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1,051 Results Found

  • Article
  • Open Access
1 Citations
1,553 Views
20 Pages

Compassion in Engineering Education: Validation of the Compassionate Engagement and Action Scales (CEAS) and Conceptual Insights

  • Alejandro Baquero-Sierra,
  • Cristian Vargas Ordóñez,
  • Jacqueline Tawney and
  • Michael Robinson

19 October 2025

This study validates the Compassionate Engagement and Action Scales for Self and Others (CEAS) for use with undergraduate engineering students in the United States. Compassion, defined as sensitivity to suffering in oneself and others coupled with a...

(This article belongs to the Special Issue Rethinking Engineering Education)
  • Article
  • Open Access
14,368 Views
12 Pages

Diagnosis of Relapse of Colorectal Adenocarcinoma through CEA Fluctuation

  • Zsolt Fekete,
  • Patricia Ignat,
  • Laura Gligor,
  • Nicolae Todor and ,
  • Alina-Simona Muntean,
  • Alexandra Gherman and
  • Dan Eniu
  • + 2 authors+ 0 author

27 July 2024

Carcinoembryonic antigen(CEA) is a routine marker employed for follow-up of colorectal tumors. We aimed to determine whether a CEA increase within the normal range can be linked to a risk of recurrence. From the period of 2006–2013 we selected...

(This article belongs to the Collection Clinical Research in Oncology)
  • Article
  • Open Access
13 Citations
3,073 Views
6 Pages

Association between Primary Perioperative CEA Ratio, Tumor Site, and Overall Survival in Patients with Colorectal Cancer

  • Thomas A. Odeny,
  • Nicole Farha,
  • Hannah Hildebrandand,
  • Jessica Allen and ,
  • Wilfred Vazquez,
  • Maximillian Martinez,
  • Ravi Kumar Paluri and
  • Anup Kasi
  • + 3 authors+ 0 author

27 November 2020

There are differences in the incidence, clinical presentation, molecular pathogenesis, and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre...

(This article belongs to the Special Issue Current Status and Future Directions of Chemotherapy in Colorectal Cancer Therapy)
  • Article
  • Open Access
163 Citations
25,834 Views
12 Pages

Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer

  • Leilani Lakemeyer,
  • Silvia Sander,
  • Mathias Wittau,
  • Doris Henne-Bruns and ,
  • Marko Kornmann and
  • Johannes Lemke
  • + 1 author+ 0 author

Colorectal cancer (CRC) is the third most common cancer worldwide. A diagnosis at early stages with enhanced screening methods is vital as metastases and recurrences increase mortality. The aim of this study was to analyze the tumor markers CEA and C...

  • Article
  • Open Access
6 Citations
5,681 Views
11 Pages

The Association of Carcinoembryonic Antigen (CEA) and Air Pollutants—A Population-Based Study

  • Yi-Jen Fang,
  • Lukas Jyuhn-Hsiarn Lee,
  • Kuei-Hau Luo,
  • Po-Sheng Fang and ,
  • Chen-Cheng Yang and
  • Hung-Yi Chuang
  • + 1 author+ 0 author

14 March 2022

Air pollutants are substances in the air that have harmful effects on humans and the ecological environment. Although slight elevations in carcinoembryonic antigen (CEA) are commonly observed in apparently healthy persons, potential associations betw...

(This article belongs to the Special Issue Air Pollution, Air Quality and Human Health)
  • Review
  • Open Access
46 Citations
24,585 Views
12 Pages

CEA (carcinoembryonic antigen), which belongs to the acidic glycoproteins, is primarily produced during the fetal period. Following this stage, low levels of CEA are considered physiological, while elevated concentrations are associated with a range...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
6 Citations
4,637 Views
13 Pages

The Advancement Stage of Gastric Cancer and the Levels of CEA and Ca19-9 in Serum and Peritoneal Lavage

  • Michał Bąk,
  • Magdalena Wojciech,
  • Adrianna Pielech,
  • Sylwia Holka and ,
  • Marek Zawadzki and
  • Dawid Murawa
  • + 1 author+ 0 author

12 November 2024

Background: This study aimed to analyze the relationship between the levels of tumor markers—specifically, carcinoembryonic antigen (CEA) and Ca19-9 antigen—determined in both serum (sCEA and sCa19-9) and intraoperative peritoneal washing...

(This article belongs to the Section Cancer Biology and Oncology)
  • Review
  • Open Access
236 Views
19 Pages

Carcinoembryonic Antigen (CEA) as a Therapeutic Target in Medullary Thyroid Cancer (MTC)

  • Kasey R. Bowyer,
  • Marice B. Alcantara,
  • Fang Fan,
  • Colt A. Egelston and ,
  • Paul J. Yazaki,
  • Jeffrey Wong,
  • Thinzar Lwin,
  • Jack Shively,
  • Maciej Kujawski and
  • Krupal B. Patel
  • + 5 authors+ 0 author

23 October 2026

Background/Objectives: Medullary thyroid cancer (MTC) is a rare but aggressive neuroendocrine malignancy arising from parafollicular C cells. Despite its low incidence, MTC has historically been estimated to account for 13.4% of thyroid cancer-relate...

(This article belongs to the Special Issue New Advances and Approaches in Thyroid Cancer)
  • Article
  • Open Access
4 Citations
2,729 Views
15 Pages

Predictive Value of the Interaction between CEA and Hemoglobin in Neoadjuvant CCRT Outcomes in Rectal Cancer Patients

  • Yi-Hsuan Lai,
  • Yu-Tien Chang,
  • Yu-Jia Chang,
  • Jo-Ting Tsai and ,
  • Ming-Hsien Li and
  • Jang-Chun Lin
  • + 1 author+ 0 author

14 December 2023

The adoption of neoadjuvant concurrent chemoradiotherapy (CCRT) has reshaped the therapeutic landscape, but response prediction remains challenging. This study investigates the interaction between pre-CCRT carcinoembryonic antigen (CEA) and post-CCRT...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
24 Citations
4,525 Views
16 Pages

The Use of Fluorescent Anti-CEA Antibodies to Label, Resect and Treat Cancers: A Review

  • Michael A. Turner,
  • Thinzar M. Lwin,
  • Siamak Amirfakhri,
  • Hiroto Nishino and ,
  • Robert M. Hoffman,
  • Paul J. Yazaki and
  • Michael Bouvet
  • + 2 authors+ 0 author

2 December 2021

A major barrier to the diagnosis and effective treatment of solid-tumor cancers is the difficulty in detection and visualization of tumor margins in primary and metastatic disease. The use of fluorescence can augment the surgeon’s ability to de...

(This article belongs to the Special Issue Feature Paper from Biomolecules Journal Reviewers)
  • Systematic Review
  • Open Access
30 Citations
5,657 Views
12 Pages

A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC)

  • Ioannis Passos,
  • Elisavet Stefanidou,
  • Soultana Meditskou-Eythymiadou,
  • Maria Mironidou-Tzouveleki and ,
  • Vasiliki Manaki,
  • Vasiliki Magra,
  • Styliani Laskou,
  • Stylianos Mantalovas,
  • Stelian Pantea and
  • Konstantinos Sapalidis
  • + 6 authors+ 1 author

11 June 2021

Background and Objectives: Medullary thyroid carcinoma (MTC) accounts for 1–2% of all thyroid malignancies, and it originates from parafollicular “C” cells. Carcinoembryonic antigen (CEA) is a tumor marker, mainly for gastrointestinal malignancies. T...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
472 Views
27 Pages

20 September 2026

The United States food system is highly centralized and heavily reliant on production and distribution methods that have significant negative environmental and social externalities. Soilless Controlled Environment Agriculture (CEA) has the potential...

(This article belongs to the Section Controlled Environment Agriculture (CEA))
  • Article
  • Open Access
14 Citations
4,116 Views
13 Pages

Longitudinal Evaluation of AFP and CEA External Proficiency Testing Reveals Need for Method Harmonization

  • Nathalie Wojtalewicz,
  • Laura Vierbaum,
  • Anne Kaufmann,
  • Ingo Schellenberg and
  • Stefan Holdenrieder

The glycoproteins alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) have long been approved as biomarkers for diagnosing and monitoring tumors. International Reference Preparations (IRPs) have been around since 1975. Nevertheless, manufactur...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
19 Citations
4,661 Views
16 Pages

Lead Time and Prognostic Role of Serum CEA, CA19-9, IL-6, CRP, and YKL-40 after Adjuvant Chemotherapy in Colorectal Cancer

  • Kaisa Lehtomäki,
  • Harri Mustonen,
  • Pirkko-Liisa Kellokumpu-Lehtinen,
  • Heikki Joensuu and ,
  • Kethe Hermunen,
  • Leena-Maija Soveri,
  • Mogens Karsbøl Boisen,
  • Christian Dehlendorff,
  • Julia Sidenius Johansen and
  • Pia Osterlund
  • + 6 authors+ 1 author

2 August 2021

In colorectal cancer (CRC), 20–50% of patients relapse after curative-intent surgery with or without adjuvant therapy. We investigated the lead times and prognostic value of post-adjuvant (8 months from randomisation to adjuvant treatment) serum CEA,...

(This article belongs to the Special Issue Molecular Biomarkers in Colorectal Cancer)
  • Article
  • Open Access
3 Citations
2,048 Views
18 Pages

CEA-Functionalized Gold Nanoparticles for Oral Prophylaxis: An In Vivo Evaluation of Safety, Biodistribution, and Cytokine Expression in Healthy Mice

  • Razvan Septimiu Zdrehus,
  • Teodora Mocan,
  • Lavinia Ioana Sabau,
  • Cristian Tudor Matea and ,
  • Alexandru-Flaviu Tabaran,
  • Teodora Pop,
  • Cristian Delcea,
  • Ofelia Mosteanu and
  • Lucian Mocan
  • + 4 authors+ 0 author

Background and Aim: Colorectal cancer remains a leading cause of cancer-related mortality, with growing interest in nanotechnology-driven immunotherapeutics. Gold nanoparticles (AuNPs) offer a promising platform due to their biocompatibility, functio...

(This article belongs to the Topic Application of Nanomaterials and Nanobiotechnology in Cancer)
  • Article
  • Open Access
38 Citations
6,214 Views
15 Pages

Plasma microRNA Levels Combined with CEA and CA19-9 in the Follow-Up of Colorectal Cancer Patients

  • Martin Pesta,
  • Radek Kucera,
  • Ondrej Topolcan,
  • Marie Karlikova and ,
  • Katerina Houfkova,
  • Jiri Polivka,
  • Tereza Macanova,
  • Iva Machova,
  • David Slouka and
  • Vlastimil Kulda
  • + 5 authors+ 0 author

21 June 2019

Colorectal cancer (CRC) ranks among the most common cancers worldwide. Surgical removal remains the best strategy for treatment of resectable tumors. An important part of caring for patients after surgery is monitoring for early detection of a possib...

(This article belongs to the Special Issue New Biomarkers in Cancers)
  • Article
  • Open Access
8 Citations
1,899 Views
15 Pages

CEA-Functionalized Gold Nanoparticles as a Nanovaccine Platform: In Vitro Evaluation of Cytocompatibility, Cellular Uptake, and Antigen Processing

  • Razvan-Septimiu Zdrehus,
  • Teodora Mocan,
  • Lavinia Ioana Sabau,
  • Cristian Tudor Matea and ,
  • Flaviu Tăbăran,
  • Teodora Pop,
  • Cristian Delcea,
  • Ofelia Mosteanu and
  • Lucian Mocan
  • + 4 authors+ 0 author

21 June 2025

Background and aim. Gold nanoparticles (AuNPs) offer promising potential as nanocarriers in vaccine development due to their biocompatibility, tunable surface properties and capacity to enhance antigen presentation. This study aimed to evaluate the i...

(This article belongs to the Special Issue Advances in Vaccine Adjuvants)
  • Article
  • Open Access
12 Citations
12,108 Views
17 Pages

Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer

  • Kaisa Lehtomäki,
  • Eetu Heervä,
  • Pirkko-Liisa Kellokumpu-Lehtinen,
  • Harri Mustonen and ,
  • Tapio Salminen,
  • Heikki Joensuu,
  • Kethe Hermunen,
  • Mogens Karsbøl Boisen,
  • Julia Sidenius Johansen and
  • Pia Osterlund
  • + 6 authors+ 1 author

Serum carcinoembryonic antigen (CEA) is frequently monitored to detect colorectal cancer (CRC) recurrence after surgery. The clinical significance of transiently increased CEA during adjuvant chemotherapy is poorly understood. Serum CEA, CA19-9, CRP,...

(This article belongs to the Special Issue 25th Anniversary of IJMS: Advances in Biochemistry)
  • Article
  • Open Access
27 Citations
9,150 Views
12 Pages

Novel Application of Cultured Epithelial Autografts (CEA) with Expanded Mesh Skin Grafting Over an Artificial Dermis or Dermal Wound Bed Preparation

  • Sadanori Akita,
  • Kenji Hayashida,
  • Hiroshi Yoshimoto,
  • Masaki Fujioka and ,
  • Chikako Senju,
  • Shin Morooka,
  • Gozo Nishimura,
  • Nobuhiko Mukae,
  • Kazuo Kobayashi and
  • Nagasaki University plastic surgeons group
  • + 12 authors+ 7 authors

Cultured epithelial autografts (CEA) with highly expanded mesh skin grafts were used for extensive adult burns covering more than 30% of the total body surface area. A prospective study on eight patients assessed subjective and objective findings up...

(This article belongs to the Special Issue Recent Advances in Scar Biology)
  • Article
  • Open Access
6 Citations
4,717 Views
14 Pages

15 August 2025

Background/Objectives: Colorectal cancer (CRC) frequently metastasizes to the peritoneum, significantly worsening patient prognosis. While serum tumor markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are routinel...

(This article belongs to the Special Issue The Role of Circulating Tumor Cells in Colorectal Cancer)
  • Article
  • Open Access
31 Citations
7,102 Views
20 Pages

Next-Generation CEA-CAR-NK-92 Cells against Solid Tumors: Overcoming Tumor Microenvironment Challenges in Colorectal Cancer

  • Alexander Sebastian Franzén,
  • Abdelhadi Boulifa,
  • Clarissa Radecke,
  • Sebastian Stintzing and ,
  • Martin J. Raftery and
  • Gabriele Pecher
  • + 1 author+ 0 author

16 January 2024

Colorectal carcinoma (CRC) presents a formidable medical challenge, demanding innovative therapeutic strategies. Chimeric antigen receptor (CAR) natural killer (NK) cell therapy has emerged as a promising alternative to CAR T-cell therapy for cancer....

(This article belongs to the Section Cancer Immunology and Immunotherapy)
  • Article
  • Open Access
15 Citations
5,406 Views
15 Pages

CEA, EpCAM, αvβ6 and uPAR Expression in Rectal Cancer Patients with a Pathological Complete Response after Neoadjuvant Therapy

  • Daan Linders,
  • Marion Deken,
  • Maxime van der Valk,
  • Willemieke Tummers and ,
  • Shadhvi Bhairosingh,
  • Dennis Schaap,
  • Gesina van Lijnschoten,
  • Elham Zonoobi,
  • Peter Kuppen and
  • Denise Hilling
  • + 9 authors+ 4 authors

Rectal cancer patients with a complete response after neoadjuvant therapy can be monitored with a watch-and-wait strategy. However, regrowth rates indicate that identification of patients with a pathological complete response (pCR) remains challengin...

(This article belongs to the Collection Biomarkers in Medicine)
  • Article
  • Open Access
8 Citations
6,081 Views
10 Pages

Pre-Operative Calcitonin and CEA Values May Predict the Extent of Metastases to the Lateral Neck Lymph Nodes in Patients with Medullary Thyroid Cancer

  • Antonio Prinzi,
  • Francesco Frasca,
  • Marco Russo,
  • Gabriella Pellegriti and ,
  • Tommaso Piticchio,
  • Dario Tumino,
  • Antonino Belfiore and
  • Pasqualino Malandrino
  • + 3 authors+ 0 author

27 August 2024

Background: In medullary thyroid cancer (MTC), lymph node metastases are often present at diagnosis and the extent of surgery is usually based upon pre-operative calcitonin and CEA levels as well as ultrasound findings. The aim of this study was to e...

(This article belongs to the Section Cancer Biomarkers)
  • Article
  • Open Access
2 Citations
1,184 Views
17 Pages

Prognostic Value of Albumin-to-CEA Ratio in Metastatic Colorectal Cancer: A Retrospective Study

  • Zekeriya Hannarici,
  • Aykut Turhan,
  • Mehmet Emin Buyukbayram,
  • Alperen Akansel Çağlar and ,
  • Mehmet Bilici,
  • Salim Başol Tekin,
  • Senar Ebinç,
  • Ali Yılmaz,
  • Birol Ocak and
  • Elif Bayraktar
  • + 7 authors+ 2 authors

Background: Finding dependable prognostic biomarkers for metastatic colorectal cancer (mCRC) is crucial. The albumin-to-carcinoembryonic antigen (CEA) ratio (ACR), a measure of nutritional-inflammatory status and tumor load, has emerged as a promisin...

(This article belongs to the Section Cancer Biology and Oncology)
  • Article
  • Open Access
1,435 Views
12 Pages

Total Neoadjuvant Therapy Versus Conventional Chemoradiotherapy in Rectal Cancer: Impact on Tumor Regression Grade and the Predictive Value of CEA

  • Aikaterini Sarafi,
  • Aikaterini Leventi,
  • Klaountia Athitaki,
  • Konstantinos Stamou and ,
  • Ioannis Papaconstantinou and
  • Dimitrios Korkolis
  • + 1 author+ 0 author

22 January 2026

Background and Objectives: The introduction of total neoadjuvant therapy (TNT) in the preoperative stage has been associated with improved oncological outcomes. However, TNT may lead to tissue fibrosis and be accompanied by increased difficulty durin...

(This article belongs to the Special Issue Novel Insights in Laparoscopic Surgery of Colorectal Carcinoma)
  • Article
  • Open Access
1 Citations
946 Views
15 Pages

CEA and CA-19-9 Dynamics Associate with Survival in Regorafenib-Treated Metastatic Colorectal Cancer: A Real-World Analysis

  • Merih Yalçıner,
  • Mehmet Berk Örüncü,
  • Mehmet Kayaalp,
  • Efe Cem Erdat and ,
  • Engin Eren Kavak and
  • Güngör Utkan
  • + 1 author+ 0 author

29 March 2026

Background: Regorafenib is a standard late-line treatment for refractory metastatic colorectal cancer (mCRC), yet clinical outcomes remain heterogeneous. Identifying accessible biomarkers to predict therapeutic benefit is crucial for balancing effica...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
455 Views
15 Pages

23 September 2026

Cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) are used alongside clinical and radiologic assessment in metastatic breast cancer, but progression may occur without a preceding increase in either marker. We examined whether this diffe...

(This article belongs to the Special Issue Breast Cancer: From Pathophysiology to Novel Therapies, 2nd Edition)
  • Article
  • Open Access
40 Citations
6,250 Views
12 Pages

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal n...

(This article belongs to the Special Issue Graphene based Electronic Devices)
  • Article
  • Open Access
1 Citations
1,596 Views
19 Pages

Significance of CEA Dynamics and Systemic Inflammatory Markers in HER2-Positive Metastatic Colorectal Cancer Patients Undergoing First-Line Chemotherapy: A Real-World Cohort Study

  • Ugur Ozkerim,
  • Oguzcan Kinikoglu,
  • Sila Oksuz,
  • Deniz Isik and ,
  • Yunus Emre Altintas,
  • Sedat Yildirim,
  • Goncagul Akdag,
  • Heves Surmeli,
  • Hatice Odabas and
  • Nedim Turan
  • + 6 authors+ 1 author

2 January 2026

Background and Objectives: HER2-positive metastatic colorectal cancer (mCRC) represents a biologically distinct and clinically aggressive subtype associated with poor response to standard first-line chemotherapy. Reliable, low-cost prognostic biomark...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
24 Citations
3,819 Views
18 Pages

The Level of Preoperative Plasma KRAS Mutations and CEA Predict Survival of Patients Undergoing Surgery for Colorectal Cancer Liver Metastases

  • Jiri Polivka,
  • Jindra Windrichova,
  • Martin Pesta,
  • Katerina Houfkova and ,
  • Hana Rezackova,
  • Tereza Macanova,
  • Ondrej Vycital,
  • Radek Kucera,
  • David Slouka and
  • Ondrej Topolcan
  • + 5 authors+ 0 author

27 August 2020

Colorectal cancer (CRC) belongs to the most common cancers. The liver is a predominant site of CRC dissemination. Novel biomarkers for predicting the survival of CRC patients with liver metastases (CLM) undergoing metastasectomy are needed. We examin...

(This article belongs to the Special Issue Metastatic Colorectal Cancer)
  • Article
  • Open Access
13 Citations
4,861 Views
18 Pages

Triplexed CEA-NSE-PSA Immunoassay Using Time-Gated Terbium-to-Quantum Dot FRET

  • Shashi Bhuckory,
  • K. David Wegner,
  • Xue Qiu,
  • Yu-Tang Wu and ,
  • Travis L. Jennings,
  • Anne Incamps and
  • Niko Hildebrandt
  • + 2 authors+ 0 author

12 August 2020

Time-gated Förster resonance energy transfer (TG-FRET) between Tb complexes and luminescent semiconductor quantum dots (QDs) provides highly advantageous photophysical properties for multiplexed biosensing. Multiplexed Tb-to-QD FRET immunoassays...

(This article belongs to the Special Issue Luminescent Lanthanide Complexes)
  • Editorial
  • Open Access
4,466 Views
2 Pages

This Special Issue contains selected papers from works presented at the 8th EASN–CEAS (European Aeronautics Science Network–Council of European Aerospace Societies) Workshop on Manufacturing for Growth and Innovation, which was held in Gl...

(This article belongs to the Special Issue 8th EASN-CEAS Workshop on Manufacturing for Growth and Innovation)
  • Article
  • Open Access
2 Citations
2,244 Views
8 Pages

Carbon Nanopowder-Based Stochastic Sensor for Ultrasensitive Assay of CA 15-3, CEA and HER2 in Whole Blood

  • Raluca-Ioana Stefan-van Staden,
  • Oana-Raluca Musat,
  • Damaris-Cristina Gheorghe,
  • Ruxandra-Maria Ilie-Mihai and
  • Jacobus (Koos) Frederick van Staden

8 September 2022

Two microsensors obtained by the physical immobilization of 5,10,15,20-tetraphenyl-21H,23H-porphine (TPP) and 5,10,15,20-tetrakis (pentafluorophenyl chloride)-21H,23H-iron (III) porphyrin (Fe(TPFPP)Cl) in carbon nanopowder decorated with gold nanopar...

  • Article
  • Open Access
5 Citations
3,221 Views
12 Pages

18 April 2023

Metabolic abnormalities are well-known risk factors for many cancers, even though no clearly established link with pancreatic neuroendocrine neoplasms (PanNENs) has yet been investigated. This research aimed to assess the serum levels of leptin, chro...

(This article belongs to the Special Issue New Biomarkers in Cancers 2nd Edition)
  • Article
  • Open Access
4 Citations
3,062 Views
15 Pages

Simultaneous Assay of CA 72-4, CA 19-9, CEA and CA 125 in Biological Samples Using Needle Three-Dimensional Stochastic Microsensors

  • Alexandru-Adrian Bratei,
  • Raluca-Ioana Stefan-van Staden,
  • Ruxandra-Maria Ilie-Mihai and
  • Damaris-Cristina Gheorghe

23 September 2023

Two-needle 3D stochastic microsensors based on boron- and nitrogen-decorated gra-phenes, modified with N-(2-mercapto-1H-benzo[d]imidazole-5-yl), were designed and used for the molecular recognition and quantification of CA 72-4, CA 19-9, CEA and CA 1...

(This article belongs to the Section Biomedical Sensors)
  • Article
  • Open Access
11 Citations
4,498 Views
15 Pages

PEC/Colorimetric Dual-Mode Lab-on-Paper Device via BiVO4/FeOOH Nanocomposite In Situ Modification on Paper Fibers for Sensitive CEA Detection

  • Xu Li,
  • Jiali Huang,
  • Jiayu Ding,
  • Mingzhen Xiu and ,
  • Kang Huang,
  • Kang Cui,
  • Jing Zhang,
  • Shiji Hao,
  • Yan Zhang and
  • Yizhong Huang
  • + 6 authors+ 1 author

6 January 2023

A dual-mode lab-on-paper device based on BiVO4/FeOOH nanocomposites as an efficient generating photoelectrochemical (PEC)/colorimetric signal reporter has been successfully constructed by integration of the lab-on-paper sensing platform and PEC/color...

(This article belongs to the Special Issue Paper-Based Biosensors)
  • Article
  • Open Access
18 Citations
5,072 Views
9 Pages

Fluorescent Anti-CEA Nanobody for Rapid Tumor-Targeting and Imaging in Mouse Models of Pancreatic Cancer

  • Thinzar M. Lwin,
  • Michael A. Turner,
  • Hiroto Nishino,
  • Siamak Amirfakhri and ,
  • Sophie Hernot,
  • Robert M. Hoffman and
  • Michael Bouvet
  • + 2 authors+ 0 author

Tumor-specific targeting with fluorescent probes can enhance contrast for identification of cancer during surgical resection and visualize otherwise invisible tumor margins. Nanobodies are the smallest naturally-occurring antigen-binding molecules wi...

  • Article
  • Open Access
2 Citations
1,498 Views
33 Pages

26 December 2024

The adoption of cloud-based building information modelling (Cloud-BIM) presents a complex landscape of potential benefits and challenges for architectural design enterprises in China. While similar opportunities and obstacles exist globally, the uniq...

(This article belongs to the Section Construction Management, and Computers & Digitization)
  • Article
  • Open Access
29 Citations
7,861 Views
19 Pages

Crop Management in Controlled Environment Agriculture (CEA) Systems Using Predictive Mathematical Models

  • Chiara Amitrano,
  • Giovanni Battista Chirico,
  • Stefania De Pascale,
  • Youssef Rouphael and
  • Veronica De Micco

31 May 2020

Proximal sensors in controlled environment agriculture (CEA) are used to monitor plant growth, yield, and water consumption with non-destructive technologies. Rapid and continuous monitoring of environmental and crop parameters may be used to develop...

(This article belongs to the Special Issue Metrology for Agriculture and Forestry 2019)
  • Article
  • Open Access
13 Citations
5,723 Views
17 Pages

RES-Q-Trace: A Mobile CEAS-Based Demonstrator for Multi-Component Trace Gas Detection in the MIR

  • Norbert Lang,
  • Uwe Macherius,
  • Henrik Zimmermann,
  • Sven Glitsch and ,
  • Mathias Wiese,
  • Jürgen Röpcke and
  • Jean-Pierre H. Van Helden
  • + 2 authors+ 0 author

27 June 2018

Sensitive trace gas detection plays an important role in current challenges occurring in areas such as industrial process control and environmental monitoring. In particular, for medical breath analysis and for the detection of illegal substances, e....

(This article belongs to the Special Issue Spectroscopy Based Sensors)
  • Article
  • Open Access
2 Citations
1,823 Views
23 Pages

10 October 2025

Colorectal carcinoma (CRC) is characterized by mutations in p53 and the Wnt signaling pathway, and immunotherapy has shown limited efficacy in microsatellite-stable CRC. Here, CEABP1, a binding protein for the CRC biomarker carcinoembryonic antigen (...

(This article belongs to the Special Issue Protein–Protein Interactions in Human Cancer)
  • Article
  • Open Access
28 Citations
6,275 Views
11 Pages

25 August 2019

The qualitative and quantitative analysis to trace gas in exhaled human breath has become a promising technique in biomedical applications such as disease diagnosis and health status monitoring. This paper describes an application of a high spectral...

(This article belongs to the Section Biomedical Sensors)
  • Article
  • Open Access
9 Citations
4,246 Views
11 Pages

26 January 2019

A trace acetylene (C2H2) detection system was demonstrated using the cavity-enhanced absorption spectroscopy (CEAS) technique and a near-infrared distributed feedback (NIR-DFB) laser. A Fabry–Perot (F–P) cavity with an effective optical p...

(This article belongs to the Section Physical Sensors)
  • Article
  • Open Access
1 Citations
707 Views
20 Pages

22 May 2026

Magnetic polymeric microspheres are pivotal solid-phase carriers in chemiluminescence enzyme immunoassays (CLEIA). However, their practical clinical application is frequently hindered by non-specific adsorption, irreversible aggregation, and the intr...

(This article belongs to the Section Biosensors and Healthcare)
  • Article
  • Open Access
40 Citations
6,521 Views
17 Pages

Carcinoembryonic Antigen Expression in Human Tumors: A Tissue Microarray Study on 13,725 Tumors

  • Kristina Jansen,
  • Lara Kornfeld,
  • Maximilian Lennartz,
  • Sebastian Dwertmann Rico and ,
  • Simon Kind,
  • Viktor Reiswich,
  • Florian Viehweger,
  • Ahmed Abdulwahab Bawahab,
  • Christoph Fraune and
  • Christian Bernreuther
  • + 23 authors+ 18 authors

3 December 2024

Background/Objectives: Carcinoembryonic antigen (CEA) is a cell-surface glycoprotein serving as a drug target, diagnostic marker, and serum marker for cancer monitoring. However, prevalence data on CEA expression in cancer tissues vary considerably....

(This article belongs to the Section Cancer Pathophysiology)
  • Article
  • Open Access
31 Citations
13,421 Views
14 Pages

Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor

  • Fengyu Su,
  • Chunye Xu,
  • Minoru Taya,
  • Kimie Murayama and ,
  • Yasuro Shinohara and
  • Shin-Ichiro Nishimura
  • + 1 author+ 0 author

18 July 2008

Carcinoembryonic antigen (CEA) is an oncofoetal cell-surface glycoprotein that serves as an important tumor marker for colorectal and some other carcinomas. In this work, a CEA immunoassay using a surface plasmon resonance (SPR) biosensor has been de...

(This article belongs to the Special Issue Bioanalysis in Vivo/in Vitro)
  • Article
  • Open Access
15 Citations
1,539 Views
4 Pages

Serum Carcinoembryonic Antigen as a Tumour Marker in Patients with Endometrial Cancer

  • Y. Hashiguchi,
  • M. Kasai,
  • T. Fukuda,
  • T. Ichimura and ,
  • T. Yasui and
  • T. Sumi
  • + 1 author+ 0 author

1 October 2016

Background: No potential tumour markers have been validated for prognosis in endometrial cancer. However, carcinoembryonic antigen (CEA) is one of the most widely used tumour markers in various types of cancer. Although CEA expression in endometrial...

  • Article
  • Open Access
7 Citations
6,375 Views
12 Pages

Evaluation of Carcinoembryonic Antigen as a Prognostic Marker for Colorectal Cancer Relapse: Insights from Postoperative Surveillance

  • Stefan Titu,
  • Radu Alexandru Ilies,
  • Teodora Mocan,
  • Alexandru Irimie and ,
  • Vlad Alexandru Gata and
  • Cosmin Ioan Lisencu
  • + 1 author+ 0 author

12 October 2025

Background/Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. This study evaluates the predictive value of Carcinoembryonic Antigen (CEA) in identifying CRC recurrence following surgical resect...

(This article belongs to the Section Cancer and Cancer-Related Research)
  • Article
  • Open Access
20 Citations
3,467 Views
15 Pages

Using Normalized Carcinoembryonic Antigen and Carbohydrate Antigen 19 to Predict and Monitor the Efficacy of Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer

  • Xiao-Huan Tang,
  • Xiao-Long Wu,
  • Xue-Jun Gan,
  • Yi-Ding Wang and ,
  • Fang-Zhou Jia,
  • Yi-Xue Wang,
  • Yan Zhang,
  • Xiang-Yu Gao and
  • Zi-Yu Li
  • + 4 authors+ 0 author

Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are established prognostic biomarkers for patients with gastric cancer. However, their potential as predictive markers for neoadjuvant chemotherapy (NACT) efficacy has not been ful...

(This article belongs to the Special Issue Focus on Gastrointestinal Diseases 2.0: Inflammation)
  • Article
  • Open Access
1,565 Views
14 Pages

Serum Carcinoembryonic Antigen Levels Across Molecular Subtypes and Their Clinical and Prognostic Implications in Metastatic Non-Small Cell Lung Cancer

  • Ali Aytac,
  • Bilgin Demir,
  • Meltem Demirtas Gulmez,
  • Hayati Arvas and ,
  • Tuba Ugur Tuzcu,
  • Enes Erul,
  • Salih Tunbekici,
  • Tahir Yerlikaya,
  • Sezai Tunc and
  • Ahmet Demirkazik
  • + 15 authors+ 10 authors

9 April 2026

Background and Objectives: Serum carcinoembryonic antigen (CEA) is a widely used biomarker in non-small cell lung cancer (NSCLC). However, its association with oncogenic driver alterations and prognostic significance across molecular subtypes in meta...

(This article belongs to the Special Issue Non-Small Cell Lung Cancer (NSCLC): Molecular Markers, Immune Therapy and Targeted Therapy)

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