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Dentistry Journal
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Contemporary Endodontics: Progress and Prospects
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Contemporary Endodontics: Progress and Prospects

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Restorative Dentistry and Traumatology".

Deadline for manuscript submissions: 20 January 2027 | Viewed by 3000

Editor

Prof. Dr. Shaul Lin

E-Mail Website
Guest Editor
1. Department of Endodontics, Rambam Health Care Campus, Haifa 3109601, Israel
2. The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 3109601, Israel
Interests: dental trauma; root resorption; bacteriology; epidemiology research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, significant advancements have taken place in the fields of endodontics and dental trauma. The aim of this Special Issue is to provide a platform for researchers who wish to publish scientific articles, with a particular emphasis on scientific innovation and clinically relevant insights.

Contributions are welcome in the form of original research, review articles, and case studies. Potential topics include, but are not limited to, the following:

  • Dental trauma;
  • Endodontic regeneration;
  • Root resorption;
  • Immunology;
  • Bacteriologic.

We would be delighted to serve as a forum for the dissemination of such contributions.

Sincerely,

Prof. Dr. Shaul Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental trauma
  • endodontic regeneration
  • immunology
  • bacteriologic

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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19 pages, 3170 KB  
Article
Local Zoledronate Administration Modulates Periapical Lesion Development in Immunologically Distinct Rat Strains
by Tamara Milunovic, Milos Papic, Mirjana V. Papić, Miona Vuletic, Aleksandra Misic, Dejan Zdravkovic, Jovan Rakic, Ksenija Vucicevic, Marina Miletic Kovacevic, Milica Popovic, Slobodanka Mitrovic, Biljana Ljujic and Suzana Zivanovic
Dent. J. 2026, 14(7), 393; https://doi.org/10.3390/dj14070393 - 26 Jun 2026
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Abstract
Background/Objectives: The objective of this study was to investigate the effects of local zoledronate treatment during periapical lesion development on inflammatory and bone remodeling responses in two immunologically distinct inbred rat strains, Dark Agouti (DA) and Albino Oxford (AO). Methods: Periapical [...] Read more.
Background/Objectives: The objective of this study was to investigate the effects of local zoledronate treatment during periapical lesion development on inflammatory and bone remodeling responses in two immunologically distinct inbred rat strains, Dark Agouti (DA) and Albino Oxford (AO). Methods: Periapical lesions were induced in the mandibular first molars of AO and DA rats (n = 44) by pulp exposure. Animals were assigned to four groups: DA + zoledronate, DA + saline, AO + zoledronate, and AO + saline. Zoledronate (0.15 mg/kg) or saline was locally administered on days 0, 7, 14, and 21 during lesion development. Animals were sacrificed on day 28. Mandibles were analyzed radiographically and histologically for lesion size, while osteogenic activity was assessed by osteocalcin immunohistochemistry. Gene expression was evaluated by qRT-PCR, and systemic oxidative stress parameters were analyzed spectrophotometrically. Statistical analysis included parametric or non-parametric tests according to data distribution, with significance set at p < 0.05. Results: Zoledronate -treated AO rats exhibited smaller periapical lesions and higher radiographic grayscale density than DA rats (p < 0.05). Histological analysis confirmed the radiographic findings and demonstrated smaller lesion areas in AO rats. Osteocalcin expression was significantly higher in AO rats (p < 0.05), indicating increased osteogenic activity. At the molecular level, DA rats showed higher expression of TNF-α and IL-1β, whereas AO rats exhibited higher expression of IL-10 and IL-4 (p < 0.05). In addition, expression of osteoclastogenic factor RANKL was significantly lower in AO rats than in DA rats (p < 0.05), while OPG expression showed a non-significant tendency toward higher levels in AO rats. Systemic redox analysis demonstrated lower NO2− and O2− levels in zoledronate-treated AO rats, whereas no significant differences were observed in the remaining oxidative stress parameters. Conclusions: Following local zoledronate treatment during lesion development, Th2-dominant AO rats exhibited reduced inflammatory responses and increased osteogenic activity compared with Th1-dominant DA rats. In contrast, DA rats primarily demonstrated attenuation of osteoclastogenic signaling without comparable osteogenic responses. These findings indicate that the biological effects of local zoledronate treatment in developing periapical lesions are influenced by the host immune phenotype. Full article
(This article belongs to the Special Issue Contemporary Endodontics: Progress and Prospects)
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13 pages, 908 KB  
Article
Assessing the Efficacy of Antibiotic Therapy: A Retrospective Study Comparing 875 mg vs. 500 mg of Amoxicillin/Clavulanic Acid for the Management of Acute Apical Abscesses
by Tal Capucha, Shaul Lin, Dani Noy, Chaim Ohayon, Mordechai Grupper, Daniel Moreinos, Marc Rothman, Dekel Shilo, Omri Emodi, Adi Rachmiel and Roni Dakar
Dent. J. 2026, 14(2), 71; https://doi.org/10.3390/dj14020071 - 26 Jan 2026
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Abstract
Introduction: Antibiotics are routinely prescribed for odontogenic abscesses in emergency departments and dental offices. Augmentin is recommended for moderate to severe dentofacial infections. It is usually prescribed in two popular regimens, namely twice (bid) or three times (tid) per day. The aim [...] Read more.
Introduction: Antibiotics are routinely prescribed for odontogenic abscesses in emergency departments and dental offices. Augmentin is recommended for moderate to severe dentofacial infections. It is usually prescribed in two popular regimens, namely twice (bid) or three times (tid) per day. The aim of this study was to compare the efficacy of two different formulations of amoxicillin–clavulanate, 875/125 mg bid versus 500/125 mg tid, for the treatment of acute dental apical abscesses with orofacial involvement. Methods: Sixty-one patients with acute apical abscesses were prescribed Augmentin in either an 875/125 mg bid or 500/125 mg tid formulation. The patients were tested for inflammatory markers upon admission and again after 72 h. Results: Although all patients experienced a decrease in inflammatory markers over 72 h of antibiotic therapy, there was a statistically significant greater decrease in white blood cells and neutrophils in the patients receiving the 500/125 mg tid regimen. Conclusions: A 500/125 mg tid Augmentin regimen results in a greater decline in inflammatory markers than 875/125 mg bid over 72 h in the setting of dentofacial infection. Full article
(This article belongs to the Special Issue Contemporary Endodontics: Progress and Prospects)
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Other

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20 pages, 2611 KB  
Systematic Review
Virtual Reality Goggles as a Distraction Technique for Managing Behavioral Conduct During Pulp Pediatric Dental Treatment: A Systematic Review and Meta-Analysis
by Carmen Machuca-Portillo, Maria Biedma-Perea, Cira Suárez-Marchena, Carolina Caleza-Jiménez, Lucy Chandler-Gutiérrez, Lydia López-del Valle and Juan J. Segura-Egea
Dent. J. 2026, 14(8), 517; https://doi.org/10.3390/dj14080517 - 13 Aug 2026
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Abstract
Objective: To systematically evaluate the effectiveness of virtual reality (VR) distraction systems in reducing pain perception and dental anxiety during pediatric pulp therapy procedures. Methods: A systematic review and meta-analysis was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD42026139774). PubMed/MEDLINE, [...] Read more.
Objective: To systematically evaluate the effectiveness of virtual reality (VR) distraction systems in reducing pain perception and dental anxiety during pediatric pulp therapy procedures. Methods: A systematic review and meta-analysis was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD42026139774). PubMed/MEDLINE, Scopus, and Embase were searched for randomized clinical trials evaluating immersive VR distraction during pediatric pulp therapy. Risk of bias was assessed using RoB 2, and certainty of evidence was evaluated with GRADE. Random-effects meta-analysis was performed for pain outcomes. Results: Seven randomized clinical trials were included in the qualitative synthesis. Three parallel-group randomized controlled trials were included in the pain meta-analysis. VR distraction significantly reduced self-reported pain (SMD) = −1.28 (95% C.I. = −2.49 to −0.07; p = 0.038) compared with control interventions. Substantial heterogeneity was observed for both outcomes (I2 > 93%). Most studies also reported improvements in behavioral cooperation, whereas physiological measures showed inconsistent findings. The certainty of evidence was rated as low for pain and anxiety outcomes. Conclusions: VR distraction may represent a promising non-pharmacological behavioral management strategy for reducing pain perception and dental anxiety during pediatric pulp therapy. However, these findings should be interpreted with caution because they are based on a small number of studies with substantial methodological heterogeneity. Further well-designed randomized clinical trials using standardized intervention protocols and outcome measures are required before firm conclusions or recommendations for routine clinical implementation can be established. Full article
(This article belongs to the Special Issue Contemporary Endodontics: Progress and Prospects)
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