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247 Results Found

  • Article
  • Open Access
16 Citations
3,715 Views
18 Pages

Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes

  • Tyler L. Stevens,
  • Heather R. Manring,
  • Michael J. Wallace,
  • Aaron Argall,
  • Trevor Dew,
  • Peter Papaioannou,
  • Steve Antwi-Boasiako,
  • Xianyao Xu,
  • Stuart G. Campbell and
  • Mona El Refaey
  • + 5 authors

29 September 2022

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete...

  • Article
  • Open Access
2 Citations
4,388 Views
23 Pages

2 September 2021

In this paper, the Adaptive Calibration Model (ACM) and Active Inference Theory (AIT) are related to future-proofing startups. ACM encompasses the allocation of energy by the stress response system to alternative options for action, depending upon in...

  • Article
  • Open Access
3 Citations
8,144 Views
24 Pages

25 March 2014

Recently, a distribution management system (DMS) that can conduct periodical system analysis and control by mounting various applications programs has been actively developed. In this paper, we summarize the development and demonstration of a databas...

  • Article
  • Open Access
8 Citations
5,215 Views
20 Pages

Bridging the Gap between Design and Simulation of Low-Voltage CMOS Circuits

  • Cristina Missel Adornes,
  • Deni Germano Alves Neto,
  • Márcio Cherem Schneider and
  • Carlos Galup-Montoro

This work proposes a truly compact MOSFET model that contains only four parameters to assist an integrated circuits (IC) designer in a design by hand. The four-parameter model (4PM) is based on the advanced compact MOSFET (ACM) model and was implemen...

  • Article
  • Open Access
30 Citations
9,518 Views
20 Pages

Social media apps provide analysts with a wide range of data to study behavioral aspects of our everyday lives and to answer societal questions. Although social media data analysis is booming, only a handful of prominent social media apps, such as Tw...

  • Article
  • Open Access
15 Citations
4,184 Views
16 Pages

Ship Segmentation in SAR Images by Improved Nonlocal Active Contour Model

  • Xiaoqiang Zhang,
  • Boli Xiong,
  • Ganggang Dong and
  • Gangyao Kuang

1 December 2018

Synthetic aperture radar (SAR) has been widely used in ocean surveillance. As an important part of shipping management and military applications, ship monitoring is a study hotspot in SAR image interpretation; hence, many researches focus on ship tar...

  • Article
  • Open Access
20 Citations
4,213 Views
17 Pages

20 May 2020

Cloud initialization is a challenge in numerical weather prediction. Probably the most relevant observations for this task come from geostationary satellites. These satellites provide the cloud mask with high spatio-temporal resolution and low latenc...

  • Article
  • Open Access
11 Citations
8,200 Views
18 Pages

10 October 2019

Accurate optic disc (OD) and optic cup (OC) segmentation play a critical role in automatic glaucoma diagnosis. In this paper, we present an automatic segmentation technique regarding the OD and the OC for glaucoma assessment. First, the robust adapti...

  • Review
  • Open Access
4 Citations
3,967 Views
21 Pages

18 February 2023

Arrhythmogenic cardiomyopathy (ACM) is largely an autosomal dominant genetic disorder manifesting fibrofatty infiltration and ventricular arrhythmia with predominantly right ventricular involvement. ACM is one of the major conditions associated with...

  • Article
  • Open Access
15 Citations
4,500 Views
22 Pages

USA300 is a predominant community-associated methicillin-resistant Staphylococcus aureus strain which carries an arginine catabolic mobile element (ACME). ACME contains potential virulence factors including an arginine deiminase (arc) pathway and an...

  • Article
  • Open Access
14 Citations
5,549 Views
23 Pages

27 February 2023

Artificial Intelligence (AI) is providing the technology for large-scale, cost-effective and current asbestos-containing material (ACM) roofing detection. AI models can provide additional data to monitor, manage and plan for ACM in situ and its safe...

  • Article
  • Open Access
3 Citations
2,332 Views
16 Pages

Effect of African Catfish Mucilage Concentration on Stability of Nanoemulsion Using D-Optimal Mixture Design

  • Adebanji Olasupo Oluwole,
  • Daniel Imwansi Ikhu-Omoregbe,
  • Victoria Adaora Jideani and
  • Seteno Karabo Ntwampe

21 July 2021

Nanoemulsions are alternative means of incorporating functional components into systems. This research aims to model the effect of African catfish mucilage (ACM) concentrations on the particle size (PS) of stable oil-in-water (O/W) nanoemulsions form...

  • Article
  • Open Access
22 Citations
5,383 Views
16 Pages

Psychosocial Stress Hastens Disease Progression and Sudden Death in Mice with Arrhythmogenic Cardiomyopathy

  • Jacopo Agrimi,
  • Arianna Scalco,
  • Julia Agafonova,
  • Larry Williams III,
  • Nainika Pansari,
  • Gizem Keceli,
  • Seungho Jun,
  • Nadan Wang,
  • Francesca Mastorci and
  • Stephen P. Chelko
  • + 6 authors

24 November 2020

Physiological stressors, such as exercise, can precipitate sudden cardiac death or heart failure progression in patients with arrhythmogenic cardiomyopathy (ACM). Yet, whether and to what extent a highly prevalent and more elusive environmental facto...

  • Review
  • Open Access
16 Citations
4,753 Views
38 Pages

Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models

  • Christianne J. Chua,
  • Justin Morrissette-McAlmon,
  • Leslie Tung and
  • Kenneth R. Boheler

25 September 2023

Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause of heart failure leading to premature death. Several CMPs are now recognized to have a strong genetic basis, including arrhythmogenic cardiomyopathy (ACM), which...

  • Article
  • Open Access
3,477 Views
27 Pages

Certificates are integral to the security of today’s Internet. Protocols like BlockVoke allow secure, timely and efficient revocation of certificates that need to be invalidated. ACME, a scheme used by the non-profit Let’s Encrypt Certifi...

  • Article
  • Open Access
835 Views
17 Pages

18 November 2025

Patulin (PAT), ochratoxin A (OTA), and acetamiprid (ACM) are common food contaminants that frequently co-occur in agricultural products, raising concerns over their cumulative health risks. This study is the first to systematically assess the combine...

  • Article
  • Open Access
6 Citations
2,918 Views
16 Pages

Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis

  • Mario Garbelli,
  • Maria Eva Baro Salvador,
  • Abraham Rincon Bello,
  • Diana Samaniego Toro,
  • Francesco Bellocchio,
  • Luca Fumagalli,
  • Milena Chermisi,
  • Christian Apel,
  • Jovana Petrovic and
  • Luca Neri
  • + 8 authors

28 September 2024

Introduction: The management of anemia in chronic kidney disease (CKD-An) presents significant challenges for nephrologists due to variable responsiveness to erythropoietin-stimulating agents (ESAs), hemoglobin (Hb) cycling, and multiple clinical fac...

  • Article
  • Open Access
839 Views
22 Pages

Poly-(D,L)-Lactide-ε-Caprolactone-Methacrylate Is a Suitable Scaffold Material for In Vitro Cartilage Regeneration

  • Michelle Sophie Wunderer,
  • Veronika Sparenberg,
  • Christoph Biehl,
  • Klaus Liefeith and
  • Katrin Susanne Lips

Due to the limited regeneration of cartilage, new implant materials are needed. Biodegradable polymers poly-(D,L)-lactide-ε-caprolactone-methacrylate (LCM) and polyamid-ε-caprolactone-methacrylate (ACM) were recently established and c...

  • Review
  • Open Access
5 Citations
3,479 Views
22 Pages

Arrhythmogenic cardiomyopathy (ACM) is a rare genetic cardiac disease characterized by the progressive substitution of myocardium with fibro-fatty tissue. Clinically, ACM shows wide variability among patients; symptoms can include syncope and ventric...

  • Article
  • Open Access
478 Views
21 Pages

The safe and stable operation of submarine cables is a critical issue in offshore wind power engineering. This study presents an experimental and theoretical study on the stability of submarine cable protected by a sleeve (SCPS) with Articulated Conc...

  • Article
  • Open Access
2 Citations
1,981 Views
11 Pages

Acemetacin (ACM) is a new non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects. However, the poor water solubility and gastrointestinal side effects limit its use. Recently, the co-amorphous (CAM) strategy h...

  • Article
  • Open Access
2 Citations
1,301 Views
11 Pages

ACM-Assessor: An Artificial Intelligence System for Assessing Angle Closure Mechanisms in Ultrasound Biomicroscopy

  • Yuyu Cong,
  • Weiyan Jiang,
  • Zehua Dong,
  • Jian Zhu,
  • Yuanhao Yang,
  • Yujin Wang,
  • Qian Deng,
  • Yulin Yan,
  • Jiewen Mao and
  • Yanning Yang
  • + 6 authors

Primary angle-closure glaucoma (PACG), characterized by angle closure (AC) with insidious and irreversible progression, requires precise assessment of AC mechanisms for accurate diagnosis and treatment. This study developed an artificial intelligence...

  • Article
  • Open Access
6 Citations
2,445 Views
23 Pages

10 April 2024

The multifaceted inductive technique of AC magnetic susceptibility (ACMS) provides versatile and reliable means for the investigation of the respective properties of magnetic and superconducting materials. Here, we explore, both mathematically and ex...

  • Article
  • Open Access
15 Citations
3,572 Views
12 Pages

Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy

  • Zirui Qiu,
  • Yawen Zhao,
  • Tian Tao,
  • Wenying Guo,
  • Ruonan Liu,
  • Jingmin Huang and
  • Geyang Xu

11 October 2022

Background: Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease characterized by progressive fibro-fatty replacement of cardiac myocytes. Up to now, the existing therapeutic modalities for ACM are mostly palliative. About 50% of ACM...

  • Article
  • Open Access
5 Citations
5,678 Views
15 Pages

Estimating the Additional Greenhouse Gas Emissions in Korea: Focused on Demolition of Asbestos Containing Materials in Building

  • Young-Chan Kim,
  • Won-Hwa Hong,
  • Yuan-Long Zhang,
  • Byeung-Hun Son,
  • Youn-Kyu Seo and
  • Jun-Ho Choi

When asbestos containing materials (ACM) must be removed from the building before demolition, additional greenhouse gas (GHG) emissions are generated. However, precedent studies have not considered the removal of ACM from the building. The present st...

  • Article
  • Open Access
15 Citations
4,414 Views
15 Pages

A Pilot Metabolomic Study on Myocardial Injury Caused by Chronic Alcohol Consumption—Alcoholic Cardiomyopathy

  • Zhipeng Cao,
  • Tianqi Wang,
  • Wei Xia,
  • Baoli Zhu,
  • Meihui Tian,
  • Rui Zhao and
  • Dawei Guan

Chronic alcohol consumption leads to myocardial injury, ventricle dilation, and cardiac dysfunction, which is defined as alcoholic cardiomyopathy (ACM). To explore the induced myocardial injury and underlying mechanism of ACM, the Liber-DeCarli liqui...

  • Article
  • Open Access
1,329 Views
13 Pages

Dehydrated human-derived amnion–chorion membranes (ACM), known for their bioactive composition of growth factors and cytokines, have demonstrated potential as a bioactive scaffold in regenerative medicine; however, their clinical application in...

  • Article
  • Open Access
3 Citations
1,811 Views
11 Pages

The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer

  • Efthymios Papadopoulos,
  • Andy Kin On Wong,
  • Sharon Hiu Ching Law,
  • Sarah Costa,
  • Angela M. Cheung,
  • Dmitry Rozenberg and
  • Shabbir M. H. Alibhai

6 December 2024

Frailty and myosteatosis are each prognostic of all-cause mortality (ACM) in patients with cancer. However, it is unclear whether myosteatosis adds value to frailty for predicting ACM. We assessed whether myosteatosis improves the predictive ability...

  • Article
  • Open Access
42 Citations
6,118 Views
15 Pages

28 October 2019

Asbestos-Containing Materials (ACMs) are hazardous and prohibited to be sold or used as recycled materials. In the past, asbestos was widely used, together with cement, to produce “asbestos cement-based” products. During the recycling pro...

  • Review
  • Open Access
1,452 Views
22 Pages

25 October 2025

Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac disease characterized by a progressive loss of cardiomyocytes associated with fibrofatty myocardial replacement, resulting in a heightened risk of ventricular arrhythmias and sudden cardiac dea...

  • Article
  • Open Access
5 Citations
3,183 Views
19 Pages

27 August 2021

With the further development of the automotive industry, the traditional vibration isolation method is difficult to meet the requirements for wide frequency bands under multiple operating conditions, the active control mount (ACM) is gradually paid a...

  • Article
  • Open Access
2,875 Views
20 Pages

Validation of an Eye-Tracking Algorithm Based on Smartphone Videos: A Pilot Study

  • Wanzi Su,
  • Damon Hoad,
  • Leandro Pecchia and
  • Davide Piaggio

Introduction: This study aimed to develop and validate an efficient eye-tracking algorithm suitable for the analysis of images captured in the visible-light spectrum using a smartphone camera. Methods: The investigation primarily focused on comparing...

  • Review
  • Open Access
33 Citations
6,155 Views
19 Pages

Calcium as a Key Player in Arrhythmogenic Cardiomyopathy: Adhesion Disorder or Intracellular Alteration?

  • Francesco Moccia,
  • Francesco Lodola,
  • Ilaria Stadiotti,
  • Chiara Assunta Pilato,
  • Milena Bellin,
  • Stefano Carugo,
  • Giulio Pompilio,
  • Elena Sommariva and
  • Angela Serena Maione

16 August 2019

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease characterized by sudden death in young people and featured by fibro-adipose myocardium replacement, malignant arrhythmias, and heart failure. To date, no etiological therapies are avai...

  • Review
  • Open Access
1,532 Views
27 Pages

Amyloid cardiomyopathy (ACM), driven by transthyretin (TTR) and immunoglobulin light chain (LC) amyloid fibrils, remains a major clinical challenge due to limited mechanistic understanding and insufficient preclinical models. Human-induced pluripoten...

  • Article
  • Open Access
1 Citations
2,137 Views
18 Pages

SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis

  • Takashi Iwai,
  • Rei Mishima,
  • Shigeto Hirayama,
  • Honoka Nakajima,
  • Misa Oyama,
  • Shun Watanabe,
  • Hideaki Fujii and
  • Mitsuo Tanabe

21 January 2024

The δ opioid receptor (DOR) inverse agonist has been demonstrated to improve learning and memory impairment in mice subjected to restraint stress. Here, we investigated the effects of SYK-623, a new DOR inverse agonist, on behavioral, immunohis...

  • Article
  • Open Access
79 Citations
9,993 Views
17 Pages

12 September 2018

Identifying and extracting building boundaries from remote sensing data has been one of the hot topics in photogrammetry for decades. The active contour model (ACM) is a robust segmentation method that has been widely used in building boundary extrac...

  • Article
  • Open Access
850 Views
13 Pages

Propensity Score-Matched Analysis of Neoadjuvant vs. Adjuvant Therapy in Renal Cell Carcinoma

  • Cesare Saitta,
  • Giacomo Musso,
  • Giuseppe Garofano,
  • Hajime Tanaka,
  • Dattatraya Patil,
  • Margaret F. Meagher,
  • Srinivas Vourganti,
  • Edward Cherullo,
  • Michael Liss and
  • Ithaar H. Derweesh
  • + 6 authors

29 October 2025

Objective: The aim was to compare outcomes in high-risk localized RCC (HRL-RCC) patients treated with adjuvant (AT) and neoadjuvant therapy (NT) utilizing a propensity score-matched model (PSM). Methods: We conducted a multicenter analysis (USA and J...

  • Article
  • Open Access
14 Citations
4,475 Views
11 Pages

Tissue-Engineering the Fibrous Pancreatic Tumour Stroma Capsule in 3D Tumouroids to Demonstrate Paclitaxel Response

  • Judith Pape,
  • Katerina Stamati,
  • Rawiya Al Hosni,
  • Ijeoma F. Uchegbu,
  • Andreas G. Schatzlein,
  • Marilena Loizidou,
  • Mark Emberton and
  • Umber Cheema

Pancreatic cancer is a unique cancer in that up to 90% of its tumour mass is composed of a hypovascular and fibrotic stroma. This makes it extremely difficult for chemotherapies to be delivered into the core of the cancer mass. We tissue-engineered a...

  • Article
  • Open Access
7 Citations
3,885 Views
15 Pages

15 June 2023

To meet the demands for miniaturization and multi-functional and high-performance electronics applications, the semiconductor industry has shifted its packaging approach to multi-chip vertical stacking. Among the advanced packaging technologies for h...

  • Article
  • Open Access
1 Citations
2,981 Views
11 Pages

Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy

  • Maicon Landim-Vieira,
  • Aida Rahimi Kahmini,
  • Morgan Engel,
  • Elisa Nicole Cannon,
  • Nuria Amat-Alarcon,
  • Daniel P. Judge,
  • José Renato Pinto and
  • Stephen P. Chelko

11 November 2022

Arrhythmogenic Cardiomyopathy (ACM) is a familial heart disease, characterized by contractile dysfunction, ventricular arrhythmias (VAs), and the risk of sudden cardiac death. Currently, implantable cardioverter defibrillators and antiarrhythmics are...

  • Article
  • Open Access
4 Citations
3,254 Views
15 Pages

Understanding and Ending the Lethal Asbestos Legacy

  • Simone Peta Stevenson,
  • Oonagh Barron,
  • Andrew Pakenham and
  • Masayoshi Hashinaka

31 January 2023

The Victorian Asbestos Eradication Agency (VAEA) was established to develop a long-term plan for the prioritised removal of asbestos containing materials (ACMs) from Victorian government-owned buildings. The safest and most sustainable way to end the...

  • Article
  • Open Access
13 Citations
4,780 Views
33 Pages

Fault-Prone Software Requirements Specification Detection Using Ensemble Learning for Edge/Cloud Applications

  • Fatin Nur Jannah Muhamad,
  • Siti Hafizah Ab Hamid,
  • Hema Subramaniam,
  • Razailin Abdul Rashid and
  • Faisal Fahmi

19 July 2023

Ambiguous software requirements are a significant contributor to software project failure. Ambiguity in software requirements is characterized by the presence of multiple possible interpretations. As requirements documents often rely on natural langu...

  • Article
  • Open Access
5 Citations
3,418 Views
14 Pages

Myocardial Injury Caused by Chronic Alcohol Exposure—A Pilot Study Based on Proteomics

  • Xiaonan Ma,
  • Zihan Liao,
  • Rongxuan Li,
  • Wei Xia,
  • Honghui Guo,
  • Jiawei Luo,
  • Huaxin Sheng,
  • Meihui Tian and
  • Zhipeng Cao

Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined as alcoholic cardiomyopathy (ACM). Alcohol-mediated myocardial injury has previously been studied through met...

  • Feature Paper
  • Review
  • Open Access
27 Citations
6,392 Views
31 Pages

Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design

  • Tyler L. Stevens,
  • Michael J. Wallace,
  • Mona El Refaey,
  • Jason D. Roberts,
  • Sara N. Koenig and
  • Peter J. Mohler

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its pathological ventricular substrate predisposes subjects to an increased r...

  • Review
  • Open Access
1 Citations
2,674 Views
11 Pages

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease associated with ventricular arrhythmias and a high risk of sudden cardiac death (SCD). Although the disease was described over 40 years ago, its diagnosis is still difficult. Several studi...

  • Article
  • Open Access
11 Citations
3,713 Views
16 Pages

The Impact of Specialised Heart Failure Outpatient Care on the Long-Term Application of Guideline-Directed Medical Therapy and on Prognosis in Heart Failure with Reduced Ejection Fraction

  • Balázs Muk,
  • Fanni Bánfi-Bacsárdi,
  • Máté Vámos,
  • Dávid Pilecky,
  • Zsuzsanna Majoros,
  • Gábor Márton Török,
  • Dénes Vágány,
  • Balázs Polgár,
  • Balázs Solymossi and
  • Noémi Nyolczas
  • + 5 authors

(1) Background: Besides the use of guideline-directed medical therapy (GDMT), multidisciplinary heart failure (HF) outpatient care (HFOC) is of strategic importance in HFrEF. (2) Methods: Data from 257 hospitalised HFrEF patients between 2019 and 202...

  • Article
  • Open Access
39 Citations
5,972 Views
12 Pages

Artificial Circulatory Model for Analysis of Human and Artificial Vessels

  • Andrzej Polanczyk,
  • Markus Klinger,
  • Josif Nanobachvili,
  • Ihor Huk and
  • Christoph Neumayer

22 June 2018

Background: Ex vivo computer controlled circulatory reactors are advantageous for the investigation of circulatory systems. So far, most of the models have dealt with laminar or pulsatile flow. This study aimed to monitor blood vessel and vessel graf...

  • Article
  • Open Access
5 Citations
3,449 Views
7 Pages

26 July 2019

We demonstrate an ultra-low efficiency droop in c-plane polar InGaN blue light-emitting diodes (LEDs) by reducing the carrier density using a wide InGaN last quantum well (LQW). It is found that the LEDs with a 5.2 nm thick LQW show a negligible effi...

  • Article
  • Open Access
6 Citations
3,087 Views
22 Pages

Simulating Meteorological and Water Wave Characteristics of Cyclone Shaheen

  • Mohsen Rahimian,
  • Mostafa Beyramzadeh,
  • Seyed Mostafa Siadatmousavi and
  • Mohammad Nabi Allahdadi

10 March 2023

The Bay of Bengal and Arabian Sea are annually exposed to severe tropical cyclones, which impose massive infrastructure damages and cause the loss of life in coastal regions. Cyclone Shaheen originally generated in the Bay of Bengal in 2021 and trans...

  • Proceeding Paper
  • Open Access
381 Views
9 Pages

25 November 2024

Guided ultrasonic wave (GUW) analysis is a well-investigated method for structural health monitoring (SHM) applications. For plate-like structures, the pitch-catch technique is a popular choice since it offers the possibility to investigate a large a...

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