The chick embryo chorioallantoic membrane (CAM) represents a powerful in vivo model to study several physiological and pathological processes including inflammation and tumor progression. Nevertheless, the possibility of deepening the molecular proce...
Based on the plane–strain assumption, a calculation model of pile–soil–pile vertical coupling vibration response considering the scattering effect of passive piles is established in this paper. Using this model, the vertical displac...
One of the advantages of surface plasmon resonance is its sensitivity and real-time analyses performed by this method. These characteristics allow us to further investigate the interactions of challenging proteins like Rap1-interacting factor 1 (Rif1...
The transcription factor CCCTC-binding factor (CTCF) modulates pleiotropic functions mostly related to gene expression regulation. The role of CTCF in large scale genome organization is also well established. A unifying model to explain relationships...
The interaction between coagulation factors Xa and IXa and the activated state of their inhibitor, antithrombin (AT),have been investigated using X-ray diffraction studies. However, only mutagenesis data are available for non-activated AT. Our aim wa...
As regional interaction increases in an open economy, a region’s green total factor productivity in agriculture must be considered alongside relationships with other regions. In this study, the slack-based model (SBM) global Malmquist–Lue...
Gross Primary Productivity (GPP) plays a vital role in the terrestrial carbon cycle and ecosystem functioning. Understanding its spatio-temporal dynamics and driving mechanisms is critical for predicting ecosystem responses to climate change. China&r...
Virulence factors (VFs), produced by pathogens, facilitate pathogenic microorganisms to invade, colonize, and damage the host cells. Accurate VF identification advances pathogenic mechanism understanding and provides novel anti-virulence targets. Exi...
Obesity in humans is a growing global problem and is one of the greatest public health challenges we face today. Most researchers agree that, as in humans, the incidence in the companion animal population is also increasing. The aim of this study was...
Voltage-gated Na+ (Nav) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Nav channel α subunit that have been described (Nav1.1-Nav1.9), Nav1.1, Nav1.2, and Nav1.6 are the primary isoforms e...
Human Antigen Leukocyte-G (HLA-G) gene encodes an immune checkpoint molecule that has restricted tissue expression in physiological conditions; however, the gene may be induced in hypoxic conditions by the interaction with the hypoxia inducible facto...
Most growth factors are naturally occurring proteins, which are signaling molecules implicated in cellular multiple functions such as proliferation, migration and differentiation under patho/physiological conditions by interacting with cell surface r...
The unique geological conditions of karst regions create highly heterogeneous habitat characteristics, and the addition of human disturbance results in rocky desertification. Water and soil loss are the core questions, and moreover, runoff is the key...
Background: Risk of metastatic recurrence of breast cancer after initial diagnosis and treatment depends on the presence of a number of risk factors. Although most univariate risk factors have been identified using classical methods, machine-learning...
The NAM, ATAF1/2, and CUC2 (NAC) transcription factors form a large plant-specific gene family, which is involved in the regulation of tissue development in response to biotic and abiotic stress. To date, there have been no comprehensive studies inve...
Background and Objectives: In the context of disease prevention, interaction on an additive scale is commonly assessed to determine synergistic effects between exposures. While the “Relative Excess Risk due to Interaction” represents the...
The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric in...
The mechanism of pipe–soil interaction under frost heaving is complicated due to many factors affecting the pipe–soil system. In order to analyze the sensitivity of various pipe–soil interaction influencing factors and highlight the...
Rockfalls pose significant threats to infrastructure, transportation routes, and human safety in mountainous regions, making them a critical concern in natural hazard and risk management. Accurate prediction of rockfall behavior is essential for desi...
An insufficient functional relationship between adjustment factors and saturation flow rate (SFR) in the U.S. Highway Capacity Manual (HCM) method increases an additional prediction bias. The error of SFR predictions can reach 8–10%. To solve t...
Ubiquitin (Ub) specifically interacts with the Ub-associating domain (UBA) in a proteasomal shuttle factor, while the latter is involved in either proteasomal targeting or self-assembly coacervation. PINK1 phosphorylates Ub at S65 and makes Ub altern...
Occupant behavior is acknowledged as a main contribution to building energy consumption. Many efforts have been devoted to identifying the impact of occupant behaviors on building energy consumption. However, the lack of understanding of the interact...
14-3-3 proteins are regulatory proteins found in all eukaryotes and are known to selectively interact with phosphorylated proteins to regulate physiological processes. Through an affinity purification screening, many light-related proteins were reco...
In testing for main effects, the use of orthogonal contrasts for balanced designs with the factor levels not ordered is well known. Here, we consider two-factor fixed-effects ANOVA with the levels of one factor ordered and one not ordered. The object...
In the context of the global environment, the rapid advancement of Internet technology has facilitated a transition from traditional offline to online modes for corporate social responsibility (CSR) activities, leading to the emergence of virtual CSR...
The identification of influencing factors (IFs) of land surface temperature (LST) is crucial for developing effective strategies to mitigate global warming and conducting other relevant studies. However, most previous studies ignored the potential im...
Plants possess the remarkable ability to sense detrimental environmental stimuli and launch sophisticated signal cascades that culminate in tailored responses to facilitate their survival, and transcription factors (TFs) are closely involved in these...
17 June 2016
Hypertension is considered to be the result of genes, environment, and their interactions. Among them age, sex, tobacco use, alcohol consumption, and being overweight/obesity are well documented environmental determinants, and methylenetetrahydrofola...
Bri1-EMS Suppressor 1 (BES1) and Brassinazole Resistant 1 (BZR1) are two key transcription factors in the brassinosteroid (BR) signaling pathway, serving as crucial integrators that connect various signaling pathways in plants. Extensive genetic and...
As the global population rapidly ages with longer life expectancy and declining birth rates, the need for healthcare services and caregivers for older adults is increasing. Current research envisions addressing this shortage by introducing domestic s...
Large-scale vegetation restoration has caused complex changes in ecosystem service (i.e., ES) interactions. However, current analysis on the spatial interactions of ESs and their driving mechanisms remains deficient, limiting the adaptive management...
The main objective of this study is to investigate how interactive factors affect the vocabulary usage of second language learners in their spoken language. Participants were 24 L1 Chinese undergraduate students of L2 English at an advanced level. L2...
Background: There is a research gap between genetic predisposition, socioeconomic factors, and their interactions on thyroid tumorigenesis. Methods: Individual and genetic data were obtained from UK Biobank. Logistic regression models were used to ev...
29 September 2017
Obesity, which develops over time, is one of the leading causes of chronic diseases such as cardiovascular disease. However, hundreds of BMI (body mass index)-associated genetic loci identified through large-scale genome-wide association studies (GWA...
Background and Objectives: Patients with schizophrenia are often exposed to polypharmacotherapy, which may lead to drug—drug interactions. The aim of the study was to investigate the prevalence of potential drug—drug interactions (pDDIs) in hospitali...
Suspension bridges are the most common type of bridge used to cross the ocean. The cable clamps in suspension bridges clamp the main cables by bolt preload, but the elastic interaction of the bolts reduces the preload, which is detrimental to the for...
Few studies of frost heave mechanisms have considered multifactor interactions, particularly in unsaturated saline soils typical of northeastern China. We collected soil samples in western Jijin Province and assessed their potential frost heave behav...
1 June 2018
In order to explore optimal strategies for managing potential human risk factors, this paper developed an interactive model among potential human risk factors based on the development processes of accidents. This model was divided into four stages, i...
Phytochrome-interacting factors (PIFs), members of the basic helix-loop-helix transcription factor family that have been extensively investigated in Arabidopsis thaliana, play essential roles in plant growth and development. However, PIF members have...
18 December 2017
Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP m...
Nowadays, drug–target interactions (DTIs) prediction is a fundamental part of drug repositioning. However, on the one hand, drug–target interactions prediction models usually consider drugs or targets information, which ignore prior knowl...
Accurate and stable positioning is significant for vehicle navigation systems, especially in complex urban environments. However, urban canyons and dynamic interference make vehicle sensors prone to disturbance, leading to vehicle positioning errors...
The multi-infeed interaction factor (MIIF) is used extensively in indicating the degree of interaction among high-voltage direct current (HVDC) converters and is currently calculated by simulation methods according to the definition, or by using the...
Urban ecological recreational space (UERS), as essential provider of ecosystem services, play a crucial role in enhancing human well-being. Nevertheless, limited research has investigated how various types of human–nature interaction influence...
Within globalization, the significance of urban innovation cooperation has become increasingly evident. However, urban innovation cooperation faces challenges due to various factors—social, economic, and spatial—making it difficult for tr...
The transcription factor SHE1 was induced by tobacco mosaic virus (TMV) infection in tobacco cv. Samsun NN (SNN) and SHE1 inhibited TMV accumulation when expressed constitutively. To better understand the role of SHE1 in virus infection, transgenic S...
1 October 2025
The purpose of this study is to examine the impact of integrity-related considerations, such as ethics, privacy, protection, security, and trust, on online consumer shopping intention within the interactive marketing environment. To achieve this, the...
The interaction between pre-sowing seed priming and soil drought on wheat physiological performance and allelopathic potential has been studied in alaboratory pot experiment. Amixture of cinnamic, salicylic and ascorbic acids (0.01, 0.1 and 1 mM) was...
Tire–road friction is a fundamental factor in vehicle safety, energy efficiency, and environmental sustainability. This narrative review synthesizes current knowledge on the tire–road friction coefficient (TRFC), emphasizing its dynamic n...
Although phenotypic plasticity facilitates the understanding of trait variation, its study remains limited. To study phenotypic plasticity, in this study, 203 inbred maize lines were phenotyped for flowering time and plant height in Zhengzhou, Ningji...
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