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34,320 Results Found

  • Article
  • Open Access
9 Citations
6,594 Views
26 Pages

22 February 2023

Human-related issues have become a popular topic in maritime safety research, with an increasing number of relevant research articles being published annually. However, a persistent problem in this field is that three terms, namely “human eleme...

  • Article
  • Open Access
55 Citations
15,164 Views
16 Pages

The Role of the Human Factor in Marine Accidents

  • Nermin Hasanspahić,
  • Srđan Vujičić,
  • Vlado Frančić and
  • Leo Čampara

A common interest of all shipping industry stakeholders is safe and accident-free shipping. To reach that goal, one of the most important actions that can be done is to analyze previous marine accidents. It means finding causes of accidents and, base...

  • Article
  • Open Access
12 Citations
3,948 Views
18 Pages

This article discusses the issues related to the safety for the transport of dangerous goods by road. Research on accidents in transport unambiguously points to the human factor, which is the most responsible for causing accidents. Determining the ca...

  • Article
  • Open Access
2 Citations
5,713 Views
27 Pages

Phishing and the Human Factor: Insights from a Bibliometric Analysis

  • Meltem Mutlutürk,
  • Martin Wynn and
  • Bilgin Metin

15 October 2024

Academic research on the human element in phishing attacks is essential for developing effective prevention and detection strategies and guiding policymakers to protect individuals and organizations from cyber threats. This bibliometric study offers...

  • Article
  • Open Access
8 Citations
3,840 Views
25 Pages

Human Factor Analysis of the Railway Traffic Operators

  • Aleš Janota,
  • Rastislav Pirník,
  • Juraj Ždánsky and
  • Peter Nagy

19 September 2022

The human factor is an essential aspect of the operability and safety of many technical systems. This paper focuses on the analysis of human errors in the railway domain. The subject of human reliability analysis is the behavior of operators of stati...

  • Article
  • Open Access
27 Citations
14,855 Views
18 Pages

Organizations adopt diverse strategies to govern the technical and managerial aspects of sustainability implementation processes. The need for better leading and managing people-related issues emerges as companies aim for more effective change toward...

  • Article
  • Open Access
11 Citations
2,364 Views
14 Pages

The disassembly of spent lithium batteries is a prerequisite for efficient product recycling, the first link in remanufacturing, and its operational form has gradually changed from traditional manual disassembly to robot-assisted human–robot co...

  • Article
  • Open Access
7 Citations
3,498 Views
16 Pages

22 June 2022

In recent years, there has been a trend toward automation and data exchange in manufacturing processes through industrial cognitive computing, the Internet of Things (IoT), and artificial intelligence. However, the human–machine interface plays...

  • Review
  • Open Access
49 Citations
6,246 Views
20 Pages

The idea of remote controlling ships for operational and commercial uses has developed beyond concepts. Controlling and monitoring vessels from a distant location requires updating the concept and requirements of shore control centers (SCCs), where h...

  • Article
  • Open Access
11 Citations
4,357 Views
16 Pages

7 March 2022

Human activities involving nature have various environmental impacts. The assessment of the spatial and temporal evolution of human activity intensity (HAI) and its driving forces is significant for determining the effects of human activities on regi...

  • Feature Paper
  • Article
  • Open Access
14 Citations
5,372 Views
11 Pages

This paper is intended to give an overview of the experiments to evaluate the cognitive load of the officer on watch (OOW) during a collision avoidance maneuver in a full-mission simulator. The main goal is to investigate the possibilities of recordi...

  • Article
  • Open Access
2 Citations
1,618 Views
16 Pages

28 February 2025

Remotely piloted aircraft are a fast-emerging sector of the aviation industry. Although technical failures have been the largest cause of accident occurrences for Remotely Piloted Aircraft Systems (RPASs), if they are to follow the path of convention...

  • Article
  • Open Access
10 Citations
3,771 Views
11 Pages

Expression of Recombinant Human Octamer-Binding Transcription Factor 4 in Rice Suspension Cells

  • Li-Fen Huang,
  • Desyanti Saulina Sinaga,
  • Chia-Chun Tan,
  • Shu-Ju Micky Hsieh and
  • Chi-Hung Huang

30 January 2021

The rice cell suspension culture system is a good way to produce recombinant human proteins, owing to its high biosafety and low production cost. Human Octamer-binding Transcription Factor 4 (Oct4) is a fundamental transcription factor responsible fo...

  • Article
  • Open Access
1,437 Views
11 Pages

Deep Learning Methods to Mitigate Human-Factor-Related Accidents in Maritime Transport

  • Genaro Cao-Feijóo,
  • José M. Pérez-Canosa,
  • Francisco J. Pérez-Castelo and
  • José A. Orosa

12 October 2024

Artificial intelligence aims to be the solution to multiple engineering problems by trying to emulate the human learning process. In this sense, maritime transport standards have clearly evolved, which are based on two principal pillars: the Internat...

  • Article
  • Open Access
10 Citations
3,638 Views
7 Pages

Macro Modeling of V-Shaped Electro-Thermal MEMS Actuator with Human Error Factor

  • Dongpeng Zhang,
  • Anjiang Cai,
  • Yulong Zhao and
  • Tengjiang Hu

The V-shaped electro-thermal MEMS actuator model, with the human error factor taken into account, is presented in this paper through the cascading ANSYS simulation model and the Fuzzy mathematics calculation model. The Fuzzy mathematics calculation m...

  • Article
  • Open Access
11 Citations
3,269 Views
31 Pages

The operational activities conducted in a shipyard are exposed to high risk associated with human factors. To investigate human factors involved in shipyard operational accidents, a double-nested model was proposed in the present study. The modified...

  • Article
  • Open Access
1 Citations
4,351 Views
14 Pages

Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

  • Kirstin O. McDonald,
  • Nikita M. A. Lyons,
  • Luca K. C. Gray,
  • Janet B. Xu,
  • Lucia Schoderboeck,
  • Stephanie M. Hughes and
  • Indranil Basak

11 June 2024

Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons hav...

  • Article
  • Open Access
25 Citations
5,281 Views
20 Pages

A Study of the Human Factor in Industry 4.0 Based on the Automotive Industry

  • Mariusz J. Ligarski,
  • Barbara Rożałowska and
  • Krzysztof Kalinowski

19 October 2021

Human factor plays an important role in the implementation of the fourth industrial revolution (Industry 4.0). The concept of Industry 4.0 is poorly researched, particularly the social aspect. The authors have conducted a study to determine the level...

  • Article
  • Open Access
4 Citations
2,035 Views
15 Pages

Human Factor Interrelationships to Improve Worker Reliability: Implementation of MCDM in the Agri-Food Sector

  • Concetta Manuela La Fata,
  • Antonio Giallanza,
  • Luca Adelfio,
  • Rosa Micale and
  • Giada La Scalia

Performance Shaping Factors (PSFs) are contextual, individual, and cognitive factors used in Human Reliability Analysis (HRA) to quantify the worker contribution to errors when performing a generic task. Although the empirical evidence demonstrates t...

  • Article
  • Open Access
786 Views
18 Pages

Biosynthesis of Bioactive Human Neurotrophic Factor 3 in Silkworms and Its Biomedical Applications

  • Wenjing Geng,
  • Liang Lu,
  • Tangmin Li,
  • Mingyi Zhou,
  • Wei Chen,
  • Hao Tan,
  • Debin Zhong,
  • Guanwang Shen,
  • Ping Lin and
  • Qingyou Xia
  • + 2 authors

27 June 2025

Neurotrophic factor 3 (NT-3), a potent neurotrophin, promotes neuronal survival and axonal regeneration while demonstrating a unique capacity to induce lineage-specific differentiation of pluripotent stem cells into functional neurons, underscoring i...

  • Article
  • Open Access
4 Citations
2,562 Views
15 Pages

Cycle-Inhibiting Factor Is Associated with Burkholderia pseudomallei Invasion in Human Neuronal Cells

  • Amporn Rungruengkitkun,
  • Niramol Jitprasutwit,
  • Watcharamat Muangkaew,
  • Chantira Suttikornchai,
  • Sarunporn Tandhavanant,
  • Nitaya Indrawattana,
  • Sumate Ampawong,
  • Passanesh Sukphopetch,
  • Narisara Chantratita and
  • Pornpan Pumirat

1 October 2022

Burkholderia pseudomallei is a pathogenic bacterium that causes human melioidosis, which is associated with a high mortality rate. However, the underlying mechanisms of B. pseudomallei pathogenesis are largely unknown. In this study, we examined the...

  • Article
  • Open Access
6 Citations
6,984 Views
14 Pages

Expression of Hepatocyte Growth Factor-Like Protein in Human Wound Tissue and Its Biological Functionality in Human Keratinocytes

  • James C. Glasbey,
  • Andrew J. Sanders,
  • David C. Bosanquet,
  • Fiona Ruge,
  • Keith G. Harding and
  • Wen G. Jiang

4 February 2015

Hepatocyte growth factor-like protein (HGFl) and its receptor, Recepteur d'Origine Nantais (RON), have been implicated in the development of wound chronicity. HGFl and RON expression was detected in acute wound tissue, chronic wound tissue and in nor...

  • Article
  • Open Access
1 Citations
2,407 Views
14 Pages

Mouse Syngeneic Melanoma Model with Human Epidermal Growth Factor Receptor Expression

  • Tatiana A. Slastnikova,
  • Andrey A. Rosenkranz,
  • Alexey V. Ulasov,
  • Yuri V. Khramtsov,
  • Tatiana N. Lupanova,
  • Georgii P. Georgiev and
  • Alexander S. Sobolev

The development of epidermal growth factor receptor (EGFR)-targeting agents for the treatment of malignant melanoma requires cheap and easy animal tumor models for high-throughput in vivo screening. Thus, the aim of this study was to develop mouse sy...

  • Article
  • Open Access
7 Citations
2,766 Views
25 Pages

Development of a Business Assessment and Diagnosis Tool That Considers the Impact of the Human Factor during Industrial Revolutions

  • Maximilian B. Torres,
  • Diego Gallego-García,
  • Sergio Gallego-García and
  • Manuel García-García

14 January 2022

Over time, the satisfaction of needs and the ability to meet them have consistently increased. However, the world of the 21st century is one in which the basic needs of millions of human beings are still not satisfied. Why? To an extent, nonprofit or...

  • Review
  • Open Access
25 Citations
5,528 Views
14 Pages

Human Factor in Food Label Design to Support Consumer Healthcare and Safety: A Systematic Literature Review

  • Angelo Corallo,
  • Maria Elena Latino,
  • Marta Menegoli,
  • Biagia De Devitiis and
  • Rosaria Viscecchia

25 July 2019

Labels play a strategic role in communication, representing the interface between consumers and the food system. Consumers’ ability to correctly understand product label information was essential for health and safety, making a sustainable choi...

  • Article
  • Open Access
11 Citations
4,815 Views
11 Pages

High Efficient Expression and Purification of Human Epidermal Growth Factor in Arachis Hypogaea L.

  • Qingshou Yao,
  • Zipeng Yu,
  • Pu Liu,
  • Hao Zheng,
  • Yang Xu,
  • Sixiang Sai,
  • Yuyong Wu and
  • Chengchao Zheng

Background: Human epidermal growth factor (hEGF) has drawn intense research attention due to its potential ability to promote healing of serious injuries, such as cuts, burns, and diabetic ulcers. Although hEGF displays prospective clinical value, th...

  • Article
  • Open Access
9 Citations
3,381 Views
10 Pages

Near-infrared technology is an emerging non-invasive technique utilized for various medical applications. Recently, there have been many attempts to utilize NIR technology for the continues monitoring of blood glucose levels through the skin. Differe...

  • Article
  • Open Access
1,160 Views
19 Pages

5 March 2025

In this paper, the authors draw attention to the significant impact of the human factor during collision situations in maritime navigation. The problems in the communication process between navigators are so excessive that the authors propose automat...

  • Article
  • Open Access
6 Citations
3,744 Views
13 Pages

Nedd8-Activating Enzyme Is a Druggable Host Dependency Factor of Human and Mouse Cytomegalovirus

  • Yulia Alejandra Flores-Martínez,
  • Vu Thuy Khanh Le-Trilling and
  • Mirko Trilling

14 August 2021

Human cytomegalovirus causes diseases in individuals with insufficient immunity. Cytomegaloviruses exploit the ubiquitin proteasome pathway to manipulate the proteome of infected cells. The proteasome degrades ubiquitinated proteins. The family of cu...

  • Article
  • Open Access
3 Citations
3,075 Views
17 Pages

Tactile feedback technology has important development prospects in interactive technology. In order to enrich the tactile sense of haptic devices under simple control, a piezoelectric haptic feedback device is proposed. The piezoelectric tactile feed...

  • Article
  • Open Access
1 Citations
3,913 Views
16 Pages

Discovery of a Novel Antiviral Effect of the Restriction Factor SPOC1 against Human Cytomegalovirus

  • Anna K. Kuderna,
  • Anna Reichel,
  • Julia Tillmanns,
  • Maja Class,
  • Myriam Scherer and
  • Thomas Stamminger

27 February 2024

The chromatin-remodeler SPOC1 (PHF13) is a transcriptional co-regulator and has been identified as a restriction factor against various viruses, including human cytomegalovirus (HCMV). For HCMV, SPOC1 was shown to block the onset of immediate-early (...

  • Article
  • Open Access
16 Citations
2,830 Views
19 Pages

In the face of resource and environmental problems caused by extensive economic development, China has put forward a green development strategy. Scientific measurement and analysis of green total factor productivity (GTFP) is of great significance fo...

  • Review
  • Open Access
38 Citations
6,878 Views
15 Pages

Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment

  • Kazuya Kitamura,
  • Narihito Nagoshi,
  • Osahiko Tsuji,
  • Morio Matsumoto,
  • Hideyuki Okano and
  • Masaya Nakamura

28 February 2019

Hepatocyte growth factor (HGF) was first identified as a potent mitogen for mature hepatocytes, and has also gained attention as a strong neurotrophic factor in the central nervous system. We found that during the acute phase of spinal cord injury (S...

  • Article
  • Open Access
1,017 Views
18 Pages

Stromal Interferon Regulatory Factor 3 Can Antagonize Human Papillomavirus Replication by Supporting Epithelial-to-Mesenchymal Transition

  • Oluwamuyiwa T. Amusan,
  • Rebecca Lopez,
  • Elijah Burks,
  • Jessica Trammel,
  • Gaurav Raikhy,
  • Hongyan Guo and
  • Jason Bodily

23 April 2025

Epithelia contribute to the innate immune system through barrier formation and through signaling to immune cells. When the barrier is breached, epithelial cells undergo epithelial-to-mesenchymal transition (EMT) as part of the wound healing process....

  • Article
  • Open Access
5 Citations
1,833 Views
25 Pages

29 January 2024

With the growing interest in radiant heating and cooling systems, driven by their improved efficiency and enhanced thermal comfort compared to air systems, there is an increasing need to develop a more accessible method for designers to understand th...

  • Article
  • Open Access
17 Citations
5,564 Views
31 Pages

Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution

  • Daniil Nikitin,
  • Andrew Garazha,
  • Maxim Sorokin,
  • Dmitry Penzar,
  • Victor Tkachev,
  • Alexander Markov,
  • Nurshat Gaifullin,
  • Pieter Borger,
  • Alexander Poltorak and
  • Anton Buzdin

6 February 2019

Background: Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulati...

  • Proceeding Paper
  • Open Access
1,224 Views
3 Pages

Aircraft are considered to be today one of the most impressive engineering marvels of mankind ever made. While servicing commercial and/or private air transport, milestones of state-of art-technology are being achieved one after another, regularly, o...

  • Article
  • Open Access
4 Citations
3,235 Views
14 Pages

Continuous Secretion of Human Epidermal Growth Factor Based on Escherichia coli Biofilm

  • Chong Zhang,
  • Jinglin Liao,
  • Yuancong Li,
  • Shuli Liu,
  • Mengting Li,
  • Di Zhang,
  • Zhenyu Wang,
  • Dong Liu and
  • Hanjie Ying

Human epidermal growth factor (hEGF) holds significant importance in the fields of medicine and cosmetics. Therefore, it becomes imperative to develop a highly efficient fermentation system for hEGF production. In this study, a stable hEGF-secreting...

  • Article
  • Open Access
5 Citations
2,252 Views
16 Pages

Expression of Glial-Cell-Line-Derived Neurotrophic Factor Family Ligands in Human Intervertebral Discs

  • Tatsuya Iwasaki,
  • Koji Akeda,
  • Koki Kawaguchi,
  • Junichi Yamada,
  • Takahiro Hasegawa,
  • Norihiko Takegami,
  • Tatsuhiko Fujiwara and
  • Akihiro Sudo

1 November 2023

Glial-cell-line-derived neurotrophic factor (GDNF) family ligands (GFLs) contribute to the sensitization of primary afferents and are involved in the pathogenesis of inflammatory pain. The purpose of this preliminary study was to examine the expressi...

  • Article
  • Open Access
39 Citations
8,310 Views
29 Pages

2 December 2020

Traditionally, inertial measurement units- (IMU) based human joint angle estimation requires a priori knowledge about sensor alignment or specific calibration motions. Furthermore, magnetometer measurements can become unreliable indoors. Without magn...

  • Article
  • Open Access
10 Citations
3,096 Views
12 Pages

P25 Gene Knockout Contributes to Human Epidermal Growth Factor Production in Transgenic Silkworms

  • Meiyu Wu,
  • Jinghua Ruan,
  • Xiaogang Ye,
  • Shuo Zhao,
  • Xiaoli Tang,
  • Xiaoxiao Wang,
  • Huiping Li and
  • Boxiong Zhong

Transgenic silkworm expression systems have been applied for producing various recombinant proteins. Knocking out or downregulating an endogenous silk protein is considered a viable strategy for improving the ability of transgenic expression systems...

  • Review
  • Open Access
8 Citations
2,412 Views
11 Pages

Human Epidermal Growth Factor Receptor-2 Gastric Adenocarcinoma: Expanding Therapy of a Recognized Target

  • Jane E. Rogers,
  • Kohei Yamashita,
  • Matheus Sewastjanow-Silva,
  • Allison Trail,
  • Rebecca E. Waters and
  • Jaffer Ajani

27 October 2023

Human epidermal growth factor receptor-2 (HER2) is a well-known cancer target. Many HER2-targeted agents are marketed and being investigated. Unfortunately, these therapies lack consistent responses and outcomes amongst different tumors. Questions re...

  • Article
  • Open Access
24 Citations
9,659 Views
13 Pages

Is Dog Owner Obesity a Risk Factor for Canine Obesity? A “One-Health” Study on Human–Animal Interaction in a Region with a High Prevalence of Obesity

  • Lourdes Suarez,
  • Inmaculada Bautista-Castaño,
  • Cristina Peña Romera,
  • José Alberto Montoya-Alonso and
  • Juan Alberto Corbera

Obesity in humans is a growing global problem and is one of the greatest public health challenges we face today. Most researchers agree that, as in humans, the incidence in the companion animal population is also increasing. The aim of this study was...

  • Article
  • Open Access
5 Citations
4,582 Views
24 Pages

A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

  • Nawal Abd El-Baky,
  • Esmail M. EL-Fakharany,
  • Soraya A. Sabry,
  • Ehab R. El-Helow,
  • Elrashdy Mustafa Redwan and
  • Amira Sabry

19 January 2022

Cell-free (in vitro) expression is a robust alternative platform to the cell-based (in vivo) system for recombinant protein production. Tumor necrosis factor-alpha (TNF-α) is an effective pro-inflammatory cytokine with pleiotropic effects. The...

  • Article
  • Open Access
5 Citations
3,311 Views
18 Pages

Selective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte Binding

  • Yuefang Ma,
  • Liam M. Ashander,
  • Binoy Appukuttan,
  • Feargal J. Ryan,
  • Alwin C. R. Tan,
  • Janet M. Matthews,
  • Michael Z. Michael,
  • David J. Lynn and
  • Justine R. Smith

7 February 2023

The interaction between leukocytes and cytokine-activated retinal endothelium is an initiating step in non-infectious uveitis involving the posterior eye, mediated by cell adhesion molecules. However, because cell adhesion molecules are required for...

  • Systematic Review
  • Open Access
5 Citations
3,622 Views
21 Pages

10 May 2024

In the realms of operations management (OM) and supply chain management (SCM), the significance of the human factor (HF) is increasingly recognised as a pivotal determinant of corporate performance. This burgeoning interest aligns with the recognitio...

  • Article
  • Open Access
37 Citations
7,504 Views
13 Pages

In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells

  • Hyun Ji Eo,
  • Tae-Hyung Kwon,
  • Gwang Hun Park,
  • Hun Min Song,
  • Su-Jin Lee,
  • Nyun-Ho Park and
  • Jin Boo Jeong

29 March 2016

Phlorofucofuroeckol A (PFF-A), one of the phlorotannins found in brown algae, has been reported to exert anti-cancer property. However, the molecular mechanism for the anti-cancer effect of PFF-A has not been known. Activating transcription factor 3...

  • Review
  • Open Access
9 Citations
6,370 Views
29 Pages

A Comprehensive Review on the Role of Human Epidermal Growth Factor Receptor 2 (HER2) as a Biomarker in Extra-Mammary and Extra-Gastric Cancers

  • Fnu Amisha,
  • Paras Malik,
  • Prachi Saluja,
  • Nitesh Gautam,
  • Tanvi Harishbhai Patel,
  • Arya Mariam Roy,
  • Sunny R. K. Singh and
  • Sindhu Janarthanam Malapati

26 May 2023

The human epidermal growth factor receptors (HERs) are expressed abundantly in the human body. The tumorigenic potential of HER2/neu is linked to its overexpression, amplification or somatic mutation. The HER2 gene amplification leading to protein ov...

  • Article
  • Open Access
5 Citations
4,420 Views
19 Pages

Thermostable Human Basic Fibroblast Growth Factor (TS-bFGF) Engineered with a Disulfide Bond Demonstrates Superior Culture Outcomes in Human Pluripotent Stem Cell

  • Sejong Kim,
  • Geun-Ho Kang,
  • Kyung Min Lim,
  • Yeokyung Shin,
  • Kwonwoo Song,
  • Sangrok Park,
  • Jongyub An,
  • Dae Young Kim,
  • Hang-Cheol Shin and
  • Ssang-Goo Cho

20 June 2023

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can differentiate into various tissues and are an essential source of various disease models and therapeutics. Various growth factors are required in order to culture pluri...

  • Article
  • Open Access
8 Citations
3,489 Views
17 Pages

Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts

  • Abigail J. Clevenger,
  • Andrea C. Jimenez-Vergara,
  • Erin H. Tsai,
  • Gabriel de Barros Righes,
  • Ana M. Díaz-Lasprilla,
  • Gustavo E. Ramírez-Caballero and
  • Dany J. Munoz-Pinto

29 December 2022

Growth factors (GF) are critical cytokines in wound healing. However, the direct delivery of these biochemical cues into a wound site significantly increases the cost of wound dressings and can lead to a strong immunological response due to the intro...

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