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  • Article
  • Open Access
4 Citations
4,053 Views
19 Pages

Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

  • Hanieh Ghassabian,
  • Federico Falchi,
  • Martina Timmoneri,
  • Beatrice Mercorelli,
  • Arianna Loregian,
  • Giorgio Palù and
  • Gualtiero Alvisi

20 May 2021

Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavaila...

  • Article
  • Open Access
8 Citations
3,720 Views
19 Pages

Human cytomegalovirus (HCMV) genome replication is a complex and still not completely understood process mediated by the highly coordinated interaction of host and viral products. Among the latter, six different proteins form the viral replication co...

  • Article
  • Open Access
2 Citations
3,502 Views
28 Pages

Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes

  • Berenike Braun,
  • Kerstin Laib Sampaio,
  • Anna K. Kuderna,
  • Miriam Widmann and
  • Christian Sinzger

18 July 2022

Polymorphonuclear leukocytes (PMNs) presumably transmit human cytomegalovirus (HCMV) between endothelial cells in blood vessels and thereby facilitate spread to peripheral organs. We aimed to identify viral components that contribute to PMN-mediated...

  • Article
  • Open Access
429 Views
15 Pages

Antigenic-Specificity and Cytokine Profile of the T-Cell Response to Human Cytomegalovirus in Transplant Recipients

  • Federica Zavaglio,
  • Paola Zelini,
  • Asja Cera,
  • Piera d’Angelo,
  • Marilena Gregorini,
  • Teresa Rampino,
  • Lucia Del Frate,
  • Federica Meloni,
  • Oscar Borsani and
  • Daniele Lilleri
  • + 2 authors

Human cytomegalovirus (HCMV) infection is a significant complication in transplant recipients. Following HCMV reactivation, the recovery of T-cell responses serves as a key indicator of protection from HCMV disease. This study aimed to assess the HCM...

  • Article
  • Open Access
1 Citations
2,820 Views
15 Pages

Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses

  • Nadine Krämer,
  • Martin Schütz,
  • Uxía Gestal Mato,
  • Lina Herhaus,
  • Manfred Marschall and
  • Christine Zimmermann

17 October 2022

The human cytomegalovirus (HCMV) is a member of the beta-herpesvirus family and inflicts life-long latent infections in its hosts. HCMV has been shown to manipulate and dysregulate many cellular processes. One major interactor with the cellular host...

  • Article
  • Open Access
17 Citations
3,806 Views
13 Pages

19 January 2021

In this report, layer by layer (LBL) fire retardant coatings were produced on wood ply and Polypropylene Homopolymer/Flax fiber composites. FE-SEM and EDAX analysis was carried out to analyze the surface morphology, thickness, growth rate and element...

  • Article
  • Open Access
1 Citations
1,267 Views
12 Pages

26 September 2024

Polypropylene and ammonium phosphate (AP) composites were synthesized at a 25 wt% concentration. The changes in the morphological, thermal, and physical behavior of the composites were analyzed with the addition of lignosulfonate (LG) and zirconium p...

  • Article
  • Open Access
7 Citations
4,297 Views
11 Pages

14 May 2020

Polypropylene (PP) is flammable material, which brings latent danger to the environment and human society. Therefore, developing new environmentally friendly and effective flame-retardant is one of the most important ways to improve the flame retarda...

  • Article
  • Open Access
14 Citations
3,330 Views
17 Pages

27 April 2023

It is challenging to improve the water resistance, flame retardancy, mechanical performance, and balance of halogen-free flame-retardant polypropylene (PP) composites. For this purpose, a linear vinyl polysiloxane (PD) was synthesized and then self-c...

  • Article
  • Open Access
189 Citations
15,619 Views
21 Pages

20 November 2014

Thermally reduced graphite oxide (TRGO), containing only four single carbon layers on average, was combined with ammonium polyphosphate (APP) and magnesium hydroxide (MH), respectively, in polypropylene (PP). The nanoparticle’s influence on different...

  • Article
  • Open Access
3 Citations
2,842 Views
15 Pages

14 March 2023

This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional H...

  • Article
  • Open Access
30 Citations
4,924 Views
17 Pages

Modified Ammonium Polyphosphate and Its Application in Polypropylene Resins

  • Lingyu Meng,
  • Xiangrui Li,
  • Mingli Liu,
  • Chunfeng Li,
  • Lipeng Meng and
  • Sen Hou

13 November 2022

Herein, a simple and environment-friendly method of coupling agent treatment of APP (ammonium polyphosphate) is provided and an optimum process of modification via coupling agent is identified. The effects of coupling agent type, dosage, modification...

  • Article
  • Open Access
6 Citations
2,817 Views
16 Pages

Green Flame-Retardant Blend Used to Improve the Antiflame Properties of Polypropylene

  • Christian J. Cabello-Alvarado,
  • Marlene Andrade-Guel,
  • Marissa Pérez-Alvarez,
  • Gregorio Cadenas-Pliego,
  • Pascual Bartolo-Pérez,
  • Diego Martínez-Carrillo and
  • Zoe V. Quiñones-Jurado

8 May 2024

The flammability properties of polymers and polymeric composites play an important role in ensuring the safety of humans and the environment; moreover, flame-retardant materials ensure a greater number of applications. In the present study, we report...

  • Article
  • Open Access
12 Citations
3,115 Views
13 Pages

Synergistic Effect of Nano-Silica and Intumescent Flame Retardant on the Fire Reaction Properties of Polypropylene Composites

  • Yongliang Wang,
  • Baoqiang Liu,
  • Ruiyang Chen,
  • Yunfei Wang,
  • Zhidong Han,
  • Chunfeng Wang and
  • Ling Weng

30 June 2023

Silica nanoparticles (nano-silica) were used as synergistic agents with ammonium polyphosphate (APP) and pentaerythritol (PER) to enhance flame retardancy of polypropylene (PP) in this research. The composites were prepared using a melt-mixing method...

  • Article
  • Open Access
765 Views
18 Pages

Analysis of the Effect of Transition-Metal Oxide Content on Reducing the Flammability of Polypropylene

  • Jacek Iwko,
  • Beata Anwajler,
  • Roman Wróblewski,
  • Oliwia Trzaska,
  • Przemysław Postawa and
  • Tomasz Jaruga

12 October 2025

Polypropylene (PP) exhibits high flammability (LOI ≈ 17.5%), which limits its industrial applications. Previous studies have primarily focused on the flame-retardant mechanisms of intumescent flame-retardant (IFR) systems, while less attention...

  • Article
  • Open Access
11 Citations
2,787 Views
13 Pages

11 February 2022

A novel composite and functional micro-nanometer particle is designed by the hydrolysis of aluminium isopropoxide on the surface of ammonium polyphosphate (APP) to prepare surface nanostructured ammonium polyphosphate (NSAPP). NSAPP is characterised...

  • Article
  • Open Access
1 Citations
922 Views
25 Pages

Synthesis of Carbon-Zinc Oxide Microspheres Decorated with Ammonium Polyphosphate (APP) for Synergistic Flame Retardancy in Polypropylene Composites

  • Juan J. Mendoza,
  • Jesús R. Campos,
  • Ramón Enrique Díaz de León-Gómez,
  • Luciano da Silva,
  • Antonio Serguei Ledezma-Pérez,
  • Arxel de León and
  • Edgar Nazareo Cabrera-Álvarez

29 October 2025

A key strategy for improving polypropylene (PP) fire safety involves developing composites with enhanced flame-retardant properties. In this study, novel flame-retardant systems were developed through the sustainable synthesis of carbon microspheres...

  • Article
  • Open Access
11 Citations
3,852 Views
16 Pages

10 December 2021

A piperazine phosphate doped with Mn2+ (HP-Mn), as a new char-forming agent for intumescent flame retardant systems (IFR), was designed and synthesized using 1-hydroxy ethylidene-1,1-diphosphonic acid, piperazine, and manganese acetate tetrahydrate a...

  • Review
  • Open Access
88 Citations
13,067 Views
69 Pages

Flame Retardant Polypropylenes: A Review

  • Farzad Seidi,
  • Elnaz Movahedifar,
  • Ghasem Naderi,
  • Vahideh Akbari,
  • Franck Ducos,
  • Ramin Shamsi,
  • Henri Vahabi and
  • Mohammad Reza Saeb

29 July 2020

Polypropylene (PP) is a commodity plastic known for high rigidity and crystallinity, which is suitable for a wide range of applications. However, high flammability of PP has always been noticed by users as a constraint; therefore, a variety of additi...

  • Article
  • Open Access
11 Citations
2,659 Views
16 Pages

Surface Modification of Intumescent Flame Retardant and Its Application in Polypropylene with Excellent Fire Performance and Water Resistance

  • Xuqiang Zheng,
  • Mike Deng,
  • Hao Jia,
  • Xinyu Chen,
  • Ruicheng Wang,
  • Jun Sun,
  • Hongfei Li,
  • Xiaoyu Gu and
  • Sheng Zhang

2 February 2025

Polypropylene (PP) has a wide range of applications in daily life but it is highly flammable. Intumescent flame retardants (IFRs) are used to improve the flame-retardant performance of polypropylene. However, the poor compatibility between IFRs and P...

  • Article
  • Open Access
1 Citations
1,460 Views
11 Pages

Different Antigen-Specific CD4+ and CD8+ T-Cell Response against HCMV Proteins in Pregnant Women with Primary Infection and in Control Subjects with Remote Infection

  • Federica Zavaglio,
  • Piera d’Angelo,
  • Chiara Fornara,
  • Paola Zelini,
  • Giuditta Comolli,
  • Milena Furione,
  • Alessia Arossa,
  • Arsenio Spinillo,
  • Daniele Lilleri and
  • Fausto Baldanti

13 September 2024

Background/Objectives: Human cytomegalovirus (HCMV) is the most frequent cause of congenital infections. The HCMV-specific T-cell response in primary infection may help define reliable correlates of immune protection in pregnancy. In this study, the...

  • Article
  • Open Access
22 Citations
3,922 Views
16 Pages

8 October 2021

This work analyzes the thermal degradation and mechanical properties of iron (Fe)-containing MgAl layered double hydroxide (LDH)-based polypropylene (PP) nanocomposite. Ternary metal (MgFeAl) LDHs were prepared using the urea hydrolysis method, and F...

  • Article
  • Open Access
24 Citations
4,303 Views
17 Pages

23 November 2020

Modified ammonium polyphosphate (MAPP) was prepared as a novel mono-component intumescent flame retardant (IFR) via the ionic exchange between ammonium polyphosphate (APP) and piperazine sulfonate, which is synthesized by self-assembly using 1-(2-ami...

  • Article
  • Open Access
2,006 Views
13 Pages

Isolation of a Monoclonal Human scFv Against Cytomegalovirus pp71 Antigen Using Yeast Display

  • Kazuhisa Aoki,
  • Rikio Yabe,
  • Sayaka Ono,
  • Mayumi Saeki,
  • Yuri Tanno and
  • Hidetaka Tanno

Background: Human cytomegalovirus (CMV) is a major pathogen that poses significant risks to immunocompromised individuals and neonates. The tegument protein pp71, encoded by the UL82 gene, plays a pivotal role in initiating viral lytic replication an...

  • Article
  • Open Access
23 Citations
3,975 Views
13 Pages

Sisal-Fiber-Reinforced Polypropylene Flame-Retardant Composites: Preparation and Properties

  • Zhenhua Wang,
  • Weili Feng,
  • Jiachen Ban,
  • Zheng Yang,
  • Xiaomin Fang,
  • Tao Ding,
  • Baoying Liu and
  • Junwei Zhao

10 February 2023

Natural-fiber-reinforced polypropylene (PP) composites with a series of advantages including light weight, chemical durability, renewable resources, low in cost, etc., are being widely used in many fields such as the automotive industry, packaging, a...

  • Article
  • Open Access
3 Citations
1,665 Views
12 Pages

3 December 2024

Epoxy resin (EP) is an indispensable packaging material for batteries. Excellent thermal and flame-retardant properties of EP can ensure the safety performance of batteries. To solve the low-efficiency flame retardant of EP, nickel phenyl phosphate (...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,450 Views
17 Pages

26 June 2021

Many polymer-made objects show a trend of melting and dripping in fire, a behavior that may be modified by adding flame retardants (FRs). These affect materials properties, e.g., heat absorption and viscosity. In this paper, the effect of a flame ret...

  • Article
  • Open Access
11 Citations
3,007 Views
13 Pages

Sequencing of the Viral UL111a Gene Directly from Clinical Specimens Reveals Variants of HCMV-Encoded IL-10 That Are Associated with Altered Immune Responses to HCMV

  • Shelley Waters,
  • Silvia Lee,
  • Ibnu Ariyanto,
  • Nina Kresoje,
  • Shay Leary,
  • Kylie Munyard,
  • Silvana Gaudieri,
  • Ashley Irish,
  • Anthony D. Keil and
  • Patricia Price
  • + 1 author

Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by ~80% of adults worldwide. Acute infections are often asymptomatic in healthy individuals but generate diverse syndromes in neonates, renal transplant recipients (RTR), and people with HIV...

  • Article
  • Open Access
1 Citations
964 Views
26 Pages

18 May 2025

PM2.5 emissions significantly impact atmospheric environments and human health in the context of forest fires. However, research on PM2.5 emissions from forest fires remains insufficient. This study systematically investigated PM2.5 emission characte...

  • Article
  • Open Access
11 Citations
5,482 Views
22 Pages

Analysis of the Fire Behavior of Polymers (PP, PA 6 and PE-LD) and Their Improvement Using Various Flame Retardants

  • Dieter Hohenwarter,
  • Hannelore Mattausch,
  • Christopher Fischer,
  • Matthias Berger and
  • Bernd Haar

16 December 2020

The fire behavior of polymers is examined primarily with the time-dependent heat release rate (HRR) measured with a cone calorimeter. The HRR is used to examine the fire behavior of materials with and without flame retardants, especially Polypropylen...

  • Article
  • Open Access
75 Citations
9,268 Views
26 Pages

Influence of Flame Retardants on the Melt Dripping Behaviour of Thermoplastic Polymers

  • Melissa Matzen,
  • Baljinder Kandola,
  • Christian Huth and
  • Bernhard Schartel

27 August 2015

Melt flow and dripping of the pyrolysing polymer melt can be both a benefit and a detriment during a fire. In several small-scale fire tests addressing the ignition of a defined specimen with a small ignition source, well-adjusted melt flow and dripp...

  • Feature Paper
  • Review
  • Open Access
83 Citations
7,982 Views
18 Pages

Human Cytomegalovirus Cell Tropism and Host Cell Receptors

  • Giuseppe Gerna,
  • Anna Kabanova and
  • Daniele Lilleri

In the 1970s–1980s, a striking increase in the number of disseminated human cytomegalovirus (HCMV) infections occurred in immunosuppressed patient populations. Autopsy findings documented the in vivo disseminated infection (besides fibroblasts)...

  • Article
  • Open Access
18 Citations
4,165 Views
19 Pages

23 October 2020

This study is based on previously reported reaction to fire properties of flax fibre-reinforced polymeric (polypropylene, PP and polylactic acid, PLA) composites, prepared by pre-treating the fabrics with different fire retardants (FRs) prior to comp...

  • Article
  • Open Access
9 Citations
2,899 Views
15 Pages

21 March 2024

In this study, a nanocomposite based on a heterophasic polypropylene copolymer containing 5 wt% of nanoclays and 3 wt% of compatibilizer was formulated via melt compounding to obtain a material suitable for Fused Filament Fabrication (FFF) processing...

  • Article
  • Open Access
1 Citations
2,384 Views
10 Pages

Antioxidant Status in Patients after Breast Mastopexy and Augmentation

  • Kirils Jurševičs,
  • Eduards Jurševičs,
  • Jeļena Krasiļņikova,
  • Andrejs Šķesters,
  • Anna Lece and
  • Ingus Skadiņš

26 June 2024

Background and Objectives: Mammary gland surgery has become very common, but there are complications of these operations, including the concept of breast implant illness (BII) in women with silicone gel breast implants (SBI), who suffer from various...

  • Article
  • Open Access
22 Citations
9,547 Views
11 Pages

Structure–Property Studies on a New Family of Halogen Free Flame Retardants Based on Sulfenamide and Related Structures

  • Teija Tirri,
  • Melanie Aubert,
  • Weronika Pawelec,
  • Anton Holappa and
  • Carl-Eric Wilén

14 October 2016

A wide variety of molecules containing S–N or S–N–S cores were synthesized, and their flame retardant properties in polypropylene (PP), low density polyethylene (LDPE) and polystyrene (PS) were investigated. In addition, polymers or oligomers bearing...

  • Article
  • Open Access
7 Citations
3,834 Views
16 Pages

17 February 2022

In this study six new s-triazine bishydrazino and bishydrazido-based polymers were synthesized via condensation of bishydrazino s-triazine derivatives with terephthaldehyde or via nucleophilic substitution of dichloro-s-triazine derivatives with tere...

  • Article
  • Open Access
6 Citations
3,699 Views
13 Pages

2 February 2023

Due to strict safety regulations, the automotive industry requires an effective reduction of flammability in polymer components. Flame retardants are usually added to the polymer matrix, affecting the viscosity of the matrix. Another possible solutio...

  • Article
  • Open Access
16 Citations
3,090 Views
11 Pages

11 February 2022

The growing increase in the production of municipal solid waste incinerator (MSWI) ashes has led to the research of new possibilities to reuse these by-products. This work aims to use MSW fly ash (FA) as a flame retardant filler. The FA was stabilize...

  • Article
  • Open Access
21 Citations
6,011 Views
16 Pages

31 December 2018

In this work, the ethylene-propylene-diene monomer/polypropylene (EPDM/PP) thermoplastic elastomer filled with intumescent flame retardants (IFR) is fabricated by melting blend. The IFR are constituted with melamine phosphate-pentaerythritol (MP/PER)...

  • Article
  • Open Access
57 Citations
7,314 Views
15 Pages

11 January 2018

In order to improve the efficiency of intumescent flame retardants (IFRs), a novel macromolecular charring agent named poly(ethanediamine-1,3,5-triazine-p-4-amino-2,2,6,6-tetramethylpiperidine) (PETAT) with gas phase and condense phase synergistic fl...

  • Article
  • Open Access
3 Citations
4,860 Views
16 Pages

18 March 2023

Background: HLRCC syndrome is a hereditary cancer predisposition syndrome caused by heterozygous germline pathogenic variant of the fumarate hydratase (FH) gene and characterized by cutaneous leiomyomas (CL), uterine leiomyomas (UL), and renal cell c...

  • Article
  • Open Access
4 Citations
2,958 Views
33 Pages

Novel Macromolecular and Biobased Flame Retardants Based on Cellulose Esters and Phosphorylated Sugar Alcohols

  • Matay Kaplan,
  • Michael Ciesielski,
  • Sabine Fuchs,
  • Christoffer Getterle,
  • Frank Schönberger and
  • Rudolf Pfaendner

27 July 2023

The increasing demand to provide sustainably produced plastic materials requires, a.o., the development of biobased flame retardants (FRs) for applications where flame retardancy is essential. To meet those challenging new sustainability requirements...

  • Article
  • Open Access
24 Citations
8,701 Views
17 Pages

7 January 2014

Human cytomegalovirus (HCMV) particle morphogenesis in infected cells is an orchestrated process that eventually results in the release of enveloped virions. Proteomic analysis has been employed to reveal the complexity in the protein composition of...

  • Article
  • Open Access
2 Citations
2,454 Views
17 Pages

24 October 2023

HCMV vaccine development has traditionally focused on viral antigens identified as key targets of neutralizing antibody (NAb) and/or T cell responses in healthy adults with chronic HCMV infection, such as glycoprotein B (gB), the glycoprotein H-ancho...

  • Article
  • Open Access
22 Citations
3,782 Views
20 Pages

Synergistic Action of Montmorillonite with an Intumescent Formulation: The Impact of the Nature and the Strength of Acidic Sites on the Flame-Retardant Properties of Polypropylene Composites

  • Raíssa Carvalho Martins,
  • Michelle Jakeline Cunha Rezende,
  • Marco Antonio Chaer Nascimento,
  • Regina Sandra Veiga Nascimento and
  • Simone Pereira da Silva Ribeiro

25 November 2020

A raw montmorillonite (Mt) was submitted to different acidic activation times in order to investigate the influence of the strength and the nature (Brønsted and Lewis) of acidic sites on the synergistic action with an intumescent formulation (...

  • Article
  • Open Access
7 Citations
3,272 Views
11 Pages

1 May 2021

Cytomegalovirus-specific cell-mediated immunity (CMV-CMI) in actively infected healthy immunocompetent hosts has been poorly investigated. Conversely, correlates of maternal protective immunity for the fetus after primary infection in pregnancy conti...

  • Article
  • Open Access
31 Citations
3,415 Views
17 Pages

A Phosphorous-Based Bi-Functional Flame Retardant Based on Phosphaphenanthrene and Aluminum Hypophosphite for an Epoxy Thermoset

  • Bo Xu,
  • Yanting Liu,
  • Simiao Wei,
  • Siheng Zhao,
  • Lijun Qian,
  • Yajun Chen,
  • Hao Shan and
  • Qinglei Zhang

24 September 2022

A phosphorous-based bi-functional compound HPDAl was used as a reactive-type flame retardant (FR) in an epoxy thermoset (EP) aiming to improve the flame retardant efficiency of phosphorus-based compounds. HPDAl, consisting of two different P-groups o...

  • Review
  • Open Access
17 Citations
5,409 Views
23 Pages

Congenital cytomegalovirus infection (cCMV) may affect about 1% of all newborns all over the world as a result of either a primary or recurrent human cytomegalovirus (HCMV) infection. While about 90% of infants affected by cCMV are asymptomatic at bi...