challenge due to their high recurrence rate of 50% in 5–10 years after the first stone episode. Using the methods of geosciences and biology, the GeoBioMed approach treats [...] Read more.
Despite the recent advances in minimally invasive surgery, kidney stones still pose a significant clinical challenge due to their high recurrence rate of 50% in 5–10 years after the first stone episode. Using the methods of geosciences and biology, the GeoBioMed approach treats kidney stones as biogenic minerals, offering a novel perspective on their formation and dissolution processes. In this review, we discuss kidney stones’ structural and mechanical properties as emerging biomarkers of urolithiasis, emphasizing the importance of a comprehensive stone analysis in developing personalized treatment strategies. By focusing on unexplored properties like crystalline architecture, porosity, permeability, cleavage, and fracture, alongside the conventionally used composition and morphology, we show how these stone characteristics influence the treatment efficacy and the disease recurrence. This review also highlights the potential of advanced imaging techniques to uncover novel biomarkers, contributing to a deeper understanding of stone pathogenesis. We discuss how the interdisciplinary collaboration within the GeoBioMed approach aims to enhance the diagnostic accuracy, improve the treatment outcomes, and reduce the recurrence of urolithiasis. Full article
(This article belongs to the Special Issue Targeted Treatment of Kidney Stones)
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