The combination of multiple imaging methods has made an indelible contribution to the diagnosis, surgical navigation, treatment, and prognostic evaluation of various diseases. Due to the unique advantages of luminogens with aggregation-induced emissi...
The aggregation operator is a potential tool to fuse the information derived from multisources, which has been applied in group decision, combination classification and scheduling clusters successfully. To better characterize complex decision situati...
Luminogens with aggregation-induced emission (AIEgens) have been widely applied in the field of photodynamic therapy. Among them, aggregation-induced emission photosensitizers (AIE–PSs) are demonstrated with high capability in fluorescence and...
In modern medicine, precision diagnosis and treatment using optical materials, such as fluorescence/photoacoustic imaging-guided photodynamic therapy (PDT), are becoming increasingly popular. Photosensitizers (PSs) are the most important component of...
Background: Disrupted proteostasis is an emerging area of research into major depressive disorder. Several proteins have been implicated as forming aggregates specifically in the brains of subsets of patients with psychiatric illnesses. These protein...
Causal emergence (CE) is a phenomenon in which macrodynamics provide better effective information (EI) than microdynamics. The CE is widely used as the objective function in Markov aggregation. The existing works focus on deterministic aggregation, w...
Fiber aggregation in nanocomposites has an important effect on macroscopic electrical performance. To quantitatively evaluate its effect, an index to characterize the degree of aggregation is imperative and, ideally, it should have three features sim...
In vivo, apolipoprotein A-I (ApoA-I) is commonly found together with lipids in so-called lipoprotein particles. The protein has also been associated with several diseases—such as atherosclerosis and amyloidosis—where insoluble aggregates...
A general characterization result of projective aggregation functions is shown, the proof of which makes use of the celebrated Arrow’s theorem, thus providing a link between aggregation functions theory and social choice theory. The result can be vie...
We introduce and discuss the concept of n-ary K-increasing fusion functions and n-ary K-increasing aggregation functions, K being a subset of the index set
Background/Objectives: Protein aggregation, particularly the aggregation of antibody-based drugs, has long been a significant challenge in downstream processes and formulation. While the inhibitory effects of excipients on aggregation have been exten...
Aggregates of TAR DNA-binding protein (TDP-43) are a hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although TDP-43 aggregates are an undisputed pathological species at the end stage of these diseases,...
Constructing a new energy-based power system is not only an important direction for the transformation and upgrade of China’s power system, but also a key to achieving peak carbon and carbon neutrality. How to fully utilize situation awareness...
Viral aggregation is a complex and pervasive phenomenon affecting many viral families. An increasing number of studies have indicated that it can modulate critical parameters surrounding viral infections, and yet its role in viral infectivity, pathog...
Homeostasis is crucial for cell function, and disturbances in homeostasis can lead to health disorders. Under normal conditions, intracellular pH is maintained between 7.35 and 7.45. Altered endosomal and lysosomal pH together with a general drop in...
The transactive energy market is an emerging development in energy economics built on advanced metering infrastructure. Data generated in this context is often required for market operations, while also being privacy sensitive. This dual concern has...
Aggregation operators have become an essential tool in many applications. The functional equations related to aggregation operators play an important role in fuzzy sets and fuzzy logic theory. The modular equation is strongly connected with the distr...
Apomyoglobin is an excellent example of a monomeric all α-helical globular protein whose folding pathway has been extensively studied and well characterized. Structural perturbation induced by denaturants or high temperature as well as amino acid sub...
This paper presents and compares the optimal solutions and the theoretical and empirical best Lipschitz constants between an aggregation function and associated idempotized aggregation function. According to an exhaustive search we performed, the mul...
We highlight camphene–camphor–polypropylene plastic as a useful material for self-propelled objects that show aggregation while floating on a water surface. We consider self-propelled rods as an example of aggregation of objects character...
It is a natural question if a Cartesian product of objects produces an object of the same type. For example, it is well known that a countable Cartesian product of metrizable topological spaces is metrizable. Related to this question, Borsík and Dobo...
Aggregation functions are mathematical operators that merge given data in order to obtain a global value that preserves the information given by the data as much as possible. In most practical applications, this value is expected to be between the in...
Controlling molecule aggregation in polymer films is one of the key factors in understanding the links between properties and structures in organic semiconductors. Here, we used poly(3-hexylthiophene-2,5-diyl) (P3HT) as the model system. By doping th...
In this paper, we propose an approach to recommender systems that incorporates human-centric aggregation via Ordered Weighted Aggregation (OWA) to prioritize the suggestions of expert rankers over the usual recommendations. We advocate for ranked rec...
Proteinopathies involve the abnormal accumulation of specific proteins. Maintaining the balance of the proteome is a finely regulated process managed by a complex network of cellular machinery responsible for protein synthesis, folding, and degradati...
Aggregation is a mathematical process consisting in the fusion of a set of values into a unique one and representing them in some sense. Aggregation functions have demonstrated to be very important in many problems related to the fusion of informatio...
We investigate two closely related Lattice Gas Cellular Automata models of the interplay of aggregation of biological cells and synchronization of intracellular oscillations (“clocks”): clock-dependent aggregation, where the adhesive forc...
Protein aggregation into amyloid fibrils is linked to multiple disorders. The understanding of how natively non-harmful proteins convert to these highly cytotoxic amyloid aggregates is still not sufficient, with new ideas and hypotheses being present...
Aggregating data is the main line of any discipline dealing with fusion of information from the knowledge-based systems to decision-making. The purpose of aggregation methods is to convert a list of objects, all belonging to a given set, into a singl...
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases. Aggregation of mAbs continues to be a major...
In this work, we synthesized a pair of positional isomers by attaching a small electron-donating pyrrolidinyl group at ortho- and para-positions of a conjugated core. These isomers exhibited totally different fluorescent properties. PDB2 exhibited ob...
Protein aggregates are central to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. This comprehensive review explores the mechanisms of protein misfolding and aggregation, their prion-lik...
Aggregation delay is the minimum number of time slots required to aggregate data along the edges of a data gathering tree (DG tree) spanning all the nodes in a wireless sensor network (WSN). We propose a benchmarking algorithm to determine the minimu...
Lipid bilayer fusion is a complex process requiring several intermediate steps. Initially, the two bilayers are brought into close contact following removal of intervening water layers and overcoming electrostatic repulsions between opposing bilayer...
Estimating and analyzing the popularity of an entity is an important task for professionals in several areas, e.g., music, social media, and cinema. Furthermore, the ample availability of online data should enhance our insights into the collective co...
Group decision-making sometimes involves evaluating the decision-makers themselves, e.g., selecting the best expert or assigning rewards within a team. In such cases, all participants should be involved, but their influence should reflect their compe...
The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and deposition into insoluble plaques and intracellular inclusions is the hallmark of several misfolding diseases known as amyloidoses. Alzheimer′s, Parkinson′s and Hu...
This review summarizes experimental data illuminating the mechanism of suppression of heat-induced protein aggregation by a-crystallin, one of the small heat shock proteins. The dynamic light scattering data show that the initial stage of thermal agg...
The applicability of the distance aggregation problem has attracted the interest of many authors. Motivated by this fact, in this paper, we face the modular quasi-(pseudo-)metric aggregation problem, which consists of analyzing the properties that a...
Naphthenic Acids (NA) are important oil extraction subproducts. These chemical species are one of the leading causes of marine pollution and duct corrosion. For this reason, understanding the behavior of NAs in different saline conditions is one of t...
Conditional aggregation operators are introduced, and coherent upper conditional previsions are constructed by sub-additive, positively homogenous, and shift-invariant conditional aggregation operators. Composed operators defined by positively homoge...
p53 is a tumor suppressor protein that is mutated in more than 50% of cancer cases. When mutated, it frequently results in p53 oncogenic gain of function (GOF), resulting in a greater tendency to aggregate in the phase separation and phase transition...
The problem of aggregating fuzzy structures, mainly fuzzy binary relations, has deserved a lot of attention in the last years due to its application in several fields. Here, we face the problem of studying which properties must satisfy a function in...
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. D...
Background: Bacterial aggregation has been well described to occur in synovial fluid, but it is unknown if bacteria form aggregates in body fluids beyond the synovial fluid. Consequently, this translational study evaluated the ability to form bacteri...
Pathological erythrocyte aggregation reduces capillary perfusion and oxygen transfer to tissue, which is determined by the negative surface charge on the erythrocyte membrane (intrinsic aggregability) and fibrinogen–erythrocyte interaction (extrinsic...
Abnormal protein aggregation has been intensively studied for over 40 years and broadly discussed in the literature due to its significant role in neurodegenerative diseases etiology. Structural reorganization and conformational changes of the second...
Simple sum monetary aggregates are based on accounting conventions and have no aggregation theoretic foundations in economic theory. In contrast, Divisia monetary aggregates are directly derived from aggregation and index number theory. Credit card s...
Energy system models that consider variable renewable energy sources (VRESs) are computationally complex. The greater spatial scope and level of detail entailed in the models exacerbates complexity. As a complexity-reduction approach, this paper cons...
Alzheimer’s disease (AD) is a neurodegenerative disease with high morbidity that has received extensive attention. However, its pathogenesis has not yet been completely elucidated. It is mainly related to β-amyloid protein deposition, the...
of 786