Focus on Gastrointestinal Diseases 2.0: Inflammation

Dear Colleagues,

Gastrointestinal diseases are common, multifactorial pathologies associated with specific genetic, infective, environmental, and host factors. The study of the molecular mechanisms underlying the interaction among these factors is essential to understand the pathophysiology of gastrointestinal diseases and to develop new therapies. These are extremely common diseases in the general population, with a high cost for health systems around the world. The emerging roles of the intestinal microbiome and of local and general immune factors are transforming our inderstanding of gastrointestinal diseases. The identification of molecular mechanisms involved in their development has also generated considerable progress in the therapeutic field in the last 20 years: the use of biological drugs that have changed the natural course of inflammatory bowel diseases is a clear example of this. The molecular characterization of the interactions between external pathogens, such as Helicobacter pylori and the host can also help to decipher the mechanisms that induce inflammatory processes of the mucosa and mutations that can predispose an individual to the onset of gastrointestinal cancers.

As volume 1 of Special Issue “Focus on gastrointestinal diseases ” is successful we reopen this issue again in the /International Journal of Molecular Sciences/ (https://www.mdpi.com/journal/ijms, ISSN 1422-0067, IF 5.923, JCR Category Q1). This second Special Issue, we invite all interested researchers to contribute with original research articles or literature reviews on all aspects related to the molecular mechanisms involved in pathologies of the gastrointestinal system, with particular interest in, but not limited to, inflammatory intestinal, pancreatic, and gastric diseases, further more, more inflammation content will be highly welcomed.

Dr. Marcello Candelli
Guest Editor

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