Background/Objectives: This study evaluated the real-world effectiveness of prophylactic Human Papillomavirus (HPV) vaccination in Korean women aged over 26 years, focusing on its impact on persistent HPV infection and disease progression. Methods: T...
Background/Objectives: Age-related macular degeneration (AMD) is a leading cause of visual impairment in older adults and often coexists with cataracts. The indication of presbyopia-correcting intraocular lenses (IOLs) in these patients remains contr...
In this paper, some new properties of Abel Grassmann‘s Neutrosophic Extended Triplet Loop (AG-NET-Loop) were further studied. The following important results were proved: (1) an AG-NET-Loop is weakly commutative if, and only if, it is a commuta...
We aimed to investigate whether a treat-and-extend regimen of intravitreal brolucizumab (6.0 mg/0.05 mL) is effective for eyes with exudative age-related macular degeneration (AMD) refractory to aflibercept for 12 months. Sixty eyes from 56 patients...
Our objective was to determine the effect of extending postmortem aging from 21 to 84 days on consumer eating quality of beef longissimus lumborum. Strip loins were collected from 108 carcasses. The longissimus lumborum muscle was isolated from strip...
Background/Objectives: Conventional audiometry assesses hearing in the frequency range of 250–8000 Hz, while humans can detect sounds from 20 to 20,000 Hz. Hearing sensitivity above 8000 Hz can be assessed through “Extended high-frequency...
Background/Objectives: We aimed to evaluate the efficacy of a flexible loading-phase treat-and-extend regimen using faricimab, in which the number of loading-phase intravitreal injections was tailored to individual disease activity. Methods: This obs...
Background/Objectives: Currently, treatments for age-related macular degeneration (AMD) consist of regular intravitreal injections that exert significant pressure on healthcare systems via their high labor costs and economic burden. To address this,...
The aim of the study was to establish the extended high frequency thresholds (EHF) of school-age children with no hearing complaints. The study was conducted on 50 children aged 8 to 12 years with pure tone thresholds (0.5, 1 and 2 kHz) of 15 dB HL o...
With the advent of anti-vascular endothelial growth factor (VEGF) therapy, clinicians are now focused on various treatment strategies to better control neovascular age-related macular degeneration (NVAMD), a leading cause of irreversible blindness. H...
Background: Mechanical thrombectomy (MT) has become increasingly common in recent years, as studies have shown that it can be an effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, the efficacy of MT i...
A group is an algebraic system that characterizes symmetry. As a generalization of the concept of a group, semigroups and various non-associative groupoids can be considered as algebraic abstractions of generalized symmetry. In this paper, the notion...
17 April 2018
Due to demographic changes, the employee structure in companies is changing dramatically. It will be necessary to offer employees suitable, age-adequate jobs. As one of its foremost goals, optimized business management strategies must create conditio...
As societies confront rapid demographic aging, developing inclusive and age-friendly environments has become a central challenge in urban and housing research. This study proposes an integrated conceptual framework for Aging in Community, extending t...
In many countries, the retirement age is postponed due to the global demographic change, and a larger amount of older people need to participate in working life. However, how and what measures and action proposals that could extend and increase emplo...
25 May 2021
Due to the global demographic change many more people will need to work until an older age, and organisations and enterprises need to implement measures to facilitate an extended working life. The aim of this study was to investigate organisational m...
18 January 2022
A larger amount of older people need to participate in working life due to the global demographic change. It is the employer, through the manager, who enables employees to have access to measures in the workplace that facilitate and enable a sustaina...
Determining the aging state of low-voltage nuclear power plant cables using a nondestructive and reliable condition monitoring technique is highly desirable as the cables experience multiple aging stresses during the service period. This paper deals...
4 March 2020
This paper identifies, within companies’ sectors of activity, predictors of Human Resource (HR) policies to extend working life (EWL) in light of increasing policy efforts at the European level to extend working life. Three types of EWL practic...
8 March 2021
To address the challenges of demographic aging, governments and organizations encourage extended working lives. This study investigates how individual health- and age-related workplace factors contribute to preferred, expected and actual retirement t...
This paper explores the evolving relationship between Digital Twins (DT) and the Metaverse, two foundational yet often conflated digital paradigms in digital architecture. While DTs function as mirrored models of real-world systems—integrating...
Our objective was to evaluate changes in patient-reported outcome measures using the NEI-VFQ 25 questionnaire during a treat and extend regimen in naive neovascular Age-Related Macular Degeneration patients, and its correlation with anatomical and fu...
Hearing is normally evaluated up to 8 kHz, even though testing can easily be performed at higher frequencies (up to 16 or 20 kHz). The range beyond 8 kHz is often referred to as the extended high frequency (EHF) range. This study aimed to explore the...
Although XLPE cables are widely used in power transmission and distribution systems, their insulating properties are susceptible to degradation due to thermal aging. In order to clarify the influence law of the thermal aging process on the structural...
Ambient temperature affects the performance of a battery power system and its accuracy in state-of-charge (SOC) estimation for electric vehicles and smart grid systems. This paper proposes a battery model that considered ambient temperature, cell tem...
There is limited research on the fracture toughness of carbon-fiber-reinforced polymer (CFRP) materials under accelerated UV aging conditions. In this study, the primary focus was on investigating the influence of varying durations of ultraviolet (UV...
Low-voltage cable systems in nuclear power plants are key components that have a crucial role in the safe operation of nuclear facilities. Thus, the aging management of cable systems is of utmost importance as they cannot easily or economically be re...
18 May 2022
To counteract the shortage of nurses in the workforce, healthcare organizations must encourage experienced nurses to extend their working lives. Intensive care (IC) has higher nurse-to-patient ratios than other settings, which includes a particular s...
Previous studies have demonstrated relationships between religiosity, physical and mental health-related outcomes, and healthy collective longevity. This qualitative study investigated the elements of pleasure and fulfillment in older adults living i...
As the world moves toward greenhouse gas reduction, there is increasingly active work around Li-ion chemistry-based batteries as an energy source for electric vehicles (EVs), hybrid electric vehicles (HEVs) and smart grids. In these applications, the...
The widespread use of drugs that bind diffusible vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (AMD). The pivotal ranibizumab and aflibercept registration trials featured mo...
Objective: The study aimed to determine the outcomes and prognostic factors of vitrectomy, subretinal injection of tissue-plasminogen activator and gas tamponade in macular hemorrhage (MaH) due to age-related macular degeneration (AMD) or retinal art...
30 August 2021
Social participation is important for health, and it is well known that high strain jobs impact negatively on mental and physical health. However, knowledge about the impact of psychosocial working conditions on social participation from a long-term...
Since battery systems typically account for over 40% of the cost of an electric vehicle, their mid-life replacements are exceptional. Therefore, the battery’s lifespan must exceed that of the vehicle. To ensure long-term and safe use, accurate...
Personalizing the management of neovascular age-related macular degeneration (nAMD) poses significant challenges for practicing retina specialists and their patients. This commentary addresses some of these complexities, particularly those that arise...
Treat and extend (T&E) is a standard treatment regimen for treating neovascular age-related macular degeneration (nAMD) with anti-vascular endothelial growth factors (anti-VEGFs), but the treatment intervals attained are not well documented. This...
Understanding of fracture mechanics of the human knee structures within total knee replacement (TKR) allows a better decision support for bone fracture prevention. Numerous studies addressed these complex injuries involving the femur bones but the fu...
Background: The aim of this study is to report short-term outcomes after the shortening of the treatment interval to 4 weeks with a treat-and-extend (TAE) regimen (Si4w) of aflibercept in patients with refractory neovascular age-related macular degen...
Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) have become the standard of care for age-related macular degeneration (AMD). Although most pivotal trials have used monthly injections, alternative strategies that e...
Egg yolk is a very common supplement of extenders aimed to protect sperm from cryoinjury, but due to their biological risks and difficulties with media standardization, there is a search for alternative. In addition, sperm cryoresistance can be affec...
Since the early 90s, Italy has undergone radical changes in the regulations of the public pension system aimed at mending its main drawbacks and improving sustainability in the long run. The reforms were intended to recover the national economy throu...
In this paper, for the case of “service life extension” with the same capacity for wind turbines, a structural safety evaluation was carried out to determine whether to extend the service life of the aged foundation. As a result of this s...
BAM15 was recently screened as a protonophore uncoupler specifically for the mitochondrial membrane but not the plasma membrane. It is equally as potent as FCCP, but less toxic. Previously, mitochondrial uncoupling via DNP alleviates neurodegeneratio...
Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging. In this study, we reveal that male Sirt7 knock...
This work investigated the role of an agnail device (manually made from a comb) on sludge size restriction and organic degradation in extended filamentous aerobic granular sludge-sequencing batch reactors (AGS-SBRs) with artificial wastewater. Two id...
In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioa...
Critical neuropsychological capabilities such as working memory, cognitive flexibility, and processing speed are foundational to many daily activities. For children, such skills are essential for school success. Thus, children who demonstrate weaknes...
β-hydroxy-β-methylbutyrate (HMB) has been shown to enhance muscle function and strength in older humans and rodents after periods of consumption extending for several weeks. We investigated the feasibility of utilizing Drosophila as a model...
The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have been explored in the current literature. However, the studies on the synergistic effects between the different flavonoid compounds were quite limited in pre...
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer. Specifically,...
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