1,327 Results Found

The wide occurrence of resistance to Cry1A and Cry2A insecticidal toxins from Bacillus thuringiensis (Bt) in the corn earworm/bollworm Helicoverpa zea (Boddie) leaves the Vip3A toxin produced during the vegetative stage of Bt as the only fully active...

Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could minimize the occurrence of microbiological failure and/or resistance development. This study aims to assess whether a PK/PD target threshold of continuous infusion...

Antimicrobial resistance poses a major threat to human health worldwide and the implementation of antimicrobial stewardship programs (ASPs), including antimicrobial de-escalation (ADE), is a multifaceted tool for minimizing unnecessary or inappropria...

We typically think of documents as carrying information. However, certain kinds of documents do more than that: they are not only informative but also performative in that they represent rights. When these documents are in paper form or some other ph...

Molecular-based carbapenem resistance testing in Gram-negative bacterial bloodstream infections (BSIs) is currently limited because of the reliance on positive blood culture (BC) samples. The T2Resistance™ panel may now allow the detection of carbape...

Background: The availability of a number of agents that are efficacious in patients with metastatic prostate cancer (mPC) has led to them being used sequentially, and this has prolonged patient survival. However, in order to maximize their efficacy,...

There is increasing evidence that human movement facilitates the global spread of resistant bacteria and antimicrobial resistance (AMR) genes. We systematically reviewed the literature on the impact of travel on the dissemination of AMR. We searched...

The aim was to estimate changes in the resistance rates of Pseudomonas aeruginosa (P. aeruginosa) strains isolated from patients treated in intensive care units of the largest university hospital. Materials and Methods. Isolates were identified with...

Millions of people around the world rely on aquaculture as a major source of food. In the recent few years, probiotics have gained considerable attention as an alternative agent to antibiotics. They have been shown to play an important role in improv...

Paper documents are an important carrier of information related to human civilization, with the reinforcement and protection of fragile paper documents being a key aspect of their protection. This research utilized amphoteric polyvinylamine polymer a...

Background: H. pylori antimicrobial resistance causes increasing treatment failure rates among H. pylori gastritis in children. This study investigates the molecular mechanisms of H. pylori antimicrobial resistance among Jordanian children. Meth...

Antimicrobial-resistance in Enterobacterales is a serious concern in Saudi Arabia. The present study retrospectively analyzed the antibiograms of Enterobacterales identified from 1 January 2019 to 31 December 2019 from a referral hospital in the Aljo...

Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams. In addition to intrinsic resistances, acq...

Traditional PDF document detection technology usually builds a rule or feature library for specific vulnerabilities and therefore is only fit for single detection targets and lacks anti-detection ability. To address these shortcomings, we build a dou...

Antibiotic resistance is a well-documented global health challenge that disproportionately impacts low- and middle-income countries. In 2019, the number of deaths attributed to and associated with antibiotic resistance in Western Sub-Saharan Africa w...

Colistin is a last resort antibiotic medication for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In recent years, various mechanisms have been reported to mediate colistin resistance in K. pneumoniae. This study r...

On the way to a completely electronic workflow, it is necessary to include customer signatures. Legislation in many countries treats electronic signatures similar to handwritten ones. Both are accepted for various purposes such as for finalization of...

A logotype is a rectangular region defined by a set of characteristics, which come from the pixel information and region shape, that differ from those of the text. In this paper, a new method for automatic logo detection is proposed and tested using...

Concrete production has significant environmental impacts due to extensive raw material use and high CO2 emissions. Reusing structural concrete elements can potentially reduce these environmental impacts by reducing the demand for new production. How...

The two most economically damaging insect pests of sugarcane in Louisiana are the sugarcane borer (SCB) and the newly invasive Mexican rice borer (MRB), both of which can be managed in part with cultivar resistance. High stalk fiber levels is a well-...

Healthcare-associated infections (HAIs) result in significant patient morbidity and can prolong the duration of the hospital stay, causing high supplementary costs in addition to those already sustained due to the patient’s underlying disease....

Uzbekistan has a high burden of drug-resistant tuberculosis (TB). Although conventional treatment for multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) has been available since 2013, there has been no systematic documentation...

Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by tra...

At present, there are no compounds in clin- ical development in the field of chronic myeloid leukemia (CML) or Philadelphia-posi- tive (Ph+) acute lymphoblastic leukemia (ALL) that have been documented to harbor signifi- cant activity against the ima...

Drug resistance threatening humans may be linked with antimicrobial and anthelmintic resistance in other species, especially among farm animals and, more in general, in the entire environment. From this perspective, Green Veterinary Pharmacology was...

Epilepsy is a critical neurological condition characterized by the disturbance of the excitatory neuron network, resulting in recurrent seizures. It is a serious health problem requiring intensive attention. The present study was designed to use bibl...

Erysipelas is a re-emerging disease in different poultry species. Antibiotic treatment is crucial to combat outbreaks in poultry flocks, but only very limited data on susceptibility are available. Recently, the Clinical and Laboratory Standard Instit...

Snake envenomation is a severe economic and health concern affecting countries worldwide. Snake venom carries a wide variety of small peptides and proteins with various immunological and pharmacological properties. A few key research areas related to...

The rapid proliferation of antimicrobial resistance has emerged as one of the most pressing animal and public health challenges of our time. Probiotics, extensively employed in human and veterinary medicine, are instrumental in maintaining a balanced...

Background/Objectives: This narrative review provided a broad synthesis of recent epidemiological trends, priority resistance mechanisms, and public health implications of multidrug-resistant (MDR) bacteria. We focused on the most clinically signific...

Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persiste...

Antimicrobial resistance (AMR) is a global health problem. Bacteria carrying resistance genes can be transmitted between humans, animals and the environment. There are concerns that the widespread use of antimicrobials in the food chain constitutes a...

Acinetobacter baumannii is one of the most difficult-to-treat pathogens worldwide, due to developed resistance. The aim of this study was to evaluate the use of widely prescribed antimicrobials and the respective resistance rates of A. baumannii, and...

The indiscriminate and excessive use of antimicrobial agents in livestock production is a major driver of antimicrobial resistance (AMR), thereby posing a grave threat to global public health. Although several surveillance studies have documented ant...

This article deals with the ballistic impact of the 7.62 mm FMJ M80 rifle projectile into the laminated Twaron/UHMWPE composite armor. The armor composition consisted of composite panels made from Twaron CT 747 para-aramid fabric and ultra-high-molec...

The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological o...

Invasive fungal disease (IFD) is a common cause of morbidity and mortality in patients with hematologic malignancies, especially among those undergoing allogeneic hematopoietic stem cell transplantation (HSCT). The epidemiology of IFD in HSCT patient...

Background/Objectives: This report documents the first confirmed case in Romania of fatal pneumonia and septicemia in a domestic rabbit caused by multidrug-resistant Escherichia coli, highlighting both its pathogenic potential and One Health implicat...

Enterococcus spp. from two poultry farms and proximate surface and ground water sites in an area of intensive poultry production were tested for resistance to 16 clinical antibiotics. Resistance patterns were compared to assess trends and possible c...

In the past few years, offshore site investigations have extensively utilized full-flow penetrometers like the Ball and T-bar penetrometers to assess penetration resistance and subsequently analyze the strength characteristics of marine clay. The rel...

The emergence of pathogenic strains resistant to multiple antimicrobials is a pressing problem in modern healthcare. Antimicrobial resistance is mediated primarily by dissemination of resistance determinants via horizontal gene transfer. The dissemin...

Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recen...

Despite the fact that Candida albicans is documented to be the main cause of human candidiasis, non-C. albicans Candida (NCAC) species, such as Candida glabrata and Candida tropicalis, are also suggested to be implicated in the etiopathogenesis of op...

Klebsiella (K.) pneumoniae is a major pathogen in human and veterinary medicine, known for its high resistance rates. Comprehensive resistance data are essential to combat global antibiotic resistance. This study aims to (a) document the prevalence o...

Cry1A.105 is a bioengineered Bacillus thuringiensis (Bt) insecticidal protein consisting of three domains derived from Cry1Ac, Cry1Ab, and Cry1F. It is one of the two pyramided Bt toxins expressed in the MON 89034 event, a commonly planted Bt maize t...

Background: Ceftazidime/avibactam (CAZ-AVI) resistance amongst Enterobacterales is worryingly increasing worldwide. Objectives: The aim of this study was to collect and describe real-life data on CAZ-AVI-resistant Klebsiella pneumoniae (KP) isolates...

Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dys...

Herbicide resistance in weeds has become a critical challenge in worldwide and Mexican agriculture. Many of these cases involve single, cross and multiple resistance to herbicides that inhibit Acetyl CoA Carboxylase (ACCase), Acetolactate Synthase (A...

Public health faces daily challenges due to increasing reports of pathogenic microorganisms with new antimicrobial resistance. Klebsiella michiganensis, an emerging pathogen, poses difficulty in its identification using conventional techniques. This...

Cleavage of Gag and Gag-Pol precursors by the viral protease is an essential step in the replication cycle of HIV. Protease inhibitors, which compete with natural cleavage sites, strongly impair viral infectivity and have proven to be highly valuable...