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436 Results Found

  • Article
  • Open Access
3 Citations
2,137 Views
26 Pages

Topological and Dynamical Aspects of Jacobi Sigma Models

  • Francesco Bascone,
  • Franco Pezzella and
  • Patrizia Vitale

5 July 2021

The geometric properties of sigma models with target space a Jacobi manifold are investigated. In their basic formulation, these are topological field theories—recently introduced by the authors—which share and generalise relevant features of Poisson...

  • Article
  • Open Access
5 Citations
3,006 Views
13 Pages

String Sigma Models on Curved Supermanifolds

  • Roberto Catenacci and
  • Pietro Antonio Grassi

We use the techniques of integral forms to analyze the easiest example of two-dimensional sigma models on a supermanifold. We write the action as an integral of a top integral form over a D = 2 supermanifold, and we show how to interpolate betw...

  • Brief Report
  • Open Access
8 Citations
3,329 Views
11 Pages

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation

  • Timur A. Mavlyutov,
  • Jing Li,
  • Xinying Liu,
  • Hongtao Shen,
  • Huan Yang,
  • Christopher R. McCurdy,
  • Bikash Pattnaik and
  • Lian-Wang Guo

16 December 2022

The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding sites. Their alleles are associated with human diseases involving neuronal systems, such as age-related macular degene...

  • Article
  • Open Access
10 Citations
2,079 Views
18 Pages

19 October 2021

We generalize the (n+1)-dimensional twisted R-Poisson topological sigma model with flux on a target Poisson manifold to a Lie algebroid. Analyzing the consistency of constraints in the Hamiltonian formalism and the gauge symmetry in the Lagrangian fo...

  • Article
  • Open Access
21 Citations
3,574 Views
8 Pages

Chiral Perturbation Theory vs. Linear Sigma Model in a Chiral Imbalance Medium

  • Alexander Andrianov,
  • Vladimir Andrianov and
  • Domenec Espriu

8 January 2020

We compare the chiral perturbation theory (ChPT) and the linear sigma model (LSM) as realizations of low energy quantum chromodynamics (QCD) for light mesons in a chirally-imbalanced medium. The relations between the low-energy constants of the chira...

  • Article
  • Open Access
838 Views
13 Pages

Reframing Classical Mechanics: An AKSZ Sigma Model Perspective

  • Thomas Basile,
  • Nicolas Boulanger and
  • Arghya Chattopadhyay

19 June 2025

The path-integral re-formulation due to E. Gozzi, M. Regini, M. Reuter, and W. D. Thacker of Koopman and von Neumann’s original operator formulation of a classical Hamiltonian system on a symplectic manifold M is identified as a gauge slice of...

  • Feature Paper
  • Review
  • Open Access
10 Citations
4,203 Views
29 Pages

6 May 2019

We review various connections between condensed matter systems with the Nambu–Jona-Lasinio model and nonlinear sigma models. The field theoretical description of interacting systems offers a systematic framework to describe the dynamical genera...

  • Article
  • Open Access
5 Citations
2,468 Views
15 Pages

7 June 2023

The high-order mechanical resonances of the sensing element in a high-vacuum environment can significantly degrade the noise and distortion performance of seismic-grade sigma–delta MEMS capacitive accelerometers. However, the current modeling a...

  • Review
  • Open Access
1 Citations
6,572 Views
22 Pages

17 April 2014

We summarize recent progress on the symmetric subtraction of the Non-Linear Sigma Model in D dimensions, based on the validity of a certain Local Functional Equation (LFE) encoding the invariance of the SU(2) Haar measure under local left transformat...

  • Article
  • Open Access
1 Citations
4,392 Views
9 Pages

The observed Tully-Fisher and Faber-Jackson laws between the baryonic mass of galaxies and the velocity of motion of stars at the edge of galaxies are explained within the framework of the model of accretion of galaxies around supermassive black hole...

  • Proceeding Paper
  • Open Access
313 Views
10 Pages

A Generic Model Integrating Machine Learning and Lean Six Sigma

  • Fadwa Farchi,
  • Chayma Farchi,
  • Badr Touzi and
  • Charif Mabrouki

19 January 2026

With rapid urbanization and population growth, efficient transportation systems are increasingly crucial, particularly in sectors like healthcare and pharmaceutical logistics, which face unique challenges. In Morocco, there is a lack of studies on ph...

  • Article
  • Open Access
6 Citations
2,921 Views
18 Pages

Mathematical Model Assisted Six-Sigma Approach for Reducing the Logistics Costs of a Pipe Manufacturing Company: A Novel Experimental Approach

  • Âli Yurdun Orbak,
  • Metin Küçük,
  • Mehmet Akansel,
  • Shubham Sharma,
  • Changhe Li,
  • Raman Kumar,
  • Sunpreet Singh and
  • Gianpaolo Di Bona

26 January 2023

This research addresses and analyzes the results of a six-sigma approach used to optimize the logistics costs of a pipe manufacturing company. Two mathematical models are developed for containers to control the company’s logistics. The Mathemat...

  • Communication
  • Open Access
1,655 Views
16 Pages

31 March 2025

For a quasi-two-dimensional nonlinear sigma model on the real Stiefel manifolds with a generalized (anisotropic) metric, the equations of a two-charge renormalization group (RG) for the homothety and anisotropy of the metric as effective couplings ar...

  • Review
  • Open Access
6 Citations
1,808 Views
45 Pages

15 January 2025

This review is devoted to summarizing recent developments of the linear sigma model (LSM) in cold and dense two-color QCD (QC2D), in which lattice simulations are straightforwardly applicable thanks to the disappearance of the sign problem. In QC2D,...

  • Article
  • Open Access
3 Citations
2,147 Views
16 Pages

Mass Spectrum of Noncharmed and Charmed Meson States in Extended Linear-Sigma Model

  • Azar I. Ahmadov,
  • Azzah A. Alshehri and
  • Abdel Nasser Tawfik

29 June 2024

The mass spectrum of different meson particles is generated using an effective Lagrangian of the extended linear-sigma model (eLSM) for scalar and pseudoscalar meson fields and quark flavors, up, down, strange, and charm. Analytical formulas for the...

  • Article
  • Open Access
1 Citations
1,903 Views
16 Pages

Derivation of Meson Masses in SU(3) and SU(4) Extended Linear Sigma Model at Finite Temperature

  • Abdel Nasser Tawfik,
  • Azar I. Ahmadov,
  • Alexandra Friesen,
  • Yuriy Kalinovsky,
  • Alexey Aparin and
  • Mahmoud Hanafy

The present study focused on the mesonic potential contributions to the Lagrangian of the extended linear sigma model (eLSM) for scalar and pseudoscalar meson fields across various quark flavors. The present study focused on the low-energy phenomenol...

  • Article
  • Open Access
1,840 Views
13 Pages

2 October 2023

Harmonic distortion is one of the dominant factors limiting the overall signal-to-noise and distortion ratio of seismic-grade sigma-delta MEMS accelerometers. This study investigates harmonic distortion based on the multiple degree-of-freedom model (...

  • Article
  • Open Access
8 Citations
3,783 Views
14 Pages

19 August 2023

The sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. The S1R plays an important role in neuronal health and it is an established therapeutic target for neurodegenerative and neuropsychiatric disorders....

  • Article
  • Open Access
2 Citations
3,466 Views
18 Pages

19 February 2021

The Sigma-Pi structure investigated in this work consists of the sum of products of an increasing number of identically distributed random variables. It appears in stochastic processes with random coefficients and also in models of growth of entities...

  • Article
  • Open Access
23 Citations
7,473 Views
20 Pages

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD

  • Emőke Borbély,
  • Viktória Varga,
  • Titanilla Szögi,
  • Ildikó Schuster,
  • Zsolt Bozsó,
  • Botond Penke and
  • Lívia Fülöp

24 February 2022

Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitive dysfunctions. Pharmacological interventions to slow the progression of AD are intensively studied. A potential direction targets neuronal sigma-1 receptors...

  • Article
  • Open Access
38 Citations
5,488 Views
16 Pages

10 March 2020

This paper deals with the state of charge (SoC) estimation of a lithium-ion battery pack (LiBP) connected by some cells in series and parallel. The voltage noise, noise and current bias of current through the LiBP are taken into account in the SoC es...

  • Article
  • Open Access
18 Citations
8,647 Views
28 Pages

The Development of an Excellence Model Integrating the Shingo Model and Sustainability

  • José Carlos Sá,
  • Manuel Reis,
  • José Dinis-Carvalho,
  • Francisco J. G. Silva,
  • Gilberto Santos,
  • Luis P. Ferreira and
  • Vanda Lima

2 August 2022

Companies are continuously looking to improve their production systems using excellence models, with lean thinking, the Shingo model, six sigma and lean six sigma being the most comprehensive and applied. It is expected that the initial focus for the...

  • Article
  • Open Access
3 Citations
3,295 Views
17 Pages

EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration

  • Núria Gaja-Capdevila,
  • Neus Hernández,
  • Sandra Yeste,
  • Raquel F. Reinoso,
  • Javier Burgueño,
  • Ana Montero,
  • Manuel Merlos,
  • José M. Vela,
  • Mireia Herrando-Grabulosa and
  • Xavier Navarro

Motor neuron diseases (MNDs) include sporadic and hereditary neurological disorders characterized by progressive degeneration of motor neurons (MNs). Sigma-1 receptor (Sig-1R) is a protein enriched in MNs, and mutations on its gene lead to various ty...

  • Article
  • Open Access
29 Citations
8,944 Views
20 Pages

Sigma Phase: Nucleation and Growth

  • Gláucio Soares da Fonseca,
  • Priscila Sousa Nilo Mendes and
  • Ana Carolina Martins Silva

3 January 2019

Duplex stainless steels (DSS) and superduplex stainless steels (SDSS) are important classes of stainless steels, because they combine the benefits of austenite and ferrite phases. This results in steels with better mechanical properties and higher co...

  • Article
  • Open Access
2 Citations
2,435 Views
19 Pages

SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models

  • Hideaki Tagashira,
  • Shinsuke Chida,
  • Md. Shenuarin Bhuiyan,
  • Kohji Fukunaga and
  • Tomohiro Numata

27 January 2025

Background/Objectives: The Sigma-1 receptor (Sigmar1), an intracellular chaperone protein, is ubiquitously expressed throughout the body, but its role in peripheral organs, such as the kidneys, remains unclear. Here, we investigated the protective ef...

  • Article
  • Open Access
10 Citations
4,525 Views
24 Pages

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

  • Beltrán Álvarez-Pérez,
  • Anna Bagó-Mas,
  • Meritxell Deulofeu,
  • José Miguel Vela,
  • Manuel Merlos,
  • Enrique Verdú and
  • Pere Boadas-Vaello

8 October 2022

Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia. The objective of this study was to evaluate the effect of a &sig...

  • Article
  • Open Access
1 Citations
1,137 Views
12 Pages

Fuzzy Evaluation Model for Critical Components of Machine Tools

  • Kuen-Suan Chen,
  • Kai-Chao Yao,
  • Chien-Hsin Cheng,
  • Chun-Min Yu and
  • Chen-Hsu Chang

14 August 2024

The rapid progression of emerging technologies like the Internet of Things (IoT) and Big Data analytics for manufacturing has driven innovation across various industries worldwide. Production data are utilized to construct a model for quality evaluat...

  • Article
  • Open Access
6 Citations
2,043 Views
34 Pages

D-Branes in Para-Hermitian Geometries

  • Vincenzo Emilio Marotta and
  • Richard J. Szabo

23 March 2022

We introduce T-duality invariant versions of D-branes in doubled geometry using a global covariant framework based on para-Hermitian geometry and metric algebroids. We define D-branes as conformal boundary conditions for the open string version of th...

  • Article
  • Open Access
7 Citations
5,298 Views
20 Pages

Design of a 1-bit MEMS Gyroscope using the Model Predictive Control Approach

  • Xiaofeng Wu,
  • Zhicheng Xie,
  • Xueliang Bai and
  • Trevor Kwan

11 February 2019

In this paper, a bi-level Delta-Sigma modulator-based MEMS gyroscope design is presented based on a Model Predictive Control (MPC) approach. The MPC is popular because of its capability of handling hard constraints. In this work, we propose to combin...

  • Article
  • Open Access
8 Citations
3,276 Views
26 Pages

KSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential

  • Kamil Mika,
  • Małgorzata Szafarz,
  • Monika Zadrożna,
  • Barbara Nowak,
  • Marek Bednarski,
  • Katarzyna Szczepańska,
  • Krzysztof Pociecha,
  • Monika Kubacka,
  • Noemi Nicosia and
  • Magdalena Kotańska
  • + 2 authors

Many studies involving compounds that enhance histamine release, such as histamine H3 receptor (H3R) antagonists, have shown efficacy in inhibiting weight gain, but none have passed clinical trials. As part of the search for H3 receptor ligands that...

  • Article
  • Open Access
1 Citations
2,166 Views
19 Pages

18 January 2023

The current deterministic optimization design method ignores uncertainties in the material properties and potential machining error which could lead to unreliable or unstable designs. To improve the design efficiency and anti-jamming ability of a hig...

  • Article
  • Open Access
8 Citations
3,902 Views
29 Pages

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

  • Giacomo Rossino,
  • Annamaria Marra,
  • Roberta Listro,
  • Marco Peviani,
  • Elena Poggio,
  • Daniela Curti,
  • Giorgia Pellavio,
  • Umberto Laforenza,
  • Giulio Dondio and
  • Simona Collina
  • + 12 authors

Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling pathways. It is a debilitating disorder that affects up to 10% of the world’s population. Although opioid analgesics are effective in reducing pain, they present...

  • Article
  • Open Access
16 Citations
3,207 Views
21 Pages

25 June 2022

The article concerns the assessment of the energy consumption of inland waterway freight transport on river sections in the context of environmental management. The research question was: Does the choice of the route determine the total energy consum...

  • Article
  • Open Access
5 Citations
1,757 Views
12 Pages

Fuzzy Evaluation Models for Accuracy and Precision Indices

  • Kuen-Suan Chen,
  • Tsun-Hung Huang,
  • Ruey-Chyn Tsaur and
  • Wen-Yang Kao

25 October 2022

The random variable X is used to represent the normal process containing two important parameters—the process average and the process standard deviation. The variable is transformed using Y = (XT)/d, where T is the target value and d is the tolera...

  • Article
  • Open Access
2,008 Views
13 Pages

13 August 2024

Bacillus subtilis is a model organism used to study molecular processes in Gram-positive bacteria. Sigma factor B, which associates with RNA polymerase, is one of the transcriptional regulators involved in the cell’s response to environmental s...

  • Article
  • Open Access
12 Citations
9,168 Views
20 Pages

Application of Six Sigma Model on Efficient Use of Vehicle Fleet

  • Tatjana Stanivuk,
  • Tamara Gvozdenović,
  • Jelena Žanić Mikuličić and
  • Vesko Lukovac

22 May 2020

Each business faces large competition in the market, and it is necessary to adopt the most effective methodology as possible in order to obtain the best solution. Six Sigma (6σ) is a set of techniques and tools for process improvement. The tool...

  • Article
  • Open Access
5 Citations
4,620 Views
11 Pages

11 January 2022

This paper analyzes and characterizes the nature of the interactions between countries of the West African Economic and Monetary Union (WAEMU) over the period 1995–2015. The analysis uses sigma-convergence on the one hand and the Dendrinos-Soni...

  • Article
  • Open Access
2 Citations
5,651 Views
13 Pages

Exact Solution and Exotic Fluid in Cosmology

  • Seyen Kouwn,
  • Taeyoon Moon and
  • Phillial Oh

20 September 2012

We investigate cosmological consequences of nonlinear sigma model coupled with a cosmological fluid which satisfies the continuity equation. The target space action is of the de Sitter type and is composed of four scalar fields. The potential which i...

  • Article
  • Open Access
14 Citations
2,446 Views
24 Pages

11 October 2022

This paper proposes a robust design approach based on the Design for Six Sigma (DFSS), to promote the robustness of our previous model-free-adaptive-control-based (MFAC-based) energy management strategy (EMS) for the plug-in hybrid electric vehicles...

  • Article
  • Open Access
7 Citations
5,478 Views
19 Pages

Role of Human Knowledge and Communication on Operational Benefits Gained from Six Sigma

  • Jorge L. García-Alcaraz,
  • Liliana Avelar-Sosa,
  • Juan I. Latorre-Biel,
  • Emilio Jiménez-Macías and
  • Giner Alor-Hernández

26 September 2017

Six Sigma (SS) is a production philosophy focused on human experiences and knowledge, aimed to minimize defects of products and services. The appropriate implementation of SS requires an education process, reliable data analysis, efficient didactic m...

  • Review
  • Open Access
5 Citations
2,867 Views
31 Pages

1 August 2021

Chiral symmetry represents a fundamental concept lying at the core of particle and nuclear physics. Its spontaneous breaking in vacuum can be exploited to distinguish chiral hadronic partners, whose masses differ. In fact, the features of this breaki...

  • Article
  • Open Access
75 Citations
10,724 Views
17 Pages

Agile Six Sigma in Healthcare: Case Study at Santobono Pediatric Hospital

  • Giovanni Improta,
  • Guido Guizzi,
  • Carlo Ricciardi,
  • Vincenzo Giordano,
  • Alfonso Maria Ponsiglione,
  • Giuseppe Converso and
  • Maria Triassi

Healthcare is one of the most complex systems to manage. In recent years, the control of processes and the modelling of public administrations have been considered some of the main areas of interest in management. In particular, one of the most probl...

  • Article
  • Open Access
5 Citations
3,129 Views
26 Pages

Duality, Generalized Global Symmetries and Jet Space Isometries

  • Athanasios Chatzistavrakidis,
  • Georgios Karagiannis and
  • Arash Ranjbar

24 December 2021

We revisit universal features of duality in linear and nonlinear relativistic scalar and Abelian 1-form theories with single or multiple fields, which exhibit ordinary or generalized global symmetries. We show that such global symmetries can be inter...

  • Article
  • Open Access
1 Citations
2,145 Views
18 Pages

Adaptive Joint Sigma-Point Kalman Filtering for Lithium-Ion Battery Parameters and State-of-Charge Estimation

  • Houda Bouchareb,
  • Khadija Saqli,
  • Nacer Kouider M’sirdi and
  • Mohammed Oudghiri Bentaie

Precise modeling and state of charge (SoC) estimation of a lithium-ion battery (LIB) are crucial for the safety and longevity of battery systems in electric vehicles. Traditional methods often fail to adapt to the dynamic, nonlinear, and time-varying...

  • Article
  • Open Access
1 Citations
734 Views
24 Pages

Business Activity Monitoring (BAM) allows organizations to capture enterprise events from their source systems and utilize these to detect non-compliant business situations. Similar concepts may be leveraged in the healthcare domain to improve the qu...

  • Article
  • Open Access
33 Citations
6,976 Views
13 Pages

Rainfall Threshold Estimation and Landslide Forecasting for Kalimpong, India Using SIGMA Model

  • Minu Treesa Abraham,
  • Neelima Satyam,
  • Sai Kushal,
  • Ascanio Rosi,
  • Biswajeet Pradhan and
  • Samuele Segoni

22 April 2020

Rainfall-induced landslides are among the most devastating natural disasters in hilly terrains and the reduction of the related risk has become paramount for public authorities. Between the several possible approaches, one of the most used is the dev...

  • Article
  • Open Access
11 Citations
2,962 Views
11 Pages

28 June 2019

The electronics industry in Taiwan has achieved a complete information and communication technology chain with a firm position in the global electronics industry. The integrated-circuit (IC) packaging industry chain adopts a professional division of...

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