Next Article in Journal
The Pleiotropic Role of Retinoic Acid/Retinoic Acid Receptors Signaling: From Vitamin A Metabolism to Gene Rearrangements in Acute Promyelocytic Leukemia
Next Article in Special Issue
The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance
Previous Article in Journal
Establishment of Efficient Genetic Transformation Systems and Application of CRISPR/Cas9 Genome Editing Technology in Lilium pumilum DC. Fisch. and Lilium longiflorum White Heaven
Previous Article in Special Issue
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy
Article Menu
Issue 12 (June-2) cover image

Export Article

Open AccessReview

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

Department of Mother and Child, 42123 Azienda USL–IRCCS di Reggio Emilia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(12), 2922; https://doi.org/10.3390/ijms20122922
Received: 17 May 2019 / Revised: 10 June 2019 / Accepted: 13 June 2019 / Published: 14 June 2019
  |  
PDF [2268 KB, uploaded 20 June 2019]
  |  

Abstract

Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with diseases including obesity and cancer. Herein we report dysregulated miRNAs in obesity both in animal models and in humans, and we also document dysregulated miRNAs in colorectal cancer (CRC), as example of an obesity-related cancer. Some of the described miRNAs are found to be similarly dysregulated both in obesity, insulin resistance (IR), and CRC. Thus, we present miRNAs as a potential molecular link between obesity and CRC onset and development, giving a new perspective on the role of miRNAs in obesity-associated cancers. View Full-Text
Keywords: obesity; insulin resistance; inflammation; microRNA; colorectal cancer; cancer obesity; insulin resistance; inflammation; microRNA; colorectal cancer; cancer
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Cirillo, F.; Catellani, C.; Sartori, C.; Lazzeroni, P.; Amarri, S.; Street, M.E. Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role? Int. J. Mol. Sci. 2019, 20, 2922.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top