The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 variants in 9 pediatric patients...
Ceramides regulate phagocytosis; however, their exact function remains poorly understood. Here, we sought (1) to develop genetically encoded fluorescent tools for imaging ceramides, and (2) to use them to examine ceramide dynamics during phagocytosis...
Kinase Suppressor of RAS 1 (KSR1) is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS-mediated transf...
Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DC...
Carcinogenesis is driven by aberrant activation of molecular signaling pathways governing cell proliferation, apoptosis, and differentiation. Among these, the RAS/RAF/MEK/ERK (RAS/MAPK) cascade is one of the most frequently dysregulated oncogenic pat...
Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2–3% of obesity in both children and adults and is most often attributable to mutations in genes...
Cotton is highly sensitive to potassium, and Xinjiang, China’s leading cotton-producing region, faces a severe challenge due to reduced soil potassium availability. Biofertilizers, particularly potassium-solubilizing rhizobacteria (KSR), conver...
Three-dimensional wind vector retrieval from Coherent Doppler Wind Lidar (CDWL) in Velocity–Azimuth Display (VAD) mode is susceptible to anomalous radial velocity observations induced by low signal-to-noise ratios, clutter echoes, and spectral...
As integrated circuit technology continues to advance, clock tree synthesis has become increasingly significant in the design of ultra-large-scale integrated circuits. Traditional clock tree synthesis methods often face challenges such as insufficien...
Signaling proteins in eukaryotes usually comprise a catalytic domain coupled to one or several interaction domains, such as SH2 and SH3 domains. An additional class of proteins critically involved in cellular communication are adapter or scaffold pro...
Chinese Kunming mice (Mus musculus Km), widely used as laboratory animals throughout China, remain very refractory for embryonic stem (ES) cell isolation. The present study was aimed to evaluate the effects of hybridization with 129/Sv mice, and cult...
Background: Potassium (K) is an essential mineral and major intracellular electrolyte involved in the regulation of blood pressure, muscle contraction and nerve transmission in humans. Major dietary sources of K include fruits and vegetables, starchy...
Conventional biochemical methods for studying cellular signaling cascades have relied on destructive cell disruption. In contrast, the live cell imaging of fluorescent-tagged transfected proteins offers a non-invasive approach to understanding signal...
KMeY(PO4)2:5% Eu3+ phosphates have been synthesized by a novel hydrothermal method. Spectroscopic, structural, and morphological properties of the obtained samples were investigated by X-ray, TEM, Raman, infrared, absorption, and luminescence studies...
A new feature extraction technique called DNST-GLCM-KSR (discrete non-separable shearlet transform-gray-level co-occurrence matrix-kernel spectral regression) is presented according to the direction and texture information of surface defects of conti...
The problem of missing values (MVs) in traffic sensor data analysis is universal in current intelligent transportation systems because of various reasons, such as sensor malfunction, transmission failure, etc. Accurate imputation of MVs is the founda...
Long-term culture of testicular tissue has important applications, including the preservation of fertility potential of prepubertal boys undergoing gonadotoxic cancer treatment. This study was designed to define optimal conditions for the long-term c...
Genome-wide, loss-of-function screening can be used to identify novel vulnerabilities upon which specific tumor cells depend for survival. Functional Signature Ontology (FUSION) is a gene expression-based high-throughput screening (GE-HTS) method tha...
Objective: This study aimed to experimentally investigate the biomechanical and performance differences between the grab start (GS) and the kick start (KS) with each leg on the kickplate (KSR, KSL) in Bi-Finswimming (BFS). It focused on the effect of...
Today, the main issue of providing adequate and affordable housing is to go beyond the mere offer of basic shelters, intending to create sustainable and durable settlements. Due to the fragile and uncertain nature of its social, political and economi...
The aim of the present research was to analyze the variability of 45 SNPs from different genes involved in metabolism and innate immunity to perform an association analysis with the milk yield, composition and milk coagulation traits. A population of...
Silver nanoparticles have gained considerable interest in recent decades due to their antimicrobial activity and are used in water disinfection, wound healing, food packaging, and plant protection. This study tested the potential of silver nanopartic...
The development of novel antimicrobial peptides (AMPs) with broad-spectrum activity represents a promising strategy to overcome multidrug resistance in pathogenic bacteria. In this study, we investigated the antimicrobial activity of three designed p...
The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor. Downstream of the receptors, this pathway involves the activation of a kinase cas...
The objective of this study was to investigate the hygroscopic characteristics of three typical bamboo engineering composites (Bamboo scrimber (BS), bamboo bundle/wood laminated veneer lumber (BLVL), and bamboo laminated timber (BLT)) as well as pred...
In vitro spermatogenesis (IVS) has important applications including fertility preservation of prepubertal cancer patients; however, thus far, IVS has only been achieved using mouse models. To study the effects of growth factors on the maintenance of...
The detection of seismic signals is vital in seismic data processing and analysis. Many algorithms have been proposed to resolve this issue, such as the ratio of short-term and long-term power averages (STA/LTA), F detector, Generalize F, and etc. Ho...
Kluyveromyces marxianus is an emerging yeast cell host for diverse products, but multiple-gene expression in K. marxianus faces challenges due to limited current knowledge of cis-regulatory elements and insertion loci. Our previous study transferred...
The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction. However, it is unknown whether MAPK also regulates insect reproductive mec...
Pluripotent stem cells (PSCs) have been successfully developed in many species. However, the establishment of bovine-induced pluripotent stem cells (biPSCs) has been challenging. Here we report the generation of biPSCs from bovine mesenchymal stem ce...
In recent years, virtual reality (VR) technologies have been increasingly used for teaching motion skills to learners. In this paper, the authors employed a VR assistive system for teaching motion skills to learners by the use of an inertial sensor-e...
It is difficult to evaluate the pre-symptomatic state of mental disorders and prevent its onset. Since stress could be a trigger of mental disorders, it may be helpful to identify stress-responsive biomarkers (stress markers) for the evaluation of st...
The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these...
This study utilizes LA-ICP-MS-determined minor and trace element contents of megacrystic blocky K-feldspar to reveal the chemical variability and fractionation degree of albite-spodumene and barren feldspar pegmatites of the Kolmozero lithium deposit...
In nematode Caenorhabditis elegans, exposure to polystyrene nanoparticles (PS-NPs) at predicted environmental concentrations can cause induction of transgenerational toxicity. However, the underlying mechanisms for toxicity formation of PS-NP in the...
Background: The Tibetan pig, a highland breed with exceptional adaptability to harsh environments (cold, hypoxia, coarse feed) but poor growth/reproductive traits, was studied to uncover genetic mechanisms and support breeding improvements. Methods:...
To achieve efficient separation of Sr2+ under complex ionic-strength conditions, porous geopolymer particles (PGs) were used as a support to construct a K2SbPO6-loaded porous geopolymer composite, denoted as K2SbPO6@PGs, via in situ loading of one-di...
Background: Asthma is a chronic inflammatory condition linked to hyperresponsiveness in the airways. There is currently no cure available for asthma, and therapy choices are limited. Asthma is the result of the interplay between genes and the environ...
6 July 2021
The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and ge...