1,096 Results Found

Slit2 expression is downregulated in various cancers, including lung cancer. We identified two Slit2 splicing variants at exon15—Slit2-WT and Slit2-ΔE15. In the RT-PCR analyses, the Slit2-WT isoform was predominantly expressed in all the...

The SLIT-ROBO axis plays an important role in normal stem-cell biology, with possible repercussions on cancer stem cell emergence. Although the Promyelocytic Leukemia (PML) protein can regulate SLIT2 expression in the central nervous system, little i...

This study aimed to understand aberrant methylation of SLITs genes as a biomarker for the early detection and prognosis prediction of non-small cell lung cancer (NSCLC). Methylation levels of SLITs were determined using the Infinium HumanMethylation4...

Slit2 (slit guidance ligand 2), a ligand of the Roundabout1 (Robo1) transmembrane receptor, is often overexpressed in colorectal carcinomas (CRCs). In this study, we performed data mining in the Metabolic gEne RApid Visualizer (MERAV) database and fo...

The Slit2/Robo signaling pathway acts as a tumor suppressor in various cancers. This study identified an 8-amino acid peptide, LT1-3, derived from the Slit2 LamG domain, and demonstrated its ability to inhibit lung cancer cell proliferation and invas...

The Contextuality-by-Default theory is illustrated on contextuality analysis of the idealized double-slit experiment. The experiment is described by a system of contextually labeled binary random variables each of which answers the question: Has the...

Slit-Robo signaling regulates midline crossing of commissural axons in different systems. In zebrafish, all retinofugal axons cross at the optic chiasm to innervate the contralateral tectum. Here, the mutant for the Robo2 receptor presents severe axo...

Purpose: To assess the usability and image quality of a smartphone adapter for direct slit lamp imaging. Methods: A single-center, prospective, clinical study conducted in the Department of Ophthalmology at the University Hospital Zurich, Switzerland...

One of the most dangerous geological disaster risks in mountainous areas is granular flow. Slit dams, which might partially block the granular flow and let downstream flow at a slower speed, have been crucial in reducing the geohazards associated wit...

This study aimed to study the cyclic behavior of two-side-connected precast-reinforced concrete infill panel (RCIP). A total of four RCIP specimens with different slit types and height-to-span ratios modeled at a one-third scale were tested subjected...

Liver fibrosis is a common outcome of most chronic liver insults/injuries that can develop into an irreversible process of cirrhosis and, eventually, liver cancer. In recent years, there has been significant progress in basic and clinical research on...

Humidity-dependent closing and reopening slit pores can produce hysteresis loops in sorption diagrams even at low relative vapor pressure. Pore closing is supported by adhesion of the slit wall surfaces. In a macroscopic model for sorption hysteresis...

Bladeless fans are more energy efficient, safer due to the hidden blades, easier to clean, and more adjustable than conventional fans. This paper investigates the influence of the airfoil’s outlet slit thickness on the discharge ratio by varyin...

Poor tendon–bone interface (TBI) integration is one of the major causes contributing to unsatisfactory healing quality in patients after anterior cruciate ligament (ACL) reconstruction. Type H vessels have been recently found to closely modulat...

The rolling process of rebar steel production is one of the well established manufacturing processes; however, it should be subjected to revision and redesign for productivity enhancement and power reduction throughout the slit rolling process. In th...

We demonstrate that the interference pattern of the plasmonic and photonic modes can be controlled by changing the slit width of a square slit structure. Based on the analyses of the plasmonic and photonic modes of slits with different widths, we the...

Internal mechano-sensors, as an indispensable part of the proprioceptive system of intelligent equipment, have attracted enormous research interest because of their extremely crucial role in monitoring machining processes, real-time diagnosis of equi...

Directional fracture blasting technology of the slit charge has broad application prospects in the drilling and blasting construction of the layered rock mass. In this paper, the method of model experiment and numerical simulation is used to prelimin...

Tunable perfect acoustic absorption at subwavelength thickness has been a prominent topic in scientific research and engineering applications. Although metamaterials such as labyrinthine metasurfaces and coiling-up-space metamaterials can achieve sub...

Although the behavior of the confined semi-dilute solutions of self-assembling copolymers represents an important topic of basic and applied research, it has eluded the interest of scientists. Extensive series of dissipative particle dynamics simulat...

Systematic three-dimensional numerical simulations of flame acceleration and deflagration-to-detonation transition (DDT) in a semi-confined flat slit combustor are performed. The combustor is assumed to be partly filled with the stoichiometric ethyle...

Unifying quantum theory with general relativity is challenging because of several problems related to time and to collapse in quantum measurements. In the double-slit experiment, the questions are how the momentum of the photon is transferred to a sp...

This article reconsiders the double-slit experiment by establishing a new type of relationship between it and the concept of entanglement. While the role of entanglement in the double-slit experiment has been considered, this particular relationship...

This article presents research into the feasibility of applying a nonlinear damper of a new conceptual structure. The key component of the damper is a circular membrane with slits that can move in a cylinder filled with viscous fluid. When an externa...

Background and objectives: Slit1 is a secreted protein that is closely related to cell movement and adhesion. Few studies related to fibrosis exist, and the preponderance of current research is confined to the proliferation and differentiation of neu...

The present work analyzes theoretically and verifies the advantage of utilizing rectangular microcantilevers with long-slits in microsensing applications. The deflection profile of these microcantilevers is compared with that of typical rectangular m...

This study aimed to determine the flow structures and heat transfer for flow past a tandem cylinder array and the effect of a slit on the enhancement of heat transfer. Different distances between cylinders and inclination angles of the slit were simu...

The SLIT3 gene encodes a secreted protein, and the ZNF280B gene is a member of the transcription factor family. Both genes have multiple biological functions. This study was conducted to investigate the association between SLIT3 and ZNF280B gene poly...

This research investigates how slitted beams fitted with piezoelectric transducers (PZTs) behave when generating energy from environmental vibrations. By changing slit widths, slit lengths, and tip masses, we investigated the frequency response of th...

Analytical approximations for the acoustical properties of a rigid-porous matrix perforated by labyrinthine slits are developed using classical theories for sound propagation in tortuous slits and for sound absorption by double porosity materials. Pr...

The Taylor vortex flow in the plain model with a constant temperature gradient effect was studied by experimental measurement, and the preliminary features of Taylor vortex flow affected by heat transfer process were obtained. This flow field in the...

To meet the recent requirements of low-damage design, there is a growing need to retrofit building structures with a self-centering dissipation system. This system serves a dual purpose: reducing lateral drift and providing supplemental damping to en...

Geocells are widely applied in numerous infrastructure constructions, like heavy-haul railways and ports. The mechanical tearing behavior of a geocell strip is crucial to the stability of the geocell-reinforced soil structures. At present, extensive...

This study presents new laboratory data on the time-varying scour upstream of a slit weir used for sediment release near hydropower intake. The governing parameters in temporal and spatial scour hole development under steady and unsteady flow conditi...

This article presents the particle capture performance of annular slits, which offer a simple alternative to complex micro/nano structures used to excite and focus surface plasmon polaritons (SPPs). Additionally, the annular slits are compatible with...

Prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer-related mortality among men. Gene expression analysis has been crucial in understanding tumor biology and providing disease progression markers. Cell surfac...

In nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components,...

An ultra-narrow precision slit with a width of less than ten micrometers is the key structure of some optical components, but the fabrication of these structures is still very difficult to accomplish. To fabricate these slits, this paper proposed a p...

There is a problem with the insufficient cleaning of the dust filter cartridge by the pulsed-jet cleaning method. This paper examines the improvement in the pulse-jet performance of cone filter cartridges achieved by using an annular-slit nozzle. Off...

Recently, nondestructive evaluation of the stresses localized in grains was achieved for plastically deformed low-carbon steel using scanning three-dimensional X-ray diffraction (S3DXRD) microscopy with a conical slit. However, applicable metals and...

Background: Visual impairments and age-related eye diseases need to be detected and treated in a timely manner. However, this is often hampered by lack of appropriate medical equipment. We have invented a portable, recordable, and smartphone-attachab...

The increasing demand for accurate imaging spectral information in remote sensing detection has driven the development of hyperspectral remote sensing instruments towards a larger view field and higher resolution. As the core component of the spectro...

In this paper, the performance of a Dual-Stator Winding Synchronous Reluctance Generator (SynRG) suitability for off-grid wind power generation is analyzed. The rotor of the SynRG has a slitted-rotor core to improve selected vital performance paramet...

Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases. However, the mechanistic role of these pathways for the glomerular filtration barrier remains...

We aimed to evaluate the depth of the demarcation line following accelerated epithelium-off corneal cross-linking (A-CXL) performed at the slit lamp with the patient sitting in an upright position. Twenty-three eyes from twenty patients, undergoing e...

Infectious keratitis (IK) is a common ophthalmic emergency that requires prompt and accurate treatment. This study aimed to propose a deep learning (DL) system based on slit lamp images to automatically screen and diagnose infectious keratitis. This...

Background: The incidence of allergic conjunctival diseases (ACDs) is gradually increasing worldwide. Both ophthalmologists and non-ophthalmologists prescribe eye drops to treat ACDs; however, there are many cases which are treated without sufficient...

Gliomas represent the most common primary Central Nervous System (CNS) tumors, characterized by increased heterogeneity, dysregulated intracellular signaling, extremely invasive properties, and a dismal prognosis. They are generally resistant to exis...

This article reconsiders the double-slit experiment from the nonrealist or, in terms of this article, “reality-without-realism” (RWR) perspective, grounded in the combination of three forms of quantum discontinuity: (1) “Heisenberg discontinuity”, de...

This study sought to experimentally develop guidelines for shaping 0.3-mm-thick cold-rolled grain-oriented ET 110-30LS steel using a shear-slitting operation. Coated and non-coated steel was used for the analysis. The coated sheet had a thin inorgani...