CCR4-NOT transcription complex subunit 2 (CNOT2), a subunit of the CCR4-NOT complex, has been described in cancer progression. The CNOT complex plays an important role in multiple cellular functions. Recent studies in our laboratory showed that CNOT2...
CNOT2, a central component of the CCR4-NOT transcription complex subunit 2, plays a pivotal role in the regulation of gene expression and metabolism. CNOT2 is involved in various cellular processes, including transcriptional regulation, mRNA deadenyl...
Though Atorvastatin has been used as a hypolipidemic agent, its anticancer mechanisms for repurposing are not fully understood so far. Thus, in the current study, its apoptotic and autophagic mechanisms were investigated in non-small cell lung cancer...
The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribu...
The human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two cataly...
Though midline1 interacting protein 1 (MID1IP1) was known as one of the glucose-responsive genes regulated by carbohydrate response element binding protein (ChREBP), the underlying mechanisms for its oncogenic role were never explored. Thus, in the p...
CNOT1, a key scaffold in the CCR4-NOT complex, plays a critical role in mRNA decay, particularly in the regulation of inflammatory responses through its interaction with tristetraprolin. A fragment of the middle part of CNOT1 (residues 800–999)...
Metastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progression and...
The quantum proxy signature is one of the most significant formalisms in quantum signatures. We put forward a quantum proxy signature scheme using quantum walk-based teleportation and quantum one-time pad CNOT (QOTP-CNOT) operation, which includes fo...
Objective, the application of genomic sequencing in clinical practice has allowed us to appreciate the contribution of co-occurring pathogenic variants to complex and unclassified clinical phenotypes. Besides the clinical relevance, these findings ha...
Recently, Zhang et al. proposed a single-state semi-quantum key distribution protocol to help a quantum participant share a secret key with a classical participant. However, this study shows that an eavesdropper can use a double C-NOT attack to obtai...
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. It is invo...
Retinitis pigmentosa 11 (RP11) is caused by dominant mutations in PRPF31, however a significant proportion of mutation carriers do not develop retinopathy. Here, we investigated the relationship between CNOT3 polymorphism, MSR1 repeat copy number and...
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, and despite advances in treatment, survival rates are still low; therefore, the development of novel drugs is imperative. Acetylcorynoline (ACN) is derived from Corydalis...
Two interacting double quantum dots (DQDs) can be suitable candidates for operation in the applications of quantum information processing and computation. In this work, DQDs are modeled by the heterostructure of two-dimensional (2D) MoS2 having 1T-ph...
We analyze schemes of high-fidelity multi-qubit CNOTN and C2NOT2 gates for alkali metal neutral atoms used as qubits. These schemes are based on the electromagnetically induced transparency and Rydberg blockade. The fidelity of homonuclear multi-qubi...
DNA mismatch repair (MMR) is a highly conserved pathway that corrects both base–base mispairs and insertion-deletion loops (IDLs) generated during DNA replication. Defects in MMR have been linked to carcinogenesis and drug resistance. However,...
Integrated photonic quantum chip provides a promising platform to perform quantum computation, quantum simulation, quantum metrology and quantum communication. Femtosecond laser direct writing (FLDW) is a potential technique to fabricate various inte...
Timosaponin A3 (TA3), extracted from the rhizome of Anemarrhenaasphodeloides Bunge, has been reported to affect various diseases, such as cancer, Alzheimer’s disease, and allergies. However, the underlying molecular mechanisms and impacts are l...
The porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. However, there is no consensus on the primary receptor associated with the PEDV invasion of host cells. An increasing number of studies have reported that...
(1) Background/aims: To examine potential genetic modifiers of disease penetrance in PRPF31-associated retinitis pigmentosa 11 (RP11). (2) Methods: Blood samples from individuals (n = 37) with PRPF31 variants believed to be disease-causing were used...
This study investigates the toxic effect of harmful materials, unfiltered by the placenta, on neonatal umbilical cord (UC) vessels, focusing on stress-induced adaptations in transcriptional and translational processes. It aims to analyze changes in p...
Mammalian oocytes must degrade maternal transcripts through a process called translational mRNA decay, in which maternal mRNA undergoes translational activation, followed by deadenylation and mRNA decay. Once a transcript is translationally activated...
Cerebral atherosclerosis is a leading cause of stroke and an important contributor to dementia. Yet little is known about its genetic basis. To examine the association of common single nucleotide polymorphisms with cerebral atherosclerosis severity,...
Chemical modifications of cellular RNAs play key roles in gene expression and host defense. The cap-adjacent N6,2′-O-dimethyladenosine (m6Am) is a prevalent modification of vertebrate and viral mRNAs and is catalyzed by the newly discovered N6...
Brassinin derived from Chinese cabbage has been reported to act as an anti-cancer agent on prostate, liver, and colon cancer cells. However, its mechanism and impact are largely unknown in colon cancer cells. Here, we first published a report that Br...
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deade...
RNA-binding motif 22 (RBM22) is an RNA-binding protein involved in gene regulation, with the capacity to bind DNA and function as a transcription factor for various target genes. Recent studies demonstrated that RBM22 depletion affects cell viability...
In this paper, we consider the optimization of the quantum circuit for discrete logarithm of binary elliptic curves under a constrained connectivity, focusing on the resource expenditure and the optimal design for quantum operations such as the addit...
Motivated by the revitalized interest in the digital simulation of medium- and high-energy physics phenomena, we investigate the dynamics following a Yukawa interaction quench on IBM Q. Adopting the zero-dimensional version of the scalar Yukawa coupl...
The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression. The proc...
In 2019, Zhou et al. proposed semi-quantum identification (also known as semi-quantum authentication, SQA), which proceeds under a measure-resend and measurement-free environment. However, Zhou et al.’s SQA protocol suffers from severe informat...
We hypothesized that Euonymus sachalinensis (ES) induces apoptosis by inhibiting the expression of c-Myc in colon cancer cells, and this study proved that the methanol extract of ES has anticancer effects in colon cancer cells. ES belongs to the Cela...
In the noisy intermediate-scale quantum (NISQ) era, as the scale of existing quantum hardware continues to expand, the demand for effective methods to schedule quantum gates and minimize the number of operations has become increasingly urgent. To add...
This paper presents a semi-quantum secret sharing (SQSS) protocol based on three-particle W states, designed for efficient and secure secret sharing in quantum-resource-constrained scenarios. In the protocol, a fully quantum-capable sender encodes bi...
This article presents a new approach to the problem of transforming one quantum state into another. It is shown that an r-qubit superposition |x⟩ can be obtained from another r-qubit superposition |y⟩, by using only (2r−1) rotatio...
We extend Bloch sphere formalism to pure two-qubit systems. Combining insights from Geometric Algebra and the analysis of entanglement in different conjugate bases we identify two Bloch sphere geometry that is suitable for representing maximally enta...
Integrated information theory (IIT) is a powerful tool that provides a framework for evaluating consciousness, whether in the human brain or in other systems. In Computing the Integrated Information of a Quantum Mechanism, the authors extend IIT from...
To address the potential threat to the power grid industry posed by quantum computers and ensure the security of bidirectional communication in smart grids, it is imperative to develop quantum-safe authentication protocols. This paper proposes a semi...
The Grover search algorithm reduces the security level of symmetric key cryptography with n-bit security level to O(2n/2). In order to evaluate the Grover search algorithm, the target block cipher should be efficiently implemented in quantum circuits...
One of the strategies to genetically improve reproductive traits, despite their low inheritability, has been the identification of candidate genes. Therefore, the objective of this study was to detect candidate genes associated with fecundity through...
This paper presents a new quantum secret sharing scheme featuring a (k, n) threshold and built-in verification. This innovative protocol takes advantage of entanglement and unfolds in three distinct phases. In anticipation of the coming of the d...
Pseudo-entropy is a complex-valued generalization of entanglement entropy defined on non-Hermitian transition operators and induced by post-selection. We present a simulation-based protocol for detecting nonclassicality and coherent errors in quantum...
The variational quantum eigensolver is one of the most promising algorithms for near-term quantum computers. It has the potential to solve quantum chemistry problems involving strongly correlated electrons with relatively low-depth circuits, which ar...
Genome-wide association studies (GWAS) have been a successful tool for identifying quantitative trait loci (QTL) for economically important traits in dairy cows. However, the availability of QTLs linked to phenotypic traits is limited in the literatu...
Identifying genes significantly related to diseases is a focus in the study of disease mechanisms. In this paper, from the perspective of integrated analysis and dynamic control, a method for identifying genes significantly related to diseases based...
Quantum computing has the potential to outperform classical computers and is expected to play an active role in various fields. In quantum machine learning, a quantum computer has been found useful for enhanced feature representation and high-dimensi...
This paper elaborates on the interpretation of time and entanglement, offering insights into the possible ontological nature of information in the emergence of spacetime, towards a quantum description of gravity. We first investigate different perspe...
Neurodevelopmental disorders (NDDs) represent a heterogeneous group of diseases with a variety of clinical presentations related to different genetic, epigenetic, and environmental etiologies. Numerous pathogenic variants have been identified by comp...
A novel encryption algorithm called the chained phase-controlled operation (CPCO) is presented in this paper, inspired by CNOT operation, which indicates a stronger correlation among message states and each message state depending on not only its cor...
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