Y-27632 inhibits Rho-associated coiled-coil-containing protein kinase (ROCK) signaling, which is involved in various embryonic developmental processes, including angiogenesis, by controlling actin cytoskeleton assembly and cell contractility. Adminis...
Y-27632 is known as a selective Rho-associated coiled coil-forming kinase (ROCK) inhibitor. Y-27632 has been shown to induce neurite outgrowth in several neuronal cells. However, the precise molecular mechanisms linking neurite outgrowth to Y-27632 a...
Y-27632, as a cytoskeleton protector, is commonly used for low-temperature preservation of cells. Goat sperm are prone to damage to the cytoskeleton under low-temperature conditions, leading to a loss of sperm vitality. However, the Y-27632 small mol...
Cultured keratinocytes are desirable models for biological and medical studies. However, primary keratinocytes are difficult to maintain, and there has been little research on lingual keratinocyte culture. Here, we investigated the effect of Y-27632,...
(1) Rho-associated coiled-coil protein kinase (ROCK) signaling cascade impacts a wide array of cellular events. For cellular therapeutics, scalable expansion of primary human corneal endothelial cells (CECs) is crucial, and the inhibition of ROCK sig...
At Arvogno, Vigezzo valley in the Central Alps, Italy, pegmatite dikes are unique in the scenario of a tertiary alpine pegmatite field because they show marked geochemical and mineralogical niobium–yttrium–fluorine features. These pegmati...
Salivary gland stem cells (SGSCs) are potential cell sources for the treatment of salivary gland diseases. The control of cell survival is an essential factor for applying stem cells to regenerative medicine or stem cell-based research. The purpose o...
A series of nonstoichiometric La1–yBayF3–y (0 ≤ y ≤ 0.12) single crystals with a tysonite-type structure (sp. gr. P-3c1) was grown from the melt by the directional crystallization method in a fluorinating atmosphere, and some physical properties were...
Eudistomin Y class compounds are a series of β-carbolines which was originally isolated from a marine turnicate or ascidian near the South Korea Sea. These compounds contain bromo-substituted groups, which is one of the typical characters of marine n...
Zirconium-89 (89Zr, t1/2 = 3.27 days) owns great potential in nuclear medicine, being extensively used in the labelling of antibodies and nanoparticules. 89Zr can be produced by cyclotron via an 89Y(p,n)89Zr reaction while using an 89Y-foil target. I...
The microstructure and properties of Mg-Y-Zn as-cast alloys with the Y/Zn ratio of approximately 1.3 (wt%) and different Y contents were studied, including an analysis of the main factors and mechanisms affecting their toughness and ductility, such a...
Thrombosis is one of the most prevalent and serious health issues amongst humans. A key component of thrombotic events is the activation and aggregation of platelets, of which the P2Y1 and P2Y12 receptors play a crucial role in this process. Despite...
While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly...
By adjusting the Y/Zn (wt.%) ratio while maintaining the total mass of Y and Zn unchanged, the evolution of the microstructure and mechanical properties of Mg-Y-Zn alloy castings with different phase types was investigated. The results indicated that...
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the adequate diagnostic radiopharmaceutical, the disease and the state of...
The existence mode of Y is an important factor affecting the oxidation resistance of NiCrAlY coating. The traditional thermal sprayed NiCrAlY coating had some problems such as internal-stress-induced coating peeling, when it was used at high temperat...
The nuclear factor Y (NF-Y) transcription factors (TFs) play vital regulatory roles in diverse developmental processes and responses to abiotic stresses in plants. However, the NF-Y genes remain largely unknown in cucumber. In this study, based on ph...
Nowadays, the use of Y-chromosome polymorphisms forms an essential part of many forensic DNA investigations. However, this was not always the case. Only since 1992 have we seen that some forensic scientists started to have an interest in this chromos...
Sintering additives are commonly used to reduce the conditions required for densification in composite ceramics without compromising their performances simultaneously. Herein, SiC/SiCw-Y2O3 composite ceramics with 10 vol.% SiC whiskers (SiCw) and dif...
Gene expansion is a common phenomenon in plant transcription factor families; however, the underlying molecular mechanisms remain elusive. Examples of gene expansion in transcription factors are found in all eukaryotes. One example is plant nuclear f...
Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stre...
In this study, Ni-Co-Y2O3 composite coating was prepared by electrodeposition, and the effect of Y2O3 particle size on the microstructure and properties of the coating was investigated. The samples were analyzed by XRD, SEM, AFM, EDS, cyclic voltamme...
Background/Objectives: The Y chromosome is a crucial tool in forensic genetics due to its unique characteristics, such as its haploid inheritance and lack of recombination. Y-STRs (short tandem repeats on the Y chromosome) are widely used for identif...
Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role...
Compositional and textural variations in the rinkite group, seidozerite supergroup minerals, batievaite-(Y), hainite-(Y) and close to them titanosilicates from the Sakharjok massif were studied. Statistical analysis allowed for defining two major sub...
Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor that binds to the CCAAT cis-element in the promoters of target genes and plays critical roles in plant growth, development, and stress responses. In the present study, we aimed to re-ch...
The aim of this study was to analyze the influence of different surface treatments and the corresponding surface roughness on the ball-on-three-balls test and piston-on-three-balls test for measuring flexural strength 3Y-TZP and 5Y-PSZ. Additionally,...
A complete understanding of the solid-state phase equilibria of the ternary Al–Sn–Y system is essential for the development of both Al-based structural materials and Sn-based lead-free solders. In this work, the phase relationships in the...
This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5′-diphosphate (ADP, 100 µmol·L−1)...
A magnesium alloy containing Al2Y particles was successfully fabricated by changing the content of Al in the Mg-6Y alloy melt. Its microstructure and mechanical properties were subsequently characterized. The results show that two types of Al2Y parti...
Neuropeptide Y (NPY) has anxiolytic-like effects and facilitates the extinction of cued and contextual fear in rodents. We previously showed that intracerebroventricular administration of NPY reduces the expression of social fear in a mouse model of...
CodY is a dominant regulator in low G + C, Gram-positive Firmicutes that governs the regulation of various metabolic pathways and cellular processes. By using various bioinformatics analyses and DNA affinity precipitation assay (DAPA), this study con...
This paper investigates the effects of Y content on the microstructure and mechanical properties of Mg-9Gd-xY-0.5Zr alloys. The mechanical properties, together with the grain size, first increase and then decrease, exhibiting a non-monotonous change...
The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In...
The YxNi2−yMny system was investigated in the region 0.825 ≤ x ≤ 0.95, 0.1 ≤ y ≤ 0.3. The alloys were synthesized by induction melting and corresponding annealing. The substitution of Mn for Ni (y = 0.1) favors the formation of a C1...
Cu2Y2O5 perovskite was reduced at different temperatures under H2 atmosphere to prepare two Cu-Y2O3 catalysts. The results of the activity test indicated that the Cu-Y2O3 catalyst after H2-reduction at 500 °C (RCYO-500) exhibited the best perform...
Zeolite Y and Ti-containing zeolite Y (1%, 2% and 5% TiO2) were synthesized by a hydrothermal seed-assisted method. In order to evidence the evolution of morphology, structure, and fractal dimensions during the zeolitization process at certain time i...
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidativ...
Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation which may allow us to predict and/or diagnose developing coronary thrombosis before myocardial necrosis occurs. The P2Y1 and P2Y12 receptors play a key role in...
The microstructures and mechanical properties of the Mg88.5Zn5Y6.5-XREX (RE = Yb and Ce, X = 0, 1.5, 3.0, and 4.5) (wt.%) alloys were investigated in the present study. Mg88.5Zn5Y6.5 is composed of three phases, namely, α-Mg, long-period stacki...
The effects of Gd, Y content on the microstructure and mechanical properties of Mg-Gd-Y-Nd-Zr alloy were investigated using hardness measurements, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and...
Zeolite Y samples with microporous and hierarchical structures containing Ti–Ni and Ti–Co oxides were obtained as active photocatalysts. Different Ti amounts (5, 10% TiO2) were supported, followed by the loading of Ni or Co oxides (5%). X...
10 September 2022
(1) Background: The recent published version with five levels of response of EQ-5D-Y needs to be studied in children with chronic illness. For this, the aim of the present study was to assess and compare the psychometric properties of EQ-5D-Y-3L and...
Background/Objectives: Y-chromosomal short tandem repeats (Y-STR) are genetic markers widely used in forensic and population genetics. However, despite their importance, many populations remain under-represented in published studies and genetic datab...
A sample of 146 Sarda bucks from eight subregions of Sardinia, Italy (Nuorese, Barbagia, Baronia, Ogliastra, Sarrabus, Guspinese, Iglesiente, Sulcis) were characterized for Y-chromosome and mtDNA markers to assess the levels of population substructur...
In this study, three slots containing an anode chamber, a cathode chamber, and a middle pole chamber were designed by applying the Hittorf method, and a two-way coupling model of the flow field and electric field was established using the COMSOL syst...
In the presented research, we investigated Ammonium Nitrate Fuel Oil (ANFO), with the addition of variously modified zeolite Y as an attractive explosive. Analysis of both blasting tests and thermodynamic models of blasting properties led to the conc...
The Y chromosome plays a crucial role in understanding the overall landscape of male health. Incorporating the Y chromosome into genomic and epigenomic research may elucidate the male-specific mechanisms behind aging and the pathogenesis of certain c...
Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite responsible for toxoplasmosis, a disease with significant health implications for humans and animals. The surface antigen 1 (SAG1) of T. gondii is a major immunodominant pr...
The widespread application of WE43 (Mg-4Y-2Nd-1Gd-0.5Zr) alloy castings in aerospace components is hindered by the frequent formation of defects such as cracks, pores, and especially yttria inclusions. These defects necessitate subsequent welding. Ho...
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