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570 Results Found

  • Article
  • Open Access
10 Citations
4,669 Views
14 Pages

Comparative Analysis of Examination Methods for Periapical Lesion Diagnostics: Assessing Cone-Beam Computer Tomography, Ultrasound, and Periapical Radiography

  • Aleksandra Karkle,
  • Anda Slaidina,
  • Maksims Zolovs,
  • Anete Vaskevica and ,
  • Dita Meistere,
  • Zanda Bokvalde and
  • Laura Neimane
  • + 2 authors+ 0 author

Introduction: Periapical lesions of teeth are typically evaluated using periapical X-rays (PA) or cone-beam computer tomography (CBCT); however, ultrasound imaging (US) can also be used to detect bone defects. A comparative analysis is necessary to e...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
11 Citations
2,576 Views
18 Pages

Artificial Intelligence Versus Human Dental Expertise in Diagnosing Periapical Pathosis on Periapical Radiographs: A Multicenter Study

  • Fatma E. A. Hassanein,
  • Radwa R. Hussein,
  • Mohamed Riad Elgarhy,
  • Shaymaa Mohamed Maher and ,
  • Ahmed Hassen,
  • Sherif Heidar,
  • Marwa Ezz El Arab,
  • Amr Edress,
  • Asmaa Abou-Bakr and
  • Mohamed Mekhemar
  • + 5 authors+ 0 author

Background: Periapical pathosis in periapical radiographs must be properly diagnosed for the success of endodontic treatment but is often muddled by 2D imaging limitations and subjective interpretation. Artificial intelligence (AI) offers a solution,...

(This article belongs to the Special Issue Artificial Intelligence in Dentistry: Innovations, Applications, and Future Perspectives, 2nd Edition)
  • Entry
  • Open Access
2 Citations
7,439 Views
16 Pages

Periapical Lesions: Diagnosis, Pathophysiology, and Management

  • Yuval Reiser,
  • Luka Marković,
  • Ivica Pelivan,
  • Ana Ivanišević and
  • Dragana Gabrić

The term “periapical lesion” refers to a pathological change in the tissues surrounding the apex of a tooth root, defined by its anatomical location rather than a distinct disease entity. Periapical lesions may be of endodontic origin, mo...

(This article belongs to the Section Medicine & Pharmacology)
  • Article
  • Open Access
48 Citations
7,281 Views
10 Pages

Automatic Feature Segmentation in Dental Periapical Radiographs

  • Tugba Ari,
  • Hande Sağlam,
  • Hasan Öksüzoğlu,
  • Orhan Kazan and ,
  • İbrahim Şevki Bayrakdar,
  • Suayip Burak Duman,
  • Özer Çelik,
  • Rohan Jagtap,
  • Karolina Futyma-Gąbka and
  • Kaan Orhan
  • + 6 authors+ 1 author

7 December 2022

While a large number of archived digital images make it easy for radiology to provide data for Artificial Intelligence (AI) evaluation; AI algorithms are more and more applied in detecting diseases. The aim of the study is to perform a diagnostic eva...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
5 Citations
7,558 Views
11 Pages

Factors Affecting the Outcome of Periapical Surgery; a Prospective Longitudinal Clinical Study

  • Muhammad Adeel Ahmed,
  • Nouman Mughal,
  • Syed Hani Abidi,
  • Muhammad Furqan Bari and ,
  • Mohammed Mustafa,
  • Fahim Vohra and
  • Ali Alrahlah
  • + 2 authors+ 0 author

10 December 2021

Wound healing following periapical surgery is influenced by age, gender, smoking, periapical lesion size, type of root-end filling, method of root-end cavity preparation and the use of microsurgical or conventional technique. This study aimed to eval...

(This article belongs to the Special Issue Celebrating Applied Sciences Reaches 20,000 Articles Milestone: Invited Papers in "Applied Dentistry and Oral Sciences" Section)
  • Feature Paper
  • Case Report
  • Open Access
6 Citations
11,478 Views
9 Pages

6 September 2018

Periapical actinomycosis is a relatively rare form of cervicofacial actinomycosis, which typically involves the periapical region with subsequent potential spread to the jaw bones. We hereby present two cases of periapical actinomycosis. Both patient...

(This article belongs to the Section Infectious Disease)
  • Article
  • Open Access
8 Citations
3,130 Views
11 Pages

24 September 2022

No prior study has evaluated the content of YouTube videos that demonstrated how to take periapical radiographs, one of the commonest radiographic examinations in dentistry. This study provided a content analysis on these YouTube videos. Three separa...

(This article belongs to the Section Applied Biosciences and Bioengineering)
  • Review
  • Open Access
23 Citations
12,098 Views
22 Pages

The Limitations of Periapical X-ray Assessment in Endodontic Diagnosis—A Systematic Review

  • Alexandru Gliga,
  • Marina Imre,
  • Simone Grandini,
  • Crystal Marruganti and ,
  • Carlo Gaeta,
  • Dana Bodnar,
  • Bogdan Alexandru Dimitriu and
  • Federico Foschi
  • + 3 authors+ 0 author

12 July 2023

Diagnosis is a key aspect in endodontic treatment, in a decade where invasive interventions are misapprehended as social tendency instead of medical necessity. All diagnostic facets should be considered before intending the operative phase. Intraoral...

(This article belongs to the Special Issue Current Topics in Endodontics)
  • Article
  • Open Access
20 Citations
8,375 Views
13 Pages

The Detection of Dental Pathologies on Periapical Radiographs—Results from a Reliability Study

  • Theresa Meusburger,
  • Annika Wülk,
  • Andreas Kessler,
  • Katrin Heck and ,
  • Reinhard Hickel,
  • Helena Dujic and
  • Jan Kühnisch
  • + 2 authors+ 0 author

13 March 2023

(1) Background: Caries, periapical lesions, periodontal bone loss (PBL), and endo-perio lesions are common dental findings that require an accurate diagnostic assessment to allow appropriate disease management. The purpose of this reliability study w...

(This article belongs to the Special Issue Recent Advances in the Management of Dental Caries)
  • Review
  • Open Access
11 Citations
3,216 Views
18 Pages

Periapical lesions (PALs) are a common sequela of pulpal pathology, and accurate radiographic detection is essential for successful endodontic diagnosis and treatment outcome. With recent advancements in Artificial Intelligence (AI), deep learning sy...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Case Report
  • Open Access
6 Citations
1 Views
3 Pages

Simple Bone Cyst of Mandible Mimicking Periapical Cyst

  • Charan Babu HS,
  • Bhagawan Das Rai,
  • Manju A. Nair and
  • Madhusudan S. Astekar

Simple bone cysts (SBC) are pseudocysts occurring less commonly in the maxillofacial region. The uncertain and unclear etiopathogenesis led to numerous synonyms to refer this particular cyst. These cysts are devoid of an epithelial lining and are usu...

  • Article
  • Open Access
6 Citations
4,313 Views
10 Pages

12 October 2022

Background and Objectives: There is limited information regarding comparison of long-term dynamics of periapical bone destruction estimated by digital periapical radiography (DPR) and by cone-beam computed tomography (CBCT). This study aimed to compa...

  • Systematic Review
  • Open Access
7 Citations
6,026 Views
15 Pages

Comparison of Immediate Implantation into the Socket with and without Periapical Pathology: Systematic Review and Meta-Analysis

  • Alma Pranckeviciene,
  • Inga Vaitkeviciene,
  • Jolanta Siudikiene,
  • Skaiste Poskeviciene and
  • Vita Maciulskiene-Visockiene

Background and Objectives: The present systematic review and meta-analysis were conducted to evaluate and compare the long-term clinical outcomes of immediate implants placed into fresh sockets with and without periapical pathology. Materials and Met...

(This article belongs to the Section Dentistry and Oral Health)
  • Systematic Review
  • Open Access
35 Citations
6,720 Views
12 Pages

Ultrasound Imaging versus Radiographs in Differentiating Periapical Lesions: A Systematic Review

  • Shankargouda Patil,
  • Ahmed Alkahtani,
  • Shilpa Bhandi,
  • Mohammed Mashyakhy and ,
  • Mario Alvarez,
  • Riyadh Alroomy,
  • Ali Hendi,
  • Saranya Varadarajan,
  • Rodolfo Reda and
  • Luca Testarelli
  • + 6 authors+ 1 author

Background: Ultrasonography is a non-invasive method of diagnosing periapical lesions while radiologic methods are more common. Periapical lesions due to endodontic infection are one of the most common causes of periapical radiolucency that need to b...

(This article belongs to the Special Issue Advanced Diagnostic Imaging in Dentistry)
  • Article
  • Open Access
20 Citations
5,305 Views
15 Pages

Association between Cone-Beam Computed Tomography and Histological and Immunohistochemical Features in Periapical Lesions Correlated with Thickened Maxillary Sinus Mucosa

  • Alexandra Dumitrescu,
  • Maria-Alexandra Martu,
  • Alexandru Nemtoi,
  • Ana Sirghe and ,
  • Liliana Chelaru,
  • Diana Tatarciuc,
  • Ana-Maria Dumitrescu and
  • Danisia Haba
  • + 3 authors+ 0 author

19 August 2021

Background and Objectives: Odontogenic sinusitis is a frequently underestimated pathology with fewer symptoms in patients with periapical lesions, periodontal disease, or iatrogenic foreign bodies in the maxillary sinus. The aim of our study was to d...

(This article belongs to the Collection New Concepts for Dental Treatments and Evaluations)
  • Article
  • Open Access
1 Citations
4,435 Views
17 Pages

Geometrical Calibration of a 2.5D Periapical Radiography System

  • Che-Wei Liao,
  • Ming-Tzu Tsai,
  • Heng-Li Huang,
  • Lih-Jyh Fuh and ,
  • Yen-Lin Liu,
  • Zhi-Teng Su and
  • Jui-Ting Hsu
  • + 2 authors+ 0 author

30 January 2020

The objective of this study was to develop a geometrical calibration method applicable to the 2.5D prototype Periapical Radiography System and estimate component position errors. A two-steel-ball phantom with a precisely known position was placed in...

(This article belongs to the Special Issue Biomedical Optics and Engineering)
  • Article
  • Open Access
6 Citations
2,403 Views
13 Pages

CD34 and Ki-67 Immunoexpression in Periapical Granulomas: Implications for Angiogenesis and Cellular Proliferation

  • Ciprian Roi,
  • Mircea Riviș,
  • Alexandra Roi,
  • Marius Raica and ,
  • Raluca Amalia Ceaușu,
  • Alexandru Cătălin Motofelea and
  • Pușa Nela Gaje
  • + 2 authors+ 0 author

31 October 2024

Background/Objectives: The main mechanism of the formation of granulation tissue is the progression of an infection from the tooth to the periapical bone. At this level, the immune system tries to localize and annihilate the microorganism’s inj...

(This article belongs to the Special Issue Advances in the Diagnosis of Oral and Maxillofacial Disease)
  • Review
  • Open Access
10 Citations
4,287 Views
11 Pages

Leptin in Dental Pulp and Periapical Tissues: A Narrative Review

  • Jenifer Martin-Gonzalez,
  • Juan J. Segura-Egea,
  • Antonio Pérez-Pérez,
  • Daniel Cabanillas-Balsera and
  • Víctor Sánchez-Margalet

11 February 2022

Leptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is to regulate energy homeostasis and weight control in a central manner. There is increasing evidence that leptin also has systemic effects,...

(This article belongs to the Section Molecular Biophysics)
  • Article
  • Open Access
46 Citations
12,631 Views
11 Pages

Detection of Periapical Lesions on Panoramic Radiographs Using Deep Learning

  • Raidan Ba-Hattab,
  • Noha Barhom,
  • Safa A. Azim Osman,
  • Iheb Naceur and ,
  • Aseel Odeh,
  • Arisha Asad,
  • Shahd Ali R. N. Al-Najdi,
  • Ehsan Ameri,
  • Ammar Daer and
  • Faleh Tamimi
  • + 8 authors+ 3 authors

24 January 2023

Dentists could fail to notice periapical lesions (PLs) while examining panoramic radiographs. Accordingly, this study aimed to develop an artificial intelligence (AI) designed to address this problem. Materials and methods: a total of 18618 periapica...

  • Article
  • Open Access
34 Citations
10,234 Views
12 Pages

Deep Learning-Based Periapical Lesion Detection on Panoramic Radiographs

  • Viktor Szabó,
  • Kaan Orhan,
  • Csaba Dobó-Nagy,
  • Dániel Sándor Veres and ,
  • David Manulis,
  • Matvey Ezhov,
  • Alex Sanders and
  • Bence Tamás Szabó
  • + 3 authors+ 0 author

19 February 2025

Background/Objectives: Our study aimed to determine the accuracy of the artificial intelligence-based Diagnocat system (DC) in detecting periapical lesions (PL) on panoramic radiographs (PRs). Methods: 616 teeth were selected from 357 panoramic radio...

(This article belongs to the Special Issue Advancements in Artificial Intelligence for Dentomaxillofacial Radiology—2nd Edition)
  • Article
  • Open Access
2 Citations
1,404 Views
10 Pages

Cytokine Profiling of Exudates from Periapical Lesions and the Efficacy of CXCL10 as a Healing Marker

  • Kazuhisa Ouhara,
  • Yuri Taniguchi,
  • Ruoqi Zhai,
  • Katsuhiro Takeda and ,
  • Ryousuke Fujimori,
  • Naoya Kuwahara,
  • Shoya Ueda,
  • Yitong Hou,
  • Nomi Honoka and
  • Noriyoshi Mizuno
  • + 9 authors+ 4 authors

7 October 2025

This study aimed to evaluate cytokine profiling in a periapical lesion to provide a rationale for future treatment strategies for periapical lesions. Thirteen samples of exudative fluid were collected from such a lesion directly through the root cana...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
889 Views
10 Pages

Periapical Status of Post-Restored Teeth: A Two-Year Follow-Up Study

  • Chaimae Loudili,
  • Amine Roufid,
  • Fatima Ezzahra Faridi,
  • Rime Chraibi and ,
  • Hicham Soualhi and
  • Babacar Toure
  • + 1 author+ 0 author

5 May 2026

Objectives: This study evaluated the prevalence of periapical lesions in endodontically treated teeth restored with cast post-and-core systems after a minimum two-year follow-up, and identified restorative and clinical factors influencing periapical...

  • Review
  • Open Access
1 Citations
5,018 Views
12 Pages

28 October 2024

Periapical radiography is a regular radiographic procedure performed by dentists. However, at times, it may not be possible to position the image receptor into a patient’s mouth in an optimized or practical way. For these cases, some dentists a...

  • Article
  • Open Access
7 Citations
3,423 Views
14 Pages

Clinical Validation of Deep Learning for Segmentation of Multiple Dental Features in Periapical Radiographs

  • Rohan Jagtap,
  • Yalamanchili Samata,
  • Amisha Parekh,
  • Pedro Tretto and ,
  • Michael D. Roach,
  • Saranu Sethumanjusha,
  • Chennupati Tejaswi,
  • Prashant Jaju,
  • Alan Friedel and
  • Mini Suri
  • + 7 authors+ 2 authors

Periapical radiographs are routinely used in dental practice for diagnosis and treatment planning purposes. However, they often suffer from artifacts, distortions, and superimpositions, which can lead to potential misinterpretations. Thus, an automat...

(This article belongs to the Special Issue Artificial Intelligence in Dentistry: Innovations, Applications, and Future Perspectives)
  • Article
  • Open Access
2 Citations
1,050 Views
17 Pages

Radiomics as a Decision Support Tool for Detecting Occult Periapical Lesions on Intraoral Radiographs

  • Barbara Obuchowicz,
  • Joanna Zarzecka,
  • Marzena Jakubowska,
  • Rafał Obuchowicz and ,
  • Michał Strzelecki,
  • Adam Piórkowski,
  • Joanna Gołda,
  • Karolina Nurzynska and
  • Julia Lasek
  • + 4 authors+ 0 author

25 January 2026

Background: Periapical lesions are common consequences of pulp necrosis but may remain undetectable on conventional intraoral radiographs, becoming evident only on cone-beam computed tomography (CBCT). Improving lesion recognition on plain radiograph...

(This article belongs to the Topic Machine Learning and Deep Learning in Medical Imaging)
  • Article
  • Open Access
5 Citations
5,113 Views
13 Pages

Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study

  • Amaar Obaid Hassan,
  • Gregory Y. H. Lip,
  • Arnaud Bisson,
  • Julien Herbert and ,
  • Alexandre Bodin,
  • Laurent Fauchier and
  • Rebecca V. Harris
  • + 2 authors+ 0 author

30 June 2021

There are limited data on the relationship of acute dental infections with hospitalisation and new-onset atrial fibrillation (AF). This study aimed to assess the relationship between acute periapical abscess and incident AF. This was a retrospective...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
3 Citations
2,818 Views
11 Pages

18 July 2021

The aim of the present study is to compare cone beam computed tomography and periapical digital radiography for the evaluation of root canal preparation. Nine extracted human molars were used in this study. Following access cavity preparation, mesio-...

(This article belongs to the Special Issue Innovative Techniques in Endodontics)
  • Article
  • Open Access
1 Citations
876 Views
29 Pages

Chronic periapical periodontitis is a persistent inflammatory disease characterized by progressive bone destruction around the tooth apex. Manual radiographic detection of these lesions is subjective and time-consuming, highlighting the need for auto...

(This article belongs to the Special Issue Deep Learning in Biomedical Image Segmentation and Classification: Advancements, Challenges and Applications, 2nd Edition)
  • Article
  • Open Access
31 Citations
8,906 Views
18 Pages

Assessment of the Diagnostic Accuracy of Artificial Intelligence Software in Identifying Common Periodontal and Restorative Dental Conditions (Marginal Bone Loss, Periapical Lesion, Crown, Restoration, Dental Caries) in Intraoral Periapical Radiographs

  • Wael I. Ibraheem,
  • Saurabh Jain,
  • Mohammed Naji Ayoub,
  • Mohammed Ahmed Namazi and ,
  • Amjad Ismail Alfaqih,
  • Aparna Aggarwal,
  • Abdullah A. Meshni,
  • Ammar Almarghlani and
  • Abdulkareem Abdullah Alhumaidan
  • + 4 authors+ 0 author

Objectives: The purpose of the study is to evaluate the diagnostic accuracy of artificial intelligence (AI) software in detecting a common set of periodontal and restorative conditions, including marginal bone loss, dental caries, periapical lesions,...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
14 Citations
7,250 Views
11 Pages

CBCT Evaluation of Periapical Pathologies in Maxillary Posterior Teeth and Their Relationship with Maxillary Sinus Mucosal Thickening

  • Rizwan Jouhar,
  • Hussain Mohammed Alkhames,
  • Muhammad Adeel Ahmed,
  • Naji Mohammad Almadeh and ,
  • Muhammad Faheemuddin and
  • Muhammad Farooq Umer
  • + 1 author+ 0 author

In modern dentistry, radiographic imaging is crucial for examining the connection between the maxillary sinus floor and the root apices of the maxillary posterior teeth, particularly when the periapical region is affected by pathology that could resu...

(This article belongs to the Special Issue Periodontal Diseases and Oral Health)
  • Case Report
  • Open Access
5 Citations
3 Pages

Central ossifying fibroma is a rare, benign fibro-osseous lesion that arises from the periodontal ligament. Periapical cemento-osseous dysplasia is another variant of fibro-osseous lesion which occurs in the anterior region of the mandible of females...

  • Case Report
  • Open Access
5 Citations
4,517 Views
12 Pages

Leukocyte-Platelet-Rich Fibrin in Bone Regeneration after Periapical Surgery: A 30-Month Follow-Up Clinical Report

  • Hatim A. Qurban,
  • Hatem Hazzaa Hamadallah,
  • Mohammad A. Madkhaly,
  • Muhannad M. Hakeem and
  • Ahmed Yaseen Alqutaibi

26 April 2024

Aim and background: Periapical lesions, which occur due to the infection and necrosis of dental pulp, are a significant dental pathology that poses risks to oral and systemic health. These lesions often require interventions such as root canal treatm...

(This article belongs to the Special Issue Clinical Research on Oral Diseases)
  • Case Report
  • Open Access
13 Citations
15,712 Views
12 Pages

Conservative Approach in the Management of Large Periapical Cyst-Like Lesions. A Report of Two Cases

  • Roxana M. Talpos-Niculescu,
  • Malina Popa,
  • Laura C. Rusu,
  • Marius O. Pricop and ,
  • Luminita M. Nica and
  • Serban Talpos-Niculescu
  • + 1 author+ 0 author

Background and Objectives: Periapical cystic lesions are a pathology frequently addressed to endodontic specialists. Although their therapy is still not standardized, the treatment should be as conservative as possible and by endodontic means, as the...

(This article belongs to the Section Dentistry and Oral Health)
  • Article
  • Open Access
26 Citations
6,354 Views
13 Pages

Evaluating a Periapical Lesion Detection CNN on a Clinically Representative CBCT Dataset—A Validation Study

  • Arnela Hadzic,
  • Martin Urschler,
  • Jan-Niclas Aaron Press,
  • Regina Riedl and ,
  • Petra Rugani,
  • Darko Štern and
  • Barbara Kirnbauer
  • + 2 authors+ 0 author

29 December 2023

The aim of this validation study was to comprehensively evaluate the performance and generalization capability of a deep learning-based periapical lesion detection algorithm on a clinically representative cone-beam computed tomography (CBCT) dataset...

(This article belongs to the Special Issue Clinical Advances in Head and Neck Imaging including Dentistry)
  • Article
  • Open Access
72 Citations
10,587 Views
9 Pages

Diagnostic Test Accuracy of Artificial Intelligence in Detecting Periapical Periodontitis on Two-Dimensional Radiographs: A Retrospective Study and Literature Review

  • Julien Issa,
  • Mouna Jaber,
  • Ismail Rifai,
  • Paul Mozdziak and ,
  • Bartosz Kempisty and
  • Marta Dyszkiewicz-Konwińska
  • + 1 author+ 0 author

15 April 2023

This study aims to evaluate the diagnostic accuracy of artificial intelligence in detecting apical pathosis on periapical radiographs. A total of twenty anonymized periapical radiographs were retrieved from the database of Poznan University of Medica...

  • Article
  • Open Access
1 Citations
1,950 Views
14 Pages

Objectives: Endodontic complications are among the most frequently reported biological complications in tooth-supported fixed dental prostheses (FDPs). The aim of this study was to evaluate the prevalence of periapical complications in FDPs placed on...

(This article belongs to the Special Issue Advancements in Prosthetic Dentistry: Materials, Techniques, Ethics, and Sustainable Clinical Applications)
  • Systematic Review
  • Open Access
6 Citations
3,715 Views
16 Pages

16 October 2025

Background: The relationship between orthodontics and endodontics during the treatment planning phase is scarcely investigated, especially when orthodontic treatment is considered for endodontically treated teeth with apical periodontitis. This syste...

(This article belongs to the Special Issue Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome)
  • Article
  • Open Access
2 Citations
1,580 Views
14 Pages

Background: Cone-beam computed tomography (CBCT) was used for a 1-year follow-up of a randomized clinical trial to compare a stainless-steel Tornado file system with OneShape and WaveOne rotary systems for biomechanical canal preparation, as indicate...

(This article belongs to the Section Biosignal Processing)
  • Article
  • Open Access
4 Citations
6,302 Views
9 Pages

26 April 2021

Background: Various parameters are known to affect the amount and type of mucosal thickening. The aim of this retrospective study was to investigate these effects through a survey of cone-beam computed tomography (CBCT) images. CBCT scans of 150 pati...

(This article belongs to the Section Applied Dentistry and Oral Sciences)
  • Article
  • Open Access
1 Citations
1,008 Views
13 Pages

Evaluation of Bone Level Using Periapical Radiography and CBCT: A Prospective Observational Accuracy Study

  • Maarten Glibert,
  • Baptist Nollet,
  • Ruben Tilburgh and
  • Véronique Christiaens

30 April 2026

Radiographic assessment plays an important role in the diagnosis of periodontal disease. However, intraoral radiographs often underestimate interproximal bone level. Cone beam CT (CBCT) has been shown to outperform 2D radiography in the detection of...

(This article belongs to the Special Issue State-of-the-Art Digital Dentistry)
  • Review
  • Open Access
2 Citations
5,227 Views
14 Pages

Analysis of the Prognostic Factors That Influence the Outcome of Periapical Surgery, including Biomimetic Membranes for Tissue Regeneration: A Review

  • Antonio J. Saiz-Pardo-Pinos,
  • Francisco J. Manzano-Moreno,
  • Esther Muñoz-Soto,
  • María Paloma González-Rodríguez and ,
  • Nuria Romero-Olid and
  • María Victoria Olmedo-Gaya
  • + 1 author+ 0 author

The objective of this study was to analyze the prognostic factors that influence the outcome of periapical surgery. A systematic search of the literature was carried out using PubMed and Scopus databases between January 2000 and December 2023 with no...

(This article belongs to the Special Issue Dentistry and Craniofacial District: The Role of Biomimetics—Second Edition)
  • Article
  • Open Access
481 Views
19 Pages

Local Zoledronate Administration Modulates Periapical Lesion Development in Immunologically Distinct Rat Strains

  • Tamara Milunovic,
  • Milos Papic,
  • Mirjana V. Papić,
  • Miona Vuletic and ,
  • Aleksandra Misic,
  • Dejan Zdravkovic,
  • Jovan Rakic,
  • Ksenija Vucicevic,
  • Marina Miletic Kovacevic and
  • Suzana Zivanovic
  • + 8 authors+ 3 authors

26 June 2026

Background/Objectives: The objective of this study was to investigate the effects of local zoledronate treatment during periapical lesion development on inflammatory and bone remodeling responses in two immunologically distinct inbred rat strains, Da...

(This article belongs to the Special Issue Contemporary Endodontics: Progress and Prospects)
  • Article
  • Open Access
37 Citations
6,595 Views
18 Pages

Deep Learning for Dental Diagnosis: A Novel Approach to Furcation Involvement Detection on Periapical Radiographs

  • Yi-Cheng Mao,
  • Yen-Cheng Huang,
  • Tsung-Yi Chen,
  • Kuo-Chen Li and ,
  • Yuan-Jin Lin,
  • Yu-Lin Liu,
  • Hong-Rong Yan,
  • Yu-Jie Yang,
  • Chiung-An Chen and
  • Patricia Angela R. Abu
  • + 9 authors+ 4 authors

Furcation defects pose a significant challenge in the diagnosis and treatment planning of periodontal diseases. The accurate detection of furcation involvements (FI) on periapical radiographs (PAs) is crucial for the success of periodontal therapy. T...

(This article belongs to the Special Issue Recent Advance in Biomaterials, Clinical Dentistry and Dental Diseases 2.0)
  • Article
  • Open Access
4 Citations
3,432 Views
15 Pages

Human Periapical Odontogenic Granulomas: Aspects of Microvessel Density (MVD), Heterogeneity of Blood Vessels and Mast Cells Density (MCD)

  • Ciprian Roi,
  • Meda Lavinia Negruțiu,
  • Alexandra Roi,
  • Mircea Riviș and ,
  • Ruxandra Elena Luca,
  • Marius Raica,
  • Raluca Amalia Ceaușu,
  • Alexandru Cătălin Motofelea and
  • Pușa Nela Gaje
  • + 4 authors+ 0 author

Periapical odontogenic granulomas are among the most encountered pathology that involve the alveolar bone, with severe consequences such as bone resorption, the presence of inflammatory infiltrate and the formation of abnormal vascularization. The pr...

(This article belongs to the Special Issue Cell Biology in Dentistry)
  • Article
  • Open Access
2 Citations
1,537 Views
17 Pages

Evaluation of Vitamin D and of Some Biomarkers of Bone Remodelling (CTX-1, Osteocalcin, BALP) in Subjects with Periapical Inflammatory Cysts: An Observational Study

  • Angela Pia Cazzolla,
  • Vincenzo Brescia,
  • Roberto Lovero,
  • Roberta Cardinali and ,
  • Francesca Di Serio,
  • Mauro Lorusso,
  • Domenico Ciavarella,
  • Nunzio Francesco Testa,
  • Gianna Dipalma and
  • Mariasevera Di Comite
  • + 8 authors+ 3 authors

26 May 2025

Objectives: The aim of this observational study was to evaluate whether the presence of periapical inflammatory cysts (PIC) is accompanied by a state of vitamin D (25OHD) 25(OH)D insufficiency or deficiency and biochemical variations in biomarkers of...

(This article belongs to the Special Issue Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition)
  • Review
  • Open Access
27 Citations
27,304 Views
13 Pages

21 June 2023

Periapical radiography is a routine radiographic procedure performed by dentists on a daily basis. It can be taken with two techniques, the paralleling technique (P tech) and the bisecting angle technique (B tech). This systematic review aimed to ide...

(This article belongs to the Special Issue Feature Review Papers in Dentistry)
  • Article
  • Open Access
22 Citations
4,899 Views
13 Pages

The present study aimed to evaluate the performance of convolutional neural networks (CNNs) that were trained with small datasets using different strategies in the detection of proximal caries at different levels of severity on periapical radiographs...

(This article belongs to the Special Issue Artificial Intelligence in Oral Health)
  • Article
  • Open Access
56 Citations
14,245 Views
14 Pages

Periapical Lesions in Panoramic Radiography and CBCT Imaging—Assessment of AI’s Diagnostic Accuracy

  • Wojciech Kazimierczak,
  • Róża Wajer,
  • Adrian Wajer,
  • Veronica Kiian and ,
  • Anna Kloska,
  • Natalia Kazimierczak,
  • Joanna Janiszewska-Olszowska and
  • Zbigniew Serafin
  • + 3 authors+ 0 author

Background/Objectives: Periapical lesions (PLs) are frequently detected in dental radiology. Accurate diagnosis of these lesions is essential for proper treatment planning. Imaging techniques such as orthopantomogram (OPG) and cone-beam CT (CBCT) ima...

(This article belongs to the Special Issue Modern Patient-Centered Dental Care)
  • Article
  • Open Access
3 Citations
1,289 Views
16 Pages

PRF Membranes Enhance Postoperative Recovery After Periapical Surgery: A Single-Blind Randomized Pilot Trial Using 3D Imaging

  • Martin Major,
  • Melinda Polyák,
  • Tamás Würsching,
  • Gábor Kammerhofer and ,
  • Éva Kocsis,
  • Zsolt Németh and
  • György Szabó
  • + 2 authors+ 0 author

3 December 2025

Background: Periapical surgery is indicated for persistent periapical lesions that do not respond to conventional endodontic therapy, yet postoperative recovery is often hindered by pain, swelling, and delayed healing. Platelet-rich fibrin (PRF) memb...

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