Objective: This study aimed to establish a pathway-driven computational drug discovery framework integrating machine learning, target prioritization, virtual screening, molecular dynamics (MD) simulations, and in vitro evaluation to identify natural...
Post-traumatic stress disorder (PTSD) is associated with immune and autonomic disturbances, but molecular programs linking PTSD-related blood transcriptional signals with autonomic–cardiac biology remain incompletely characterized. The public G...
Background: The entomopathogenic fungus Metarhizium brunneum (M. brunneum) is an effective biocontrol agent against various vector arthropods such as ticks, mosquitoes, and flies. However, its virulence mechanisms remain poorly understood, which hind...
Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide. Only 5% of all CRC cases are due to germline mutations in known predisposition genes, and the remaining genetic burden still has to be discovered. In this study, we...
Alzheimer’s disease (AD) is a polygenic multifactorial neurodegenerative disease that, after decades of research and development, is still without a cure. There are some symptomatic treatments to manage the psychological symptoms but none of th...
Background: Primary open-angle glaucoma (POAG) is the most prevalent glaucoma subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most likely ‘causal’ genes and identify functional characteristics a...
Graduate Teaching Assistants (GTAs) play a pivotal role in supporting and advancing the educational mission of universities globally. They are fundamental to a university’s instructional workforce and their roles are critical to the undergradua...
Male pattern baldness (MPB) is a highly prevalent condition with a complex, poorly understood molecular basis that limits therapeutic innovation. This study aimed to bridge the gap between statistical genetic associations and biological function by i...
Background: Microalgae and cyanobacteria represent a largely unexplored source of bioactive compounds, but systematic screening of extensive strain collections is limited by the cost and complexity of conventional chemical and pharmacological charact...
Background: Bariatric surgery improves metabolic health, but long-term transcriptomic remodeling of white adipose tissue (WAT) after Roux-en-Y gastric bypass (RYGB) remains incompletely defined. This study aimed to characterize longitudinal WAT gene-...
Oleanolic acid (OA) is a pentacyclic triterpenoid with broad biological activity, but its primary molecular points of engagement remain incompletely resolved. Most available studies describe OA through selected pathway markers, particularly within PI...
As social media becomes increasingly embedded in daily life, understanding the psychological mechanisms that shape users’ digital experiences is essential for promoting healthy, sustainable digital behavior. This study examines two motivational...
Background: Although genetic-environmental interactions are established in autism spectrum disorder (ASD), how environmental toxicants confer susceptibility remains unclear. This study aimed to investigate potential relationship between genetically p...
High-dimensional metabolomics analyses may identify convergent and divergent markers, potentially representing aligned or orthogonal disease pathways that underly conditions such as pulmonary arterial hypertension (PAH). Using a comprehensive PAH met...
Background/Objectives: Colorectal neoplasia is accompanied by reproducible changes in the gut microbiome and fecal metabolome, but the receptor systems through which altered microbial metabolic outputs may interface with the host remain incompletely...
19 April 2016
In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a fra...
The global shortage of qualified cybersecurity professionals continues to intensify, underscoring the need for targeted and practice-oriented education and training. This study examines and compares the cybersecurity competencies emphasized in higher...
Evidence of familial inheritance in non-medullary thyroid cancer (NMTC) has accumulated over the last few decades. However, known variants account for a very small percentage of the genetic burden. Here, we focused on the identification of common pat...
In a prospective study, 48 fetuses were evaluated with Doppler ultrasound after 34 weeks and classified, according to the cerebroplacental ratio (CPR) and estimated fetal weight (EFW), into fetuses with normal growth and fetuses with late-onset fetal...
Background/Objectives: The COVID-19 pandemic highlighted the critical need for drug repurposing. While computational graph-based approaches show promise, single analytical methods often fail to capture the complex pathological mechanisms needed for c...
Smart aviation has received significant attention from various stakeholders in China as its advancement holds crucial implications for the aviation industry, and there is a growing need for aviation authorities to assess the extent of its development...
Chronic lung diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, and idiopathic pulmonary fibrosis, are clinically distinct but share epithelial injury, host-defense, inflammatory, and remodeling processes. We integrate...
The vast majority of today’s chemical products are based on crude oil. An attractive and sustainable alternative feedstock is biomass. Since crude oil and biomass differ in various properties, new synthesis pathways and processes have to be develope...
Depression and breast cancer (BC) demonstrate significant clinical comorbidity, yet their shared molecular mechanisms remain unclear, particularly regarding immune pathway regulation. This study systematically analyzed Depression-associated gene expr...
27 September 2023
The participation of civil society is essential for environmental health policies to be accepted. The objective of this study was to know the perceptions of government officials, members of civil society, and academics about environmental health prob...
Bridging high-throughput screening (HTS) with RNA interference (RNAi) has allowed for rapid discovery of the molecular basis of many diseases, and identification of potential pathways for developing safe and effective treatments. These features have ...
COVID-19 remains a relevant area of biomedical investigation because its pathogenesis involves complex virus–host interactions. This study aimed to explore, through purely in silico and hypothesis-generating insights, the predicted molecular as...
Osteosarcoma is the most common subtype of primary bone cancer, affecting mostly adolescents. In recent years, several studies have focused on elucidating the molecular mechanisms of this sarcoma; however, its molecular etiology has still not been de...
Background/Objectives: Asthenozoospermia, characterized by reduced sperm motility, is a common cause of male infertility. Emerging evidence suggests that noncoding RNAs, particularly long noncoding RNAs (lncRNAs), play a critical role in the regulati...
Feline intestinal inflammation is a common gastrointestinal disorder in cats and is associated with immune dysregulation, epithelial barrier injury, microbial imbalance, and persistent inflammatory signaling. This entirely in silico study investigate...
Identifying causal genetic variants and candidate genes underlying complex traits remains a central challenge in animal breeding and genetics. Genome-wide association studies (GWAS) are widely used for this purpose. However, their reliance on margina...
The consolidation and closure of small schools in rural areas has not only worsened the educational environment but also risked accelerating the socioeconomic decline of rural communities. This study examines how elementary school closures affect edu...
Background/Objectives: Oligozoospermia is a common cause of male infertility, yet its genetic basis remains incompletely understood, particularly in underrepresented populations. This exploratory pooled-WGS study aimed to identify and prioritize cand...
Urban environments in developing countries remain affected by legacy asbestos-containing materials, yet integrated assessments of multi-pathway asbestos release and environmental mobilization integrated with demographic distribution remain limited. T...
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial disorder driven by tightly interconnected metabolic, inflammatory, and lipid dysregulation pathways. Glycyrrhetinic acid, a pentacyclic triterpenoid deri...
Over the past few years, sustainable supply chain initiatives (SSCIs) have grabbed attention in the domestic, as well as global, marketplace of the food sector. Nowadays, the success of the entire food supply chain depends on the prosperity of farms,...
In small islands, the potential for new coastal activities and management options are often spatially limited. To reduce dependence on external factors and increase the resilience of populations to global changes and fluctuations in international mar...
Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have e...
As a necessarily political act, the theorizing, debating and enacting of ecological economies offer pathways to radical socio-economic transformations that emphasize the ecological and prioritize justice. In response to a research agenda call for eco...
Pesticides kill neurons, but the mechanism leading to selective dopaminergic loss in Parkinson’s disease (PD) is unknown. Understanding the pesticide’s effect on dopaminergic neurons (DA) can help to screen and treat PD. The critical upta...
Drought significantly disrupts rice productivity under increasing climate volatility. Identifying robust molecular determinants for resilience remains a critical priority for crop improvement. Following the PRISMA guidelines, we performed a large-sca...
Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies that are the leading cause of cancer-related death worldwide. Although many NSCLC-related genes and pathways have been identified, there remains an urgent need to mec...
How can transforming monocultures to diverse polycultures address and solve the intersecting issues of our food system? This literature review offers community resources, practical examples, and academic research to support the shift away from monocu...
Large-scale genome-mining analyses have identified an enormous number of cryptic biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products. Given the sheer number of natural product (NP) candidates, effective strategies...
This study proposes an explainable artificial intelligence (XAI) engineering workflow for provider-level healthcare claim audit prioritization using SHAP-guided hybrid retrieval-augmented generation (RAG). The framework integrates provider-level clai...
Background/Objectives: Obesity and related metabolic diseases arise from an interplay of lipid overload, insulin resistance and oxidative stress. Acetyl-CoA carboxylase 2 (ACC2) controls malonyl-CoA production and thereby gates mitochondrial fatty-ac...
The convenience of commuting for individuals using mobility aids (IMAs) depends on various features of urban road infrastructure. The present research selected different pathways based on the relevance and convenience of IMAs in three regions of Saud...
Background/Objectives: The mTOR serine/threonine kinase coordinates protein translation, cell growth, and metabolism, and its dysregulation promotes tumorigenesis. We present a reproducible, pan-cancer, network-aware framework that integrates curated...
Autism spectrum disorder (ASD) is a complex multifactorial neurodevelopmental disorder. Despite extensive research involving genome-wide association studies, copy number variant (CNV) testing, and genome sequencing, the comprehensive genetic landscap...
As drivers of climate action, cities are taking measures to reduce greenhouse gas (GHG) emissions, which if left unabated pose a challenge to meeting long-term climate targets. The economics of climate action needs to be at the forefront of climate d...
of 32