Bridge construction accidents are often caused by a variety of factors, so it is particularly important to explore the role mechanism of bridge construction accident risk factors to effectively prevent construction safety accidents and ensure the smo...
The failure of tailings pond dams represents a complex coupled system involving various risk factors, including human, governance, facilities, and environmental aspects. It is crucial to identify key risk factors at the system level to enhance the sa...
In the construction of water conveyance tunnels with the shield method, accidents have occurred from time to time, such as collapses and explosions, and it is of practical significance to explore the cause mechanism of the accident. However, previous...
Preventing collision accidents between merchant ships and fishing vessels has long been a significant challenge for maritime safety in coastal waters. To quantitatively analyze the relationship between the risk factors contributing to these collision...
Because deep foundation pits and tunnels are deformation-sensitive structures, the safety of these projects is generally affected by coupled risks. In deep foundation pit construction, if the existing tunnel structure adjacent to the deposit is damag...
Tunnel construction is characterized by its large scale, long periods and vulnerability to environmental impact, which pose great challenges to tunnel construction safety. In order to analyze the coupling mechanism of tunnel construction safety risks...
The causes of maritime accidents are complex, mostly due to the coupling of four types of factors: human-ship-environmental-management. To effectively analyze the causes of maritime accidents in China, and reveal the risk coupling characteristics of...
In view of the sociality, complexity, and uncertainty of major engineering projects, social stability poses many problems for social contradictions and conflicts in the whole life cycle of the project. This study aimed to investigate the approach of...
Public transport accidents pose a significant threat to public safety, so it is necessary to conduct an in-depth exploration of their risk mechanisms. In this study, risk factors were first identified through statistical analysis of the time, road se...
This study suggests a method for analyzing the risk of methane explosions using the N-K model and Social Network Analysis (SNA) to understand how different risk factors related to coal-mine methane explosions are connected and change over time, aimin...
In order to effectively reduce the probability of subway operation accidents and explore the key risk factors and multi-factor risk coupling mechanism during the subway operation period, this paper classifies the risk factors affecting subway operati...
Monitoring critical transmission sections is essential for ensuring the operational security of power grids. This paper proposes a systematic method to identify critical transmission sections using the maximum flow–minimum cut theorem. The appr...
NK cells are key components of the innate immune system, capable of recognizing and eliminating tumor or virus-infected cells and able to modulate both innate and adaptive immune responses. This makes NK cells attractive candidates for cancer immunot...
Vehicle scheduling at shipyards can involve delays due to numerous risk factors encountered in the complicated shipyard road environment. This paper studies the problems of risk coupling in shipyard vehicle scheduling based on the risk matrix approac...
Analyzing risk coupling effects in highway accidents provides guidance for preventive decoupling measures. Existing studies rarely explore the differences in risk coupling between primary accidents (PA) and secondary accidents (SA) from a quantitativ...
The aim of this study is to simulate the self-organized evolution mechanism of inner innovation of large-scale construction enterprises (LSCE) under different contexts. Based on NK stochastic combinatorial optimization model with two parameters (N, K...
Background/objectives: The functional activity of a certain tumor determines the effectiveness of primary NK cells and NK-92 cell line-based cancer therapy; their therapeutic effectiveness against different tumors can vary. This work provides a direc...
Current coal mine fire risk assessments often rely on static models and isolated factors, failing to capture the complex, dynamic interactions that lead to fires. To address this gap, we propose a comprehensive framework—termed INK-FBSD—i...
Cardiovascular disease is one of many risk factors that have been linked to increased severity or mortality in coronavirus disease 2019 (COVID-19) patients; however, the exact role of SARS-CoV-2 in the pathogenesis of cardiac inflammatory injury has...
Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology is limited by the availability of sufficient numbers of fully functional cells. Here, we investigated the ef...
Secret image sharing is a hot issue in the research field of data hiding schemes for digital images. This paper proposes a general k,n threshold secret image sharing scheme, which distributes secret data into n meaningful image shadows based on a non...
A discrete time modeling method is employed in this paper to analyze and evaluate the reliability of a discrete time K/N: G repairable retrial system with Bernoulli shocks and two-stage repair. Lifetime and shocks are two factors that lead to compone...
Housing sustainability is a cornerstone element of sustainable economic and social development. This is particularly true for China, where high-rise residential buildings are the primary form of housing. In recent years, China has experienced frequen...
In order to reduce the conservatism of the robust optimization method and the complexity of the stochastic optimization method and to enhance the ability of power systems to deal with occasional line fault disturbance, this paper proposes a distribut...
Given a graph G=(V(G),V(E)), a non-negative integer g and a set of faulty vertices F⊆V(G), the g-extra connectivity of G, denoted by κg(G), is the smallest cardinality of F, whose value of deletion, if exists, will disconnec...
Colorectal carcinoma (CRC) presents a formidable medical challenge, demanding innovative therapeutic strategies. Chimeric antigen receptor (CAR) natural killer (NK) cell therapy has emerged as a promising alternative to CAR T-cell therapy for cancer....
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a dismal prognosis. Natural killer (NK) cells are large granular lymphocytes with natural cytotoxicity against tumor cells, and they should be established for the novel tr...
Nature killer (NK) cells are increasingly considered important in tumor microenvironment, but their role in predicting the prognosis of ovarian cancer has not been revealed. This study aimed to develop a prognostic risk model for ovarian cancer based...
Despite standard multimodality treatment, containing maximum safety resection, temozolomide, radiotherapy, and a tumor-treating field, patients with glioblastoma (GBM) present with a dismal prognosis. Natural killer cell (NKC)-based immunotherapy wou...
Human hepatocellular carcinoma (HCC) is the most common and even worse at prognosis. The patients with HCC which accompanied by other diseases, such as cirrhosis, can be limited in various treatments, such as chemotherapy, not HCC patients without ot...
This paper studies a model for competition between natural killer (NK) cells, cytotoxic T lymphocytes (CTLs) and tumor cells, and evaluates the outcomes in the absence and presence of chemotherapy treatment. The growth rate of the tumor is presumed t...
Oncolytic virotherapy (OV) is a cancer therapy utilizing lytic viruses that specifically target cancer cells for elimination. In this relatively new therapy, two contradictory observations have been made. Some studies showed that immune responses inc...
A tunnel is a complex network system with multiple risk factors interacting. At present, the cause analysis of tunnel fire accidents focuses on exploring risk sources and risk assessment, ignoring the interaction between risk factors. A single model...
Cells of the innate immune system, particularly natural killer (NK) cells, serve as the first line of defense against tumor development and play a critical role in antitumor immunity. Characterizing the immune cell pool and its functional state is es...
Reliability and sensitivity issues are very close and important problems in any technical system. The system’s sensitivity is understood as the dependence of its behavior on changes in some internal parameters. To perform sensitivity analysis,...
Paraoxonase 1 (PON1), a homocysteine (Hcy)-thiolactone detoxifying enzyme, has been associated with Alzheimer’s disease (AD), suggesting that PON1 plays an important protective role in the brain. To study the involvement of PON1 in the developm...
12 October 2022
To explore the niche improvement path of photovoltaic agriculture in China, a niche influencing factor system was constructed first. Then, this study innovatively combined the DEMATEL and analytic network process (DANP) method and the NK model, which...
It is evident that several real-life applications, such as telecommunication systems, call for the establishment of consecutive-type networks. Moreover, some of them require more complex connectors than the ones that exist already in the literature....
Background and Objectives: Toll-like receptors (TLRs) are pattern recognition receptors with an essential role in regulating both the innate and adaptive immune response. Given their pleiotropic effects in mounting an immune response, previous studie...
To address the common issues of lacking indicator system identification, causal relationship quantification, and path simulation analysis in the current research on safety performance in prefabricated construction, a method for improving safety perfo...
Trigeminal neuralgia (TN) is a common type of peripheral neuralgia in clinical practice, which is usually difficult to cure. Common analgesic drugs are difficult for achieving the desired analgesic effect. Syb-prII-1 is a β-type scorpion neuroto...
Fatigue has always been one of the major causes of structural failure, where repeated loading and unloading cycles reduce the fracture energy of the material, causing it to fail at stresses lower than its monotonic strength. However, predicting fatig...
The rapid and accurate detection of soil nutrient content through spectral technology is one of the requisite technologies for precision fertilization, which, however, is an unsolved issue. In order to achieve this purpose, a more robust and accurate...
Quantifying uncertainty in complex systems is a central problem in reliability analysis and engineering applications. In this work, we develop an information-theoretic framework for analyzing linear consecutive k-out-of-n:G systems using the cumulati...
Purpose—Through the study, we discovered the key factors for decision makers involved in public crisis governance with respect to deciding whether to cooperate or not, and to understanding how they relate to governance performance. Methodology&...
Natural killer cells (NK cells) exert cytotoxicity towards target cells in several ways, including the expression of apoptosis-mediating ligands (TRAIL, FasL). In addition, NK cells themselves may be susceptible to apoptosis due to the expression of...
Due to the complexity of modeling tumor-host interactions within the tumor microenvironment in vitro, we developed a 3D heterotypic cellular breast cancer (BC) model. We generated spheroid models using MCF7, MDA-MB-231, and SK-BR-3 cell lines alongsi...
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for hematological malignancies. However, improvements in CAR T-cell therapies are urgently needed since CAR T cell application is associated with toxicities, exhausti...
Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity. Concomitantly,...
Cell therapies, including adoptive immune cell therapies and genetically engineered chimeric antigen receptor (CAR) T or NK cells, have shown promise in treating hematologic malignancies. Yet, immune cell infiltration and expansion has proven challen...
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