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Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

Department of Mother and Child, 42123 Azienda USL–IRCCS di Reggio Emilia, Italy
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(12), 2922; https://doi.org/10.3390/ijms20122922
Received: 17 May 2019 / Revised: 10 June 2019 / Accepted: 13 June 2019 / Published: 14 June 2019
Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with diseases including obesity and cancer. Herein we report dysregulated miRNAs in obesity both in animal models and in humans, and we also document dysregulated miRNAs in colorectal cancer (CRC), as example of an obesity-related cancer. Some of the described miRNAs are found to be similarly dysregulated both in obesity, insulin resistance (IR), and CRC. Thus, we present miRNAs as a potential molecular link between obesity and CRC onset and development, giving a new perspective on the role of miRNAs in obesity-associated cancers. View Full-Text
Keywords: obesity; insulin resistance; inflammation; microRNA; colorectal cancer; cancer obesity; insulin resistance; inflammation; microRNA; colorectal cancer; cancer
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MDPI and ACS Style

Cirillo, F.; Catellani, C.; Sartori, C.; Lazzeroni, P.; Amarri, S.; Street, M.E. Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role? Int. J. Mol. Sci. 2019, 20, 2922.

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