(1) Background: Foster Kennedy syndrome (FKS) is an ophthalmological condition characterized by an insidious reduction in vision in one eye, accompanied by clinically significant papilledema in the fellow eye. The unilateral loss of vision and optic...
Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutatio...
It is well established that Cholangiocarcioma (CCA) drug resistance plays a crucial role in the spread and survival of cancer cells. The major enzyme in the nicotinamide-adenine dinucleotide (NAD+)-mediated pathways, nicotinamide phosphoribosyltransf...
Tacrolimus (FK506), an immunosuppressant and calcineurin inhibitor, has fungicidal effects. However, its fungicidal effect is thought to be limited to basidiomycetes, such as Cryptococcus and Malassezia, and not to ascomycetes. FK506 had no fungicida...
The efficiency and stability of perovskite solar cells (PSCs) depend not only on the perovskite film quality, but they are also influenced by the charge carriers of both the electron and hole transport layers (ETL and HTL). Doping of the carrier tran...
Glioblastoma, a formidable brain tumor characterized by dysregulated NAD metabolism, poses a significant therapeutic challenge. The NAMPT inhibitor FK866, which induces NAD depletion, has shown promise in controlling tumor proliferation and modifying...
NAMPT is an attractive target in cancer therapy and numerous NAMPT inhibitors have been developed. However, the clinical activities of NAMPT inhibitors have displayed disappointing results in clinical trials for their dose-limiting toxicities. In thi...
Increasing extracellular osmolarity 100 mOsm/kg above plasma level to the physiological levels for cartilage induces chondrogenic marker expression and the differentiation of chondroprogenitor cells. The calcineurin inhibitor FK506 has been reported...
Antifungal susceptibility testing is important in guiding patient therapy due to an increasing number of resistant Candida isolates. In the clinical strain collection of the Austrian resistance report (AURES), a high number of micafungin-resistant C....
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin fol...
Ground-penetrating radar (GPR) is a classic geophysical exploration method that utilizes the emission and reception of electromagnetic waves to non-destructively detect target objects in the target medium. It has been widely applied in various fields...
The quality of the surrounding rock is crucial to the stability of underground caverns, thereby requiring an effective monitoring technology. Ground-penetrating radar (GPR) can reconstruct the subterranean profile by electromagnetic waves, but two si...
Alzheimer’s disease (AD) is the most common age-associated neurodegenerative disorder, characterized by progressive cognitive decline, memory impairment, and structural brain changes, primarily involving Aβ plaques and neurofibrillary tang...
Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of...
Macrophages emerge in the milieu around innervated neurons after nerve injuries. Following nerve injury, autophagy is induced in macrophages and affects the regulation of inflammatory responses. It is closely linked to neuroinflammation, while the im...
Exosomes secreted by adipose-derived stem cells (ADSC-exo) reportedly improve nerve regeneration after peripheral nerve injury. Herein, we investigated whether pretreatment of ADSCs with FK506, an immunosuppressive drug that enhances nerve regenerati...
Candida auris is an emerging yeast pathogen that has recently caused major outbreaks in healthcare facilities worldwide. Clinical C. auris isolates are usually resistant to fluconazole and readily develop resistance to echinocandins and amphotericin...
Invasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical...
Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (...
The frequency of invasive fungal infections shows a rising trend as well as a high morbidity and mortality. Among the causative agents, a shift toward the non-albicans Candida species including Candida glabrata species complex is being observed in se...
The confluence of a large variety of factors, achievements and developments has resulted in the current long-term success in graft transplants. Some of these events are reviewed, paying special attention to immunosuppressant drugs, which are one of t...
Feline infectious peritonitis (FIP) is a fatal feline immune-mediated disease caused by feline infectious peritonitis virus (FIPV). Little is known about the biological pathways associated in FIP pathogenesis. This is the first study aiming to determ...
Schizandrol A (SZA) and schizandrol B (SZB) are two active ingredients of Wuzhi capsule (WZC), a Chinese proprietary medicine commonly prescribed to alleviate tacrolimus (FK-506)-induced hepatoxicity in China. Due to their inhibitory effects on cytoc...
As the number and length of high-speed railway tunnels increase in China, implicit defects such as insufficient lining thicknesses, voids, and poor compaction have become increasingly common, posing a serious threat to train operation safety. It is,...
In this paper, we focus on the symmetrical relationship between multi-properties objective reachability problems and multi-objective sets reachability problems over FKS based on Zadeh logic. First, we give the formal definitions of those two problems...
Daporinad (FK866) is one of the highly specific inhibitors of nicotinamide phosphoribosyl transferase (NAMPT) and known to have its unique mechanism of action that induces the tumor cell apoptosis. In this study, a simple and sensitive liquid chromat...
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient...
This paper focuses on infinite-volume bosonic states for a quantum particle system (a quantum gas) in Rd. The kinetic energy part of the Hamiltonian is the standard Laplacian (with a boundary condition at the border of a ‘box’). The parti...
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specif...
We evaluated the utility of optical redox imaging (ORI) to identify the therapeutic response of triple-negative breast cancers (TNBC) under various drug treatments. Cultured HCC1806 and MDA-MB-231 cells treated with FK866 (nicotinamide phosphoribosyl...
Destruxin A (DA), a major secondary metabolite of Metarhizium anisopliae, has anti-immunity to insects. However, the detailed mechanism and its interactions with target proteins are elusive. Previously, three immunophilins, peptidyl–prolyl cis&...
Immune rejection is a significant concern in organ transplantation, as it can lead to damage to and failure of the transplanted organ. To prevent or treat immune rejection, transplant recipients are commonly administered immunosuppressive drugs. Tacr...
Staphylococcus species are often the cause of implant-related infections, posing a significant clinical challenge in orthopedics. Antimicrobial peptides (AMPs) like LL-37-derived FK-16 and GF-17 offer promising alternatives to conventional antibiotic...
Precise patient positioning is paramount in radiosurgery to ensure the accurate targeting of tumors while minimizing damage to surrounding healthy tissues. This study focuses on the development and validation of a robust forward kinematics (FK) model...
Metastatic prostate cancer/PCa is the second leading cause of cancer deaths in US men. Most early-stage PCa are dependent on overexpression of the androgen receptor (AR) and, therefore, androgen deprivation therapies/ADT-sensitive. However, eventual...
The continuous data from the YL array and four AU stations during the lifetime of the cyclone TOMAS in March 2010 were downloaded from IRIS. By performing frequency-wave number (F-K) analysis on the array data, it was found that the orientation of th...
This paper investigates the effectiveness and limitations of the traditional Fine-Kinney method for occupational risk assessment, emphasizing its shortcomings in addressing complex and dynamic work environments. To overcome these challenges, two adva...
Glioblastoma (GBM) cells require high levels of nicotinamide adenine dinucleotide (NAD) to fuel metabolic reactions, regulate their cell cycle and support DNA repair in response to chemotherapy and radiation. Inhibition of a key enzyme in NAD biosynt...
Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections. The number of effective therapies is limited; thus, new, even-combination-based st...
As the demand for advanced cooling solutions increases with the rise in artificial intelligence and high-performance computing, efficient thermal management becomes critical, particularly for data centers and electronic systems. Triply Periodic Minim...
An integrated method for fault detection of bearing using wavelet packet energy (WPE) and fast kurtogram (FK) is proposed. The method consists of three stages. Firstly, several commonly used wavelet functions were compared to select the appropriate w...
Linear noise, a significant type of interference in exploration seismic data, adversely affects the signal-to-noise ratio (SNR) and imaging resolution. As seismic exploration advances, the constraints of the acquisition environment hinder the ability...
This paper proposes a novel automatic recognition method for distinguishing voids and severe loosening in road structures based on features of ground-penetrating radar (GPR) B-scan images. By analyzing differences in image texture, the intensity and...
Effectively managing Construction and Demolition Waste (CDW) requires prioritizing multi-dimensional risks, a task complicated by the inherent uncertainty and subjectivity of expert judgments. While classical methods like Failure Modes and Effects An...
Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuror...
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods. We describe herein...
This study investigates the structure of shear-wave velocities (Vs) in the shallow layers of the Oran region, north-west of Algeria, using non-invasive techniques based on ambient vibration arrays. The region has experienced several moderate earthqua...
This paper proposes an innovative method for identifying the locations of multiple simultaneous acoustic emission (AE) events in plate-like structures from the view of image processing. By using a linear lead zirconium titanate (PZT) sensor array to...
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C. glabrata has emerged as a leading...
Peripheral nerve injuries (PNIs) occur frequently and can lead to devastating and permanent sensory and motor function disabilities. Systemic tacrolimus (FK506) administration has been shown to hasten recovery and improve functional outcomes after PN...
of 10