The MORET 5 code, which has been developed over more than 50 years at IRSN, has recently evolved, in its continuous energy version, from a criticality oriented code to a code also focused on reactor physics applications. Some developments such as the...
Compositional variations of major and minor elements were examined in Pt–Fe alloys from various geological settings and types of deposits, both lode and placer occurrences. They included representatives of layered intrusions, Alaskan-Uralian-(Aldan)-...
The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biom...
Ferrotorryweiserite, Rh5Fe10S16, occurs as small grains (≤20 µm) among droplet-like inclusions (up to 50 μm in diameter) of platinum-group minerals (PGM), in association with oberthürite or Rh-bearing pentlandite, laurite, and a Pt-P...
In a world where technology is assuming a pervasive role, sports sciences are also increasingly exploiting the possibilities opened by advanced sensors and intelligent algorithms. This paper focuses on the development of a convenient, practical, and...
Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from...
The suppression of side reactions is one of the most important objectives in peptide synthesis, where highly reactive compounds are involved. Recently, the violuric acid derivative Oxyma-B was introduced into peptide synthesis protocols as a promisin...
The supramolecular structure in peptides’ prolonged-released gel formulations is the most critical parameter for the determination of the pharmaceutical profile of the drug. Here, we report our investigation on lanreotide Autogel as a case stud...
Today’s applications and providers are very interested in knowing the social aspects of users in order to customize the services they provide and to be more effective. Among the others, the most frequented places and the paths to reach them are...
The technological advancements promote the rise of the fourth industrial revolution, where key terms are efficiency, innovation, and enterprises’ digitalization. Market globalization, product mass customization, and more complex products need to refl...
Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and th...
The market of biomolecules with therapeutic scopes, including peptides, is continuously expanding. The interest towards this class of pharmaceuticals is stimulated by the broad range of bioactivities that peptides can trigger in the human body. The m...
Bioactive peptides are increasingly used in clinical practice. Reversed-phase chromatography using formic or trifluoroacetic acid in the mobile phase is the most widely used technique for their analytical control. However, sometimes it does not prove...
Since its identification in the early 1970s, artemisinin, as well as semi-synthetic derivatives and synthetic trioxanes, have been used in malaria therapy. Reduction of artemisinin by NaBH4 produced dihydroartemisinin (DHA), and yielded a new stereoc...
Measuring dynamic postural control and mobility using task-based full-body movements has been advocated. The star excursion balance test (SEBT) is well-established, but it does not elicit large upper body joint movements. Therefore, the hand reach st...
Patients undergoing total knee arthroplasty (TKA) often ask when they can safely resume driving. Answering this question is an important matter, which might entail legal and insurance issues. In the present review, the following questions are address...
We are pleased to introduce the fourth Journal Club. This edition is focused on several relevant studies published in the last years in the field of movement analysis, chosen by our Editorial Board members. We hope to stimulate your curiosity in this...
Aggregation is among the most critical parameters affecting the pharmacological and safety profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost importance to define the exact aggregation state of peptide drugs...
Peptides are a class of biomolecules with a great potential from the therapeutic point of view, because of their unique biological properties. Industrially, the production stategies adopted produce both the target peptide and a series of impurities t...
Background: Emerging evidence indicates that epilepsy extends beyond the brain, involving systemic metabolic, immune, and microbiome perturbations that shape neuronal excitability and treatment response. Canine idiopathic epilepsy (CE) offers a natur...
The rapid advancement of technology has led to a substantial increase in Waste Electrical and Electronic Equipment (WEEE), which poses significant environmental threats and increases pressure on the planet’s limited natural resources. In respon...
The ever-growing volume of global electronic waste (e-waste) poses significant environmental and health challenges. Printed circuit boards (PCBs), which form the core of most electronic devices, contain valuable metals as well as hazardous materials....
This review paper examines how Generative AI (GAI) and Large Language Models (LLMs) can transform smart cities in the Industry 5.0 era. Through selected case studies and portions of the literature, we analyze these technologies’ impact on industrial...
Autonomous driving is a rising technology expected to revolutionize commuting. Even if the spread of autonomous vehicles is slower than expected some years ago, their progress will not stop and will become a reality shortly. Therefore, we must manage...
Modern systems often employ decentralised and distributed approaches. This can be attributed, among others, to the increasing complexity of system processes, which go beyond the capabilities of singular components. Additionally, with the growth in de...
The primary objective of a depalletizing system is to automate the process of detecting and locating specific variable-shaped objects on a pallet, allowing a robotic system to accurately unstack them. Although many solutions exist for the problem in...
With the advent of IoT, cities will soon be populated by autonomous vehicles and managed by intelligent systems capable of actively interacting with city infrastructures and vehicles. In this work, we propose a model based on reinforcement learning t...
The transition from a linear to a circular, resource-efficient economy is crucial in order to address the growing scarcity of resources, environmental degradation and the rapid increase in electronic waste and end-of-life products. Artificial Intelli...
E-bikes, i.e., bikes equipped with a small electrical engine, are becoming increasingly widespread, thanks to their positive contribution to mobility and sustainability. A key component of an e-bike is the battery that feeds the drive unit: clearly,...
In the context of smart cities, reservation-based parking systems may accept more requests than they can ultimately honor when users stay longer than declared. This paper introduces a risk-aware admission-control framework that explicitly accounts fo...
This study presents research aimed at analyzing whether, in contrast with traditional methodologies, the usage of information and communication technologies (ICTs) in the process of learning mathematics affects gender distinctions by affecting the lo...
Decarbonisation of the aviation sector is essential for achieving global-climate targets, with hydrogen propulsion emerging as a viable alternative to battery–electric systems for vertical flight. Unlike previous studies focusing on clean-sheet...
The Lymphocyte-Activation Protein 3 (LAG-3) inhibitory receptor is expressed on regulatory plasma cells (PCs). Micro-environmental cells that express LAG-3 were found to be increased during the progression of smoldering multiple myeloma (SMM). To ass...