This paper presents a new macroscopic method for identifying chop marks on archaeological faunal assemblages and highlights the major differences in the morphology of chop marks created by stone and metal axes. The method provides macroscopic criteri...
This study aimed to investigate the effect of arabinoxylans (AX) partial de-esterification with feruloyl esterase on the polysaccharide conformational behavior, topographical features, and antioxidant activity. After enzyme treatment, the ferulic aci...
Few examples of original strainers for paintings from the eighteenth century or earlier still exist as they have commonly been replaced due to their often-weak construction and inability to expand. Several original strainers, however, are still prese...
The replacement of fishmeal with plant-based proteins in aquafeeds is key for sustainable aquaculture but may compromise filet pigmentation in rainbow trout (Oncorhynchus mykiss), a quality trait dependent on astaxanthin (Ax) deposition and metabolis...
Rapid progress in the study on the association of histone modifications with chromatin remodeling factors has broadened our understanding of chromatin dynamics in DNA transactions. In DNA double-strand break (DSB) repair, the well-known mark of histo...
The present study reported, for the first time, the fabrication and characterization of electrospun nanofibers based on arabinoxylans (AXs) alone. The Fourier transform infrared spectrum of ferulated water-extractable AXs recovered from wheat endospe...
p53 protein is a nuclear phosphoprotein that is a critical tumor suppressor, playing a key role in regulating the cell cycle and initiating apoptosis in response to DNA damage. As a transcription factor, it also activates genes involved in DNA repair...
Background: In nuclear medicine, numerous cancer types are treated via internal irradiation with radiopharmaceuticals, including low-LET (linear energy transfer) beta-emitting radionuclides like Lu-177. In most cases, such treatments lead to low-dose...
Regioselective deprotection of acetylated mannose-based mono- and disaccharides differently functionalized in anomeric position was achieved by enzymatic hydrolysis. Candida rugosa lipase (CRL) and Bacillus pumilus acetyl xylan esterase (AXE) were im...
Background: Cancer patients are increasingly treated with alpha-particle-emitting radiopharmaceuticals. At the subcellular level, alpha particles induce densely spaced ionizations and molecular damage. Induction of DNA lesions, especially clustered D...
In the present investigation, we study the influence of conventual foundations on the origin of the urban layout of two of the first cities in the Spanish colonization of America: Santo Domingo (1502) and Panama Viejo (1519), examples of early coloni...
The prognosis and management of machine health statuses are emerging research topics. In this study, the performance degradation of a wafer-handling robot arm (WHRA) was predicted using the proposed machine-learning approach. This method considers th...
Micromagnetic computations were performed to predict the magnetisation maps in thin elliptically shaped nanoparticles under a variable external magnetic field. Two materials were compared as the constituents of the nanoparticles: permalloy as an exam...
Optical remote sensing has been widely used for the identification of archaeological proxies. Such proxies, known as crop or soil marks, can be detected in multispectral images due to their spectral signatures and the distinct contrast that they prov...
DNA lesions trigger DNA damage checkpoint (DDC) signaling which arrests cell cycle progression and promotes DNA damage repair. In Saccharomyces cerevisiae, phosphorylation of histone H2A (γH2A, equivalent to γH2AX in mammals) is an early...
This study presents a multidisciplinary forensic experiment evaluating the destructive effects of household chemical agents on animal bone and soft tissue analogues, with a particular focus on traumatic lesion persistence and trace evidence detection...
Homologous recombination is essential for chromosome segregation during meiosis I. Meiotic recombination is initiated by the introduction of double-strand breaks (DSBs) at specific genomic locations called hotspots, which are catalyzed by Spo11 and i...
The study investigated egg quality aspects such as astaxanthin concentration, E/Z-isomer ratio, and yolk color in laying hens fed with astaxanthin-containing diets. Dried Paracoccus carotinifaciens cell powder (Panaferd-AX) and fine cell powder (Pana...
The presence of distinctive imprinted signs on old forestry tools reflects a little-documented tradition practiced by artisanal blacksmiths in the Alpine region until the early 20th century. These marks, hammered onto tools such as axes and pickaroon...
The association between pre-harvest sprouting (PHS) and seed coat color has long been recognized. Red-grained wheats generally exhibit greater PHS resistance compared to white-grained wheat, although variability in PHS resistance exists within red-gr...
This study evaluates the performance of a fully automated algorithm to detect active inflammation in the form of bone marrow edema (BME) in iliac and sacral bones, depending on the quality of the coronal oblique plane in patients with axial spondyloa...
Obesity is an increasingly widespread disease worldwide because of lifestyle changes. It is associated with an increased risk of cardiovascular disease, primarily type 2 diabetes mellitus, with an increase in major cardiovascular adverse events. Bari...
One of the aims of successful total knee arthroplasty (TKA) is to restore the natural range of motion of the infected joint. The operated leg motion highly depends on the coordinate systems that have been used to prepare the bone surfaces for an impl...
Polycomb group proteins (PcG) are major epigenetic regulators, essential for establishing heritable expression patterns of developmental control genes. The mouse PcG family member M33/Cbx2 (Chromobox homolog protein 2) is a component of the Polycomb-...
Numerous studies have shown that following retrieval, a previously consolidated memory requires increased transcriptional regulation in order to be reconsolidated. Previously, it was reported that histone H3 lysine-4 trimethylation (H3K4me3), a marke...
We report on a novel evaluation framework to globally assess the footprint of smart cities and communities (SCC) projects, being also expandable to the case of smart grid related projects. The uniform smart city evaluation (USE) framework is construc...
Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer. There are nine hot spots of DSBs (denoted Pleiades) in human rDNA units that are located exclusively inside the intergenic spacer (IGS)...
Bioinspired walking hexapod robots are a relatively young branch of robotics. Despite the high degree of flexibility and adaptability derived from their redundant design, open-source implementations do not fully utilize this potential. This paper pro...
This paper presents a comparative analysis of the ability to recognize three mirror forms in visual and acoustic tasks: inversion (reflection on a horizontal axis), retrograde (reflection on a vertical axis) and retrograde inversion (reflection on bo...
Background: Citizenship plays a fundamental role in the management of socio-natural disaster risk, especially given the increasing impact and frequency of these events. In this context, disaster response is marked by both formal and spontaneous volun...
This paper presents a comprehensive study on a novel voltage injection based offline parameter identification method for surface mounted permanent magnet synchronous motors (SPMSMs). It gives solutions to obtain stator resistance, d- and q-axes induc...
Hepatocellular carcinoma (HCC) cells critically depend on PARP1 and CHK1 activation for survival. Combining the PARP inhibitor (PARPi) olaparib with a CHK1 inhibitor (MK-8776, CHK1i) produced a synergistic effect, reducing cell viability and inducing...
The advent of artificial intelligence marks a decisive turning point in the evolution of Industry 5.0, redefining the paradigms of industrial performance. This holistic transformation affects not only technological aspects but also the entire industr...
During an automatic power transmission line inspection, a large number of images are collected by unmanned aerial vehicles (UAVs) to detect existing defects in transmission line components, especially insulators. However, with twin insulator strings...
The following study investigated a rare case of adult immersion in a second language context without prior exposure to the language. It aimed to investigate whether Length of Residence (LoR) acts as a strong index of L2 speech performance when couple...
Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits GLI1 and the associated DDR pathway i...
The Brazilian National Institutes are strategic elements for the growth and development of Brazilian society since they have the purpose of meeting social and economic demands. However, for this purpose to be materialized, it is essential to develop...
In biomechanics, movement is typically recorded by tracking the trajectories of anatomical landmarks previously marked using passive instrumentation, which entails several inconveniences. To overcome these disadvantages, researchers are exploring dif...
Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human cells, especially at the telomeric level. The presence of oxidative lesions in the DNA can hinder the replication fork and is able to activate the DNA d...
Topoisomerases have been shown to have roles in cancer progression. Here, we have examined the effect of cryptolepine, a plant alkaloid, on the growth of human non-melanoma skin cancer cells (NMSCC) and underlying mechanism of action. For this purpos...
Objectives: Intermittent fasting regimens that include periods of prolonged fasting may mimic certain well-documented benefits of calorie restriction. In this narrative review, we synthesize preclinical and human data on endocrine adaptations during...
Mitotic slippage (MS), the incomplete mitosis that results in a doubled genome in interphase, is a typical response of TP53-mutant tumors resistant to genotoxic therapy. These polyploidized cells display premature senescence and sort the damaged DNA...
Histone post-translational modifications (PTMs) have emerged as promising epigenetic biomarkers with increasing forensic relevance. Unlike conventional genetic markers such as short tandem repeats (STRs), histone modifications can offer additional la...
To date, the effect of habitat conditions on the characteristics of pollen has not been extensively investigated; however, it needs to be remembered that it may be highly significant for the quality of their generative reproduction success. It was de...
The study aimed to investigate the extended effects and interrelations of corneal biomechanics, corneal optical density (COD), corneal thickness (CT), and intraocular pressure (IOP) following cataract surgery. Sixteen eyes were analyzed prospectively...
The phosphatidyl-inositol 3 kinase (PI3K) δ inhibitor, idelalisib (IDE), is a potent inhibitor of the B-cell receptor pathway and a novel and highly effective agent for the treatment of chronic lymphocytic leukemia (CLL). We evaluated the activ...
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signa...
Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inflammation a...
Background: Well-differentiated (WD)/dedifferentiated (DD) liposarcoma (LPS) accounts for ~60% of retroperitoneal sarcomas. WDLPS and DDLPS divergently evolve from a common precursor and are both marked by the amplification of the 12q13–q15 reg...
In addition to representing a significant part of the natural background radiation exposure, α-particles are thought to be a powerful tool for targeted radiotherapy treatments. Understanding the molecular mechanisms of recognition, signaling, a...
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