You are currently on the new version of our website. Access the old version .

405 Results Found

  • Article
  • Open Access
6 Citations
5,588 Views
15 Pages

Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression

  • Seonju Lee,
  • Sanghyun Ye,
  • Mina Kim,
  • Hyejin Lee,
  • Seung-Hyun Jun and
  • Nae-Gyu Kang

26 February 2024

Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of sev...

  • Article
  • Open Access
2 Citations
3,046 Views
14 Pages

27 February 2024

As the aging population increases, so has interest among emerging seniors in anti-aging ingredients that enhance functionality by incorporating fermentation with natural materials. In this study, fermentation conditions for enhancing the functionalit...

  • Article
  • Open Access
9 Citations
4,970 Views
14 Pages

21 January 2021

Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal contro...

  • Article
  • Open Access
1,754 Views
11 Pages

Wrinkle Improvement in HanDam (Twist) on Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice

  • Inbong Song,
  • Judong Song,
  • Ilseok Jang,
  • Dayoung Noh,
  • Chaemyeong Lee and
  • Jungkee Kwon

28 April 2025

Background: Skin photoaging caused by ultraviolet B (UV-B) irradiation leads to the formation of wrinkles. A method to lessen wrinkles is the application of Polydioxanone (PDO) lifting threads. HanDam (Twist) is a PDO lifting thread with a unique mor...

  • Article
  • Open Access
1 Citations
5,977 Views
12 Pages

Hibiscus Collagen Alternative (VC-H1) as an Oral Skin Rejuvenating Agent: A 12-Week Pilot Study

  • Yujin Baek,
  • Ngoc Ha Nguyen,
  • Young In Lee,
  • Min Joo Jung,
  • In Ah Kim,
  • Sung Jun Lee,
  • Hyun Min Kim and
  • Ju Hee Lee

Skin aging causes reduced hydration, elasticity, and increased wrinkles. Recent safety and compliance concerns over oral collagen supplements have increased interest in plant-based alternatives like Hibiscus sabdariffa with antioxidant and anti-aging...

  • Article
  • Open Access
2 Citations
3,916 Views
15 Pages

Skin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating...

  • Article
  • Open Access
4,089 Views
19 Pages

Improvement of Skin Condition Through RXR Alpha-Activating Materials

  • Sanghyun Ye,
  • Seonju Lee,
  • Seongsu Kang,
  • Seung-Hyun Jun and
  • Nae-Gyu Kang

17 February 2025

Retinol is well-known anti-aging material in the cosmetics industry, owing to its proven superior efficacy both in vitro and in vivo. Despite its high efficacy, retinol is associated with limitations, such as skin irritation and its potential photode...

  • Article
  • Open Access
1,412 Views
10 Pages

Improvement in Wrinkles by a Fairy Chemical, 2-Aza-8-oxohypoxanthine

  • Hisae Aoshima,
  • Rinta Ibuki and
  • Hirokazu Kawagishi

2-aza-8-oxohypoxanthine (AOH) has been shown to improve skin barrier function according to DNA microarray studies of normal human epidermal keratinocytes. This study aimed to evaluate the cosmetic efficacy of AOH in wrinkle improvement. A 12-week cli...

  • Article
  • Open Access
5 Citations
4,995 Views
18 Pages

Enhanced Micro-Channeling System via Dissolving Microneedle to Improve Transdermal Serum Delivery for Various Clinical Skincare Treatments

  • Jeeho Sim,
  • SeongDae Gong,
  • Geonwoo Kang,
  • Mingyu Jang,
  • Huisuk Yang,
  • Jaesung Park,
  • Youngchan Kim,
  • Hyunkyu Lee,
  • Hyunji Jung and
  • Hyungil Jung
  • + 6 authors

Topical liquid formulations, dissolving microneedles (DMNs), and microscale needles composed of biodegradable materials have been widely used for the transdermal delivery of active compounds for skincare. However, transdermal active compound delivery...

  • Article
  • Open Access
1 Citations
5,951 Views
14 Pages

Wrinkle-Improving Effect of Novel Peptide That Binds to Nicotinic Acetylcholine Receptor

  • Jinho Bang,
  • Yul-Lye Hwang,
  • Mi Yoon Kim,
  • Jae Nam Yun,
  • Eujin Hyun,
  • Min Youl Chang,
  • Dae Hwan Shin,
  • Sunghyun Kim and
  • Jeung-Hoon Lee

Wrinkles, one of the most common signs of aging, are primarily caused by the continuous contraction of muscles. Muscle contraction is induced by the binding of acetylcholine (ACh), released at the neuromuscular junction, to nicotinic acetylcholine re...

  • Article
  • Open Access
15 Citations
5,335 Views
13 Pages

22 October 2022

Wrinkles are one of the most intuitive manifestations of skin aging. Complex polypeptide-loaded dissolving microneedles (CP-DMNs) for facial wrinkles in different areas have been developed and evaluated for the first time. In optimizing formulations,...

  • Article
  • Open Access
41 Citations
34,773 Views
11 Pages

Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study

  • Tzu-Fang Hsu,
  • Zi-Rong Su,
  • Yao-Hao Hsieh,
  • Ming-Fu Wang,
  • Mariko Oe,
  • Ryosuke Matsuoka and
  • Yasunobu Masuda

28 June 2021

Hyaluronan (HA) is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization. In this...

  • Article
  • Open Access
19 Citations
3,538 Views
19 Pages

A Novel Approach to Predict Wrinkling of Aluminum Alloy During Warm/Hot Sheet Hydroforming Based on an Improved Yoshida Buckling Test

  • Gaoshen Cai,
  • Jubo Fu,
  • Dongxing Zhang,
  • Jinlin Yang,
  • Yongfeng Yuan,
  • Lihui Lang and
  • Sergei Alexandrov

5 March 2020

In order to predict the wrinkling of sheet metal under the influence of fluid pressure and temperature during warm/hot hydroforming, a numerical simulation model for sheet wrinkling prediction was established, taking into account through-thickness no...

  • Article
  • Open Access
2,530 Views
12 Pages

Trifluorometyl Phenethyl Mesalazine (TFM) Acts as an Antioxidant and Improves Facial Skin Wrinkles and Whitening

  • Sojung Won,
  • Jane Melissa Lim,
  • Jin Hwan Lee,
  • Young J. Oh,
  • Jin-Hee Shin,
  • Byoung Joo Gwag and
  • Eui-Ju Choi

13 September 2024

Oxidative stress is a primary contributor to human skin aging, while antioxidants are known to mitigate skin damage related to aging processes. In this study, we investigated the possible action of trifluoromethyl phenethyl mesalazine (TFM), an antio...

  • Article
  • Open Access
139 Citations
84,631 Views
13 Pages

26 June 2018

Collagen-peptide supplementation could be an effective remedy to improve hydration, elasticity, and wrinkling in human skin. The aim of this study was to conduct a double-blind, randomized, placebo-controlled trial to clinically evaluate the effect o...

  • Article
  • Open Access
1 Citations
1,884 Views
14 Pages

20 August 2024

Skin aging is a complex process with internal and external factors. Recent studies have suggested that enlargement and elongation of skin pores may be early signs of aging in addition to wrinkles and loss of elasticity. This study explores the potent...

  • Article
  • Open Access
10 Citations
5,538 Views
14 Pages

26 December 2022

Yuja (Citrus junos) has been cultivated and used for food and medicinal purposes in China and Korea. Its antioxidant, anti-wrinkle, moisturizing, and whitening effects were evaluated in HaCaT, HDF, and B16F10 cells. UVB has been known to cause cellul...

  • Article
  • Open Access
22 Citations
8,777 Views
16 Pages

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

  • Da-Bin Myung,
  • Jeong-Hun Lee,
  • Hee-Soo Han,
  • Kwang-Young Lee,
  • Hye Shin Ahn,
  • Yu-Kyong Shin,
  • Eunjung Song,
  • Bo-Hyung Kim,
  • Kwang Hoon Lee and
  • Kyung-Tae Lee
  • + 1 author

28 May 2020

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-con...

  • Article
  • Open Access
1,877 Views
13 Pages

Enhanced Performance of Micro Deep Drawing through the Application of TiO2 Nanolubricant and Graphene Lubricants on SUS 301 Stainless Steel Foil

  • Di Pan,
  • Guangqing Zhang,
  • Fanghui Jia,
  • Yao Lu,
  • Jun Wang,
  • Zhou Li,
  • Lianjie Li,
  • Ming Yang and
  • Zhengyi Jiang

23 October 2023

In recent years, the quest for effective lubrication in micro deep drawing (MDD) has seen promising advancements. In this study, the influence of TiO2 nanolubricants and graphene lubricants on the performance of 301 stainless steel foil in MDD is exa...

  • Article
  • Open Access
7 Citations
23,299 Views
18 Pages

1 April 2022

Hydrogen-rich warm water (HW) has not been verified yet for skin anti-aging effects. Daily 10 min HW (dissolved hydrogen: 338–682 μg/mL, 41 °C) bathing and skin poultice with HW-impregnated towels for 11–98 days were demonstrated t...

  • Article
  • Open Access
8 Citations
4,347 Views
24 Pages

24 May 2023

Hydrangea serrata is a plant grown in Korea and Japan with a particular natural compound, hydrangenol. H. serrata has been researched for its anti-fungal properties, and ability to attenuate allergies and promote muscle growth. Its ability to re...

  • Article
  • Open Access
18 Citations
3,595 Views
14 Pages

Dieckol Isolated from Eisenia bicyclis Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice

  • Jae-Min Kim,
  • Kyung-Sook Chung,
  • Young-Seo Yoon,
  • Seo-Yun Jang,
  • So-Won Heo,
  • Geonha Park,
  • Young-Pyo Jang,
  • Hye-Shin Ahn,
  • Yu-Kyong Shin and
  • Kyung-Tae Lee
  • + 1 author

14 December 2022

Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from Eisenia bicyclis extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to...

  • Article
  • Open Access
5 Citations
4,399 Views
20 Pages

5 December 2023

Wrinkles, crucial for age estimation and skin quality assessment, present challenges due to their uneven distribution, varying scale, and sensitivity to factors like lighting. To overcome these challenges, this study presents facial wrinkle detection...

  • Article
  • Open Access
1,942 Views
13 Pages

19 September 2024

Ironing roll is vital equipment in the production of wide aluminum foil, which has a significant impact on the wrinkling defects of aluminum foil during the winding process of the cleaning production line. In this paper, wrinkling defects in 4N6 alum...

  • Article
  • Open Access
27 Citations
5,582 Views
17 Pages

Simulation of Wrinkling during Bending of Composite Reinforcement Laminates

  • Jin Huang,
  • Philippe Boisse,
  • Nahiène Hamila and
  • Yingdan Zhu

21 May 2020

When a thick laminate is subjected to bending, under certain boundary conditions, wrinkles may appear and develop due to the inextensibility of the fibers. Wrinkling is one of the most critical defects in composite manufacturing. Numerical simulation...

  • Article
  • Open Access
10 Citations
10,540 Views
10 Pages

Facial wrinkles (considered to be natural features) appear as people get older. Wrinkle detection is an important aspect of applications that depend on facial skin changes, such as face age estimation and soft biometrics. While existing wrinkle detec...

  • Article
  • Open Access
11 Citations
5,037 Views
11 Pages

Clinical Evidence of Effects of Green Mandarin (Putgyul) Extract on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study

  • Young-Min Ham,
  • Seon-A Yoon,
  • Hyejin Hyeon,
  • Ho-Bong Hyun,
  • Sung-Chun Kim,
  • Boram Go,
  • Yong-Hwan Jung and
  • Weon-Jong Yoon

24 March 2022

Green mandarins are widely consumed unripe as mandarin oranges (Citrus unshiu Marcov.), which exhibit anti-inflammatory and anti-wrinkle effects by inhibiting the production of inflammatory cytokines and matrix metalloproteinase. A randomized, double...

  • Article
  • Open Access
11 Citations
3,727 Views
17 Pages

Micrometric Wrinkled Patterns Spontaneously Formed on Hydrogel Thin Films via Argon Plasma Exposure

  • Carmen M. González-Henríquez,
  • Diego F. Veliz-Silva,
  • Mauricio A. Sarabia-Vallejos,
  • Adolfo del Campo-García and
  • Juan Rodríguez-Hernández

19 February 2019

The generation of microstructured patterns on the surface of a specific polymeric material could radically improve their performance in a particular application. Most of the interactions with the environment occur at the material interface; therefore...

  • Brief Report
  • Open Access
1,135 Views
12 Pages

3 December 2025

Since the causes of aging are diverse, anti-aging requires a wide range of strategies. Kampo, a traditional medicine of Japan, which has its roots in traditional Chinese medicine, is generally prepared by combining several natural compounds to produc...

  • Article
  • Open Access
2,024 Views
18 Pages

Wrinkling of Toroidal Shells in Free Hydroforming

  • Xiaobin Liu,
  • Jian Zhang,
  • Ming Zhan,
  • Xilu Zhao,
  • Wenwei Wu and
  • Kaiwei Xu

In this study, we investigated toroidal shell wrinkling in free hydroforming. We specifically focused on toroidal shells with a regular hexagonal cross-section. Membrane theory was used to examine the distribution of stress and yield load in both pre...

  • Article
  • Open Access
3 Citations
2,778 Views
12 Pages

Natural wrinkling of metal films on silicone substrates can appear by means of the metal sputtering process and can be described by the continuous elastic theory and non-linear wrinkling model. Here, we report the fabrication technology and behavior...

  • Article
  • Open Access
1 Citations
2,910 Views
10 Pages

Wrinkled CNTs@PLLA Composite Membranes for Enhanced Separation Performance

  • Jinyan Xu,
  • Bajin Chen,
  • Lu Yin,
  • Liang Zhang,
  • Yongjin Li and
  • Jichun You

28 February 2022

To break the trade-off effect between permeability and selectivity in separation, wrinkled carbon nanotubes@polylactic acid (CNTs@PLLA) composite membranes were successfully fabricated in this work. On pre-deformed PLLA membranes, CNTs were loaded by...

  • Article
  • Open Access
8 Citations
3,209 Views
11 Pages

21 November 2022

The aim of this clinical study was to demonstrate that through a micrograft of viable adipose tissue cells microfiltered at 50 microns to exclude fibrous shoots and cell debris in a suspension of cross-linked hyaluronic acid, we were able to improve...

  • Article
  • Open Access
18 Citations
31,250 Views
12 Pages

Prospective Randomized Controlled Trial on the Effects of Almonds on Facial Wrinkles and Pigmentation

  • Iryna Rybak,
  • Alexis E. Carrington,
  • Simran Dhaliwal,
  • Aliza Hasan,
  • Hera Wu,
  • Waqas Burney,
  • Jessica Maloh and
  • Raja K. Sivamani

27 February 2021

Background: Almonds have long been studied as a rich source of fatty acids, phytochemical polyphenols and antioxidants such as vitamin E. A recent study compared almond supplementations to a calorie-matched intervention for 16 weeks, yielding statist...

  • Article
  • Open Access
2 Citations
9,891 Views
15 Pages

Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

  • Hyun Kyung Sung,
  • Tae Jeong Kim,
  • Hyung Mook Kim,
  • Sang Jun Youn,
  • Yong Choi,
  • Na Young Lee,
  • Hyun Jeong Oh,
  • Hyuck Se Kwon and
  • Seon Mi Shin

9 January 2024

7-MEGATM is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged fem...

  • Article
  • Open Access
1,207 Views
24 Pages

An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial

  • Jintanaporn Wattanathorn,
  • Wipawee Thukham-mee,
  • Sophida Phuthong,
  • Weerapon Sangartit,
  • Terdthai Thong-un,
  • Praew Kotruchin,
  • Thapanawong Mitsungnern,
  • Suphap Im-uan,
  • Nitiwat Sirijun and
  • Supaporn Muchimapura

11 November 2025

Owing to the great demand for healthy ageing promotion, and the anti-ageing reputation of anthocyanins and amino acids, we aimed to assess the effect of anthocyanin- and anti-ageing amino acids-enriched pigmented rice innovation on age-related cognit...

  • Article
  • Open Access
9 Citations
3,680 Views
15 Pages

Improving Interaction at Polymer–Filler Interface: The Efficacy of Wrinkle Texture

  • Pietro Russo,
  • Virginia Venezia,
  • Fabiana Tescione,
  • Joshua Avossa,
  • Giuseppina Luciani,
  • Brigida Silvestri and
  • Aniello Costantini

25 January 2020

One of the main issues in preparing polymer-based nanocomposites with effective properties is to achieve a good dispersion of the nanoparticles into the matrix. Chemical interfacial modifications by specific coupling agents represents a good way to r...

  • Article
  • Open Access
628 Views
28 Pages

10 October 2025

Pipelines are critical infrastructure for energy transportation, but long-term service under complex loading can cause local buckling failures. This study investigates the wrinkle behavior of API-X80 pipelines under combined internal pressure and ben...

  • Article
  • Open Access
7 Citations
3,516 Views
19 Pages

17 March 2022

Morphing wing skin can greatly improve the performance of aircraft by adjusting the shape of the wings according to different flight conditions. However, it is a challenge to maintain a smooth aerodynamic wing skin surface during the deformation proc...

  • Article
  • Open Access
4 Citations
11,091 Views
14 Pages

The Role of Cacao Powder in Enhancing Skin Moisture and Reducing Wrinkles: A 12-Week Clinical Trial and In Vitro Study

  • Sang Gyu Lee,
  • Ngoc Ha Nguyen,
  • Young In Lee,
  • Inhee Jung,
  • In Ah Kim,
  • Hyunsook Jang,
  • Hoyeon Shin and
  • Ju Hee Lee

6 November 2024

Skin aging is driven by a combination of internal and external mechanisms, with ultraviolet (UV) radiation being a prominent external factor contributing to photoaging. Photoaging manifests through several signs, including decreased skin hydration, d...

  • Article
  • Open Access
4 Citations
7,601 Views
14 Pages

Clinical Tolerability and Efficacy Establishment of a New Cosmetic Treatment Regimen Intended for Sensitive Skin

  • María Vitale,
  • Maria Teresa Truchuelo,
  • Vincenzo Nobile and
  • María José Gómez-Sánchez

18 July 2024

Sensitive skin has a great impact on the quality of life of subjects. In this research, we evaluated the efficacy and tolerance of a cosmetic treatment for facial skincare, consisting of a cleanser, serum and cream. A clinical-instrumental study was...

  • Article
  • Open Access
1 Citations
1,717 Views
17 Pages

Factors Influencing Web Wrinkling in Roll-to-Roll Coating Production Systems

  • Li’e Ma,
  • Kanghui Yu,
  • Zhenlong Zhao,
  • Yi Guo,
  • Yijun Ma,
  • Zehang Li and
  • Jimei Wu

29 January 2025

The web-wrinkle phenomenon always occurs in the roll-to-roll coating production process, which leads to the decline of coating quality and an increase in waste. A theoretical analysis of the phenomenon is presented, and a simulation research method i...

  • Review
  • Open Access
37 Citations
8,788 Views
12 Pages

19 November 2019

Photoaged skin is characterized clinically by apparent manifestations such as wrinkles and sagging, and histologically by an accumulation of abnormal elastin and a severe loss of collagen fibers in the dermis. Quantitative and qualitative alterations...

  • Article
  • Open Access
2 Citations
9,783 Views
13 Pages

Peptides, composed of 2–50 amino acids, have gained attention in anti-aging treatments due to their high safety, low irritation, and cost-effective production. This study aimed to evaluate the anti-wrinkle efficacy of Tetrapeptide-68, derived f...

  • Article
  • Open Access
2 Citations
1,365 Views
12 Pages

Inter-Ply Slipping Behaviors and Kinetic Equation of Carbon Fiber-Reinforced Epoxy Prepregs for Hot Diaphragm Preforming

  • Haoxuan Zhang,
  • Jintong Liu,
  • Congfa Zhang,
  • Hongfu Li,
  • Guangquan Yue,
  • Baozhong Sun and
  • Boyan He

15 November 2024

Wrinkles are urgent problems to be solved in the process of hot diaphragm preforming. Inter-ply slipping resistance is one of the causes of wrinkles. In this paper, based on the vertical inter-ply slipping test system, the inter-ply slipping behavior...

  • Article
  • Open Access
1 Citations
1,074 Views
19 Pages

27 May 2025

An enhanced process for shaping thermoset fiber-reinforced composites using Modified Double-Diaphragm Forming (mDDF) in Prepreg Compression Molding (PCM) is proposed to address limitations in conventional forming quality. To minimize surface defects,...

  • Review
  • Open Access
1 Citations
3,153 Views
18 Pages

Microbiome–Aging–Wrinkles Axis of Skin: Molecular Insights and Microbial Interventions

  • Varun Challa,
  • Santosh Kumar Prajapati,
  • Surabhi Gangani,
  • Dhananjay Yadav,
  • Lalitha Lekkala,
  • Shalini Jain and
  • Hariom Yadav

15 October 2025

Skin aging is a complex biological process influenced by both intrinsic factors such as hormonal changes, genetic programming, and immunosenescence and extrinsic stressors including ultraviolet (UV) radiation (particularly UV-A and UV-B), pollution,...

  • Communication
  • Open Access
9 Citations
6,356 Views
11 Pages

New 675 nm Laser Device: The Innovative and Effective Non-Ablative Resurfacing Technique

  • Domenico Piccolo,
  • Giuliana Crisman,
  • Caterina Dianzani,
  • Iris Zalaudek,
  • Irene Fusco and
  • Claudio Conforti

4 July 2023

Background and Objectives: Photo/chrono-aging is usually expressed as facial discolouration, wrinkles, redness, elastosis, laxity, and dehydration, thus representing major signs of ageing that often lead to a negative phycological impact on a patient...

  • Article
  • Open Access
17 Citations
8,301 Views
13 Pages

Facial skin analysis has attracted considerable attention in the skin health domain. The results of facial skin analysis can be used to provide skin care and cosmetic recommendations in aesthetic dermatology. Because of the existence of several skin...

  • Article
  • Open Access
3 Citations
9,504 Views
11 Pages

Facial Anti-Aging Treatments with Soft Peeling and Microneedling Technique

  • Roberto Amore,
  • Fiorella Deriu,
  • Andrea Sbarbati,
  • Domenico Amuso,
  • Massimo Vitale,
  • Ilaria Patruno,
  • Anna Perna and
  • Antonio Scarano

30 June 2021

Background: The interest in maintaining a young and attractive appearance in an era with increasingly hectic rhythms has generated a pressing demand for effective aesthetic procedures with the shortest possible recovery period, stimulating the search...

of 9