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New Advances and Approaches in Thyroid Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 715

Special Issue Editors


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Guest Editor
1. Endocrine Surgery Unit, General Surgery Service, Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain
2. Department of Surgery, Pediatrics, Obstetrics and Ginecology, Faculty of Medicine, University of Murcia, Murcia, Spain
3. Instituto Murciano de Investigación Biosanitaria (IMIB) Pascual Parrilla, El Palmar, 30120 Murcia, Spain
Interests: thyroid cancer; parathyroid diseases; neuroendocrine tumours; multiple endocrine neoplasia syndrome
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Endocrine Surgery Unit, General Surgery Service, Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain
2. Department of Surgery, Pediatrics, Obstetrics and Ginecology, Faculty of Medicine, University of Murcia, Murcia, Spain
3. Instituto Murciano de Investigación Biosanitaria (IMIB) Pascual Parrilla, El Palmar, 30120 Murcia, Spain
Interests: thyroid cancer; parathyroid diseases; neuroendocrine tumours; multiple endocrine neoplasia syndrome

Special Issue Information

Dear Colleagues,

We are delighted to announce this Special Issue and invite submissions a manuscript focused on diagnostics, therapies, surgical approaches, and prognostic biomarkers in thyroid cancers. This Special Issue aims to cover the full spectrum of thyroid malignancies, including papillary, follicular, medullary, anaplastic, and poorly differentiated thyroid carcinomas.

Keeping abreast of the evolving landscape in thyroid oncology is critical. Emerging molecular markers, advanced imaging techniques, and novel approaches in patient stratification continue to enhance early detection and risk assessment across all thyroid cancer types. Likewise, progress in precision therapies and targeted treatments offers improved outcomes for patients with aggressive or treatment‑resistant disease. Innovators are also refining surgical strategies and integrating multimodal diagnostic–therapeutic frameworks for more personalized care.

This Special Issue aims to foster knowledge exchange that propels toward more precise, individualized, and effective management of thyroid cancer. Submissions will contribute to elevating clinical practice and patient outcomes in this dynamic and high‑impact field.

Prof. Dr. Beatriz Febrero
Prof. Dr. José Manuel Rodríguez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thyroid cancer
  • medullary thyroid cancer
  • papillary thyroid cancer
  • follicular thyroid cancer
  • poorly differentiated thyroid tumours
  • novel approaches
  • prognostic biomarkers
  • risk stratification

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Published Papers (1 paper)

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Research

15 pages, 497 KB  
Article
Predictors of Distant Metastasis in Patients with Medullary Thyroid Carcinoma
by Inmaculada Ros-Madrid, Beatriz Febrero, Rosario Paloma Cano-Mármol, Mercedes Ferrer-Gómez and José M. Rodríguez
Cancers 2025, 17(19), 3193; https://doi.org/10.3390/cancers17193193 - 30 Sep 2025
Viewed by 563
Abstract
Background/Objectives: The presence of distant metastases is the main cause of death in medullary thyroid carcinoma (MTC). However, due to the rarity of this cancer, few studies have thoroughly analyzed the variables influencing the development of distant metastases. The objective of this [...] Read more.
Background/Objectives: The presence of distant metastases is the main cause of death in medullary thyroid carcinoma (MTC). However, due to the rarity of this cancer, few studies have thoroughly analyzed the variables influencing the development of distant metastases. The objective of this study was to evaluate, in patients with MTC, the factors associated with the occurrence of synchronous and metachronous distant metastases. Methods: An analytical, observational, retrospective cohort study was conducted at a tertiary hospital. Patients with histologically confirmed MTC, both sporadic and familial (MEN2 syndrome), were included. The influence of epidemiological variables, heredity, complementary tests, surgical factors, histological features, staging, and disease progression was assessed. A univariate comparative analysis was first performed, followed by a multivariate analysis using logistic regression. Results: This study included 146 patients, of whom 75% (n = 109) had familial MTC. Lymph node involvement at diagnosis was observed in 36% (n = 52). During follow-up, distant metastases developed in 14% (n = 21) of patients, including five cases present at the time of diagnosis. The median follow-up was 214 months (IQR 106–289). The presence of distant metastases was associated with an increased risk of mortality. Factors associated with distant metastases included age, calcitonin level, hereditary status, lymph node involvement, and overall stage. In multivariate analysis, the lymph node ratio (LNR) remained the only significant predictor (OR 29.124). Conclusions: Several variables were related to the presence of distant metastases. Among them, the LNR emerged as the independent predictor of both synchronous and metachronous distant metastases. Full article
(This article belongs to the Special Issue New Advances and Approaches in Thyroid Cancer)
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