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Review

The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

1
Bristol Medical School, University of Bristol, Bristol BS8 1QU, UK
2
Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge CB2 0SL, UK
3
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UK
*
Author to whom correspondence should be addressed.
Genes 2020, 11(11), 1273; https://doi.org/10.3390/genes11111273
Received: 9 September 2020 / Revised: 19 October 2020 / Accepted: 26 October 2020 / Published: 29 October 2020
(This article belongs to the Special Issue Complex Genetic Loci, 2nd Edition)
The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY. View Full-Text
Keywords: Y chromosome; Y haplogroups; complex locus; genetic association analyses; genetic epidemiology; complex human traits Y chromosome; Y haplogroups; complex locus; genetic association analyses; genetic epidemiology; complex human traits
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MDPI and ACS Style

Parker, K.; Erzurumluoglu, A.M.; Rodriguez, S. The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. Genes 2020, 11, 1273. https://doi.org/10.3390/genes11111273

AMA Style

Parker K, Erzurumluoglu AM, Rodriguez S. The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. Genes. 2020; 11(11):1273. https://doi.org/10.3390/genes11111273

Chicago/Turabian Style

Parker, Katherine, A. Mesut Erzurumluoglu, and Santiago Rodriguez. 2020. "The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits" Genes 11, no. 11: 1273. https://doi.org/10.3390/genes11111273

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