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Review

Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction

by 1,†, 2,†, 1, 1,* and 1,3,4,*
1
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
2
Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
3
Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China
4
Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Anna Barattucci
Molecules 2021, 26(2), 268; https://doi.org/10.3390/molecules26020268
Received: 26 November 2020 / Revised: 29 December 2020 / Accepted: 4 January 2021 / Published: 7 January 2021
(This article belongs to the Special Issue Photoactive Organic Molecules in the Biological Field)
Luminogens with aggregation-induced emission (AIEgens) have been widely applied in the field of photodynamic therapy. Among them, aggregation-induced emission photosensitizers (AIE–PSs) are demonstrated with high capability in fluorescence and photoacoustic bimodal imaging, as well as in fluorescence imaging-guided photodynamic therapy. They not only improve diagnosis accuracy but also provide an efficient theranostic platform to accelerate preclinical translation as well. In this short review, we divide AIE–PSs into three categories. Through the analysis of such classification and construction methods, it will be helpful for scientists to further develop various types of AIE–PSs with superior performance. View Full-Text
Keywords: aggregation-induced emission; reactive oxygen species; electron transfer; energy transfer; photodynamic therapy aggregation-induced emission; reactive oxygen species; electron transfer; energy transfer; photodynamic therapy
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MDPI and ACS Style

Ni, J.; Wang, Y.; Zhang, H.; Sun, J.Z.; Tang, B.Z. Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction. Molecules 2021, 26, 268. https://doi.org/10.3390/molecules26020268

AMA Style

Ni J, Wang Y, Zhang H, Sun JZ, Tang BZ. Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction. Molecules. 2021; 26(2):268. https://doi.org/10.3390/molecules26020268

Chicago/Turabian Style

Ni, Juechen; Wang, Yijia; Zhang, Haoke; Sun, Jing Z.; Tang, Ben Z. 2021. "Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction" Molecules 26, no. 2: 268. https://doi.org/10.3390/molecules26020268

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