Pathogenesis of Pregnancy-Related Complications

Dear Colleagues,

Preeclampsia, HELLP syndrome, fetal growth restriction, gestational diabetes mellitus, preterm birth (preterm prelabor rupture of membranes and spontaneous preterm labour) and invasive placenta are major complications responsible for maternal and perinatal morbidity and mortality. Elucidation of the pathogenetic mechanisms related to the initiation and onset of severe pregnancy-related complications enables the identification of potential biomarkers for early stratification of at-risk patients. Additionally, pregnancy-related complications induce long-term metabolic and vascular abnormalities that might increase the overall risk of metabolic, cardiovascular, cerebrovascular, kidney, and other diseases later in life in mothers and their offspring. This Topic aims to provide an overview of the latest research on the mechanisms associated with pregnancy-related complications, as well as the contribution of pregnancy-related complications to the later development of various diseases. This will include the underlying mechanisms, diagnostics/prognostics and treatment strategies associated with pregnancy-related complications, and will be of interest to scientists and clinicians working in this quickly expanding area.

Topics will include (but are not limited to):

• Pathogenesis of pregnancy-related complications
• Diagnosis and prognosis of pregnancy-related complications
• Short-term and long-term follow-up after pregnancy-related complications (mothers and offspring)
• Novel treatment modalities of pregnancy-related complications and their short-term and long-term consequences.

Prof. Dr. Ilona Hromadnikova
Dr. Katerina Kotlabova
Topic Editors