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409 Results Found

  • Article
  • Open Access
1 Citations
5,018 Views
10 Pages

This paper employs the two-step procedure to analyze the causality-in-mean and causality-in-variance between the housing and stock markets of the UK. The empirical findings make two key contributions. First, although previous studies have indicated a...

  • Article
  • Open Access
29 Citations
5,984 Views
22 Pages

21 October 2018

This study examines the Granger-causal relationships between oil price movements and global stock returns by using time-varying Granger-causality tests in mean and in variance. We use the daily returns from Morgan Stanley Capital International (MSCI)...

  • Article
  • Open Access
17 Citations
3,889 Views
13 Pages

5 November 2021

While human capital and foreign capital have received considerable attention in the study of economic growth, foreign remittances are less of a focus. Though some studies have identified the increasing importance of remittances, they have failed to a...

  • Article
  • Open Access
7 Citations
4,184 Views
11 Pages

4 April 2022

China is the second largest aviation country in the world. The Chinese aviation industry and economy both developed quickly in the last two decades. However, the interaction mechanisms of aviation and the regional economy were different in each provi...

  • Article
  • Open Access
10 Citations
4,277 Views
20 Pages

A considerable number of studies have examined the relationship between global prices and local prices in food-importing nations, but the linkages between international prices and the producer prices of large agricultural exporters have been largely...

  • Article
  • Open Access
1 Citations
5,543 Views
30 Pages

10 December 2015

The results of the single-equation cointegration tests indicate that patterns of cointegration in the two main and four sub-periods are not homogeneous. Two key findings emerge from the study. First, fewer stock markets cointegrated with S&P 500...

  • Article
  • Open Access
2 Citations
4,426 Views
22 Pages

20 January 2023

The aim of this article is to supply the first empirical research inspecting how changes in diesel prices influence the prices of four agricultural commodities in Bulgaria. For this purpose, using a VECM and monthly agricultural commodity prices betw...

  • Article
  • Open Access
18 Citations
8,320 Views
5 Pages

A Simple Test for Causality in Volatility

  • Chia-Lin Chang and
  • Michael McAleer

An early development in testing for causality (technically, Granger non-causality) in the conditional variance (or volatility) associated with financial returns was the portmanteau statistic for non-causality in the variance of Cheng and Ng (1996). A...

  • Article
  • Open Access
1 Citations
2,278 Views
23 Pages

9 April 2021

Land use/cover and vegetation patterns are influenced by many ecological factors. However, the effect of various factors on different classification systems and different levels of the same system is unclear. We conducted a redundancy analysis with 1...

  • Article
  • Open Access
29 Citations
5,472 Views
10 Pages

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study

  • Weijie Cao,
  • Xingang Li,
  • Xiaoyu Zhang,
  • Jie Zhang,
  • Qi Sun,
  • Xizhu Xu,
  • Ming Sun,
  • Qiuyue Tian,
  • Qihuan Li and
  • Wei Wang
  • + 7 authors

14 February 2019

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association betwe...

  • Article
  • Open Access
3 Citations
3,376 Views
12 Pages

13 January 2023

The summary-data-based Mendelian randomization (SMR) method is gaining popularity in estimating the causal effect of an exposure on an outcome. In practice, the instrument SNP is often selected from the genome-wide association study (GWAS) on the exp...

  • Article
  • Open Access
7 Citations
7,345 Views
21 Pages

This paper reports a study on the causal dynamics between spot oil price, exchange rates, and stock prices in Poland, the Czech Republic, Hungary, Romania, and Serbia. The results are compared with a benchmark analysis in which U.S. monthly data are...

  • Article
  • Open Access
2 Citations
3,401 Views
25 Pages

Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus

  • Karen Chau,
  • Yanint Raksadawan,
  • Kristen Allison,
  • John A. Ice,
  • Robert Hal Scofield,
  • Iouri Chepelev and
  • Isaac T. W. Harley

22 September 2023

SjD (Sjögren’s Disease) and SLE (Systemic Lupus Erythematosus) are similar diseases. There is extensive overlap between the two in terms of both clinical features and pathobiologic mechanisms. Shared genetic risk is a potential explanation...

  • Article
  • Open Access
50 Citations
6,816 Views
17 Pages

Short and Long-Run Causal Effects of CO2 Emissions, Energy Use, GDP and Population Growth: Evidence from India Using the ARDL and VECM Approaches

  • Duraisamy Pachiyappan,
  • Yasmeen Ansari,
  • Md Shabbir Alam,
  • Prabha Thoudam,
  • Kuppusamy Alagirisamy and
  • Palanisamy Manigandan

10 December 2021

This paper investigates the nexus between CO2 emissions (CO2E), GDP, energy use (ENU), and population growth (PG) in India from 1980–2018 by comparing the “vector error correction” model (VECM) and “auto regressive distributed...

  • Article
  • Open Access
2 Citations
2,390 Views
14 Pages

The Causal Relationship between Inflammatory Cytokines and Liver Cirrhosis in European Descent: A Bidirectional Two-Sample Mendelian Randomization Study and the First Conclusions

  • Shiya Shi,
  • Yanjie Zhou,
  • He Zhang,
  • Yalan Zhu,
  • Pengjun Jiang,
  • Chengxia Xie,
  • Tianyu Feng,
  • Yuping Zeng,
  • He He and
  • Jie Chen
  • + 1 author

Background: Observational studies have highlighted the pivotal role of inflammatory cytokines in cirrhosis progression. However, the existence of a causal link between inflammatory cytokines and cirrhosis remains uncertain. In this study, we conducte...

  • Article
  • Open Access
22 Citations
4,121 Views
17 Pages

8 November 2019

This study is a maiden empirical attempt to examine the long-run linkage between households’ usage of energy and economic progression in Pakistan from the period of 1972–2017. The Autoregressive Distributive Lag (ARDL) bounds testing meth...

  • Article
  • Open Access
5 Citations
3,347 Views
14 Pages

A growing number of studies indicate that mitochondrial dysfunction serves as a pathological mechanism for periodontitis. Therefore, this two-sample Mendelian randomization (MR) study was carried out to explore the causal associations between mitocho...

  • Article
  • Open Access
22 Citations
3,112 Views
15 Pages

How Do Urban Land Expansion, Land Finance, and Economic Growth Interact?

  • Ke Zhao,
  • Danling Chen,
  • Xupeng Zhang and
  • Xiaojie Zhang

Land finance has consumed a lot of China’s urban land resources while contributing to its economic growth. Urban land expansion, land finance, and economic growth have attracted significant scholarly and social attention. However, the influence...

  • Article
  • Open Access
2 Citations
2,078 Views
25 Pages

Financial assets often exhibit explosive price surges followed by abrupt collapses, alongside persistent volatility clustering. Motivated by these features, we introduce a mixed causal–noncausal invertible–noninvertible autoregressive mov...

  • Article
  • Open Access
27 Citations
3,833 Views
26 Pages

Spillover and Drivers of Uncertainty among Oil and Commodity Markets

  • Muhammad Abubakr Naeem,
  • Saqib Farid,
  • Safwan Mohd Nor and
  • Syed Jawad Hussain Shahzad

23 February 2021

The paper aims to examine the spillover of uncertainty among commodity markets using Diebold–Yilmaz approach based on forecast error variance decomposition. Next, causal impact of global factors as drivers of uncertainty transmission between oil and...

  • Article
  • Open Access
3 Citations
2,262 Views
13 Pages

Piecewise Causality Study between Power Load and Vibration in Hydro-Turbine Generator Unit for a Low-Carbon Era

  • Lianda Duan,
  • Dekuan Wang,
  • Guiping Wang,
  • Changlin Han,
  • Weijun Zhang,
  • Xiaobo Liu,
  • Cong Wang,
  • Zheng Che and
  • Chang Chen

7 February 2022

With the rapid development of wind and photovoltaic power generation, hydro-turbine generator units have to operate in a challenging way, resulting in obvious vibration problems. Because of the significant impact of vibration on safety and economical...

  • Article
  • Open Access
8 Citations
4,014 Views
16 Pages

26 March 2024

Common age-related eye disorders include glaucoma, cataract, and age-related macular degeneration (AMD); however, little is known about their relationship with age. This study investigated the potential causal relationship between glaucoma and AMD wi...

  • Article
  • Open Access
2 Citations
4,232 Views
17 Pages

The potential relationship between type 2 diabetes (T2D) and candidiasis is of concern due to the respective characteristics of these conditions, yet the exact causal link between the two remains uncertain and requires further investigation. In this...

  • Article
  • Open Access
8 Citations
3,082 Views
20 Pages

The Causal Nexus among Energy Consumption, Environmental Degradation, Financial Development and Health Outcome: Empirical Study for Pakistan

  • Weal M.Gh. M. Arafat,
  • Ihtisham ul Haq,
  • Bahtiyar Mehmed,
  • Azeem Abbas,
  • Sisira Kumara Naradda Gamage and
  • Oruj Gasimli

3 March 2022

Pakistan is facing an energy crisis and is also severely affected by climate change. Moreover, Pakistan is not doing well as far as health outcome indicators are concerned. The causal nexus among energy, environment, and health outcomes is well-estab...

  • Article
  • Open Access
1 Citations
2,084 Views
21 Pages

A Novel Improvement of Feature Selection for Dynamic Hand Gesture Identification Based on Double Machine Learning

  • Keyue Yan,
  • Chi-Fai Lam,
  • Simon Fong,
  • João Alexandre Lobo Marques,
  • Richard Charles Millham and
  • Sabah Mohammed

13 February 2025

Causal machine learning is an approach that combines causal inference and machine learning to understand and utilize causal relationships in data. In current research and applications, traditional machine learning and deep learning models always focu...

  • Article
  • Open Access
115 Citations
9,066 Views
18 Pages

Green Finance, Chemical Fertilizer Use and Carbon Emissions from Agricultural Production

  • Lili Guo,
  • Shuang Zhao,
  • Yuting Song,
  • Mengqian Tang and
  • Houjian Li

22 February 2022

This study aimed to understand green finance’s impact on fertilizer use and agricultural carbon emissions. We selected the macro panel data of 30 provinces (cities) in China from 2000 to 2019. The main research methods are standardized test fra...

  • Article
  • Open Access
4 Citations
3,712 Views
17 Pages

The Causal Relationship between the Morning Chronotype and the Gut Microbiota: A Bidirectional Two-Sample Mendelian Randomization Study

  • Manman Chen,
  • Zhenghe Wang,
  • Din Son Tan,
  • Xijie Wang,
  • Zichen Ye,
  • Zhilan Xie,
  • Daqian Zhang,
  • Dandan Wu,
  • Yuankai Zhao and
  • Yu Jiang
  • + 1 author

22 December 2023

Background: Numerous observational studies have documented an association between the circadian rhythm and the composition of the gut microbiota. However, the bidirectional causal effect of the morning chronotype on the gut microbiota is unknown. Met...

  • Article
  • Open Access
7 Citations
2,943 Views
14 Pages

Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship between CRP levels and AMD. Single-nucleotide polym...

  • Article
  • Open Access
2 Citations
3,160 Views
13 Pages

12 June 2024

Recent research has highlighted associations between sleep and microbial taxa and pathways. However, the causal effect of these associations remains unknown. To investigate this, we performed a bidirectional two-sample Mendelian randomization (MR) an...

  • Communication
  • Open Access
28 Citations
6,522 Views
9 Pages

13 February 2023

Epidemiological studies have linked particulate matter (PM2.5) to gestational diabetes mellitus (GDM). However, the causality of this association has not been established; Mendelian randomization was carried out using summary data from genome-wide as...

  • Article
  • Open Access
2 Citations
2,622 Views
11 Pages

Bidirectional Two-Sample Mendelian Randomization Study of Immunoglobulin G N-Glycosylation and Senescence-Associated Secretory Phenotype

  • Haotian Wang,
  • Di Liu,
  • Xiaoni Meng,
  • Wenxin Sun,
  • Cancan Li,
  • Huimin Lu,
  • Deqiang Zheng,
  • Lijuan Wu,
  • Shengzhi Sun and
  • Youxin Wang

Observational studies revealed changes in Immunoglobulin G (IgG) N-glycosylation during the aging process. However, it lacks causal insights and remains unclear in which direction causal relationships exist. The two-sample bidirectional Mendelian ran...

  • Article
  • Open Access
1 Citations
2,083 Views
13 Pages

17 October 2024

Background: Glaucoma is a neurodegenerative ocular disease that is accompanied by cerebral damage extending beyond the visual system. Recent studies based on diffusion tensor tractography have suggested an association between glaucoma and brain struc...

  • Article
  • Open Access
6 Citations
4,072 Views
14 Pages

15 November 2024

Objectives: Observational research shows associations of the gut microbiota and its metabolites with autoimmune thyroid disease (AITD), but the causality is undetermined. Methods: Two-sample Mendelian randomization (MR) was employed to analyze the as...

  • Article
  • Open Access
7 Citations
3,265 Views
9 Pages

The Association between Blood Lipids and Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Research

  • Yang Ding,
  • Shasha Fan,
  • Yi Tang,
  • Mengjiao He,
  • Mingyang Ren,
  • Yunjuan Shi,
  • Xiaohua Tao and
  • Wei Lu

23 December 2022

We evaluated the causal effects of blood lipid levels on systemic lupus erythematosus with a two-sample Mendelian randomization analysis. Independent single-nucleotide polymorphisms related to blood lipids levels (p < 5 × 10−8) were se...

  • Article
  • Open Access
47 Citations
7,059 Views
14 Pages

28 February 2019

There exists a highly interrelated relationship between energy, the environment and growth where the efficient management of this nexus is not only a must for sustainable development and human wellbeing but is also a basis for formulating sound econo...

  • Article
  • Open Access
9 Citations
4,964 Views
14 Pages

1 December 2022

Several observational studies have indicated the potential associations among calcium, vitamin D (Vit-D), and irritable bowel syndrome (IBS). However, the causal relationship deduced from these studies is subject to residual confounding factors and r...

  • Article
  • Open Access
8 Citations
10,627 Views
23 Pages

Fluid Intelligence Is (Much) More than Working Memory Capacity: An Experimental Analysis

  • Dirk Hagemann,
  • Max Ihmels,
  • Nico Bast,
  • Andreas B. Neubauer,
  • Andrea Schankin and
  • Anna-Lena Schubert

Empirical evidence suggests a great positive association between measures of fluid intelligence and working memory capacity, which implied to some researchers that fluid intelligence is little more than working memory. Because this conclusion is most...

  • Article
  • Open Access
8 Citations
7,284 Views
18 Pages

On Spurious Causality, CO2, and Global Temperature

  • Philippe Goulet Coulombe and
  • Maximilian Göbel

Stips et al. (2016) use information flows (Liang (2008, 2014)) to establish causality from various forcings to global temperature. We show that the formulas being used hinge on a simplifying assumption that is nearly always rejected by the data. We p...

  • Feature Paper
  • Article
  • Open Access
925 Views
10 Pages

Testing for Causal Association Between Serum Urate, Gout, and Prostatic Cancer in European Males

  • Sumanth Chandrupatla,
  • Nicholas Sumpter,
  • Riku Takei,
  • Tony R. Merriman and
  • Jasvinder Singh

We conducted a two-sample Mendelian randomization (MR) study including only European men to test for a causal relationship between serum urate (SU), gout, and prostate cancer. Using genome-wide association (GWAS) data, we generated instrumental varia...

  • Article
  • Open Access
1,625 Views
13 Pages

16 December 2024

Background: A few studies have reported controversial relationships between atrial fibrillation/flutter (AF/L) and primary open-angle glaucoma (POAG). This study aimed to investigate the potential causal relationship between AF/L and POAG. Methods: S...

  • Article
  • Open Access
736 Views
13 Pages

Exploring the Links Between Ankylosing Spondylitis and Amyotrophic Lateral Sclerosis: A Bidirectional Mendelian Randomization Study

  • Adeyemi Timothy Akinade,
  • Ezekiel Damilare Jacobs,
  • Chucks Marvellous Obere,
  • Victor Omeiza Ogaji,
  • Emmanuel Alakunle and
  • Olaitan I. Awe

16 November 2025

Background: Very few case reports have explored a potential link between ankylosing spondylitis (AS), an autoimmune disorder, and amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative condition. We aimed to investigate whether genetic...

  • Article
  • Open Access
2 Citations
3,108 Views
23 Pages

Latent Association Between Diets and Glioma Risk: A Mendelian Randomization Analysis

  • Jixiang Zhao,
  • Changjia He,
  • Haoqun Xie,
  • Yunzhi Zou,
  • Zeming Yan,
  • Jingen Deng,
  • Yizhi Du,
  • Wenzhuo Yang and
  • Xiangheng Zhang

5 February 2025

Background: Gliomas, particularly high-grade gliomas such as glioblastoma, represent a major challenge due to their poor prognosis. While dietary factors have been proposed as potential modulators of glioma risk, causal inference has been hindered by...

  • Article
  • Open Access
10 Citations
9,248 Views
21 Pages

Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis

  • Shupeng Liu,
  • Yinyun Deng,
  • Hui Liu,
  • Zhengzheng Fu,
  • Yinghui Wang,
  • Meijuan Zhou and
  • Zhijun Feng

26 July 2024

Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore the causal relationship between different types of meat intake and ag...

  • Article
  • Open Access
28 Citations
3,177 Views
13 Pages

Causal Relationships of General and Abdominal Adiposity on Osteoarthritis: A Two-Sample Mendelian Randomization Study

  • Leifeng Lyu,
  • Yuanqing Cai,
  • Mofan Xiao,
  • Jialin Liang,
  • Guangyang Zhang,
  • Zhaopu Jing,
  • Rupeng Zhang and
  • Xiaoqian Dang

31 December 2022

Background: Adiposity is closely related to osteoarthritis, but the causal effects of different types of adiposity on osteoarthritis are indistinct. This study conducted a Mendelian Randomization (MR) analysis for the causal effects of general adipos...

  • Article
  • Open Access
13 Citations
3,981 Views
11 Pages

Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study

  • Ruyi Cong,
  • Xiaoyu Zhang,
  • Zihong Song,
  • Shanshan Chen,
  • Guanhua Liu,
  • Yizhi Liu,
  • Xiuyu Pang,
  • Fang Dong,
  • Weijia Xing and
  • Xizhu Xu
  • + 1 author

5 March 2022

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effect...

  • Brief Report
  • Open Access
3 Citations
2,106 Views
8 Pages

Both chronic hepatitis B (CHB) and stroke contribute to a high burden of disease in the majority of low- and middle-income countries. Epidemiological studies yield conflicting results on the association between CHB and stroke, and the causal relation...

  • Article
  • Open Access
1,941 Views
11 Pages

23 September 2024

This study explored the potential causal relationship between ibuprofen (IBU) use and the risk of developing osteoarthritis, a prevalent joint disorder characterized by pain and stiffness. We conducted a two-sample MR analysis using four distinct OA...

  • Article
  • Open Access
2,578 Views
14 Pages

13 January 2024

Background: Patients with angina are often suffering from comorbidities such as varying degrees of hepatic dysfunction. However, the impact of angina on the incidence of hepatic failure (HF) remains unclear. Methods: The genetic data were retrieved f...

  • Article
  • Open Access
3 Citations
3,684 Views
11 Pages

2 December 2022

Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of A...

  • Article
  • Open Access
503 Views
11 Pages

12 December 2025

Background/Objectives: Psoriasis and age-related macular degeneration (AMD) may share immune-related pathophysiologic characteristics. However, few studies have investigated the relationship between psoriasis and AMD. We assessed the possible causal...

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